Comparative study of carbohydrate antigen 195 and carcinoembryonic antigen for the diagnosis of pancreatic carcinoma.

Abstract:

:The expression CA195 in serum, defined by monoclonal antibody CC3C195 (IgM), was studied in 67 patients with pancreatic cancer and in 138 patients with biliary or pancreatic benign disease. The results were compared with carcinoembryonic antigen (CEA) expression. The overall sensitivity of the CA195 assay (> 12 U/ml) was higher than that for CEA (89.5% vs. 53.7%) (p < 0.001). Sensitivity was increased to 92.5% with the simultaneous use of the two antigens, but the difference was statistically significant only with CEA (p < 0.001). The specificity of CA195 calculated from all patients with benign diseases was lower than that of CEA (73.1% vs. 89.8%). However, using a cutoff value of 100 U/ml for CA195, the specificity of this antigen (82%) was higher than that of CEA. These results demonstrate that marked elevations of tumor antigen CA195 are relatively specific for pancreatic carcinoma, and that this antigen is superior to CEA for diagnosing pancreatic cancer by virtue of its higher sensitivity.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Andicoechea A,Vizoso F,Alexandre E,Martínez A,Cruz Díez M,Riera L,Martinez E,Ruibal A

doi

10.1007/pl00013182

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

227-31; discussion 231-2

issue

3

eissn

0364-2313

issn

1432-2323

journal_volume

23

pub_type

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