Abstract：
BACKGROUND:Binding of the lectin Helix pomatia agglutinin (HPA) has been shown to be associated with poor prognosis in many human cancers, but not in thyroid cancer. The aims of the present study were to assess alteration in cellular glycosylation, detected by HPA binding, in thyroid tumors; to determine if such altered glycosylation carries any prognostic significance; and to analyze qualitative and quantitative differences of HPA-binding glycoproteins in various thyroid tumors. METHODS:Lectin histochemistry was performed on 110 archival paraffin wax embedded specimens of various thyroid tumors excised between the years 1983-1993. Demographic data, histological data, and time to death were recorded, and multivariate Cox regression analysis was performed to determine a prognostic model for patient survival based on the data. Helix pomatia agglutinin binding glycoproteins were isolated from 128 fresh specimens of various thyroid tissues by affinity chromatography, analyzed by SDS-PAGE and western blotting. RESULTS:There was a marked qualitative difference in the profile of HPA-binding glycoproteins, with the malignant thyroid tumors showing a heterogeneous profile of numerous HPA binding glycoprotein bands. Lectin histochemistry showed significant positive HPA binding in malignant thyroid tumors (p = 0.0009). Kaplan-Meir survival analysis revealed that among patients who died of their disease those with HPA-positive tumors had a significantly shorter survival (p = 0.009). CONCLUSIONS:This is the first study showing that HPA binding glycoproteins are synthesized by thyroid tumors. Thyroid cancers show a broader profile of HPA binding glycoproteins compared to benign thyroid tumors, and positive HPA binding is significantly associated with shorter survival and poorer prognosis in thyroid cancers.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Parameswaran R,Sadler G,Brooks Sdoi
10.1007/s00268-011-1196-2subject
Has Abstractpub_date
2011-10-01 00:00:00pages
2219-27issue
10eissn
0364-2313issn
1432-2323journal_volume
35pub_type
杂志文章abstract：:This prospective study was instituted to assess whether the use of the on-pump method or the off-pump method affects changes in health-related quality of life (QOL) as evaluated a year after coronary artery bypass graft (CABG) surgery. Data including preoperative risk factors and postoperative morbidity up to discharg...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7486-1
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND:Primary hyperparathyroidism (PHPT) is a common endocrine disorder that predominantly affects patients >60 and is increasing in prevalence. Identifying risk factors for poor outcomes after parathyroidectomy in older adults will help tailor operative decision making. The impact of frailty on surgical outcomes ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4629-3
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Many patients who undergo emergency laparotomy are working, which is a key determinant for an individual's socio-economic status and financial security. The objectives of this study were to compare labour market participation and sick leave in a nationwide patient population undergoing non-malignant emergenc...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4830-4
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Gastrointestinal (GI) tract perforation during endoscopy is a rare but severe complication. The aim of this study was to determine predictors of morbidity and mortality after iatrogenic endoscopic perforation. MATERIALS AND METHODS:All cases with iatrogenic endoscopic perforation receiving surgery at a tert...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3986-7
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Measurement of the parathyroid hormone (PTH) level following total thyroidectomy (TTx) may allow prediction of postoperative hypocalcemia. We present an algorithmic method of managing hypocalcemia pre-emptively, based on the PTH level 1 h after operation. MATERIALS AND METHODS:We examined 423 consecutive pa...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0348-0
更新日期：2010-03-01 00:00:00
abstract：:Noninvasive diagnosis of cavernous hemangioma of the liver is an important step in the investigation of patients with focal hepatic lesions since biopsy may result in life-threatening hemorrhage. To determine the diagnostic accuracy of 99m-technetium red blood cell (99mTc-RBC) imaging with tomography, 50 patients with...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658668
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND:Retroperitoneal soft tissue sarcomas (RSTS) are a rare and uncommon entity with a poor 5-year overall survival (OS) of approximately 50%, even though they rarely metastasize. The aim of the present study was to analyze the survival of patients with RSTS treated at our institution. PATIENTS AND METHODS:Patie...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0473-9
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:This study aims to determine the prevalence and predictive factors for recurrence after sentinel lymph node biopsy (SLNB) and for sentinel lymph node positivity by SLNB in our population. METHODS:We followed up all SLNBs performed between 2002 and 2010 and analyzed data by R (version2.10.1), considering p <...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1420-0
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:The retained knife blade is an unusual and spectacular injury. The aim of this study was to review our experience with the management of such injuries. METHODS:A retrospective chart review of patients with retained knife blades treated at Groote Schuur Hospital Trauma Centre from January 1996 to December 20...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0514-4
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to evaluate the efficacy of 10 % sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy. METHODS:A total of 48 patients (24 men and 24 women) between 20 and 70 years of age who underwent open hemorrhoidectomy were included in this prospe...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-012-1805-8
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:In 2002, the UICC/AJCC TNM classification for papillary thyroid carcinoma was revised. In this study, we examined the validity of this classification system by investigating the predictors of disease-free survival (DFS) and cause-specific survival (CSS) in patients. METHODS:We examined various clinicopathol...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-006-0455-0
更新日期：2007-04-01 00:00:00
abstract：:Abdominal infections are treated by resuscitation, abdominal drainage, control of the source of infection, and antimicrobial agents. Ideally, antimicrobial therapy is active against expected pathogens, safe and effective in clinical trials, inexpensive, and unlikely to promote drug resistance. Numerous single-agent an...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002689900363
更新日期：1998-02-01 00:00:00
abstract：:A variety of techniques have been used for surgical treatment of hepatic hydatid cysts. The objective of this study is to describe the technique of diaphragm myoplasty, and to present our experience in the treatment of selected patients with hydatid disease of the liver by means of this alternative surgical technique....
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6558-3
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Primary hyperparathyroidism (HPT) is often caused by a benign parathyroid tumor, adenoma; less commonly by multiglandular parathyroid disease/hyperplasia; and rarely by parathyroid carcinoma. Patients with multiple tumors require wider exploration to avoid recurrence and have increased risk for hereditary di...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-009-0022-6
更新日期：2009-11-01 00:00:00
abstract：:Pancreas transplantation has emerged as the single most effective way to achieve normal glucose homeostasis inpatients with type I insulin-dependent diabetes mellitus. Optimal immunosuppressive strategies for pancreas transplantation continue to evolve with the use of newer, more potent immunosuppressive agents,partic...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-001-0207-0
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:In patients with negative sentinel lymph node biopsy (SLNB), axillary dissection (AD) can be avoided to reduce morbidities. However, there is only limited data on the rate of positive non-SLN (NSLN) in those who have micrometastasis and isolated tumor cells (ITC) in the literature. METHODS:We did a retrospe...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-2984-x
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Accurate presurgical assessment is important to anticipate postoperative complications, especially in the growing proportion of elderly cancer patients. We designed a study to define which comorbid conditions at the time of diagnosis predict complications after surgery for colorectal cancer. PATIENTS:A rand...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0711-8
更新日期：2007-01-01 00:00:00
abstract：:The radiological features of common benign conditions of the breast and the radiological procedures used in the investigation of benign breast disorders are presented. ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01658415
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:It is now generally believed that regulatory T cells (Tregs) play an important role in peripheral tolerance, and a defect in Tregs is considered one of the most important factors in the induction of various kinds of autoimmune disease including ulcerative colitis (UC). Here, we examined the change in frequen...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0301-9
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:The commonest surgical treatment used for peptic ulcer perforation is omental patching. If, however, the perforation leaks, it rarely heals by itself due to persistence of duodenal fistula (DF). We present our experience with a T-tube placed into the DF for better outcome of the patients. METHODS:All patien...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2196-1
更新日期：2013-11-01 00:00:00
abstract：INTRODUCTION:Sentinel lymph node biopsy (SLNB) is the standard of care for staging N0 primary early breast cancers (EBC). Patients in developing countries mostly present with large (LOBC) or locally advanced cancers (LABC) and are treated with neo-adjuvant chemotherapy (NACT). Accuracy of SLNB in staging stage III N0 a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3222-2
更新日期：2016-07-01 00:00:00
abstract：:Node dissection for melanoma remains the most important therapeutic decision for the optimal management of the patient with melanoma. In Australia and in some parts of the United States, the majority of patients with intermediate thickness melanoma (1.6-4.00 mm) will undergo elective lymph node dissection. In Europe, ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：
更新日期：1992-03-01 00:00:00
abstract：:The present article summarizes scientific observations of the endocrine pancreas anatomy and physiology into a unifying hypothesis. The data were generated over the years by surgical fellows using human and rat isolated perfused pancreas models and in vivo islet microcirculation models. The endocrine pancreas secretes...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002680020339
更新日期：2001-04-01 00:00:00
abstract：:Surgical resection is the treatment of choice for patients with stage I and stage II non-small-cell lung cancer (NSCLC--squamous cell, adenocarcinoma, and large-cell carcinoma). Distant recurrence is an important cause of death after complete surgical resection, occurring in 30-60% of patients. Postoperative adjuvant ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01659083
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:We aimed to describe the pattern of solid organ injuries (SOIs) and analyze the characteristics, management and outcomes based on the multiplicity of SOIs. METHODS:A retrospective study in a Level 1 trauma center was conducted and included patients admitted with blunt abdominal trauma between 2011 and 2014....
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4087-3
更新日期：2017-11-01 00:00:00
abstract：:This paper reviews aspects of head injury management and research in the United Kingdom (UK). We discuss evidence about the scale and etiology of head injury in Britain and how this information has supported a triage-based approach, incorporating risk analysis. A Cohesive organization based upon nationally accepted, y...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-001-0084-6
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:Solitary fibrous tumor of the pleura (SFTP) represents a clinical entity rarely encountered, especially in giant forms. Complete surgical resection for giant tumor of pleura is a challenge. The aim of this article is to present five new cases of giant SFTP, and to discuss their clinical characteristics and t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0715-x
更新日期：2010-11-01 00:00:00
abstract：:Chondrosarcomas of the head and neck are uncommon. Over a 35-year period (1950-1985) at our institution, 557 patients had an established diagnosis of chondrosarcoma. In 28 (5%) of these patients, the tumor was located in the head and neck region. A retrospective analysis was performed in an attempt to accurately defin...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02067021
更新日期：1992-09-01 00:00:00
abstract：:The aim of this study was to investigate the effects of various surgical modalities directed at the cavity of hydatid cysts in patients with occult intrabiliary rupture. In this respect, 324 patients with hydatid cyst of the liver operated on during 1983-2003 were analyzed; among them, 39 patients with occult intrabil...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7571-5
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND:Esophagorespiratory fistula (ERF) caused by esophageal carcinoma is a fatal complication. In our institution, esophageal bypass surgery has been indicated when possible. We herein retrospectively describe the clinical results of esophageal bypass surgery for ERF. PATIENTS AND METHODS:Between April 2001 and ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3391-z
更新日期：2016-05-01 00:00:00
