Abstract：
BACKGROUND:Neoadjuvant chemotherapy (NC) is standard therapy for patients with locally advanced breast cancer and is increasingly used for early-stage operable disease. Clinical and pathological responses are important prognostic parameters for NC, which aims to achieve a pathological complete response or tumor reduction to reduce the volume of subsequent breast resection. Clinicopathological markers that predict patient response to NC are needed to individualize treatment. METHODS:From 1998 to 2006, 368 patients with primary breast cancer underwent curative surgical treatment after NC (anthracycline and/or taxane without trastuzumab). We retrospectively evaluated the clinicopathological features and classification of the tumors using computed tomography (CT) before NC and analyzed the correlation with the pathological complete response (pCR) and reduction of tumor size after treatment. RESULTS:The overall response and pCR rates in these patients were 86% and 17%, respectively. In multivariate analysis, classification as a scirrhous-type tumor was an independent predictor of reduced likelihood of pCR (p=0.0115; odds ratio 0.21). For tumor reduction, histological grade 3 (p=0.0002; odds ratio 3.3) and localized tumors identified by using CT imaging (p=0.0126; odds ratio 2.4) were independent predictors in multivariate analysis. CONCLUSIONS:In this study, NC often did not result in pCR for breast cancers classified as scirrhous. Furthermore, tumor type classification using CT imaging and histological grading was effective to predict tumor reduction in response to NC that included an anthracycline and/or a taxane.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Shien T,Akashi-Tanaka S,Miyakawa K,Hojo T,Shimizu C,Seki K,Ando M,Kohno T,Taira N,Doihara H,Katsumata N,Fujiwara Y,Kinoshita Tdoi
10.1007/s00268-008-9800-9subject
Has Abstractpub_date
2009-01-01 00:00:00pages
44-51issue
1eissn
0364-2313issn
1432-2323journal_volume
33pub_type
杂志文章abstract：BACKGROUND:It is generally believed that the accompanying conditions in patients with inflammatory bowel disease (IBD) are associated with a high incidence of surgical site infection (SSI), and sometimes these patients are classified as compromised hosts without definitive clinical evidence. The aim of this study was t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-9934-4
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:The efficacy and the indications of resection of synchronous or metachronous hepatic and pulmonary metastases from colorectal cancer (CRC) are controversial. This study retrospectively reviewed the cases of CRC patients who underwent both liver and lung resection to define the appropriate indications for sur...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1708-8
更新日期：2012-11-01 00:00:00
abstract：:Since the pathogenesis of endocrine ophthalmopathy is unclear, there has been little agreement on the treatment of the disease. The influence of thyroid surgery on endocrine ophthalmopathy is controversial. To evaluate the effect of thyroid surgery on the course of the disease, we developed a special ophthalmopathy in...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658552
更新日期：1990-05-01 00:00:00
abstract：:Previous analysis of this prospective randomized trial and meta-analysis of published randomized trials of adjuvant intraperitoneal chemotherapy demonstrated improved survival in patients with advanced gastric cancer. Simple criteria applicable at the time of surgery for patient selection were sought in this analysis....
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00268-001-0067-7
更新日期：2001-08-01 00:00:00
abstract：:Carnitine, an important carrier of free fatty acid that is transported into mitochondria for beta-oxidation, was thought to be one of the key factors in the regulation of liver regeneration. If the carnitine content is insufficient in the hepatocyte, it might impair the energy substrate's transport and the energy char...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900347
更新日期：1998-01-01 00:00:00
abstract：:In a retrospective study the clinical course of 40 patients with symptomatic persistent or recurrent parathyroid cancer was analyzed in order to assess the value of aggressive surgical intervention. Recurrence was diagnosed after a median period of 33 months (1-228 months). Twenty-two patients had locoregional disease...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00353773
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:Intestinal ostomies are common surgical procedures performed in visceral surgery as part of management for several gastrointestinal diseases. This study aims to report the socio-demographic characteristics, indications and prognosis of intestinal ostomies in low-income country. METHODS:This was a 4-year ret...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4338-3
更新日期：2018-06-01 00:00:00
abstract：:Studies have recorded significant patient discomfort during flexible sigmoidoscopy when it is performed without sedation/analgesia. This study observed whether a single dose of 50 mcg intravenous fentanyl reduces pain, improving compliance, acceptability, and completion rates. In a prospective study, 109 consecutive p...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章
doi：10.1007/s00268-004-7374-8
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:The commonest surgical treatment used for peptic ulcer perforation is omental patching. If, however, the perforation leaks, it rarely heals by itself due to persistence of duodenal fistula (DF). We present our experience with a T-tube placed into the DF for better outcome of the patients. METHODS:All patien...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2196-1
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Venous thromboembolism (VTE) is a condition that has always been perceived to be rare in Asia. The aim of this systematic review was to gather the current available evidence on the incidence of VTE in this population. A secondary aim was to assess the efficacy of pharmacological prophylaxis, and hence determ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-014-2763-0
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:This study was intended to compare the prognostic power of the number of positive lymph nodes with that of the lymph node ratio in patients with ampullary carcinoma. METHODS:A retrospective analysis was conducted of the medical records of 71 consecutive patients with ampullary carcinoma who underwent pancre...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1175-7
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Routine preoperative staging in pancreas cancer is controversial. We sought to evaluate the rates of diagnostic laparoscopy (DLAP) for pancreatic cancer. METHODS:We queried the National Surgical Quality Improvement Program for patients with pancreas cancer (2005-2013) and compared groups who underwent DLAP,...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4855-8
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:The goal of the present study was to critically review and identify the strength of available evidence in the literature on the use of laparoscopic appendectomy (LA) in complicated appendicitis (CA). METHODS:The Cochrane Library and Controlled Trials Registry, MEDLINE (Ovid), PubMed, Web of knowledge, and S...
journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00268-010-0669-z
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Postoperative liver failure (PHLF) is one of the most common complications following major hepatectomy. The preoperative assessment of future liver remnant (FLR) function is critical to predict the incidence of PHLF. OBJECTIVE:To determine the efficacy of the plasma clearance rate of indocyanine green clear...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3441-1
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Postoperative outcome prediction in elderly is based on preoperative physical status but its predictive value is uncertain. The goal was to evaluate the value of risk assessment performed perioperatively in predicting outcome in case of admission to an intensive care unit (ICU). METHODS:A total of 108 posts...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05742-5
更新日期：2020-12-01 00:00:00
abstract：:The hospital records of 639 patients affected by primary gastric cancer who were consecutively admitted to our unit during the period 1981-1995 were reviewed. Overall 220 underwent total gastrectomy (38 palliative), 12 had resection of the gastric stump, 195 had distal subtotal gastrectomy (55 palliative), 78 had bypa...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689910073
更新日期：2000-04-01 00:00:00
abstract：:Medical errors from communication failures are enormous during the perioperative period of cardiac surgical patients. As caregivers change shifts or surgical patients change location within the hospital, key information is lost or misconstrued. After a baseline cognitive study of information need and caregiver workflo...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0319-5
更新日期：2010-04-01 00:00:00
abstract：:Eighty patients undergoing cholecystectomy were either assigned deliberately (n = 30) or randomized (n = 50) to drainage (n = 38) or nondrainage (n = 42). Subhepatic collections were seen on ultrasonography (US) after 48 to 72 hours in 12 of 35 patients with drainage and 24 of 42 patients without drainage (p < 0.05). ...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01655718
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:The purposes of this study were to determine clinical presentations and surgical outcomes of perforated peptic ulcer (PPU), and to evaluate the accuracy of the Boey scoring system in predicting mortality and morbidity. METHODS:We carried out a retrospective study of patients undergoing emergency surgery for...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9796-1
更新日期：2009-01-01 00:00:00
abstract：:Cardiovascular disease [atherosclerosis and subsequent myocardial infarction (MI)] has been associated with primary hyperparathyroidism. We aimed at studying cardiovascular events before and after surgery and mortality after surgery for primary hyperparathyroidism using a historical follow-up design. A total of 674 pa...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6541-z
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Human factors research has suggested benefits of consistent teams yet no surgical team consistency measures have been established for teamwork improvement initiatives. METHODS:Retrospective analysis was conducted of teams performing consecutive elective procedures of unilateral primary total knee and hip re...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2866-7
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:The aim of this study was to report on the application of a minimally invasive technique to the radical extirpation of primary and recurrent pilonidal disease. This technique does not require specific equipments, is ordinarily performed under local anesthesia on an outpatient basis, and provides optimal cosm...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05313-3
更新日期：2020-04-01 00:00:00
abstract：INTRODUCTION:Hypocalcemia is a well-known complication after total thyroidectomy. Studies have indicated that the presence of low postoperative parathyroid hormone (PTH) levels can predict hypocalcemia. However, definitive study designs are lacking. The aim of this study was to determine whether postoperative PTH alone...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4444-2
更新日期：2018-07-01 00:00:00
abstract：:Video-assisted thyroidectomy, although an increasingly used method to treat benign thyroid nodules, is rarely used to treat thyroid cancer. We performed gasless video-assisted total thyroidectomy for the treatment of papillary carcinoma of the thyroid. The patients were two men and five women with ages ranging from 29...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7446-9
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Adenocarcinoma of the small bowel is relatively less common than malignancies of the esophagus, stomach, and colorectum. In small bowel adenocarcinoma, various prognostic factors influence the disease-free status and overall survival rates. MATERIALS AND METHODS:Eighty patients who were diagnosed with small...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7898-6
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:The role of circular staplers in gastroduodenostomy during subtotal gastrectomy for gastric cancer has not been defined clearly. METHODS:A randomized clinical trial included patients with gastric cancer who underwent subtotal gastrectomy with either stapled (99 patients) or handsewn gastroduodenostomy (98 p...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-011-1038-2
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:It is now generally believed that regulatory T cells (Tregs) play an important role in peripheral tolerance, and a defect in Tregs is considered one of the most important factors in the induction of various kinds of autoimmune disease including ulcerative colitis (UC). Here, we examined the change in frequen...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0301-9
更新日期：2006-04-01 00:00:00
abstract：:Bacterial biofilms develop on a number of living and inert surfaces within the urinary tract, producing chronic intractable infections. The role of exopolysaccharides in producing a variety of extracellular polymeric substances according to the infection site and bacterial species and the clinical features of the resu...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002680010203
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Barriers to female surgeons entering the field are well documented in Australia, the USA and the UK, but how generalizable these problems are to other regions remains unknown. METHODS:A cross-sectional survey was developed by the International Federation of Medical Students' Associations (IFMSA)'s Global Su...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05199-1
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to compare single-port access cholecystectomy (SPA) with the standard laparoscopic technique (LC) regarding the duration of the operation, complications, learning curve, late postoperative quality of life (QoL) and the incidence of incisional hernias. METHODS:Between June 2009 and ...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章
doi：10.1007/s00268-013-1946-4
更新日期：2013-05-01 00:00:00
