Abstract：
:Although most papillary thyroid microcarcinomas (PMCs) are of little clinical significance, patients with PMCs occasionally have an unfavorable outcome, especially when they present with bulky nodal metastasis or distant metastasis. We have attempted to identify "high-risk" PMCs by evaluating clinical, pathologic, and immunohistochemical prognostic factors. Among 190 patients with a PMC, 156 without clinically apparent nodal metastasis had a benign course. The remaining 34 patients, who presented with cervical lymphadenopathy of at least 1 cm, were studied. Three of the four patients who developed distant metastasis died of the disease, and the other died of local recurrence. All patients who developed distant metastasis or died of the disease had both nodal metastasis of at least 3 cm and a nonencapsulated type of primary lesion. All patients who developed distant metastasis showed both extracapsular extension of the metastatic lesions in lymph nodes and positive staining for transforming growth factor-beta3 (TGFbeta3) (a potent growth inhibitor) in the primary lesion. The Ki-67 (an indicator of cell proliferation) labeling indices in the primary and metastatic nodal lesions of patients who died of cancer were significantly higher than those of the others with nonfatal disease. None of the patients showed P53 (nuclear tumor-suppressor phosphoprotein) overexpression. In conclusion, patients with PMC who have both 3 cm or larger lymphadenopathy and a nonencapsulated type of primary lesion may be regarded as high-risk patients. Immunohistologic positivity for Ki-67 and TGFbeta3 in cancer cells is a potential indicator of aggressively malignant PMC.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Sugitani I,Yanagisawa A,Shimizu A,Kato M,Fujimoto Ydoi
10.1007/s002689900461subject
Has Abstractpub_date
1998-07-01 00:00:00pages
731-7issue
7eissn
0364-2313issn
1432-2323journal_volume
22pub_type
杂志文章abstract：BACKGROUND:Anastomotic leakage is a serious clinical problem after colorectal resections and is associated with a significantly increased length of stay, morbidity and mortality. The aim of the present study was to evaluate the effect of changes in clinical practice on anastomotic leakage rate after colorectal resectio...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4423-7
更新日期：2018-07-01 00:00:00
abstract：:The angiogenic factor called vascular endothelial growth factor (VEGF)-D is a ligand for VEGF receptor-2 (VEGFR-2/KDR) and receptor-3 (VEGFR-3/Flt-4). It is implicated in the development of lymphatic vessels and promotion of lymphatic metastasis. The purpose of this study was to investigate the prognostic significance...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0076-z
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:LLR is widely adapted for HCC, while LLR in PS segments is still challenging. With recent improvement of techniques and accumulation of experiences, LLR in PS segments is feasible, but studies investigating the result after the modifications are lacking. METHODS:In this single-center, retrospective study, 1...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05912-5
更新日期：2021-01-13 00:00:00
abstract：BACKGROUND:Delayed access to surgical care for congenital conditions in low- and middle-income countries is associated with increased risk of death and life-long disabilities, although the actual burden of delayed access to care is unknown. Our goal was to quantify the burden of disease related to delays to surgical ca...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05239-w
更新日期：2020-03-01 00:00:00
abstract：:Controversy remains regarding the best surgical approach for toxic multinodular goiter (MNG). The aim of this study was to evaluate the results of various thyroid operations for managing toxic MNG. A group of 100 patients with toxic MNG were divided into three groups and managed with total thyroidectomy (TT; group I, ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7767-3
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND:Laparoscopic intersphincteric resection (ISR) after neoadjuvant chemoradiation is helpful in the management of patients with low rectal cancer. With the advent of this technique, the need for performance of abdominoperineal resection seems to have decreased in patients with very low rectal tumors. The aim of...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1277-2
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Organ shortage is the greatest challenge facing the field of organ transplantation today. Use of more organs of marginal quality has been advocated to address the shortage. METHOD:We examined the pattern of donation and organ use in the United States as shown in the Organ Procurement and Transplantation Net...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1748-0
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:The commonest surgical treatment used for peptic ulcer perforation is omental patching. If, however, the perforation leaks, it rarely heals by itself due to persistence of duodenal fistula (DF). We present our experience with a T-tube placed into the DF for better outcome of the patients. METHODS:All patien...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2196-1
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:The aim of this work was to study the impact of anemia on surgical outcomes and the impact of instituting appropriate workup and treatment of anemia on surgical outcomes. METHODS:We conducted a case-control retrospective chart review of all hernia repair, hydrocele repair, and hysterectomy cases at the SEAR...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1615-z
更新日期：2012-09-01 00:00:00
abstract：INTRODUCTION:The impact of diabetes mellitus (DM) on outcomes in patients undergoing emergency laparotomy for adhesive small bowel obstruction (ASBO) remains unknown. METHODS:Low-risk (ASA class of I and II) patients requiring emergency operation for ASBO were identified using the ACS NSQIP database. Propensity score ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3338-4
更新日期：2016-04-01 00:00:00
abstract：:Surgical education in the United Kingdom has evolved to meet the need of the National Health Service (NHS) for a relatively small body of consultants practicing autonomously and carrying ultimate clinical responsibility for their patients. This form of specialist practice is markedly different from that found in most ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF00298916
更新日期：1994-09-01 00:00:00
abstract：:During the three decades since the recognition of the Zollinger-Ellison syndrome (ZES), major progress has been made in the diagnosis and treatment of this disease. However, the many failed operations in patients with ZES, the existence of primary lymph node gastrinomas, and the surgical approach of patients with ZES ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01655107
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:Abdominal compartment syndrome (ACS) is a difficult entity with two main problems during its course: (1) survival of the patient during the early period and (2) closure of the open wounds during the late period. In this study we evaluated the decision to decompress according to the level of intraabdominal pr...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9286-x
更新日期：2008-01-01 00:00:00
abstract：:The goal of fluid resuscitation in the burn patient is maintenance of vital organ function at the least immediate or delayed physiological cost. To optimize fluid resuscitation in severely burned patients, the amount of fluid should be just enough to maintain vital organ function without producing iatrogenic pathologi...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02067109
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:The skin is closed in open appendectomy traditionally with few interrupted nonabsorbable sutures. The use of this old method is based on a suggestion that this technique decreases wound infections. In pediatric surgery, skin closure with running intradermal absorbable sutures has been found to be as safe as ...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-012-1664-3
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:The aim of this study was to compare the influence of either general (GA) or local (LA) anesthesia on the postoperative neurocognitive outcome in patients undergoing carotid endarterectomy (CEA) in a randomized study. Therefore, we performed a subgroup analysis of the multicenter GALA study. METHODS:A total...
journal_title：World journal of surgery
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00268-009-0047-x
更新日期：2009-07-01 00:00:00
abstract：:The aim of this study was to investigate the prognostic factors for hepatocellular carcinoma (HCC) in patients without cirrhosis who underwent hepatectomy. Between 1986 and 1998 a total of 197 men and 57 women with noncirrhotic HCC underwent hepatic resection in the Department of Surgery, Chang Gung Memorial Hospital,...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6708-7
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:Despite its wide use, catheter tract recurrence after percutaneous biliary drainage (PBD) is rarely reported. However, one recent large-scale study reported a catheter tract recurrence rate as high as 5.2 % in patients with perihilar or distal bile duct cancer. We report on our 20 years of experience with ca...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1844-1
更新日期：2013-02-01 00:00:00
abstract：:The success of parathyroid surgery is determined by the identification and removal of all parathyroid tumors. Parathyroid tumors accumulate and retain 2-methoxyisobutylisonitrile (MIBI) labeled with technetium-99m. Intravenous injection of this radiopharmacon prior to parathyroid surgery allows identification of parat...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章
doi：10.1007/s002689900427
更新日期：1998-06-01 00:00:00
abstract：BACKGROUND:Intense disease surveillance and frequent lymph node metastases (LNMs) in papillary thyroid cancer (PTC) have resulted in increased locoregional recurrences. We examined the safety and efficacy of an optimized surgical approach including preoperative ultrasonography (US), bilateral thyroidectomy, routine com...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0307-9
更新日期：2010-06-01 00:00:00
abstract：:Laparoscopic fundoplication is increasingly used for treating gastro-esophageal reflux disease in children. Mechanical and pharmacological effects may contribute to hemodynamic and respiratory changes during carbon dioxide pneumoperitoneum. The aim of the present study was to evaluate the hemodynamic and respiratory e...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7695-2
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND:The open surgical wound is exposed to cold dry ambient air, resulting in substantial heat loss through radiation, evaporation, and convection. At the same time, anesthesia decreases the patient's core temperature. Despite preventive measures, mild intraoperative hypothermia has been associated with postopera...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-012-1735-5
更新日期：2012-11-01 00:00:00
abstract：:To clarify the clinical significance of the status of surgical margins, especially the dissected margin in the transverse direction, a clinicopathologic study was performed on 60 patients with carcinoma of the bile duct who underwent radical resection. The patients in group A (n = 28) had no cancer invasion within 5 m...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00298931
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND:The present study evaluated outcomes of patients undergoing proximal diversion using either a loop ileostomy or loop colostomy following distal colorectal resection for malignant and non-malignant disease. METHODS:A literature search of the Medline, Ovid, Embase and Cochrane databases was performed to ident...
journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00268-006-0218-y
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:In this retrospective cohort single-institutional study, we report the outcomes of implementing a standardized protocol of multimodal pain management with thoracic epidural analgesia via the acute pain service (APS) for patients undergoing ventral hernia repair with mesh placement and abdominal wall recons...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05915-2
更新日期：2021-01-16 00:00:00
abstract：BACKGROUND:Laparoscopic cholecystectomy (LC) with common bile duct exploration (LCBDE) is nowadays a preferred one-stage treatment. However, the influence of complicated cholecystitis (CC) on LCBDE has rarely been addressed. In the present study we aimed to verify whether severe gallbladder inflammation would adversely...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1696-8
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:A majority of patients with small intestinal neuroendocrine tumors (SI-NETs) present with or develop liver metastases (LM). A number of treatments for LM are used clinically, including liver transplantation (LTx). Indications for LTx are under debate; young age(<65 years), absence of extrahepatic disease, re...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2331-z
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Traditional perioperative care for colonic surgery in elderly patients is associated with increased morbidity and mortality compared to that of younger patients. Although multimodal perioperative rehabilitation has evolved as a valid concept to improve postoperative outcome, its use has not yet been establis...
journal_title：World journal of surgery
pub_type： 杂志文章,多中心研究
doi：10.1007/s00268-009-0018-2
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Surgical care is not uniformly available worldwide. Inequities in surgical care and access may also vary within countries, and the present study aimed to explore these disparities in Pakistan. METHODS:The National Health Survey of Pakistan was analyzed. The proportion of people with a history of abdominal s...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1732-8
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:The goal of the present study was to determine the frequency, mode of presentation, and need for reoperation in the treatment of recurrent inguinal hernia at Liaquat University Hospital, Jamshoro, Sindh, Pakistan. METHODS:This descriptive, cross-sectional study was conducted over a period of four years, fro...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1897-1
更新日期：2013-03-01 00:00:00
