Abstract：
:Technetium 99m ((99m)Tc)-methoxyisobutylisonitrile (MIBI) scintigraphy has been reported to be a useful method for visualizing the parathyroid glands for the diagnosis of hyperparathyroidism. Some drug metabolism transporters, such as p-glycoprotein (P-GP) or multidrug resistance-associated protein (MRP), are believed to be involved with one mechanism of (99m)Tc-MIBI accumulation in the parathyroid glands. We analyzed the expression of P-GP and MRP in 40 parathyroid glands from eight patients with primary hyperparathyroidism and six patients with secondary hyperparathyroidism using an immunohistochemical procedure. These patients underwent (99m)Tc-MIBI scintigraphy and thallium 201 ((201)Tl)/(99m)Tc subtraction scintigraphy preoperatively. We investigated the relation between the scintigraphic images and the expression of P-GP and MRP. The positive findings of (99m)Tc-MIBI accumulation in the hyperfunctioning parathyroids were increased significantly. There was a significant difference between the expression of P-GP and the (99m)Tc-MIBI scintigraphy findings. High expression of P-GP in parathyroid cells resulted in the negative image of (99m)Tc-MIBI, and low or no expression of P-GP made the image positive. There was no significant difference between the expression of MRP and the (99m)Tc-MIBI scintigraphic imaging. The (99m)Tc-MIBI image was also related to the weight of the parathyroid glands but not to the type of the parathyroid cells. Based on these clinical findings, we can hypothesize that P-GP functions as a drug transporter not only for chemotherapeutic agents but also for (99m)Tc-MIBI.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Yamaguchi S,Yachiku S,Hashimoto H,Kaneko S,Nishihara M,Niibori D,Shuke N,Aburano Tdoi
10.1007/s00268-001-0177-2keywords:
subject
Has Abstractpub_date
2002-01-01 00:00:00pages
29-34issue
1eissn
0364-2313issn
1432-2323journal_volume
26pub_type
杂志文章abstract：BACKGROUND:Currently, most patients undergoing laparoscopic cholecystectomy (LC) in Switzerland are inpatients for 2-3 days. Due to a lack of available hospital beds, we asked whether day-case surgery would be an option for patients in central Switzerland. The questions of acceptability of outpatient LC and factors con...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4098-0
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Peritoneal adhesions are recognized as an important cause for patient morbidity, but complications related to adhesions occur relatively late after the original operation. Therefore preoperative consent may not adequately reflect the proportions of the problem. METHODS:A total of 200 patients admitted for i...
journal_title：World journal of surgery
pub_type： 杂志文章,多中心研究
doi：10.1007/s00268-008-9917-x
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:The only potential cure for neuroendocrine tumors (NETs) is operative resection, which may also offer a survival benefit for advanced disease. We aimed to assess the role of 68Ga-DOTATATE PET/CT in preoperative planning and compared its performance to CT with IV contrast and MRI with Eovist®, for abdominal N...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05216-3
更新日期：2020-02-01 00:00:00
abstract：OBJECT:The massive typhoon Haiyan (Yolanda) ripped across the central Philippines on November 8, 2013, and damaged infrastructure including hospitals. The Israeli Defense Forces field hospital was directed by the Philippine authorities to Bogo City in the northern part of the island of Cebu, to assist the damaged local...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3692-x
更新日期：2017-02-01 00:00:00
abstract：:The aim of this study was to investigate the prognostic factors for hepatocellular carcinoma (HCC) in patients without cirrhosis who underwent hepatectomy. Between 1986 and 1998 a total of 197 men and 57 women with noncirrhotic HCC underwent hepatic resection in the Department of Surgery, Chang Gung Memorial Hospital,...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6708-7
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:Treatment of peripherally located liver tumors with diaphragmatic invasion is technically demanding but does not preclude resection for cure. The aim of the present study was to compare patients undergoing combined liver and diaphragmatic resection with those submitted to hepatectomy alone so as to evaluate ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2083-9
更新日期：2013-09-01 00:00:00
abstract：:Pancreas transplantation has emerged as the single most effective way to achieve normal glucose homeostasis inpatients with type I insulin-dependent diabetes mellitus. Optimal immunosuppressive strategies for pancreas transplantation continue to evolve with the use of newer, more potent immunosuppressive agents,partic...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-001-0207-0
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:Pilonidal sinus is a common chronic disease affecting young adults. Many surgical procedures have been developed for its treatment, but an optimal one has still not been achieved. This study presents a modification to the Karydakis operation. METHODS:A total of 265 patients with chronic pilonidal sinus betw...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4406-8
更新日期：2018-06-01 00:00:00
abstract：:Transcutaneous laryngeal ultrasonography (TLUSG) is a promising alternative to laryngoscopy in vocal cords (VCs) assessment which might be challenging in the beginning. However, it remains unclear when an assessor can provide proficient TLUSG enough to abandon direct laryngoscopy . Eight surgical residents (SRs) witho...
journal_title：World journal of surgery
pub_type： 历史文章,杂志文章
doi：10.1007/s00268-015-3348-2
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:The appropriate surgical approach for hepatocellular carcinoma (HCC) patients of Child-Pugh class B is unclear. The aim of this study was to clarify the prognostic factors after hepatectomy in Child-Pugh class B patients and to delineate the selection criteria for hepatectomy. METHODS:One hundred fifty pati...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0929-y
更新日期：2011-04-01 00:00:00
abstract：INTRODUCTION:Parathyroid cysts are rare but clinically significant lesions. They can be functional, mistaken for a thyroid cyst, and/or managed nonoperatively on occasion. METHODS:We identified seven patients (1 male, 6 females) with the diagnosis of parathyroid cyst from 1998 to 2003. RESULTS:Altogether, 33% of the ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0748-8
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Roux-en-Y anastomosis is the standard of care for biliary reconstruction. Yet, a direct bilio-biliary anastomosis preserves the normal sphincter mechanism and endoscopic access to the biliary tree for diagnostic and therapeutic purposes. Duct-to-duct biliary reconstruction is widely used in liver transplanta...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1318-x
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Parathyroid glands can mimic thyroid follicular lesions on fine-needle aspiration (FNA) cytology and can lead to unnecessary or incorrect surgery. Newer molecular panel tests using next-generation sequencing (NGS) include analysis of cell type-specific gene expression profiles such as parathyroid. The study ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4548-3
更新日期：2018-09-01 00:00:00
abstract：:Adenocarcinomas of the esophagogastric junction (AEG) are now recognized as a separate tumor entity with increasing incidence. The aim of the present study was to evaluate whether positron emission tomography (PET) using the glucose analog F-18-fluorodeoxyglucose (FDG) can be used for metabolic characterization of thi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-7058-9
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:The present study evaluated outcomes of patients undergoing proximal diversion using either a loop ileostomy or loop colostomy following distal colorectal resection for malignant and non-malignant disease. METHODS:A literature search of the Medline, Ovid, Embase and Cochrane databases was performed to ident...
journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00268-006-0218-y
更新日期：2007-05-01 00:00:00
abstract：:Clinical, endoscopic, and laboratory data were collected prospectively in 701 patients with bleeding peptic ulcer. The overall rebleeding rate was 16.1% and increased the risk of a fatal outcome by 17 fold (1.2% versus 20.6%, p less than 0.001). Rebleeding was documented in more than 75% of the group who did not survi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01664889
更新日期：1990-03-01 00:00:00
abstract：:Incisional hernia repair without mesh mainly consists of tissue transfer to bridge or close the defect. Bridging includes rotational or free musculocutaneous flaps, rendering acceptable short-term results but a rather disappointing long-term outcome. Abdominal wall closure where there has been significant loss of doma...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-005-7972-0
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:The impact of postoperative complications (POCs) on long-term survival outcomes following hepatic resection for colorectal liver metastasis (CRLM) is in controversy. The aim of the present meta-analysis was to systematically evaluate the POC effect on overall survival (OS) and disease-free survival (DFS) in ...
journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00268-015-3019-3
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:The aim of this study was to compare the perioperative outcomes when using a micropuncture access set (MS) to those when using a conventional puncture set (CS) for implantation of totally implantable venous access device (TAVID). METHODS:A total of 314 patients undergoing chemotherapy for colorectal cancer ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05336-w
更新日期：2020-04-01 00:00:00
abstract：:The surgical management of pancreatic islet cell carcinomas poses a complicated set of questions resulting from their rare occurrence and the difficulty in establishing a diagnosis in early cases or, conversely, the problems inherent in dealing with metastatic disease. However, because their biologic behavior is rathe...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01655109
更新日期：1993-07-01 00:00:00
abstract：:Distinguishing cellular follicular adenomas (FA) from minimally invasive follicular carcinomas (FC) continues to plague even experienced thyroid pathologists. DNA ploidy analysis has been promoted as a means of making this differentiation; however, the finding of DNA aneuploidy in FA has caused concern that they may d...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658504
更新日期：1990-05-01 00:00:00
abstract：:Intraabdominal hypertension (IAH) and abdominal compartment syndrome (ACS) have detrimental effects on all organ systems and are associated with significant morbidity and mortality. In recent years, the diagnosis and management of these syndromes has evolved tremendously, and the importance of comprehensive strategies...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0003-9
更新日期：2009-06-01 00:00:00
abstract：:To illustrate how the high incidence of arrow wounds provided a major stimulus for the development of surgery until a century ago, we conducted a literature search. Our research shows that archaic peoples developed considerable surgical skill for extraction of arrows, including thoracotomy and trephination. A classica...
journal_title：World journal of surgery
pub_type： 历史文章,杂志文章
doi：10.1007/s00268-001-0168-3
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:Closure of loop ileostomy can be safely performed using sutures or staplers. The aim of the present study was to compare the cost effectiveness of three different techniques. METHODS:A total of 128 consecutive patients who underwent closure of loop ileostomy between January 2002 and December 2008 were analy...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0787-7
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:The objective of this study was to determine whether rat insulin promoter (RIP) could, in a mouse model, direct expression of an adenovirus-mediated reporter gene specifically into pancreatic islets via systemic delivery. METHODS:Five hundred and eight base pairs of the RIP DNA sequence were constructed int...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0688-3
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:Postoperative peritonitis (POP) following gastrointestinal surgery is associated with significant morbidity and mortality, with no clear management option proposed. The aim of this study was to report our surgical management of POP and identify pre- and perioperative risk factors for morbidity and mortality....
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4687-6
更新日期：2018-11-01 00:00:00
abstract：:Most adrenal incidentalomas are nonfunctioning cortical adenomas that do not require surgery. Operative treatment is indicated if the incidentaloma has malignant features as seen during the radiologic workup, is hormonally active, or grows during follow-up. A conservative attitude is justified in asymptomatic patients...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689910095
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:A recent analysis found bradycardia during laparoscopy as a potential early warning sign of cardiac arrest. Knowledge regarding bradycardia frequency and its consequences during laparoscopy is limited. METHODS:Using the computerized record database, files of 9915 patients undergoing laparoscopic surgery, be...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-04935-x
更新日期：2019-06-01 00:00:00
abstract：:In an attempt to prevent the sequelae of conventional gastrectomy, such as rapid gastric emptying, dumping syndrome, intestinal content reflux, indigestion, and poor absorption, we have devised the pylorus and pyloric vagus preserving gastrectomy (PPVPG). Experimenting on 48 dogs, we found theoretic grounds for using ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01655114
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND:Chronic anal fissure (CAF) is a linear split of the anoderm. The minimally invasive management of CAF such as botulinum toxin (BT) injection is recommended. However, the exact efficient dose of BT, number of injections per session and the injection sites are still debatable. The aim of this analysis was to a...
journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00268-016-3693-9
更新日期：2016-12-01 00:00:00
