Abstract:
:Acetone-butanol-ethanol (ABE) fermentation is a metabolic process of clostridia that produces bio-based solvents including butanol. It is enabled by an underlying metabolic reaction network and modulated by cellular gene regulation and environmental cues. Mathematical modeling has served as a valuable strategy to facilitate the understanding, characterization and optimization of this process. In this review, we highlight recent advances in system-level, quantitative modeling of ABE fermentation. We begin with an overview of integrative processes underlying the fermentation. Next we survey modeling efforts including early simple models, models with a systematic metabolic description, and those incorporating metabolism through simple gene regulation. Particular focus is given to a recent system-level model that integrates the metabolic reactions, gene regulation and environmental cues. We conclude by discussing the remaining challenges and future directions towards predictive understanding of ABE fermentation.
journal_name
FEMS Microbiol Lettjournal_title
FEMS microbiology lettersauthors
Liao C,Seo SO,Lu Tdoi
10.1093/femsle/fnw074subject
Has Abstractpub_date
2016-05-01 00:00:00issue
9eissn
0378-1097issn
1574-6968pii
fnw074journal_volume
363pub_type
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