Abstract：
:Hepatoblastoma is a rare pediatric malignancy that frequently appears in an advanced unresectable stage. Improved resectability and survival rate have been reported with the help of neoadjuvant chemotherapy. Between January 1987 and June 1995 a series of 20 patients were managed with a diagnosis of hepatoblastoma. The median age at diagnosis was 13 months (2 months to 7 years 10 months) with a male/female ratio of 13:7. Chemotherapy effectively reduced the tumor volume (with statistical significance: p = 0.008) and was able to convert seven of nine initially unresectable tumors (78%) to resectable ones. Altogether, 14 operations were done, 12 radical and 2 palliative, with or without adjuvant chemotherapy. The whole population was followed for a median duration of 33 months; and the median survival for the whole group was 26 months. The curative resection group displayed a 5-year survival rate of 61.1%, but none in the noncurative group survived more than 13 months (p = 0.0001). In the univariate analysis for prognostic factors, large tumor size at diagnosis and the absence of thrombocytopenia were associated with poor survival, but these differences were not statistically significant. Pure fetal histology was not associated with better prognosis. In this new era of neoadjuvant chemotherapy, the optimal management strategy for hepatoblastoma is still debated, with radical surgical resection at the earliest possible time being the final goal. For now an individualized approach appears to be the protocol of choice.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Jung SE,Kim KH,Kim MY,Kim DY,Lee SC,Park KW,Kim WKdoi
10.1007/s002680020052keywords:
subject
Has Abstractpub_date
2001-02-01 00:00:00pages
126-30issue
2eissn
0364-2313issn
1432-2323journal_volume
25pub_type
杂志文章abstract：BACKGROUND:The skin is closed in open appendectomy traditionally with few interrupted nonabsorbable sutures. The use of this old method is based on a suggestion that this technique decreases wound infections. In pediatric surgery, skin closure with running intradermal absorbable sutures has been found to be as safe as ...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-012-1664-3
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:The purposes of this study were to determine clinical presentations and surgical outcomes of perforated peptic ulcer (PPU), and to evaluate the accuracy of the Boey scoring system in predicting mortality and morbidity. METHODS:We carried out a retrospective study of patients undergoing emergency surgery for...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9796-1
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Every day thousands of surgeons and patients negotiate their way through the complex process of decision-making about operative treatments. We conducted a series of qualitative studies, asking patients and surgeons to describe their experience and beliefs about informed decision-making and consent. This stud...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0021-7
更新日期：2009-07-01 00:00:00
abstract：:Duodenal leiomyomas are rare neoplasms and when present are usually asymptomatic. There are, however, isolated case reports of such leiomyomas giving rise to complications including gastrointestinal hemorrhage and obstruction. The purpose of this study was to review the surgical experience with duodenal leiomyomas at ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002680020083
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND:The pancreatic fistula rate following distal pancreatectomy ranges widely, from 13.3 to 64.0 %. The optimal closure method of the pancreatic remnant remains controversial, especially regarding whether to use a stapler. METHODS:All patients who underwent distal pancreatectomy in five Japanese hospitals from ...
journal_title：World journal of surgery
pub_type： 杂志文章,多中心研究
doi：10.1007/s00268-012-1595-z
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Gastrointestinal (GI) tract perforation during endoscopy is a rare but severe complication. The aim of this study was to determine predictors of morbidity and mortality after iatrogenic endoscopic perforation. MATERIALS AND METHODS:All cases with iatrogenic endoscopic perforation receiving surgery at a tert...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3986-7
更新日期：2017-08-01 00:00:00
abstract：:This retrospective study in 79 surgically treated patients with a proximal bile duct carcinoma revealed 12 patients with a median age of 59.5 years (range 21-73 years) who survived more than 5 years. These 12 patients were analyzed to identify specific patient characteristics for long-term survival. Fifteen patients d...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900571
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Our aim was to evaluate the advantages and limitations of delayed laparoscopic cholecystectomy (LC) in a tertiary center. MATERIALS AND METHODS:A retrospective analysis of all patients admitted to our institution with acute calculous cholecystitis (ACC) between January 2003 and December of 2012 was performe...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3928-4
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Venous thromboembolism (VTE) is a condition that has always been perceived to be rare in Asia. The aim of this systematic review was to gather the current available evidence on the incidence of VTE in this population. A secondary aim was to assess the efficacy of pharmacological prophylaxis, and hence determ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-014-2763-0
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Strong evidence has confirmed the benefit of laparoscopy in colorectal cancer resection but remains a challenging procedure. It is not clear that such promising results in selected patients translate into a favorable risk-benefit balance in real practice. We conducted a multicenter national observational reg...
journal_title：World journal of surgery
pub_type： 杂志文章,多中心研究
doi：10.1007/s00268-015-3050-4
更新日期：2015-08-01 00:00:00
abstract：:This study was designed to investigate the optimal dose of garlic during long-term feeding and its preventive and therapeutic effects on colon cancer in rats induced by 1,2-dimethylhydrazine (DMH). A total of 240 male Sprague-Dawley rats were grouped and fed with either a basal or a garlic diet of different concentrat...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00294738
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:Binding of the lectin Helix pomatia agglutinin (HPA) has been shown to be associated with poor prognosis in many human cancers, but not in thyroid cancer. The aims of the present study were to assess alteration in cellular glycosylation, detected by HPA binding, in thyroid tumors; to determine if such altere...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1196-2
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Utilization of breast reconstruction (BR) is low in many jurisdictions. We studied the geographical and surgical workforce factors that contribute to access and use of BR using a small area analysis approach with a geographical unit of analysis. METHODS:We linked administrative data from Ontario Canada to c...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3060-2
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:It is generally believed that the accompanying conditions in patients with inflammatory bowel disease (IBD) are associated with a high incidence of surgical site infection (SSI), and sometimes these patients are classified as compromised hosts without definitive clinical evidence. The aim of this study was t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-9934-4
更新日期：2009-05-01 00:00:00
abstract：:Mass screening for the purpose of detecting thyroid cancer at its earliest stage may not be recommended at the present time, but screening focused on certain risk groups is advocated. Familial nonmedullary thyroid carcinoma (FNMTC) is a distinct clinical entity with a high incidence of multifocality and association wi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7676-x
更新日期：2004-11-01 00:00:00
abstract：:Organ transplantation continues to be hindered by a limited supply of organs. A significant percentage of potential organ donors are lost to either medical failure or inability to obtain consent for donation. In a surgical intensive care unit (ICU) we have refocused our efforts toward aggressive resuscitation, directe...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/pl00012362
更新日期：1999-07-01 00:00:00
abstract：:Secretin is a stimulator of both endocrine and exocrine secretions of the pancreas, and we aimed to evaluate its effects on splanchnic blood flow in rats with a microsphere technique. Anesthetized rats were infused with secretin (0.5 or 2.0 micrograms/kg body weight/hr) for 10 minutes. Some animals were normoglycemic,...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-001-0037-0
更新日期：2001-07-01 00:00:00
abstract：:Recently, surgical services have been gaining greater attention as an integral part of public health in low-income countries due to the significant volume and burden of surgical conditions, growing evidence of the cost-effectiveness of surgical intervention, and global disparities in surgical care. Nonetheless, there ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0585-2
更新日期：2010-11-01 00:00:00
abstract：:Fifty patients reoperated for failed Nissen fundoplication are presented; 29 patients (group 2) were operated between 1983 and 1988 while 21 patients (group 1) were operated before 1983. In group 1, the "slipped Nissen" had been the most frequent cause of reoperation (48%). In group 2, the most frequent causes for the...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658439
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:The goal of the present study was to evaluate the effects of preoperative oral carbohydrate supplementation (OCH) on the postoperative metabolic stress response of patients undergoing elective abdominal surgery. METHODS:The study was designed as a controlled, prospective, cohort study including 38 patients ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1590-4
更新日期：2012-08-01 00:00:00
abstract：:The aim of this study was to identify the risk factors for bacterial translocation and to determine the clinical significance of bacterial translocation in patients with colorectal cancer. Mesenteric lymph node sampling was performed to identify the presence of bacterial translocation in 75 patients with colorectal ca...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7576-0
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND:Molecular diagnostics can allow some patients with indeterminate thyroid nodule cytopathology to avoid diagnostic hemithyroidectomy; however, the testing is costly. We hypothesized that molecular testing with the intention of preventing unnecessary diagnostic hemithyroidectomy would be cost-effective if this...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05177-7
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Neuroendocrine neoplasias (NEN) of the gastroenteropancreatic (GEP) system frequently present with metastatic deposits. The proliferation marker Ki-67 is used for diagnosis and to assess the prognosis of disease. The aim of our study was to evaluate the usefulness of Ki-67 % in the assessment of NEN patients...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2451-0
更新日期：2014-06-01 00:00:00
abstract：:The role of the tumor suppressor gene p53 and proto-oncogenes mdm-2, waf-1,and bcl-2 in sporadic colorectal carcinoma (CRC) has been well investigated. However, little is known about the role of these genes in the development of ulcerative colitis-associated colorectal carcinoma (CAC). Colectomy specimens from patient...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-001-0237-7
更新日期：2002-03-01 00:00:00
abstract：:Although HLA matching can improve organ graft survival, well matched grafts fail and poorly matched ones survive. Recently evidence has been found that perinatal exposure to noninherited antigens (NIMAs) has a lifelong impact on the immune repertoire of the individual. The state of the art of the influence of NIMAs on...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002680010132
更新日期：2000-07-01 00:00:00
abstract：:We investigated the effect of radiofrequency ablation (RFA) of the liver on cell-mediated immunity in rats. Sprague-Dawley rats were divided into five groups: control group that did not have any procedure, a sham-operation group that underwent laparotomy, a lobectomy group that had left lateral lobectomy of the liver,...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7728-x
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Neoadjuvant chemotherapy (NC) is standard therapy for patients with locally advanced breast cancer and is increasingly used for early-stage operable disease. Clinical and pathological responses are important prognostic parameters for NC, which aims to achieve a pathological complete response or tumor reducti...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9800-9
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Teamwork is fundamental to effective surgery, yet there are currently no measures of teamwork to guide training, evaluate team interventions or assess the impact of teamwork on outcomes. We report the first steps in the development of an observational assessment of teamwork and preliminary findings. METHOD:...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0488-9
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:Surgeon performed ultrasound (US) is being increasingly embraced by breast surgeons worldwide as an integral part of patient assessment. The extent of its application within Australia and New Zealand is not well documented. The present study aimed to evaluate its current usage patterns and to determine suita...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2076-8
更新日期：2013-09-01 00:00:00
abstract：:Angiogenesis is of vital importance during the development and progression of solid tumors. Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis and could be produced by some cancer cells. To investigate the clinical relevance of VEGF in the tumorigenesis of human thyroid, an immunohistochemi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002680020085
更新日期：2001-03-01 00:00:00
