Pheochromocytoma with Synchronous Ipsilateral Adrenal Cortical Adenoma.

Abstract:

BACKGROUND:Pheochromocytoma with synchronous ipsilateral adrenal cortical adenoma (PSCA) may present with mixed clinical, biochemical, and radiological features characteristic to each neoplasm subtype. METHODS:All patients with a pathological diagnosis of pheochromocytoma were evaluated for an ipsilateral cortical adenoma from 1994 through 2015. Retrospectively extracted data included indications for adrenalectomy, diagnostic workup (biochemical and radiographic), operative characteristics, pathological findings, and postoperative complications. RESULTS:Sixteen of 413 patients (4%) undergoing adrenalectomy for pheochromocytoma had a PSCA. Median patient age was 57.7 years (IQR 50.1, 63.1); 50% were male. On imaging, 75% of the adrenal neoplasms were found incidentally and only 50% were reported to have a synchronous ipsilateral neoplasm based on imaging findings. Clinically important cortical hormone secretion was diagnosed in 38% of these patients; 25% had glucocorticoid secretory autonomy; and 13% had primary aldosteronism. CONCLUSION:Physicians should be aware that adrenal neoplasms with mixed diagnostic findings may represent PSCA. Evaluation should be performed on this co-occurrence to prevent perioperative complications from resection of an unexpected secretory cortical neoplasm.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Hasassri ME,Pandian TK,Bobr AA,Bancos I,Young WF Jr,Richards ML,Farley DR,Thompson GB,McKenzie TJ

doi

10.1007/s00268-017-4110-8

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

3147-3153

issue

12

eissn

0364-2313

issn

1432-2323

pii

10.1007/s00268-017-4110-8

journal_volume

41

pub_type

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