Disordered metabolic response with cancer and its management.

Abstract:

:The metabolic changes in cancer cachexia appear to be mediated by a complex network of proinflammatory cytokines, neuroendocrine hormones, neurotransmitters, eicosanoids, and tumor-derived factors produced by the body in response to the tumor and by the tumor itself. The relative importance of these various mediator pathways in relation to either the anorexia or hypermetabolism associated with weight loss in cancer remains to be fully elucidated. Our current understanding suggests that proinflammatory mediators may indeed be a valid target for therapeutic intervention. Trials attempting to modify the inflammatory response to cancer with the hope of improving appetite and reversing catabolism and perhaps thereby improving qualityof life and survival are currently underway.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Barber MD,Ross JA,Fearon KC

doi

10.1007/s002689910110

keywords:

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

681-9

issue

6

eissn

0364-2313

issn

1432-2323

pii

10.1007/s002689910110

journal_volume

24

pub_type

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