Abstract：
BACKGROUND:Esophagectomy remains the standard treatment for resectable esophageal cancer, but the cure rate is low. Neoadjuvant therapy has been tried in attempts to prolong survival and reduce tumor recurrence. The aim of this study was to assess the surgical outcomes with and without neoadjuvant treatment for resectable esophageal cancer in a population-based setting. METHODS:All 1,155 patients treated with esophagectomy for esophageal cancer in Sweden in 1987 through 2000 with or without neoadjuvant therapy were identified and followed up in nationwide registers up to 18 October 2004. Tumor characteristics and response to neoadjuvant treatment were obtained from histopathological reports. Hazard ratios (HRs) with 95% confidence intervals (CIs) adjusted for potential confounding factors were calculated by a Cox proportional hazards regression model. RESULTS:Overall survival was similar in the groups with and without neoadjuvant therapy (adjusted HR 0.99, 95% CI 0.86-1.16). The 3-year survival rates were 34.6% and 32.0%, respectively. Survival was better among the 27.6% of the neoadjuvant group with a complete histopathological response (HR 0.71, 95% CI 0.53-0.94) compared with the surgery only group. Patients without complete response to neoadjuvant therapy had seemingly poorer survival (HR 1.10, 95% CI 0.94-1.29). CONCLUSIONS:Surgical outcomes with and without neoadjuvant therapy were equivalent. Only patients with a complete histopathological response after neoadjuvant treatment had better survival.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Rouvelas I,Zeng W,Lindblad M,Viklund P,Ye W,Lagergren Jdoi
10.1007/s00268-006-0016-6subject
Has Abstractpub_date
2006-12-01 00:00:00pages
2182-90; discussion 2191-2issue
12eissn
0364-2313issn
1432-2323journal_volume
30pub_type
杂志文章abstract：BACKGROUND:We describe a new technique of segment-based liver resection by inserting a 6 French balloon catheter into the portal vein via a branch of the superior mesenteric vein. MATERIALS AND METHODS:The catheter was guided into the relevant portal branch supplying the liver segment that contained the tumor. Injecti...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9043-1
更新日期：2007-06-01 00:00:00
abstract：:The aim of this study was to identify the risk factors for bacterial translocation and to determine the clinical significance of bacterial translocation in patients with colorectal cancer. Mesenteric lymph node sampling was performed to identify the presence of bacterial translocation in 75 patients with colorectal ca...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7576-0
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND:Few clinical studies or randomized clinical trial results have reported the impact of fast-track surgery on human immunity. This study aimed to investigate the clinical and immune impact of fast-track surgery in colorectal cancer patients undergoing elective open surgery. METHODS:A controlled randomized cli...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-012-1606-0
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Due to advances in operative methods and perioperative care, mortality and morbidity following major hepatic resection have decreased substantially, making long-term quality of life (QoL) an increasingly prominent issue. We evaluated whether postoperative diagnosis was associated with long-term QoL and healt...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0032-4
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:A precise understanding of anastomotic recurrence (AR) permits efficient surveillance and treatment strategies. This study aimed to evaluate the clinicopathologic characteristics of patients with AR undergoing curative resection for colorectal cancer (CRC), compare colonic with rectal tumors and investigate ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3663-2
更新日期：2017-01-01 00:00:00
abstract：:Acute biliary pancreatitis is a serious complication of biliary calculous disease and is associated with significant morbidity and mortality. The role of endoscopic retrograde cholangiopancreatography (ERCP) in the management of acute biliary pancreatitis has been the focus of discussion in recent years. In addition, ...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章
doi：10.1007/s002689900207
更新日期：1997-02-01 00:00:00
abstract：:Subtotal esophagectomy still is the major treatment for early Barrett's carcinoma. The inevitable loss of the gastric reservoir leaves an unresolved functional problem. Distal esophageal resection combined with a short jejunal interposition might be a safe alternative with the advantage of better functional results. I...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-7203-5
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:The incidence of thyroid cancer is increasing globally. This is mainly due to the increase in the detection of small papillary carcinomas, including papillary microcarcinomas (PMC) 1 cm or smaller. It was suggested recently that PMCs are overdiagnosed and overtreated. METHODS:In 1993, the author proposed a ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3392-y
更新日期：2016-03-01 00:00:00
abstract：:Those benign breast disorders that are amenable to improvement by aesthetic surgery are discussed from the points of view of indications, techniques, and results. ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01658430
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:The selection of the type of fundoplication or the necessity for an added fundoplication after esophagomyotomy (Heller's operation) for the treatment of achalasia remains controversial. The present retrospective study was designed to compare the long-term results of total and partial fundoplication on the my...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9385-8
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Appendiceal neuroendocrine tumors (aNET) are a common entity in routine medical care, with a rate per appendectomy as high as 0.3-0.9 %. Considering the relatively young age at diagnosis for these patients, exact information about the long-term prognosis of aNET is required. Survival rates vary substantially...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3164-8
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:The optimal timing of VTE prophylaxis initiation after blunt solid organ injury is controversial. Retrospective studies suggest initiation ≤48 h is safe. This prospective study examined the safety and efficacy of early VTE prophylaxis initiation after nonoperative blunt solid organ injury. METHODS:All patie...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05096-7
更新日期：2019-11-01 00:00:00
abstract：:The measurement of the burden of disease and the interventions that address that burden can be done in various units. Reducing these measures to the common denominator of economic units (i.e., currency) enables comparison with other health entities, interventions, and even other fields. Economic assessment is complex,...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1796-5
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Hepatic trisectionectomy is a challenge for surgeons. We describe a technique by combination of the Glisson pedicle method and anterior approach to perform hepatic trisectionectomy. METHODS:In this technique, the Glisson pedicles are isolated above the hilar plate without hilar dissection. After dividing th...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2579-y
更新日期：2014-09-01 00:00:00
abstract：:With limited resources and the current concerns about using animals for research purposes, the needs must be clear when setting up trauma and sepsis experiments for pharmacologic interventions. Such interventions are performed typically for four reasons: (1) to study the pathophysiologic role of certain mediators (whi...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002689900077
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:Pheochromocytoma with synchronous ipsilateral adrenal cortical adenoma (PSCA) may present with mixed clinical, biochemical, and radiological features characteristic to each neoplasm subtype. METHODS:All patients with a pathological diagnosis of pheochromocytoma were evaluated for an ipsilateral cortical ade...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4110-8
更新日期：2017-12-01 00:00:00
abstract：:Different types of vagotomy have been widely used in the treatment of peptic ulcer disease. A close relationship between the vagus nerve and the release or action of gastrointestinal hormones is necessary for the optimal activation of the gastrointestinal tract. The serum concentrations of the antral hormone gastrin a...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01654771
更新日期：1979-09-20 00:00:00
abstract：BACKGROUND:Although various complications after hepatectomy have been reported, there have been no large studies on postoperative portal vein thrombosis (PVT) as a complication. This study evaluated the incidence, risk factors, and clinical outcomes of PVT after hepatectomy. METHODS:The preoperative and postoperative ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2440-8
更新日期：2014-06-01 00:00:00
abstract：:The hospital records of 639 patients affected by primary gastric cancer who were consecutively admitted to our unit during the period 1981-1995 were reviewed. Overall 220 underwent total gastrectomy (38 palliative), 12 had resection of the gastric stump, 195 had distal subtotal gastrectomy (55 palliative), 78 had bypa...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689910073
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:The 'gentle' handling of tissue (i.e., 'respect for tissue') is a fundamental aspect of surgical performance and learning. To date, there have been no methodological assessments that quantitatively measure 'gentleness.' Therefore, the aims of this study were (1) to propose a novel metric for gentle surgical ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05018-7
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:It has been suggested that gender and age could be factors that influence the likelihood of success following antireflux surgery, and our anecdotal impression has been that the outcome following Nissen fundoplication in older women is often disappointing. If correct, characterization of the extent of any dif...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0216-y
更新日期：2009-12-01 00:00:00
abstract：PURPOSE:Restorative surgery for rectal cancer is usually criticized by its functional outcomes. The aim of this study is to assess the efficacy "taeniectomy" pouch in comparison with transverse coloplasty pouch. STUDY DESIGN:This was a prospective controlled study. Most patients who were candidate for low rectal resec...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-04890-z
更新日期：2019-04-01 00:00:00
abstract：:Chronic alcoholism is the etiologic factor initiating most instances of chronic pancreatitis and its complications in the United States of America. The goal of operative intervention is to relieve incapacitating abdominal and back pain, while preserving as much endocrine and exocrine function as possible. Ultrasound a...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01670548
更新日期：1990-01-01 00:00:00
abstract：:Burn patients develop a number of physiologic alterations among which is a markedly increased metabolic rate. Other metabolic changes include an increased rate of glucose production and utilization, a decreased rate of lipid metabolism, and an increased rate of both protein catabolism and anabolism. These alterations ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02067118
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Duct-to-mucosa pancreatojejunostomy after pancreatoduodenectomy can be technically difficult, particularly in cases with a non-dilated pancreatic duct. We devised a novel procedure employing a pancreatic duct holder and mucosa squeeze-out technique facilitating duct-to-mucosa anastomosis. We compared the per...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3659-y
更新日期：2016-12-01 00:00:00
abstract：:Although HLA matching can improve organ graft survival, well matched grafts fail and poorly matched ones survive. Recently evidence has been found that perinatal exposure to noninherited antigens (NIMAs) has a lifelong impact on the immune repertoire of the individual. The state of the art of the influence of NIMAs on...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002680010132
更新日期：2000-07-01 00:00:00
abstract：:Genital manifestations of lymphatic filariasis (genital LF) are a significant cause of disfigurement and disability in the developing world. Surgery is the standard treatment; however, definitive publications are lacking and best practice remains unclear. An exhaustive search strategy using keyword and subject heading...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-015-3220-4
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Nipple-sparing mastectomy (NSM) has gained widespread popularity in recent years. Nonetheless, patient selection, technical consideration and oncological safety of its extension to breast cancer treatment remain uncertain. Few publications have reviewed the application of NSM in Asian populations. METHODS:W...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4197-y
更新日期：2018-05-01 00:00:00
abstract：INTRODUCTION:Pharmacological prophylaxis for early seizures following traumatic brain injury (TBI) is a recommendation in the Brain Trauma Foundation Guidelines. However, several studies have challenged the efficacy and safety of this practice, resulting in varied practice across centers around the world. The purpose o...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4373-0
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:The impact of preoperative enteral nutrition (EN) on postoperative complications and recurrence in Crohn's disease (CD) has not been investigated to date. The purpose of the present study was to determine the effect of preoperative exclusive EN on postoperative complications and recurrence after bowel resect...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3488-z
更新日期：2016-08-01 00:00:00
