Abstract:
BACKGROUND:Pulmonary large cell neuroendocrine carcinoma (LCNEC) is pathologically classified as non-small-cell lung cancer (NSCLC), but its clinical behavior is more aggressive than other types of NSCLC. Accordingly, the optimal treatment strategy for LCNEC, including the indication of adjuvant treatment, remains controversial. METHODS:A retrospective review of 139 patients who underwent curative-intent surgery for LCNEC was performed to investigate clinicopathologic features and survival outcomes and to evaluate whether adjuvant treatment affected survival outcomes. RESULTS:The mean patient age was 64 years (126 men, 90.6%). Operative procedures included 111 lobectomies (79.8%), 12 pneumonectomies (8.6%), and 2 sublobar resections. Pathologic stage was IA in 31 (22%), IB in 36 (26%), IIA in 34 (24%), IIB in 9 (6%), IIIA in 19 (14%), IIIB in 2 (1.4%), and IV in 4 patients (2.9%). Postoperatively, 50 patients (36%) received adjuvant treatment. The median follow-up duration was 33 months. The 5-year overall survival (OS) rate was 53%, and 5-year disease-free survival (DFS) rate was 39%. In patients with pathologic stage I, there was no significant difference in either OS or DFS according to the addition of adjuvant treatment. However, in patients with pathologic stage II or higher, patients who underwent adjuvant treatment showed significantly better OS (p = 0.023) and DFS (p = 0.038). CONCLUSIONS:Our findings showed that patients who underwent curative-intent surgery for LCNEC benefitted from the use of adjuvant treatment especially in pathologic stage II or higher.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Kim KW,Kim HK,Kim J,Shim YM,Ahn MJ,Choi YLdoi
10.1007/s00268-017-3908-8subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1820-1827issue
7eissn
0364-2313issn
1432-2323pii
10.1007/s00268-017-3908-8journal_volume
41pub_type
杂志文章abstract::Childhood papillary thyroid carcinoma is associated with more locally aggressive and more frequent distant disease than its adult counterpart. Recurrence rates tend to be higher in children, but cause-specific mortality remains low. Optimal initial treatment of childhood papillary thyroid carcinoma should include tota...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
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journal_title:World journal of surgery
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abstract::In the original article, the units indicated on the y-axes of Fig. 3 are incorrectly labelled. The correct label is pg/mL. Following is the corrected Fig. 3. ...
journal_title:World journal of surgery
pub_type: 杂志文章,已发布勘误
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abstract:BACKGROUND:The objective of this study was to determine whether rat insulin promoter (RIP) could, in a mouse model, direct expression of an adenovirus-mediated reporter gene specifically into pancreatic islets via systemic delivery. METHODS:Five hundred and eight base pairs of the RIP DNA sequence were constructed int...
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journal_title:World journal of surgery
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journal_title:World journal of surgery
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journal_title:World journal of surgery
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journal_title:World journal of surgery
pub_type: 杂志文章,meta分析,评审
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journal_title:World journal of surgery
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journal_title:World journal of surgery
pub_type: 杂志文章
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2532-0
更新日期:2014-06-01 00:00:00
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更新日期:2015-04-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4331-x
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journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900217
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-7721-4
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journal_title:World journal of surgery
pub_type: 杂志文章,评审
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doi:10.1007/s00268-007-9285-y
更新日期:2008-01-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章,评审
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更新日期:1994-09-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-0742-1
更新日期:2007-04-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01658934
更新日期:1993-03-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4234-x
更新日期:2018-03-01 00:00:00
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更新日期:2018-06-01 00:00:00