Abstract:
:The major haem component in the black pigment of Porphyromonas gingivalis is the mu-oxo bishaem of iron protoporphyrin IX and formation and cell-surface binding of this haem species is proposed as an extracellular buffer against reactive oxidants [Smalley, J.W. et al. (1998) Biochem. J. 331, 681-685]. P. gingivalis cells grown in the presence of the mu-oxo bishaem were protected against H(2)O(2) compared to control cells grown without it. When added to the growth medium, soluble mu-oxo bishaem inactivated H(2)O(2) and supported cell growth. Cells carrying a surface layer of mu-oxo bishaem were less susceptible to peroxidation by H(2)O(2). Cell-surface haems were slowly destroyed during reaction with H(2)O(2). Binding of mu-oxo bishaem by P. gingivalis may aid survival during neutrophil attack through inactivation of hydrogen peroxide.
journal_name
FEMS Microbiol Lettjournal_title
FEMS microbiology lettersauthors
Smalley JW,Birss AJ,Silver Jdoi
10.1111/j.1574-6968.2000.tb08951.xkeywords:
subject
Has Abstractpub_date
2000-02-01 00:00:00pages
159-64issue
1eissn
0378-1097issn
1574-6968pii
S0378-1097(99)00660-6journal_volume
183pub_type
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