Abstract：
:Distinguishing cellular follicular adenomas (FA) from minimally invasive follicular carcinomas (FC) continues to plague even experienced thyroid pathologists. DNA ploidy analysis has been promoted as a means of making this differentiation; however, the finding of DNA aneuploidy in FA has caused concern that they may demonstrate potential for malignant behavior or should even be reclassified as low-grade noninvasive cancers. In histologically-proven FC, nuclear DNA content has been claimed to have predictive power equivalent to that of all other prognostic factors combined. The aims of the present study, therefore, were to define the DNA ploidy characteristics of FA and FC, to assess the diagnostic potential of cell-cycle parameters, and, in FC, to investigate the prognostic role of such measurements. We measured DNA content of 124 tumors (60 FA, 64 FC). DNA pattern was normal (diploid) in 75% of FA and 45% of FC, tetraploid/polyploid (T/P) in 13% of FA and 25% of FC, and aneuploid in 12% of FA and 30% of FC. FC was histologically verified in 39% of DNA normal, 67% of T/P, and 73% of aneuploid tumors. DNA index, S-phase, G2M, and S-phase plus G2M were analyzed and were not helpful in differentiating between FA and FC. No patient with FA developed tumor recurrence. In FC (excluding the Hürthle cell variant), no significant differences were found among the 3 DNA ploidy groups with respect to either cancer death or tumor recurrence; however, combining the Hürthle cell variant of follicular carcinomas with pure follicular carcinomas, the presence of distant metastases, DNA aneuploidy, and patient age were the only independently significant prognostic variables.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Grant CS,Hay ID,Ryan JJ,Bergstralh EJ,Rainwater LM,Goellner JRdoi
10.1007/BF01658504subject
Has Abstractpub_date
1990-05-01 00:00:00pages
283-9; discussion 289-90issue
3eissn
0364-2313issn
1432-2323journal_volume
14pub_type
杂志文章abstract：BACKGROUND:The Mangled Extremity Severity Score (MESS) was constructed as an objective quantification criterion for limb trauma. A MESS of or greater than 7 was proposed as a cut-off point for primary limb amputation. Opinions concerning the predictive value of the MESS vary broadly in the literature. The aim of this s...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05263-w
更新日期：2020-03-01 00:00:00
abstract：:Chronic alcoholism is the etiologic factor initiating most instances of chronic pancreatitis and its complications in the United States of America. The goal of operative intervention is to relieve incapacitating abdominal and back pain, while preserving as much endocrine and exocrine function as possible. Ultrasound a...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01670548
更新日期：1990-01-01 00:00:00
abstract：:From the earliest description of dysphagia relieved by dilatation with a whalebone in 1674 we have witnessed the evolution of esophageal function testing from the conventional manometry to the high-resolution manometry (HRM) and esophageal topography pressure plotting that have led to the revised Chicago classificatio...
journal_title：World journal of surgery
pub_type： 历史文章,杂志文章
doi：10.1007/s00268-014-2939-7
更新日期：2015-07-01 00:00:00
abstract：BACKGROUND:In patients with well-differentiated thyroid cancer, the incidence of pathologic central compartment lymph node metastases is reported to be approximately 50%. Recently level VI lymph node dissection has been advocated as a means of reducing recurrence rates in these patients, even if there are no clinically...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1507-2
更新日期：2012-06-01 00:00:00
abstract：:Open gastric surgery in elderly patients is associated with higher morbidity and mortality rates than those reported among younger individuals. Therefore, minimally invasive surgery may have a larger impact on the elderly compared to the younger age group. The objective of this study was to evaluate the experience of ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0208-5
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:There is no consensus opinion on a definitive surgical management option for ranulas to curtail recurrence, largely from the existing gap in knowledge on the pathophysiologic basis. AIM:To highlight the current scientific basis of ranula development that informed the preferred surgical approach. DESIGN:Ret...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3901-2
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze the prognostic factors associated with long-term outcome after liver resection for colorectal metastases. The retrospective analysis included 297 liver resections for colorectal metastases. METHODS:The variables considered included disease stage, differentiation grade, s...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9285-y
更新日期：2008-01-01 00:00:00
abstract：:Although widely practiced, laparoscopic appendectomy (LA) has not met with universal approval. Several controlled trials have been conducted, some in favor, others not. The goal of this review was to ascertain (1) if laparoscopy was capable of improving the diagnostic and therapeutic difficulties encountered during op...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002689900587
更新日期：1999-08-01 00:00:00
abstract：:The aim of this study was to investigate the effects of various surgical modalities directed at the cavity of hydatid cysts in patients with occult intrabiliary rupture. In this respect, 324 patients with hydatid cyst of the liver operated on during 1983-2003 were analyzed; among them, 39 patients with occult intrabil...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7571-5
更新日期：2005-02-01 00:00:00
abstract：:Laparoscopic fundoplication is increasingly used for treating gastro-esophageal reflux disease in children. Mechanical and pharmacological effects may contribute to hemodynamic and respiratory changes during carbon dioxide pneumoperitoneum. The aim of the present study was to evaluate the hemodynamic and respiratory e...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7695-2
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND:Splenic trauma is a common organ injury following blunt abdominal trauma. In order to establish the contemporary epidemiology of blunt splenic trauma in Scotland and to detect risk factors associated with patient outcomes, analysis of a multi-center database of trauma patients was performed. METHODS:The stu...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9218-9
更新日期：2007-11-01 00:00:00
abstract：:Surgical resection is the treatment of choice for patients with stage I and stage II non-small-cell lung cancer (NSCLC--squamous cell, adenocarcinoma, and large-cell carcinoma). Distant recurrence is an important cause of death after complete surgical resection, occurring in 30-60% of patients. Postoperative adjuvant ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01659083
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:The 6th edition TNM staging (TNM-6) for hepatocellular carcinoma (HCC) has been recommended. However, its superiority, in contrast to the previous 5th edition (TNM-5), has not been fully recognized. Besides, tumor differentiation was not included. The current study was designed to compare the value of these ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9615-8
更新日期：2008-08-01 00:00:00
abstract：:The past decade has seen a maturation of the art and science of perioperative nutritional support. We now have sufficient data to make informed and reasonable judgments regarding when we should and should not provide perioperative TPN. These judgments can be considered medically sound and fiscally responsible. The fol...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,随机对照试验,评审
doi：10.1007/BF01658923
更新日期：1993-03-01 00:00:00
abstract：:In a prospective multicenter study, 186 patients with squamous cell esophageal carcinoma, who after evaluation were considered suitable for surgery, were randomized to 4 treatment groups: Group 1, surgery alone; Group 2, pre-operative chemotherapy (cisplatin and bleomycin) and surgery; Group 3, pre-operative irradiati...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02067069
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:Transient postthyroidectomy hypocalcemia occurs in up to 30% of patients. We evaluated the effect of vitamin D deficiency on postthyroidectomy hypocalcemia. METHODS:Data were collected prospectively between January 2006 and March 2009. A total of 166 consecutive total thyroidectomies were analyzed regarding...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0872-y
更新日期：2011-02-01 00:00:00
abstract：:Surgery is the main modality in the treatment of hepatic hydatid disease. In this report, a laparoscopic surgical method is described, and the results in the first 16 cases are presented. The method involves the use of an aspirator-grinder apparatus that achieves effective evacuation of viable cyst contents with the p...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00295914
更新日期：1995-09-01 00:00:00
abstract：:Herniographic examinations were performed on more than 4,000 patients. The method was found to be of great value in patients with obscure symptoms in the groin or pelvis. Herniography shows not only hernial sacs but also the general condition and tissue strength of the inguinal part of the abdominal wall. The differen...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658871
更新日期：1989-09-01 00:00:00
abstract：:The treatment results of mycobacterial cervical lymphadenitis in 69 patients between 1990 and 1993 are reviewed. All patients underwent surgical procedures consisting of total excision or selective nodal dissection for lymphadenopathies and curettage for fluctuant cases, followed by antituberculous chemotherapy applie...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900265
更新日期：1997-06-01 00:00:00
abstract：INTRODUCTION:The use of outcomes to evaluate surgical quality implies the need for detailed risk adjustment. The physiological and operative severity score for the enumeration of mortality and morbidity (POSSUM) is a generally applicable risk adjustment model suitable for pancreatic surgery. A pancreaticoduodenectomy (...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2554-7
更新日期：2014-09-01 00:00:00
abstract：:Hepatoblastoma is a rare pediatric malignancy that frequently appears in an advanced unresectable stage. Improved resectability and survival rate have been reported with the help of neoadjuvant chemotherapy. Between January 1987 and June 1995 a series of 20 patients were managed with a diagnosis of hepatoblastoma. The...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002680020052
更新日期：2001-02-01 00:00:00
abstract：:A total of 143 patients who underwent hepatic resection for hepatocellular carcinoma in our department were reviewed. The review was conducted for two periods: 1970-1982 (early period) and 1983-1990 (late period), that is, the periods before and after introduction of the hepatic surgical technique involving the use of...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01659138
更新日期：1993-09-01 00:00:00
abstract：BACKGROUND:Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder for which appropriate diagnostic treatments are uncertain. The response to splenectomy varies from 60% to 90%, and the remaining patients relapse and require further treatment. Therefore, it is important to predict the outcome of splenectomy...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7964-0
更新日期：2006-04-01 00:00:00
abstract：:This retrospective study reports our experience managing 78 patients with adenocarcinoma of the esophagus and gastroesophageal junction operated between January 1982 and December 1996. Altogether 18 patients presented with stage I and II disease, and 60 patients had stage III and IV disease at presentation; 56 patient...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/pl00013179
更新日期：1999-03-01 00:00:00
abstract：INTRODUCTION:The coexistence of an enterocutaneous fistula (ECF) with large abdominal wall defects represent one of the most demanding situations seen by a surgeon. Simultaneous treatment of ECF closure with abdominal wall defect closure has been widely debated. Our objective was to determine if the type of abdominal w...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05635-7
更新日期：2020-10-01 00:00:00
abstract：:It has been widely acknowledged that exomphalos and gastroschisis are two different clinical entities. Their etiology and pathogenesis, however, remain controversial. Several techniques are available for making a prenatal diagnosis of these as well as many other malformations. Some prenatal treatment is possible, but ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01658701
更新日期：1993-05-01 00:00:00
abstract：:The goal of fluid resuscitation in the burn patient is maintenance of vital organ function at the least immediate or delayed physiological cost. To optimize fluid resuscitation in severely burned patients, the amount of fluid should be just enough to maintain vital organ function without producing iatrogenic pathologi...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02067109
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Billions of people worldwide lack access to safe affordable surgery. Surgical missions and non-governmental organisations (NGO) are vital in meeting this need, but long-term outcomes are rarely reported. Mercy Ships is a surgical NGO, and we aimed to measure disability-free survival, impact and patient satis...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3745-1
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Many patients who undergo emergency laparotomy are working, which is a key determinant for an individual's socio-economic status and financial security. The objectives of this study were to compare labour market participation and sick leave in a nationwide patient population undergoing non-malignant emergenc...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4830-4
更新日期：2019-03-01 00:00:00
abstract：:The aim of the present study was to determine whether patients with the incident hospital diagnosis of primary hyperparathyroidism (PHPT) in Denmark during the period 1977-1993 had an increased mortality from cardiovascular disease and cancer compared to the rest of the Danish population. In a random sample of half of...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-7046-0
更新日期：2004-01-01 00:00:00
