Analysis of prognostic factors influencing long-term survival after hepatic resection for metastatic colorectal cancer.

Abstract:

BACKGROUND:The aim of this study was to analyze the prognostic factors associated with long-term outcome after liver resection for colorectal metastases. The retrospective analysis included 297 liver resections for colorectal metastases. METHODS:The variables considered included disease stage, differentiation grade, site and nodal metastasis of the primary tumor, number and diameter of the lesions, time from primary cancer to metastasis, preoperative carcinoembryonic antigen (CEA) level, adjuvant chemotherapy, type of resection, intraoperative ultrasonography and portal clamping use, blood loss, transfusions, complications, hospitalization, surgical margins status, and a clinical risk score (MSKCC-CRS). RESULTS:The univariate analysis revealed a significant difference (p < 0.05) in overall 5-year survival rates depending on the differentiation grade, preoperative CEA >5 and >200 ng/ml, diameter of the lesion >5 cm, time from primary tumor to metastases >12 months, MSKCC-CRS >2. The multivariate analysis showed three independent negative prognostic factors: G3 or G4 grade, CEA >5 ng/ml, and high MSKCC-CRS. CONCLUSIONS:No single prognostic factor proved to be associated with a sufficiently disappointing outcome to exclude patients from liver resection. However, in the presence of some prognostic factors (G3-G4 differentiation, preoperative CEA >5 ng/ml, high MSKCC-CRS), enrollment of patients in trials exploring new adjuvant treatments is suggested to improve the outcome after surgery.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Arru M,Aldrighetti L,Castoldi R,Di Palo S,Orsenigo E,Stella M,Pulitanò C,Gavazzi F,Ferla G,Di Carlo V,Staudacher C

doi

10.1007/s00268-007-9285-y

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

93-103

issue

1

eissn

0364-2313

issn

1432-2323

journal_volume

32

pub_type

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