Abstract:
BACKGROUND:Conflicting findings have been reported concerning the survival of patients treated with limb salvage and amputation for osteosarcoma. This study aimed to identify predictors associated with surgery types and survival difference. METHODS:Patients with osteosarcoma were selected from the Surveillance Epidemiology and End Results database (1975-2016). Multivariable logistic regression analysis was conducted, and a nomogram was further established. Propensity score matching (PSM)-adjusted Kaplan-Meier curves, log-rank tests, Cox proportional hazards regression analysis were performed to compare overall survival (OS) and cancer-specific survival (CSS). RESULTS:Among 3363 patients with osteosarcoma, 2447 and 916 underwent limb salvage and amputation. Predictors associated with amputation in the nomogram included age, gender, primary tumor site, tumor grade, tumor stage, tumor size and radiotherapy. Totally 900 pairs of patients treated with limb salvage and amputation were matched after PSM. Limb salvage was significantly associated with improved OS (HR, 0.773; 95% CI, 0.670-0.892; p < 0.001) and CSS (HR, 0.795; 95% CI, 0.681-0.927; p = 0.003) in PSM-adjusted cohort after adjusting for related variables. The significant treatment effect of limb salvage was consistent within most subgroups. Among patients treated with surgery for osteosarcoma, age between 41 and 60, age ≥ 61, pelvis as the primary site, high tumor grade (III/IV), regional and distant tumor stage, tumor size ≥ 92 mm and radiotherapy were independent prognostic factors in PSM cohort. CONCLUSIONS:Limb salvage exhibits significant benefit on OS and CSS compared with amputation for osteosarcoma. Predicators and survival differences should be given full consideration for the treatment of osteosarcoma.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Qi L,Ren X,Liu Z,Li S,Zhang W,Chen R,Chen C,Tu C,Li Zdoi
10.1007/s00268-020-05471-9subject
Has Abstractpub_date
2020-07-01 00:00:00pages
2201-2210issue
7eissn
0364-2313issn
1432-2323pii
10.1007/s00268-020-05471-9journal_volume
44pub_type
杂志文章abstract:BACKGROUND:We analyzed perioperative platelet counts as a potential clinical marker for survival after transthoracic en bloc resection for esophageal cancer. Recent data described preoperative thrombocytosis in malignancies to be associated with poor prognosis. METHODS:A retrospective analysis from a prospective datab...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0707-x
更新日期:2010-11-01 00:00:00
abstract::The surgical morbidity, mortality, and effectiveness of a modified nonshunting operation that includes splenic artery division instead of splenectomy, devascularization, and esophageal transection (SAD group) were evaluated. Eighteen cirrhotic patients with varices who underwent this modified procedure were compared w...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00299180
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:The evolution of diagnostic procedures has resulted in an increase in early detection of pathologically T1 (pT1) colorectal cancer (CRC). However, the risk factors affecting long-term outcomes of patients with pT1 CRCs have been unclear. The aim of the present study was to identify risk factors for postopera...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1378-y
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Accurate, complete and sustainable methods of tracking patients and outcomes in low-resource settings are imperative as we launch efforts to improve surgical care globally. The Surgical services QUality Assessment Database (SQUAD) at the Mbarara Regional Referral Hospital in Uganda is one of very few electro...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4172-7
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Open surgical cricopharyngeal myotomy(CM) is considered standard of care for Zenker's diverticulum(ZD). Trans-oral CM has been described using a rigid stapling device for two decades; however, this remains problematic for severely kyphotic patients. This problem can be overcome with flexible endoscopy utiliz...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-016-3442-0
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Primary hyperparathyroidism (PHPT) is a common endocrine disorder that predominantly affects patients >60 and is increasing in prevalence. Identifying risk factors for poor outcomes after parathyroidectomy in older adults will help tailor operative decision making. The impact of frailty on surgical outcomes ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4629-3
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:This is a baseline assessment of surgical capacity in the Federal Capital Territory (FCT), in preparation for the creation of a National Surgical, Obstetric, Anesthesia, and Nursing Plan. METHODS:In October 2017, all 10 of the 11 secondary hospitals in FCT that provide surgical and/or obstetric care were su...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4835-z
更新日期:2019-03-01 00:00:00
abstract::Organ transplantation continues to be hindered by a limited supply of organs. A significant percentage of potential organ donors are lost to either medical failure or inability to obtain consent for donation. In a surgical intensive care unit (ICU) we have refocused our efforts toward aggressive resuscitation, directe...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/pl00012362
更新日期:1999-07-01 00:00:00
abstract::Surgical resection is the treatment of choice for patients with stage I and stage II non-small-cell lung cancer (NSCLC--squamous cell, adenocarcinoma, and large-cell carcinoma). Distant recurrence is an important cause of death after complete surgical resection, occurring in 30-60% of patients. Postoperative adjuvant ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF01659083
更新日期:1993-11-01 00:00:00
abstract::The phrase "outcomes studies" is usually used to describe those studies where outcome is assessed in large cohorts of patients, often using data from administrative databases. They are used to determine the role and impact of variations in the structure and process of health care delivery play in routine practice. Opt...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s002689900651
更新日期:1999-12-01 00:00:00
abstract::Among 26 patients with gallbladder carcinoma, 11 resected cases were studied retrospectively with respect to the preoperative imaging techniques and the operative procedures employed. Ultrasonography, endoscopic ultrasonography, and computed tomography were valuable in detecting gallbladder carcinoma preoperatively wh...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01658723
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Surgical disease burden falls disproportionately on individuals in low- and middle-income countries. These populations are also the least likely to have access to surgical care. Understanding the barriers to access in these populations is therefore necessary to meet the global surgical need. METHODS:Using g...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-016-3765-x
更新日期:2017-03-01 00:00:00
abstract::Herniographic examinations were performed on more than 4,000 patients. The method was found to be of great value in patients with obscure symptoms in the groin or pelvis. Herniography shows not only hernial sacs but also the general condition and tissue strength of the inguinal part of the abdominal wall. The differen...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01658871
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:The extent to which obesity and genetics determine postoperative complications is incompletely understood. METHODS:We performed a retrospective study using two population cohorts with electronic health record (EHR) data. The first included 736,726 adults with body mass index (BMI) recorded between 1990 and ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05202-9
更新日期:2020-01-01 00:00:00
abstract::Resection remains the treatment of choice in liver cancer. In order to avoid liver transplantation in conventionally unresectable tumors ex-situ ("bench" procedure), in-situ and ante-situm resection technique should be preferred whenever feasible. Despite the deficiency of donor organs, a single center experience with...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00299775
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:In 2002, the UICC/AJCC TNM classification for papillary thyroid carcinoma was revised. In this study, we examined the validity of this classification system by investigating the predictors of disease-free survival (DFS) and cause-specific survival (CSS) in patients. METHODS:We examined various clinicopathol...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-006-0455-0
更新日期:2007-04-01 00:00:00
abstract::Individuals in clinical training programs concerned with critical medical care must learn to manage clinical cases effectively as a member of a team. However, practice on live patients is often unpredictable and frequently repetitive. The widely substituted alternative for real patients-high-fidelity, manikin-based si...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9354-2
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Inguinal hernia is thought to be common in rural Ghana, though no recent data exist on hernia prevalence in the country. This information is needed to guide policy and increase access to safe hernia repair in Ghana and other low-resource settings. METHODS:Adult men randomly selected from the Barekese sub-di...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-3335-7
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Construction of a gastric tube that is well perfused with blood during esophagectomy is the most important factor in avoiding anastomotic leakage. We clarified the hemodynamics of the reconstructed gastric tube with indocyanine green (ICG) fluorescence. METHODS:In 20 patients undergoing gastric tube reconst...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2237-9
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Total thyroidectomy is a well-established surgical approach for the management of papillary thyroid cancer (PTC). However, the best surgical approach for papillary microcarcinoma is nowadays still debated. Both total thyroidectomy and simple lobectomy are used. We report the experience of a single University...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-3327-7
更新日期:2016-03-01 00:00:00
abstract::This paper summarizes the place of thoracic surgery in the management of hydatid disease. Although based on the author's 31-year personal experience, it draws on the experience of others where that of the author is deficient. The treatment of pulmonary, pleural, liver, and cardiac cysts is discussed. The importance of...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900631
更新日期:1999-11-01 00:00:00
abstract:BACKGROUND:Restless legs syndrome (RLS) is a common and poorly understood movement disorder that leads to unpleasant leg sensations. Although RLS can be idiopathic, secondary etiologies such as iron deficiency and renal failure are common. The aim of this prospective cohort study was to evaluate whether RLS is a common...
journal_title:World journal of surgery
pub_type: 临床试验,杂志文章
doi:10.1007/s00268-013-2185-4
更新日期:2013-12-01 00:00:00
abstract::The major goal of wound healing biology is to determine how a wound can be induced to repair damaged tissue faster and more efficiently. Enhancement of dermal and epidermal regeneration is an extremely important goal for the treatment of many different types of wounds. Exogenous application of growth factors to the wo...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-004-2062-2
更新日期:2005-01-01 00:00:00
abstract::The most appropriate approach to treating hepatocellular carcinoma (HCC) in the caudate lobe has not yet been determined. A series of 197 patients who had undergone curative hepatic resection for HCC were analyzed. Fifteen patients had HCC in the caudate lobe: three in the Spiegel lobe (SP), three in the caudate proce...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-004-7341-4
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Early mortality in ruptured abdominal aneurysm (rAAA) is high, but data on long-term outcome are scarce. The aim of this study was to investigate the long-term outcome in survivors after open surgery for rAAA in well-defined population. METHODS:This is a population-based, observational long-term follow-up (...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05457-7
更新日期:2020-06-01 00:00:00
abstract::Angiogenesis is of vital importance during the development and progression of solid tumors. Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis and could be produced by some cancer cells. To investigate the clinical relevance of VEGF in the tumorigenesis of human thyroid, an immunohistochemi...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002680020085
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND:Despite its wide use, catheter tract recurrence after percutaneous biliary drainage (PBD) is rarely reported. However, one recent large-scale study reported a catheter tract recurrence rate as high as 5.2 % in patients with perihilar or distal bile duct cancer. We report on our 20 years of experience with ca...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1844-1
更新日期:2013-02-01 00:00:00
abstract::To clarify the clinical significance of the status of surgical margins, especially the dissected margin in the transverse direction, a clinicopathologic study was performed on 60 patients with carcinoma of the bile duct who underwent radical resection. The patients in group A (n = 28) had no cancer invasion within 5 m...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00298931
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:There is a consensus on the indication of laparoscopy-assisted distal gastrectomy (LADG) for early gastric cancer that needs D1 + alpha or D1 + beta lymph node dissection. However, many gastrointestinal surgeons consider D2 lymph node dissection in LADG to be difficult, therefore, only a few medical institut...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9697-3
更新日期:2008-11-01 00:00:00
abstract::Acute acalculous cholecystitis (AAC) is a well known complication in severely traumatized patients. Existing data of AAC originate from retrospective analyses and episodic case reports. In a prospective study 45 polytraumatized patients admitted to our intensive care unit from January 1989 to June 1990 were clinically...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF02067089
更新日期:1992-11-01 00:00:00