Abstract：
:Angiogenesis is of vital importance during the development and progression of solid tumors. Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis and could be produced by some cancer cells. To investigate the clinical relevance of VEGF in the tumorigenesis of human thyroid, an immunohistochemical study was performed on archival materials of follicular adenomas (n = 13), Hürthle cell adenomas (n = 6), papillary carcinomas (n = 76), follicular carcinomas (n = 12), Hürthle cell carcinomas (n = 2), and anaplastic carcinomas (n = 8). Patterns of VEGF expression were analyzed in relation to histologic subtypes of thyroid tumors and were correlated to biologic indicators of papillary carcinoma. All papillary carcinomas and Hürthle cell neoplasms revealed a strong, diffuse staining reaction, whereas anaplastic carcinoma usually exhibited weak and infrequent immunoreactivity. VEGF levels were usually higher in follicular adenomas than in follicular carcinomas. With regard to prognostic value, VEGF expression did not correlate with tumor size, extent of invasion, or scores on the AGES system (i.e., patient age, tumor size, histologic grade, tumor extent, distant metastasis) or the MACIS system (i.e., metastasis, age, completeness of resection, invasion, tumor size) for papillary carcinomas (p > 0.05, respectively). The results of the current study indicate that VEGF may play a role in the development of human thyroid cancer. Determination of the angiogenic phenotype may have limited prognostic value for patients with papillary carcinoma.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Huang SM,Lee JC,Wu TJ,Chow NHdoi
10.1007/s002680020085keywords:
subject
Has Abstractpub_date
2001-03-01 00:00:00pages
302-6issue
3eissn
0364-2313issn
1432-2323journal_volume
25pub_type
杂志文章abstract：:This study was first designed to investigate systematically the kinetics of surface expression of scavenger receptors (SRs) and CD14 on alveolar macrophages in vivo and in vitro and their relation with local pro- and antiinflammatory responses in endotoxemia. The expression of SR and CD14 in lungs was down- and up-reg...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6548-5
更新日期：2003-01-01 00:00:00
abstract：INTRODUCTION:Response rates to systemic chemotherapy for patients who have failed irinotecan-based chemotherapy for liver-dominant metastatic colorectal cancer range between 10 and 18 % with overall survival between 7 and 9 months. The aim of this study was to assess the efficacy and safety of hepatic arterial irinotec...
journal_title：World journal of surgery
pub_type： 杂志文章,多中心研究
doi：10.1007/s00268-015-3386-9
更新日期：2016-05-01 00:00:00
abstract：:To characterize hepatocellular carcinoma (HCC) cells with mutant (m) p53 protein histologically, we examined 68 main nodules and 20 accessory lesions of 72 patients with HCC who underwent hepatic resection between October 1990 and September 1993. Some sections were fixed in periodate-lysine-paraformaldehyde, embedded ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900033
更新日期：1996-02-01 00:00:00
abstract：INTRODUCTION:Thyroid cancer (TC) incidence has been increasing in recent years. The aim of this study was to investigate our institution-based estimates of operative volumes for TC over the last three decades. MATERIALS AND METHODS:This was a retrospective cohort study of patients undergoing thyroid surgery at our ins...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3322-z
更新日期：2016-03-01 00:00:00
abstract：:Fifty patients reoperated for failed Nissen fundoplication are presented; 29 patients (group 2) were operated between 1983 and 1988 while 21 patients (group 1) were operated before 1983. In group 1, the "slipped Nissen" had been the most frequent cause of reoperation (48%). In group 2, the most frequent causes for the...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658439
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:Insertion of a nasogastric tube (NGT) in an anesthetized, paralyzed, and intubated patient is difficult, and many methods have been proposed to aid in the procedure. We present a simple insertion technique. METHODS:A silicone NGT was made rigid by filling it with distilled water and freezing it. Patients we...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-009-0144-x
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:We aimed to systematically review the literature on the educational impact of Advanced Trauma Life Support (ATLS) courses and their effects on death rates of multiple trauma patients. METHODS:All Medline, Pubmed, and the Cochrane Library English articles on the educational impact of ATLS courses and their e...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-013-2294-0
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:Few guidelines exist for the initial management of wounds in disaster settings. As wounds sustained are often contaminated, there is a high risk of further complications from infection, both local and systemic. Healthcare workers with little to no surgical training often provide early wound care, and where r...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-014-2663-3
更新日期：2015-04-01 00:00:00
abstract：:In a prospective multicenter study, 186 patients with squamous cell esophageal carcinoma, who after evaluation were considered suitable for surgery, were randomized to 4 treatment groups: Group 1, surgery alone; Group 2, pre-operative chemotherapy (cisplatin and bleomycin) and surgery; Group 3, pre-operative irradiati...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02067069
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:Trauma continues to be a major health problem worldwide, particularly in the developing world, with high mortality and morbidity. Yet most developing countries lack an organized trauma system. Furthermore, developing countries do not have in place any accreditation process for trauma centers; thus, no accept...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2538-7
更新日期：2014-08-01 00:00:00
abstract：:Nuss described a minimally invasive technique for correcting pectus excavatum in children. A curved stainless-steel bar is inserted behind the sternum through the chest cavity with the convex surface face down, then rotated 180 degrees to elevate the sternum and correct the deformity. The procedure gained wide accepta...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6519-x
更新日期：2002-10-01 00:00:00
abstract：:Previous analysis of this prospective randomized trial and meta-analysis of published randomized trials of adjuvant intraperitoneal chemotherapy demonstrated improved survival in patients with advanced gastric cancer. Simple criteria applicable at the time of surgery for patient selection were sought in this analysis....
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00268-001-0067-7
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND:Open surgical cricopharyngeal myotomy(CM) is considered standard of care for Zenker's diverticulum(ZD). Trans-oral CM has been described using a rigid stapling device for two decades; however, this remains problematic for severely kyphotic patients. This problem can be overcome with flexible endoscopy utiliz...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3442-0
更新日期：2016-06-01 00:00:00
abstract：INTRODUCTION:Preventing secondary insult to the brain is imperative following traumatic brain injury (TBI). Although TBI does not preclude nonoperative management (NOM) of splenic injuries, development of hypotension in this setting may be detrimental and could therefore lead trauma surgeons to a lower threshold for op...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4494-0
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the factors for considering surgery on thyroid nodules that had non-diagnostic results on two consecutive cytology examinations. METHODS:A total of 104 thyroid nodules with two consecutive non-diagnostic cytology examinations in 104 patients were investigated. Nodule...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1397-8
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:The use of pulmonary artery catheter (PAC) is controversial. The purpose of this study was to document the changing pattern of PAC use and to determine its effect on outcome. METHODS:The use of PAC was analyzed in patients ≥16 years old admitted to the surgical intensive care unit (SICU) over a 9-year period...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1149-9
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Mutations in BRCA1 and BRCA2 confer an increased risk to breast and other cancers, but to date there have only been limited numbers of studies of BRCA1- and BRCA2-associated cancers among Asians. Malaysia is a multiracial country with three main races: Malays, Chinese, Indians. We determined whether tumor pa...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0146-8
更新日期：2009-10-01 00:00:00
abstract：:Some 25%-70% of sporadic medullary thyroid carcinomas (MTCs) are associated with somatic mutations within the RET proto-oncogene. In a significant number of MTCs, however, no such genetic variations can be detected, which implies alternative pathogenic molecular alterations. To assess altered RET mutation-specific gen...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7748-y
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Laparoscopic proximal gastrectomy (LPG) is performed as a function-preserving surgery for patients with early proximal gastric malignant tumors; however, whether LPG has advantages postoperatively compared with laparoscopic total gastrectomy (LTG) is debatable, especially with regard to nutritional outcomes....
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4625-7
更新日期：2018-10-01 00:00:00
abstract：:The loss or failure of an organ or tissue is one of the most frequent, devastating, and costly problems in healthcare. Current treatment modalities include transplantation of organs, surgical reconstruction, use of mechanical devices, or supplementation of metabolic products. A new field, tissue engineering, applies t...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-001-0131-3
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:The Lancet recently sponsored a commission examining the role of surgery in global health. There is a paucity of published information on the cost-effectiveness of surgery in low- and middle-income countries, a key metric in the prioritisation of limited resources. METHODS:All patients undergoing emergency ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3271-6
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Acute appendicitis is the most common abdominal emergency in clinical surgery. This study was designed to compare the diagnostic value of the Pediatric Appendicitis Score (PAS) with that of the Alvarado score based on different time points in children with right lower quadrant (RLQ) abdominal pain. METHODS:...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章
doi：10.1007/s00268-011-1310-5
更新日期：2012-01-01 00:00:00
abstract：:A mathematic model is created to determine the economic cost per year of anticipated prolongation of life that would result from a program of abdominal ultrasonographic (US) screening for abdominal aortic aneurysm. The protocol involves US screening at age 60, 67, and 74 years with additional annual follow-up US and e...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01659032
更新日期：1989-05-01 00:00:00
abstract：BACKGROUND:There is a consensus on the indication of laparoscopy-assisted distal gastrectomy (LADG) for early gastric cancer that needs D1 + alpha or D1 + beta lymph node dissection. However, many gastrointestinal surgeons consider D2 lymph node dissection in LADG to be difficult, therefore, only a few medical institut...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9697-3
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:Early mortality in ruptured abdominal aneurysm (rAAA) is high, but data on long-term outcome are scarce. The aim of this study was to investigate the long-term outcome in survivors after open surgery for rAAA in well-defined population. METHODS:This is a population-based, observational long-term follow-up (...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05457-7
更新日期：2020-06-01 00:00:00
abstract：:Evaluation of prognostic factors of adenocarcinoma of Vater's ampulla is still a matter of debate. The aim of this study was to evaluate retrospectively factors that influence early and long-term outcomes in a 20-year single-institution experience on ampullary carcinoma. A total of 94 consecutive patients with ampulla...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7498-x
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Total thyroidectomy is now accepted worldwide as the standard surgical procedure for the management of benign bilateral nodular thyroid disease. Hypocalcemia is the most common complication of that procedure and a variety of strategies for diagnosing and managing post-thyroidectomy hypocalcemia have been adv...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-008-9545-5
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Laparoscopic hepatectomy (LH) is established as a safe and feasible treatment option for liver tumors. However, whether the adoption of laparoscopic approach for malignant tumors, such as hepatocellular carcinoma (HCC), will compromise the long-term result is still unknown. This study was designed to evaluat...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1212-6
更新日期：2011-10-01 00:00:00
abstract：:Patients with short bowel syndrome (SBS) receiving total parenteral nutrition (TPN) have a high incidence of catheter-related sepsis, one of its major complications. The aim of this study was to correlate the length of remaining small bowel (RSB) with septic episodes related to the central venous catheter in a group o...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002680010274
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:This is the fourth updated Enhanced Recovery After Surgery (ERAS®) Society guideline presenting a consensus for optimal perioperative care in colorectal surgery and providing graded recommendations for each ERAS item within the ERAS® protocol. METHODS:A wide database search on English literature publication...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-018-4844-y
更新日期：2019-03-01 00:00:00
