Bacterial differentiation, development, and disease: mechanisms for survival.

Abstract:

:Bacteria have the exquisite ability to maintain a precise diameter, cell length, and shape. The dimensions of bacteria size and shape are a classical metric in the distinction of bacterial species. Much of what we know about the particular morphology of any given species is the result of investigations of planktonic cultures. As we explore deeper into the natural habitats of bacteria, it is increasingly clear that bacteria can alter their morphology in response to the environment in which they reside. Specific morphologies are also becoming recognized as advantageous for survival in hostile environments. This is of particular importance in the context of both colonization and infection in the host. There are multiple examples of bacterial pathogens that use morphological changes as a mechanism for evasion of host immune responses and continued persistence. This review will focus on two systems where specific morphological changes are essential for persistence in animal models of human disease. We will also offer insight into the mechanism underlying the morphological changes and how these morphotypes aid in persistence. Additional examples of morphological changes associated with survival will be presented.

journal_name

FEMS Microbiol Lett

authors

Justice SS,Harrison A,Becknell B,Mason KM

doi

10.1111/1574-6968.12602

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1-8

issue

1

eissn

0378-1097

issn

1574-6968

journal_volume

360

pub_type

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