Abstract：
BACKGROUND:Intraoperative cerebral oxygen desaturation was reported to be associated with postoperative cognitive dysfunction in elderly patients. The effect of the anesthesia method on regional cerebral oxygen saturation (rSO(2)) is still a question under debate. The purpose of this study was to compare the effects of three common anesthesia methods on intraoperative rSO(2) changes in elderly patients. METHODS:In this prospective randomized clinical trial, 87 patients scheduled for elective transurethral prostatectomy were allocated to receive general inhalational anesthesia (GA group, n = 30), spinal anesthesia (SA group, n = 28), or spinal anesthesia plus sedation with midazolam (SA+S group, n = 29). RESULTS:The numbers of patients showing a decrease in rSO(2) below the baseline value were higher in the SA (92.9 %) and SA+S (100 %) groups than in the GA group (33.3 %). The number of patients with a ≥ 50 % decrease in rSO(2) below baseline was greater in the SA+S (31.0 %) group than in the GA (0 %) or SA (3.6 %) group. During surgery, patients subjected to general anesthesia had higher rSO(2) than those with spinal anesthesia. Blood pressures and heart rates were similar in three groups except 5 and 10 min after anesthesia. Intraoperative SpO(2) was higher in the GA group than in the two spinal anesthesia groups. CONCLUSIONS:Spinal anesthesia is associated with more frequent cerebral desaturation than general anesthesia; and it was aggravated when combined with midazolam sedation. The cerebral effects of anesthesia should be considered when managing high-risk elderly patients.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Lee A,Kim SH,Hong JY,Hwang JHdoi
10.1007/s00268-012-1676-zsubject
Has Abstractpub_date
2012-10-01 00:00:00pages
2328-34issue
10eissn
0364-2313issn
1432-2323journal_volume
36pub_type
杂志文章,随机对照试验abstract：:In the original article, Mehreen K. Bhettani's last name and Mubarik Rehman's first name are misspelled. ...
journal_title：World journal of surgery
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00268-019-05334-y
更新日期：2020-06-01 00:00:00
abstract：:Technetium 99m ((99m)Tc)-methoxyisobutylisonitrile (MIBI) scintigraphy has been reported to be a useful method for visualizing the parathyroid glands for the diagnosis of hyperparathyroidism. Some drug metabolism transporters, such as p-glycoprotein (P-GP) or multidrug resistance-associated protein (MRP), are believed...
journal_title：World journal of surgery
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journal_title：World journal of surgery
pub_type： 杂志文章
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
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journal_title：World journal of surgery
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,meta分析,评审
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更新日期：2008-11-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
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更新日期：2000-11-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
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journal_title：World journal of surgery
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2008-01-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1991-03-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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journal_title：World journal of surgery
pub_type： 杂志文章
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
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journal_title：World journal of surgery
pub_type： 杂志文章
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
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更新日期：2000-10-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
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journal_title：World journal of surgery
pub_type： 杂志文章
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
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