Abstract：
:To characterize hepatocellular carcinoma (HCC) cells with mutant (m) p53 protein histologically, we examined 68 main nodules and 20 accessory lesions of 72 patients with HCC who underwent hepatic resection between October 1990 and September 1993. Some sections were fixed in periodate-lysine-paraformaldehyde, embedded in OCT compound, and stained with the mouse monoclonal antibody PAb1801 to m-p53 protein by the immunoperoxidase technique with avidin-biotin complexes. Other sections were fixed in 20% buffered formalin, embedded in paraffin, and stained with the mouse monoclonal antibody DO-1 to m-p53 protein in the same way. Lesions in which cells had nuclei stained for m-p53 protein were defined as being positive for the protein; 25 of the 68 main nodules and 14 of the 20 accessory lesions were positive. Large main nodules were more likely to be positive than small ones. Microscopic examination showed that a larger proportion of poorly differentiated main nodules than well differentiated nodules were positive. Larger proportions of main nodules with extracapsular invasion, septa, portal thrombi, or intrahepatic metastases were positive than main nodules without these features. Accessory lesions that seemed to be metastatic were almost all positive, but few accessory lesions that seemed to be of multicentric occurrence were positive. Our results suggest that lesions with m-p53 protein had a high grade of malignancy and metastasized readily.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Okuda T,Hirohashi K,Kinoshita H,Wakasa K,Sakurai Mdoi
10.1007/s002689900033subject
Has Abstractpub_date
1996-02-01 00:00:00pages
215-20issue
2eissn
0364-2313issn
1432-2323journal_volume
20pub_type
杂志文章abstract：:The aim of this study was to investigate the prognostic factors for hepatocellular carcinoma (HCC) in patients without cirrhosis who underwent hepatectomy. Between 1986 and 1998 a total of 197 men and 57 women with noncirrhotic HCC underwent hepatic resection in the Department of Surgery, Chang Gung Memorial Hospital,...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6708-7
更新日期：2003-04-01 00:00:00
abstract：:Normal cellular survival is dependent on the cooperative expression of genes' signaling through a broad array of DNA patterns. Cancer, however, has an Achilles' heel. Its altered cellular survival is dependent on a limited subset of signals through mutated DNA, possibly as few as three. Identification and control of t...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-011-1100-0
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:The profile and management of self-inflicted abdominal stab wounds (SI-ASW) patients is still obscure. METHODS:The National Trauma Data Bank (2012) was queried for adults with abdominal stab wounds (n = 9544). Patients with SI-ASW (n = 1724) and non-SI-ASW (n = 7820) were compared. Predictors for non-therap...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4083-7
更新日期：2017-11-01 00:00:00
abstract：:Jejunostomy is a surgical procedure by which a tube is situated in the lumen of the proximal jejunum, primarily to administer nutrition. There are many techniques used for jejunostomy: longitudinal Witzel, transverse Witzel, open gastrojejunostomy, needle catheter technique, percutaneous endoscopy, and laparoscopy. Th...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/pl00012353
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:Surgery for Graves' disease (GD) is usually performed after adequate control with medical treatment. Occasionally, rapid pre-operative optimization is required. The primary objective was to compare the outcomes of patients undergoing elective surgery for well-controlled GD with those undergoing rapid pre-ope...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05125-5
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND AND STUDY AIMS:Post-lobectomy bronchopleural fistula is a rare complication of lung resection surgery, and proper management is crucial for the successful resolution. Most published papers deal with surgical treatment. We report our experience with a new interventional management, endobronchial naso-bronchia...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3779-4
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Complications are important indicators of immediate postoperative outcomes. The Clavien-Dindo classification (CDC) is a widely used index for the classification of surgical complications. More recently, the comprehensive complication index (CCI) has also been introduced for classifying postoperative complica...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05859-7
更新日期：2021-03-01 00:00:00
abstract：:Noninvasive diagnosis of cavernous hemangioma of the liver is an important step in the investigation of patients with focal hepatic lesions since biopsy may result in life-threatening hemorrhage. To determine the diagnostic accuracy of 99m-technetium red blood cell (99mTc-RBC) imaging with tomography, 50 patients with...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658668
更新日期：1990-07-01 00:00:00
abstract：:Although palpable axillary lymphadenopathy is most often related to benign disorders, it may be a harbinger of an underlying advanced malignancy. Fewer than 1% of patients diagnosed with breast cancer initially present with axillary metastases as their only clinical manifestation. This study represents the Mayo Clinic...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7290-y
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Although ultrasonographic (US) evaluation is currently recommended for the workup of all palpable thyroid nodules, little guidance exists regarding the manner in which US data are to be used. Herein, we examine the available evidence and recommend how US can be used most effectively to predict malignancy. We...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-008-9494-z
更新日期：2008-07-01 00:00:00
abstract：INTRODUCTION:The impact of diabetes mellitus (DM) on outcomes in patients undergoing emergency laparotomy for adhesive small bowel obstruction (ASBO) remains unknown. METHODS:Low-risk (ASA class of I and II) patients requiring emergency operation for ASBO were identified using the ACS NSQIP database. Propensity score ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3338-4
更新日期：2016-04-01 00:00:00
abstract：:The expression CA195 in serum, defined by monoclonal antibody CC3C195 (IgM), was studied in 67 patients with pancreatic cancer and in 138 patients with biliary or pancreatic benign disease. The results were compared with carcinoembryonic antigen (CEA) expression. The overall sensitivity of the CA195 assay (> 12 U/ml) ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/pl00013182
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:Chronic pilonidal disease is a debilitating condition that typically affects young adults. There is a wide variety of available therapeutic strategies reflecting the inconsistent outcomes attributed to the various operative approaches. The majority involve excision of the sinus tract followed by either prima...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1138-z
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Preoperative assessment of geriatric-specific determinants of health may enhance perioperative risk stratification among elderly patients. This study examines effects of geriatric-specific variables on postoperative outcomes in patients undergoing elective major abdominal operations. METHODS:Patients includ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05515-0
更新日期：2020-08-01 00:00:00
abstract：:Radiologically demonstrable pancreatic endocrine tumors are a frequent requirement for exploration in patients with multiple endocrine neoplasia type I (MEN-I). Such delayed intervention is accompanied by a 30% to 50% incidence of pancreatic endocrine metastases. This study explores biochemical tumor markers and opera...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900451
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to evaluate the efficacy of cholestyramine ointment (15 %) in reducing postoperative pain at rest and during defecation after open hemorrhoidectomy. METHODS:A total of 91 patients with third and fourth degree hemorrhoids undergoing open hemorrhoidectomy were included in this...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-012-1895-3
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND:Molecular diagnostics can allow some patients with indeterminate thyroid nodule cytopathology to avoid diagnostic hemithyroidectomy; however, the testing is costly. We hypothesized that molecular testing with the intention of preventing unnecessary diagnostic hemithyroidectomy would be cost-effective if this...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05177-7
更新日期：2020-02-01 00:00:00
abstract：INTRODUCTION:Despite formal definitions of mucinous cystic neoplasms (MCNs) and intraductal papillary neoplasms (IPMNs) by the World Health Organization (WHO) and Armed Forces Institute of Pathology (AFIP), several controversies with regard to MCNs remain. The aim of this review was to determine the clinicopathological...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-006-0126-1
更新日期：2006-12-01 00:00:00
abstract：:A review of the recent literature is cited in support of the use of total parenteral nutrition (TPN) in Crohn's disease. The principal indications for this use are described and some of the disadvantages are discussed. ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02393566
更新日期：1980-01-01 00:00:00
abstract：OBJECTIVE:Gastroesophageal reflux disease (GERD) symptoms are commonly reported in primary hyperparathyroidism (pHPT). Although a calcium-mediated cause-and-effect relationship has been suggested, it remains unknown if parathyroidectomy improves GERD symptoms. METHODS:Over a 22-month period, 1,175 (39%) of 3,000 conse...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2876-5
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Spleen-preserving procedures deserve every effort by surgeons to reduce the risk of overwhelming postsplenectomy infection. Partial splenectomy at hospitals with restricted sources remains technically demanding. We describe our method of partial splenectomy for benign splenic cysts with the aid of a Lin clam...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9240-y
更新日期：2007-11-01 00:00:00
abstract：:Intraperitoneal forgotten foreign bodies are prone to create adhesions and to encapsulate, or to provoke an exudative response, with or without accompanying bacterial infection. Often a process of self-extrusion is initiated. This is also true for gossypibomas, retained surgical sponges. Presentation is possible as a ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002689910084
更新日期：2000-05-01 00:00:00
abstract：:Mass screening for the purpose of detecting thyroid cancer at its earliest stage may not be recommended at the present time, but screening focused on certain risk groups is advocated. Familial nonmedullary thyroid carcinoma (FNMTC) is a distinct clinical entity with a high incidence of multifocality and association wi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7676-x
更新日期：2004-11-01 00:00:00
abstract：:Little evidence is available regarding long-term survival of patients with gallbladder cancer that is discovered at the time of laparoscopic cholecystectomy (LC). Therefore the present study was performed to evaluate long-term outcomes of this disease. Of 1546 patients who underwent LC for benign gallbladder disease b...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7886-x
更新日期：2005-09-01 00:00:00
abstract：:Surgical resection is the treatment of choice for patients with stage I and stage II non-small-cell lung cancer (NSCLC--squamous cell, adenocarcinoma, and large-cell carcinoma). Distant recurrence is an important cause of death after complete surgical resection, occurring in 30-60% of patients. Postoperative adjuvant ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01659083
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:Surgical site infection (SSI) is a common cause of major morbidity after liver resection. This study aimed to identify the risk factors for incisional and organ/space SSIs after liver resection. METHODS:Our liver surgery database was retrospectively analyzed for patients treated between January 2009 and Nov...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2922-3
更新日期：2015-05-01 00:00:00
abstract：:To pursue a suitable central airway replacement, we conducted central airway reconstruction using autologous pulmonary tissue flaps lined with alloy stents in five patients after extensive tracheal resection. Preoperative and postoperative arterial blood gas analysis and pulmonary function tests were used to evaluate ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3066-9
更新日期：2015-08-01 00:00:00
abstract：:Large ventral hernias are a significant surgical challenge. "Loss of domain" (LOD) expresses the relationship between hernia and abdominal volume, and is used to predict operative difficulty and success. This systematic review assessed whether different definitions of LOD are used in the literature. The PubMed databas...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4783-7
更新日期：2019-02-01 00:00:00
abstract：:In spite of recent therapeutic advances, severe overt secondary hyperparathyroidism due to chronic renal failure necessitates parathyroidectomy and recurrent hyperparathyroidism is one of the most significant problems in this patient population. In the present study, the incidence of recurrent hyperparathyroidism was ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02067331
更新日期：1992-07-01 00:00:00
abstract：:Among 26 patients with gallbladder carcinoma, 11 resected cases were studied retrospectively with respect to the preoperative imaging techniques and the operative procedures employed. Ultrasonography, endoscopic ultrasonography, and computed tomography were valuable in detecting gallbladder carcinoma preoperatively wh...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658723
更新日期：1991-05-01 00:00:00
