How to manage thyroid nodules with two consecutive non-diagnostic results on ultrasonography-guided fine-needle aspiration.

Abstract:

BACKGROUND:The aim of this study was to investigate the factors for considering surgery on thyroid nodules that had non-diagnostic results on two consecutive cytology examinations. METHODS:A total of 104 thyroid nodules with two consecutive non-diagnostic cytology examinations in 104 patients were investigated. Nodules with one or more suspicious ultrasonography (US) features of marked hypoechogenicity, a not well defined margin, microcalcifications, or a taller-than-wide shape were assessed as sonographically suspicious. Those without any suspicious features were assessed as sonographically benign. The clinicopathologic characteristics of patients and US features of the nodules were compared according to malignancy and benignity. The odds ratio for predicting malignancy was calculated. RESULTS:Altogether, 12 nodules were malignant, and 92 were benign. Age, sex, nodule size, and solidness were not associated with malignancy (P = 0.73, 0.92, 0.48, and 0.73, respectively). The malignancy rate of sonographically suspicious nodules was 25.7%, higher than the 4.3% of sonographically benign nodules (P = 0.002). The odds ratio of sonographically suspicious nodules for predicting malignancy was 16.01 (95% confidence interval 2.36-108.54, P = 0.005). CONCLUSIONS:Based on sonographic features, surgery can be performed selectively on nodules with two consecutive non-diagnostic cytology results.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Moon HJ,Kwak JY,Choi YS,Kim EK

doi

10.1007/s00268-011-1397-8

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

586-92

issue

3

eissn

0364-2313

issn

1432-2323

journal_volume

36

pub_type

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