Abstract:
:During the three decades since the recognition of the Zollinger-Ellison syndrome (ZES), major progress has been made in the diagnosis and treatment of this disease. However, the many failed operations in patients with ZES, the existence of primary lymph node gastrinomas, and the surgical approach of patients with ZES and multiple endocrine neoplasia type I (MEN-I) have remained controversial issues. In this review, our experience with the pathology of immunocytochemically identified gastrinomas in 44 patients with ZES is presented and related to the relevant literature. (1) Gastrinomas occur frequently in the duodenum (> 40%) and are commonly small (< 1 cm). They can therefore easily be missed at surgical exploration; lymph node metastases from such occult gastrinomas may be mistaken for primary tumors. (2) Most pancreatic gastrinomas reside in the head of the gland and have a diameter of 1 to 3 cm. (3) Gastrinomas associated with MEN-I are predominantly of duodenal origin and frequently multicentric; sporadic gastrinomas are single and more often pancreatic. Because MEN-I associated pancreatic tumors seldom contain gastrin, ZES in MEN-I patients is almost never cured by resection of the pancreatic tumors. (4) The metastatic potential of most small duodenal gastrinomas seems to be restricted to the regional lymph nodes.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Pipeleers-Marichal M,Donow C,Heitz PU,Klöppel Gdoi
10.1007/BF01655107subject
Has Abstractpub_date
1993-07-01 00:00:00pages
481-8issue
4eissn
0364-2313issn
1432-2323journal_volume
17pub_type
杂志文章,评审abstract:BACKGROUND:Neoadjuvant chemotherapy (NC) is standard therapy for patients with locally advanced breast cancer and is increasingly used for early-stage operable disease. Clinical and pathological responses are important prognostic parameters for NC, which aims to achieve a pathological complete response or tumor reducti...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9800-9
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Thymic epithelial tumors are characterized by slow growth and variable malignant behavior. We present our experience on the surgical management of these tumors. MATERIALS AND METHODS:We conducted a retrospective analysis of patients with thymomas undergoing modified maximal thymectomy over a period of 16 ye...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0097-0
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Up to 50% of patients in intensive care units develop intraabdominal hypertension (IAH) in the course of medical treatment. If not detected on time and treated adequately, IAH may develop into an abdominal compartment syndrome (ACS) which is associated with a high mortality rate. Patients undergoing cardiac ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05917-0
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND:Perioperative blood transfusion has been shown to be associated with poor outcome in various types of malignancy. However, the relationship between the amount of blood loss and specific types of cancer recurrence has not been documented. METHODS:We retrospectively examined the amount of intraoperative blood...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-9979-4
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Laparoscopic intersphincteric resection (ISR) after neoadjuvant chemoradiation is helpful in the management of patients with low rectal cancer. With the advent of this technique, the need for performance of abdominoperineal resection seems to have decreased in patients with very low rectal tumors. The aim of...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1277-2
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The technical complexity of pancreatic resection has made it a specialized procedure performed in high-volume centers. It has been shown that patients operated on in high-volume pancreatobiliary centers have fewer complications and better survival. The purpose of this study was to share our experience with a...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2644-6
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Billions of people worldwide lack access to safe affordable surgery. Surgical missions and non-governmental organisations (NGO) are vital in meeting this need, but long-term outcomes are rarely reported. Mercy Ships is a surgical NGO, and we aimed to measure disability-free survival, impact and patient satis...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-016-3745-1
更新日期:2017-02-01 00:00:00
abstract::Laparoscopic fundoplication is increasingly used for treating gastro-esophageal reflux disease in children. Mechanical and pharmacological effects may contribute to hemodynamic and respiratory changes during carbon dioxide pneumoperitoneum. The aim of the present study was to evaluate the hemodynamic and respiratory e...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-7695-2
更新日期:2005-05-01 00:00:00
abstract::Pectus excavatum (PE) is one of the most common anomalies of childhood. It occurs in approximately 1 in every 400 births, with males afflicted 5 times more often than females. PE is usually recognized in infancy, becomes much more severe during adolescent growth years, and remains constant throughout adult life. Sympt...
journal_title:World journal of surgery
pub_type: 社论,评审
doi:10.1007/s00268-003-7025-5
更新日期:2003-05-01 00:00:00
abstract::There is debate regarding use of the stereotactic core-needle biopsy (SCNB) for highly suspicious mammographic lesions. This study compares a serial group of mammography-detected breast cancer patients treated before and after the use of SCNB. We studied 113 consecutive nonpalpable breast cancers between 1994 and 1996...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900510
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:The morbidity and mortality of anastomotic complications after esophagectomy have gradually decreased in recent years. However, swallowing difficulties and reflux continue to burden patients jeopardizing their quality of life. In the present study we performed endoscopic evaluation of the outcomes of esophag...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9664-z
更新日期:2008-09-01 00:00:00
abstract::There is a need for relevant, valid, and practical metrics to better quantify both need and progress in global pediatric surgery and for monitoring systems performance. There are several existing surgical metrics in use, including disability-adjusted life years (DALYs), surgical backlog, effective coverage, cost-effec...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-018-4868-3
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:The postoperative functional advantages of a proximal gastrectomy over a total gastrectomy remain debatable. The aim of this study was to evaluate the functional outcomes of a proximal gastrectomy with jejunal interposition (PG-JI), compared with those for a total gastrectomy with Roux-en-Y esophagojejunosto...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-3180-8
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Patients with stage II colorectal cancer (CRC) have a higher risk of recurrence when they have certain risk factors, including clinical and pathological patterns. However, as the prognostic role of molecular patterns for stage II disease is still unclear, this study aimed to investigate it. METHODS:A total ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05158-w
更新日期:2019-12-01 00:00:00
abstract::The pathogenesis of pain in chronic pancreatitis remains an enigma. The cause of pain is almost certainly multifactorial and may vary at different stages of the disease process. These factors may include the release of excessive oxygen-derived free radicals, tissue hypoxia and acidosis, inflammatory infiltration with ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-003-7235-x
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) plays an essential role in the evaluation of lymph node (LN) metastasis status and the extent of LN dissection in gastric cancer. The aim of our study was to perform a systematic review and meta-analysis for corresponding identification rate and sensitivity of different SLNB...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-020-05900-9
更新日期:2021-01-03 00:00:00
abstract:BACKGROUND:Exact tissue identification during parathyroidectomy is essential to successfully cure hyperparathyroidism. PTH level determination from tissue aspirates has been advocated as a "biochemical frozen section" for parathyroid tissue identification. We investigated the sensitivity and specificity of this method ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0351-5
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Whilst injuries are a major cause of disability and death worldwide, a large proportion of people in low- and middle-income countries lack timely access to injury care. Barriers to accessing care from the point of injury to return to function have not been delineated. METHODS:A two-day workshop was held in ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05571-6
更新日期:2020-09-01 00:00:00
abstract::Carnitine, an important carrier of free fatty acid that is transported into mitochondria for beta-oxidation, was thought to be one of the key factors in the regulation of liver regeneration. If the carnitine content is insufficient in the hepatocyte, it might impair the energy substrate's transport and the energy char...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900347
更新日期:1998-01-01 00:00:00
abstract::The metabolic changes in cancer cachexia appear to be mediated by a complex network of proinflammatory cytokines, neuroendocrine hormones, neurotransmitters, eicosanoids, and tumor-derived factors produced by the body in response to the tumor and by the tumor itself. The relative importance of these various mediator p...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s002689910110
更新日期:2000-06-01 00:00:00
abstract::Treacher Collins Syndrome is a rare bilateral congenital deformity occurring in 1 in 10,000 births. It is also known, in the European literature, as Franceschetti Syndrome, and is additionally known as mandibulofacial dysostosis. It is a syndrome with a very wide spectrum of manifestations characterized by distortions...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01660753
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Mutations in BRCA1 and BRCA2 confer an increased risk to breast and other cancers, but to date there have only been limited numbers of studies of BRCA1- and BRCA2-associated cancers among Asians. Malaysia is a multiracial country with three main races: Malays, Chinese, Indians. We determined whether tumor pa...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0146-8
更新日期:2009-10-01 00:00:00
abstract::The aim of this study was to investigate the collagen matrix in recurrent inguinal hernias. Total ribonucleic acid (RNA) was extracted from skin fibroblasts of three groups (control group I = healthy skin; control group II = plain skin scar; recurrent inguinal hernia group = skin of recurrent inguinal hernias; each n ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-001-0239-5
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Pulmonary resection is the best therapeutic option for lung metastases from colorectal cancer (CRC) today. However, recurrences are frequent following pulmonary resection. We aimed to evaluate the recurrence pattern and treatment of initial pulmonary resection for metastases from CRC. METHODS:Data from 76 p...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-3006-8
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:This is a baseline assessment of surgical capacity in the Federal Capital Territory (FCT), in preparation for the creation of a National Surgical, Obstetric, Anesthesia, and Nursing Plan. METHODS:In October 2017, all 10 of the 11 secondary hospitals in FCT that provide surgical and/or obstetric care were su...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4835-z
更新日期:2019-03-01 00:00:00
abstract::To clarify the clinical significance of the status of surgical margins, especially the dissected margin in the transverse direction, a clinicopathologic study was performed on 60 patients with carcinoma of the bile duct who underwent radical resection. The patients in group A (n = 28) had no cancer invasion within 5 m...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00298931
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Surgery is the best treatment for primary GIST and may be curative, but resection extension/completeness impact on the prognosis remains controversial. The authors aim was to evaluate the clinicopathological (CP) parameters and surgical margins status influence on GIST patients' outcome. MATERIALS AND METHO...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9704-8
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:The aim of the study was to compare the changes in health-related quality of life (QOL) after lung surgery between young and old patients. METHODS:We performed a prospective, population-based, cohort study to investigate health-related QOL before and 6 months after lung surgery. We used the validated instru...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0430-7
更新日期:2010-04-01 00:00:00
abstract::The release of the neuronal protein S-100B into the circulation has been suggested as an early indication of cellular brain damage. The objective of this prospective pilot study was to determine S-100B serum levels in patients undergoing cross-clamping during carotid endarterectomy (CEA) and to correlate the results w...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-002-6547-6
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:There is increasing interest in provision of essential surgical care as part of public health policy in low- and middle-income countries (LMIC). Relatively simple interventions have been shown to prevent death and disability. We reviewed the published literature to examine the cost-effectiveness of simple su...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2243-y
更新日期:2014-01-01 00:00:00