Abstract：
:Hereditary breast cancers, mainly due to BRCA1 and BRCA2 mutations, account for only 5-10% of this disease. The threshold for genetic testing is a 10% likelihood of detecting a mutation, as determined by validated models such as BOADICEA and Manchester Scoring System. A 90-95% reduction in breast cancer risk can be achieved with bilateral risk-reducing mastectomy in unaffected BRCA mutation carriers. In patients with BRCA-associated breast cancer, there is a 40% risk of contralateral breast cancer and hence risk-reducing contralateral mastectomy is recommended, which can be performed simultaneously with surgery for unilateral breast cancer. Other options for risk management include surveillance by mammogram and breast magnetic resonance imaging, and chemoprevention with hormonal agents. With the advent of next-generation sequencing and development of multigene panel testing, the cost and time taken for genetic testing have reduced, making it possible for treatment-focused genetic testing. There are also drugs such as the PARP inhibitors that specifically target the BRCA mutation. Risk management multidisciplinary clinics are designed to quantify risk, and offer advice on preventative strategies. However, such services are only possible in high-income settings. In low-resource settings, the prohibitive cost of testing and the lack of genetic counsellors are major barriers to setting up a breast cancer genetics service. Family history is often not well documented because of the stigma associated with cancer. Breast cancer genetics services remain an unmet need in low- and middle-income countries, where the priority is to optimise access to quality treatment.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Yip CH,Evans DG,Agarwal G,Buccimazza I,Kwong A,Morant R,Prakash I,Song CY,Taib NA,Tausch C,Ung O,Meterissian Sdoi
10.1007/s00268-018-04897-6subject
Has Abstractpub_date
2019-05-01 00:00:00pages
1264-1270issue
5eissn
0364-2313issn
1432-2323pii
10.1007/s00268-018-04897-6journal_volume
43pub_type
杂志文章,评审abstract：:The surgical morbidity, mortality, and effectiveness of a modified nonshunting operation that includes splenic artery division instead of splenectomy, devascularization, and esophageal transection (SAD group) were evaluated. Eighteen cirrhotic patients with varices who underwent this modified procedure were compared w...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00299180
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:Donor variational arteries often require complex reconstruction. METHODS:We analysed the incidence of different variations, types of arterial reconstructions and their impact on post-operative results from 409 patients undergoing liver transplantation at Karolinska Institute between 2007 and 2015. RESULTS:...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05406-4
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Management of anal fistula represents a balance between curing the condition and maintaining anal continence. Recent reports of the results of the porcine anal fistula plug have demonstrated excellent fistula healing rates without reporting significant complications. METHODS:The outcome of patients who underwe...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9504-1
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Laparoscopic cholecystectomy (LC) is the most performed minimal invasive surgical procedure and has a relatively high complication rate. As complications are often revealed postoperatively, clear, accurate, and timely written operative notes are important in order to recall the procedure and start follow-up ...
journal_title：World journal of surgery
pub_type： 杂志文章,多中心研究
doi：10.1007/s00268-010-0422-7
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:Closure of loop ileostomy can be safely performed using sutures or staplers. The aim of the present study was to compare the cost effectiveness of three different techniques. METHODS:A total of 128 consecutive patients who underwent closure of loop ileostomy between January 2002 and December 2008 were analy...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0787-7
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:This study was intended to compare the prognostic power of the number of positive lymph nodes with that of the lymph node ratio in patients with ampullary carcinoma. METHODS:A retrospective analysis was conducted of the medical records of 71 consecutive patients with ampullary carcinoma who underwent pancre...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1175-7
更新日期：2011-09-01 00:00:00
abstract：:Carnitine, an important carrier of free fatty acid that is transported into mitochondria for beta-oxidation, was thought to be one of the key factors in the regulation of liver regeneration. If the carnitine content is insufficient in the hepatocyte, it might impair the energy substrate's transport and the energy char...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900347
更新日期：1998-01-01 00:00:00
abstract：INTRODUCTION:Unilateral adrenal hyperplasia (UAH) is a rare, surgically correctable cause of primary hyperaldosteronism (PH). We report 2 cases and review the literature for cases of PH secondary to UAH successfully treated via surgery. METHODS:Two cases of UAH treated at our institution were retrospectively reviewed....
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-005-0594-8
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:The lung is the most common site of extrahepatic metastasis from hepatocellular carcinoma (HCC). The aim of this study was to evaluate the significance and long-term outcomes of pulmonary metastasectomy for HCC, especially in patients with multiple nodules or repeated pulmonary recurrence. METHODS:We retros...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3213-3
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Acute appendicitis is the most common reason for abdominal surgery in young adults and children. Open appendectomy is still the treatment often chosen because it is simple, safe, and effective. Our aim was to study whether cosmetic results of appendectomy wounds are better after using continuous absorbable i...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-013-2396-8
更新日期：2014-05-01 00:00:00
abstract：:This paper reviews aspects of head injury management and research in the United Kingdom (UK). We discuss evidence about the scale and etiology of head injury in Britain and how this information has supported a triage-based approach, incorporating risk analysis. A Cohesive organization based upon nationally accepted, y...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-001-0084-6
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:Never events (NEs) are serious clinical incidents that cause potentially avoidable harm and impose a significant financial burden on healthcare systems. The purpose of this study was to identify common never events. METHODS:We analysed the NHS England NE data from 2012 to 2020 to identify common never event...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05867-7
更新日期：2021-03-01 00:00:00
abstract：BACKGROUND:The aim of this study was to compare the perioperative outcomes when using a micropuncture access set (MS) to those when using a conventional puncture set (CS) for implantation of totally implantable venous access device (TAVID). METHODS:A total of 314 patients undergoing chemotherapy for colorectal cancer ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05336-w
更新日期：2020-04-01 00:00:00
abstract：PURPOSE:Advanced Trauma Life Support (ATLS®) is one of the world's best-known training programs for medical providers. Revisions of the ATLS manual have been evidence based for a number of years. In 2011, a level 3 (S3) evidence- and consensus-based guideline on the treatment of patients with severe and multiple injuri...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3063-z
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Conflicting findings have been reported concerning the survival of patients treated with limb salvage and amputation for osteosarcoma. This study aimed to identify predictors associated with surgery types and survival difference. METHODS:Patients with osteosarcoma were selected from the Surveillance Epidemi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05471-9
更新日期：2020-07-01 00:00:00
abstract：:Cancers of the distal rectum (less than 7.5 cm from the anal verge) that are freely mobile, moderately well or well differentiated, less than 4 cm in size, limited to the bowel wall, and without evidence of metastasis should be considered candidates for treatment with electrocoagulation for cure. Tumor cell ploidy and...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02104447
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND:Our laboratory has previously shown that the levels of secreted prostaglandin E(2) (PGE(2)), Thromboxane B(2) (TxB(2)), and interleukin-6 (IL-6) by aortic explant cultures were high in patients with ruptured abdominal aortic aneurysm (AAA). In the present study, we sought to examine the secretory levels of t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9279-9
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Although laparoscopic appendectomy (LA) is widely performed in many countries, LA for complicated appendicitis, which includes perforated or gangrenous appendicitis with or without localized or disseminated peritonitis, has not become a common practice yet. METHODS:We retrospectively analyzed the clinical r...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9843-y
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Ultrasound (US) and sestamibi (MIBI) are traditionally considered positive or negative. The purpose of this study was to define and test a new scoring system for MIBI and US and to determine whether this can improve their accuracy for primary hyperparathyroidism. METHODS:This is a prospective study of 200 c...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1666-1
更新日期：2012-10-01 00:00:00
abstract：PURPOSE:This study was designed to assess the chronological change in health-related quality of life (HRQOL) following robot-assisted distal gastrectomy (RADG) for early gastric cancer (EGC) and to compare the HRQOL of the patients undergoing RADG with that of the general population. METHODS:Patients undergoing RADG f...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2390-1
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Total mesorectal excision (TME) and preoperative chemoradiation therapy (PCRT) for rectal cancer are used sequentially in our center. The aim of this study was to evaluate survival of patients with stage II/III rectal cancer chronologically and to determine whether therapeutic advances associated with TME an...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2168-5
更新日期：2013-11-01 00:00:00
abstract：:Patients with short bowel syndrome (SBS) receiving total parenteral nutrition (TPN) have a high incidence of catheter-related sepsis, one of its major complications. The aim of this study was to correlate the length of remaining small bowel (RSB) with septic episodes related to the central venous catheter in a group o...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002680010274
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:The aims of this study were to investigate predictive factors for microscopic portal venous invasion (mPVI) in hepatocellular carcinoma (HCC) and whether anatomical liver resection (ALR) was useful in such cases. METHODS:We analyzed 852 patients with HCC without macroscopic portal venous invasion who were t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3964-0
更新日期：2017-08-01 00:00:00
abstract：:Among 26 patients with gallbladder carcinoma, 11 resected cases were studied retrospectively with respect to the preoperative imaging techniques and the operative procedures employed. Ultrasonography, endoscopic ultrasonography, and computed tomography were valuable in detecting gallbladder carcinoma preoperatively wh...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658723
更新日期：1991-05-01 00:00:00
abstract：:The management of metastatic neuroendocrine tumors incorporates multimodal therapy with surgery, biotherapy, and chemotherapy. Tumor-targeted therapies using radiolabeled octreotide and metaiodobenzylguanidine (mIBG) represent a novel treatment approach. The aim of this study was to evaluate the effectiveness of 131I-...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7603-1
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:In 2002, the UICC/AJCC TNM classification for papillary thyroid carcinoma was revised. In this study, we examined the validity of this classification system by investigating the predictors of disease-free survival (DFS) and cause-specific survival (CSS) in patients. METHODS:We examined various clinicopathol...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-006-0455-0
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:The prognosis for stage III melanoma patients is mixed, and there is need for new prognostic factors to be incorporated into a revision of melanoma TNM staging. We analyzed the possible role of the timing of lymph node involvement as an important prognostic factor. METHODS:Among 249 melanoma patients who under...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9895-z
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Incidental gallbladder cancer (GBC) is frequently discovered on the specimen when cholecystectomy for a benign disease is performed. The objective of the present study was to assess the management of incidental GBC patients in a French registry. METHODS:Data on patients with GBC treated between 1998 and 200...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1134-3
更新日期：2011-08-01 00:00:00
abstract：:Jejunostomy is a surgical procedure by which a tube is situated in the lumen of the proximal jejunum, primarily to administer nutrition. There are many techniques used for jejunostomy: longitudinal Witzel, transverse Witzel, open gastrojejunostomy, needle catheter technique, percutaneous endoscopy, and laparoscopy. Th...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/pl00012353
更新日期：1999-06-01 00:00:00
abstract：:Aerodigestive tract injuries in the neck are found in about 7% of penetrating neck injuries and are very rare in blunt trauma. A combination of a good physical examination with endoscopy and esophagography can reliably diagnose all significant injuries. Airway control in laryngotracheal trauma is the most urgent prior...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-001-0057-9
更新日期：2001-08-01 00:00:00
