Abstract:
BACKGROUND:The incidence, pattern, and severity of sleep disturbance and cognitive dysfunction has not been well characterized for patients with primary hyperparathyroidism (PHPT). There is no agreement on the mechanism of the development or resolution of such symptoms, and in no previous study has cerebral activity been functionally assessed and change documented following surgical cure of patients with PHPT. METHODS:We undertook a prospective analysis to obtain pilot data on 6 patients with PHPT. Functional magnetic resonance imaging (fMRI), formal neuropsychologic (NP) tests, and health-related quality of life (HRQL) measures that included sleep assessments were performed on patients before and after parathyroidectomy. Changes in cortical activation under both conflict and neutral conditions (distracting tasks) were recorded. RESULTS:Functional MRI demonstrated postoperative changes in medial prefrontal cortex activity during cognitive processing of conflict and nonconflict tasks. Further postoperative changes were noted in the dorsolateral prefrontal cortex and parietal cortex with shifts in activations. In addition to the fMRI findings, the patients demonstrated improvements in sleep and social behavior. They tended to experience less fatigue and their processing speed on cognitive tests improved. CONCLUSIONS:These data support the feasibility and willingness of patients with PHPT to undergo fMRI assessment. Preliminary findings reflected a generalized improvement in processing efficiency postoperatively compared with a patient's preoperative state, and the HRQL measures showed improved sleep. These findings mirror those expected with sleep dysfunction. Longitudinal assessment with advanced brain imaging technology, neuropsychological (NP), and sleep evaluations is warranted to further explore cognitive, sleep, and HRQL improvement after parathyroidectomy.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Perrier ND,Coker LH,Rorie KD,Burbank NS,Kirkland KA,Passmore LV,Tembreull T,Stump DA,Laurienti PJdoi
10.1007/s00268-005-0361-xkeywords:
subject
Has Abstractpub_date
2006-05-01 00:00:00pages
686-96issue
5eissn
0364-2313issn
1432-2323journal_volume
30pub_type
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journal_title:World journal of surgery
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journal_title:World journal of surgery
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journal_title:World journal of surgery
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journal_title:World journal of surgery
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journal_title:World journal of surgery
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journal_title:World journal of surgery
pub_type: 杂志文章
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journal_title:World journal of surgery
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更新日期:1996-09-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章,评审
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更新日期:2019-03-01 00:00:00
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journal_title:World journal of surgery
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更新日期:2006-07-01 00:00:00
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更新日期:2003-12-01 00:00:00
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journal_title:World journal of surgery
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更新日期:2009-08-01 00:00:00
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journal_title:World journal of surgery
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journal_title:World journal of surgery
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更新日期:1999-02-01 00:00:00
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更新日期:2007-11-01 00:00:00
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journal_title:World journal of surgery
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更新日期:2006-09-01 00:00:00
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更新日期:2013-01-01 00:00:00
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journal_title:World journal of surgery
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更新日期:2013-02-01 00:00:00
abstract::The authors' affiliations are updated as reflected here. ...
journal_title:World journal of surgery
pub_type: 杂志文章,已发布勘误
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更新日期:2020-08-01 00:00:00
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更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-10-01 00:00:00