Surgery for Pheochromocytoma: A Single-Center Review of 60 Cases from South Africa.


BACKGROUND:There is a paucity of data on the presentation and surgical management of pheochromocytoma in developing nations, particularly in Africa. METHODS:This study was a retrospective review, which included all patients managed by the Groote Schuur Hospital/University of Cape Town Endocrine Surgery unit for pheochromocytoma and abdominal paragangliomas, from January 2002 to June 2019. RESULTS:Sixty patients were included in the study, of which 33% were male and 67% female. The mean age was 47 years (range 14-81). The median tumor size was 6 cm, with 45% larger than 6 cm. 92% were located in the adrenal gland (87% unilateral, 5% bilateral), and 8% were extra-adrenal. The conversion rate for laparoscopic cases was 20%, with 55% of cases overall completed laparoscopically. Eleven patients with tumors > 6 cm were initially attempted laparoscopically, of which 3 were converted to open, without any associated increased morbidity. A major adverse event was recorded for 5 cases (8%), including 1 mortality. Overall morbidity, blood loss, operating time and hospital stay were all significantly reduced in the laparoscopic group. There were 5 patients with malignant disease (8%). CONCLUSION:This large series, from an established academic endocrine surgery unit in Africa, can serve as a benchmark for units with similar settings and resource limitations, to compare their surgical management and perioperative outcomes.


World J Surg


World journal of surgery


Nel D,Panieri E,Malherbe F,Steyn R,Cairncross L




Has Abstract


2020-06-01 00:00:00














  • Adenocarcinoma of distal esophagus and gastroesophageal junction: long-term results of surgical treatment in a North Indian Center.

    abstract::This retrospective study reports our experience managing 78 patients with adenocarcinoma of the esophagus and gastroesophageal junction operated between January 1982 and December 1996. Altogether 18 patients presented with stage I and II disease, and 60 patients had stage III and IV disease at presentation; 56 patient...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Parshad R,Singh RK,Kumar A,Gupta SD,Chattopadhyay TK

    更新日期:1999-03-01 00:00:00

  • Risk factors and management of local recurrence following breast conservation surgery.

    abstract::Although a number of histologic and treatment factors that individually and in combination predict for an increased risk of local recurrence after breast conserving surgery can be identified, none so obviously compromises survival that breast conservation is contraindicated because that risk factor is present. In-brea...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Osteen RT

    更新日期:1994-01-01 00:00:00

  • The Challenges of Implementing Artificial Intelligence into Surgical Practice.

    abstract:BACKGROUND:Artificial intelligence is touted as the future of medicine. Classical algorithms for the detection of common bile duct stones (CBD) have had poor clinical uptake due to low accuracy. This study explores the challenges of developing and implementing a machine-learning model for the prediction of CBD stones i...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Tranter-Entwistle I,Wang H,Daly K,Maxwell S,Connor S

    更新日期:2021-02-01 00:00:00

  • Building a comprehensive genomic program for hepatocellular carcinoma.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is the most common primary liver cancer, causing approximately 660,000 deaths worldwide annually. The preferred treatment of HCC is surgical resection or orthotopic liver transplantation (OLT) for patients meeting specific criteria. For patients outside these criteria, options ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Harring TR,Guiteau JJ,Nguyen NT,Cotton RT,Gingras MC,Wheeler DA,O'Mahony CA,Gibbs RA,Brunicardi FC,Goss JA

    更新日期:2011-08-01 00:00:00

  • Surgery for digestive malignancies in patients with psychiatric disorders.

    abstract:BACKGROUND:The psychiatric population has been reported to be accompanied with a higher morbidity and mortality in several situations. However, little is known about the effect of co-morbid psychiatric disorders on surgical risk during major digestive surgery for malignancies. Our purpose in the present study, therefor...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Aoyanagi N,Iizuka I,Watanabe M

    更新日期:2007-12-01 00:00:00

  • Resection of hilar cholangiocarcinomas: pivotal prognostic factors and impact of tumor sclerosis.

    abstract::The well-known poor prognosis of proximal bile duct cancer is due to its unfortunate anatomical location and its late diagnosis. Successful tumor resection, which is considered to be optimal treatment, depends on many factors. Eighty-eight patients suffering from proximal bile duct cancer underwent surgical exploratio...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Puhalla H,Gruenberger T,Pokorny H,Soliman T,Wrba F,Sponer U,Winkler T,Ploner M,Raderer M,Steininger R,Mühlbacher F,Laengle F

    更新日期:2003-06-01 00:00:00

  • The treatment of complicated groin and incisional hernias.

    abstract::One hundred years ago, Edoardo Bassini said: "L'ernia é una malattia meccanica." Before that, Ambroise Paré (1598) and Joseph-Pierre Desault (1798) asserted the mechanical nature of strangulation. Beside strangulation, the most serious of all complications even today, I have studied huge hernias, which are natural com...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Stoppa RE

    更新日期:1989-09-01 00:00:00

  • Investigation of the lymphatic stream of the stomach in gastric cancer with solitary lymph node metastasis.

    abstract:BACKGROUND:Understanding the lymphatic drainage route in gastric cancer is crucial for complete lymph node retrieval from sites susceptible to metastasis. However, the lymphatic stream of the stomach is complex and remains incompletely characterized. METHODS:Patients with small (<4 cm) serosa-negative gastric cancer w...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Tokunaga M,Ohyama S,Hiki N,Fukunaga T,Yamada K,Sano T,Yamaguchi T

    更新日期:2009-06-01 00:00:00

  • Emergency department thoracotomy: survival of the least expected.

    abstract::Although emergency department thoracotomy (EDT) is often considered a controversial "last chance" method of resuscitation, we hypothesized that EDT performed in a busy urban Level I trauma center has significant salvage rates despite the absence of traditional survival predictors. A retrospective review revealed that ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Seamon MJ,Fisher CA,Gaughan JP,Kulp H,Dempsey DT,Goldberg AJ

    更新日期:2008-04-01 00:00:00

  • Enhanced recovery after surgery pathway in patients undergoing pancreaticoduodenectomy.

    abstract:BACKGROUND:Enhanced recovery after surgery (ERAS(®)) pathways have reduced morbidity and length of hospital stay (LOS) in orthopedics, bariatric, and colorectal surgery. New perioperative care protocols have been tested in patients undergoing pancreaticoduodenectomy (PD), with controversial results on morbidity. Incomp...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Braga M,Pecorelli N,Ariotti R,Capretti G,Greco M,Balzano G,Castoldi R,Beretta L

    更新日期:2014-11-01 00:00:00

  • Impact of general versus local anesthesia on early postoperative cognitive dysfunction following carotid endarterectomy: GALA Study Subgroup Analysis.

    abstract:BACKGROUND:The aim of this study was to compare the influence of either general (GA) or local (LA) anesthesia on the postoperative neurocognitive outcome in patients undergoing carotid endarterectomy (CEA) in a randomized study. Therefore, we performed a subgroup analysis of the multicenter GALA study. METHODS:A total...

    journal_title:World journal of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Weber CF,Friedl H,Hueppe M,Hintereder G,Schmitz-Rixen T,Zwissler B,Meininger D

    更新日期:2009-07-01 00:00:00

  • Carcinoembryonic antigen levels in the peritoneal cavity: useful guide to peritoneal recurrence and prognosis for gastric cancer.

    abstract::At the time of laparotomy, peritoneal washings were collected from 155 gastric cancer patients and the levels of carcinoembryonic antigen (CEA) determined. The CEA levels in peritoneal washings were statistically independent of those in sera and could more reliably predict the presence of peritoneal metastasis than a ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Nishiyama M,Takashima I,Tanaka T,Yoshida K,Toge T,Nagata N,Iwamori S,Tamura Y

    更新日期:1995-01-01 00:00:00

  • Clinical Significance of Multiple Pulmonary Metastasectomy for Hepatocellular Carcinoma.

    abstract:BACKGROUND:The lung is the most common site of extrahepatic metastasis from hepatocellular carcinoma (HCC). The aim of this study was to evaluate the significance and long-term outcomes of pulmonary metastasectomy for HCC, especially in patients with multiple nodules or repeated pulmonary recurrence. METHODS:We retros...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Mizuguchi S,Nishiyama N,Izumi N,Tsukioka T,Komatsu H,Iwata T,Tanaka S,Takemura S,Kubo S

    更新日期:2016-02-01 00:00:00

  • Effects of early eschar excision en masse at one operation for prevention and treatment of organ dysfunction in severely burned patients.

    abstract::We sought to determine whether early eschar excision en masse (EEE) at one operation would be effective in the prevention and treatment of postburn organ dysfunction (OD) and multiple organ dysfunction syndrome (MODS). A total of 60 patients, with total body surface burned area over 35% and a third degree burn area ov...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Huang Y,Yang Z,Chen F,Crowther RS,Li A

    更新日期:1999-12-01 00:00:00

  • Preoperative magnetic resonance angiography as a predictive test for cerebral ischemia during carotid endarterectomy.

    abstract:BACKGROUND:To evaluate whether the preoperative magnetic resonance angiography (MRA) can predict the risk of cerebral ischemia associated with the carotid endarterectomy (CEA). METHODS:Between January 2004 and December 2010, 382 consecutive patients (mean age: 56.6 years; range: 45-78 years) were identified to have un...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Shin S,Kwon TW,Cho YP,Shin JH,Yi A,Kim H,Kim GE

    更新日期:2013-03-01 00:00:00

  • Preoperative ultrasonography assessment of vocal cord movement during thyroid and parathyroid surgery.

    abstract:BACKGROUND:Preoperative detection of vocal cord palsy is important in thyroid and parathyroid surgery. However, routine fiberoptic laryngoscopy may bring patients unnecessary discomfort. The aim of this study was to determine the feasibility of using surgeon-performed ultrasonography (US) as a screening tool for preope...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Cheng SP,Lee JJ,Liu TP,Lee KS,Liu CL

    更新日期:2012-10-01 00:00:00

  • Specific targeting of pancreatic islet cells in vivo by insulin-promoter-driven adenoviral conjugated reporter genes.

    abstract:BACKGROUND:The objective of this study was to determine whether rat insulin promoter (RIP) could, in a mouse model, direct expression of an adenovirus-mediated reporter gene specifically into pancreatic islets via systemic delivery. METHODS:Five hundred and eight base pairs of the RIP DNA sequence were constructed int...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Wang X,Olmsted-Davis E,Davis A,Liu S,Li Z,Yang J,Brunicardi FC

    更新日期:2006-08-01 00:00:00

  • Application of formaldehyde for treatment of hemorrhagic radiation-induced proctitis.

    abstract::Radiation-induced proctitis with hemorrhage is not a common complication of radiotherapy to the pelvis for carcinoma. In the most severe forms, massive hemorrhage may necessitate repeated transfusions and inpatient treatment. In severe cases medical treatment has not been proved effective. Surgery may lead to serious ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Roche B,Chautems R,Marti MC

    更新日期:1996-10-01 00:00:00

  • An observational trial for papillary thyroid microcarcinoma in Japanese patients.

    abstract:BACKGROUND:The recent development and spread of ultrasonography and ultrasonography-guided fine needle aspiration biopsy (FNAB) has facilitated the detection of small papillary microcarcinomas of the thyroid measuring 1 cm or less (PMC). The marked difference in prevalence between clinical thyroid carcinoma and PMC det...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Ito Y,Miyauchi A,Inoue H,Fukushima M,Kihara M,Higashiyama T,Tomoda C,Takamura Y,Kobayashi K,Miya A

    更新日期:2010-01-01 00:00:00

  • Can local secretion of prostaglandin E2, thromboxane B2, and interleukin-6 play a role in ruptured abdominal aortic aneurysm?

    abstract:BACKGROUND:Our laboratory has previously shown that the levels of secreted prostaglandin E(2) (PGE(2)), Thromboxane B(2) (TxB(2)), and interleukin-6 (IL-6) by aortic explant cultures were high in patients with ruptured abdominal aortic aneurysm (AAA). In the present study, we sought to examine the secretory levels of t...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Cheuk BL,Cheng SW

    更新日期:2008-01-01 00:00:00

  • Sutureless onlay omental patch for the laparoscopic repair of perforated peptic ulcers.

    abstract:BACKGROUND:Because the feasibility and safety of laparoscopic approaches for the treatment of perforated peptic ulcer (PPU) have been fully recognized, laparoscopic repair of PPU (LPPU) has become a widely accepted procedure. Following closure of a PPU, the rationale to add an omental patch is based on the assumptions ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Wang YC,Hsieh CH,Lo HC,Su LT

    更新日期:2014-08-01 00:00:00

  • Percutaneous radiofrequency ablation versus partial hepatectomy for multicentric small hepatocellular carcinomas: a nonrandomized comparative study.

    abstract:BACKGROUND:The aim of this study was to compare the results of percutaneous radiofrequency ablation (RFA) with those of partial hepatectomy (PH) in the treatment of multicentric small hepatocellular carcinomas (HCCs). With advances in RFA, it is not known whether the minimally invasive approach with percutaneous RFA co...

    journal_title:World journal of surgery

    pub_type: 临床试验,杂志文章


    authors: Guo WX,Zhai B,Lai EC,Li N,Shi J,Lau WY,Wu MC,Cheng SQ

    更新日期:2010-11-01 00:00:00

  • Anastomotic Recurrence After Curative Resection for Colorectal Cancer.

    abstract:BACKGROUND:A precise understanding of anastomotic recurrence (AR) permits efficient surveillance and treatment strategies. This study aimed to evaluate the clinicopathologic characteristics of patients with AR undergoing curative resection for colorectal cancer (CRC), compare colonic with rectal tumors and investigate ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Jung WB,Yu CS,Lim SB,Park IJ,Yoon YS,Kim JC

    更新日期:2017-01-01 00:00:00

  • Intraoperative Identification of the Parathyroid Gland with a Fluorescence Detection System.

    abstract:BACKGROUND:Intraoperative identification of the difficult-to-spot parathyroid gland is critical during surgery for thyroid and parathyroid disease. Recently, intrinsic fluorescence of the parathyroid gland was identified, and a new method was developed for intraoperative detection of the parathyroid with an original fl...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Shinden Y,Nakajo A,Arima H,Tanoue K,Hirata M,Kijima Y,Maemura K,Natsugoe S

    更新日期:2017-06-01 00:00:00

  • Comparative study of carbohydrate antigen 195 and carcinoembryonic antigen for the diagnosis of pancreatic carcinoma.

    abstract::The expression CA195 in serum, defined by monoclonal antibody CC3C195 (IgM), was studied in 67 patients with pancreatic cancer and in 138 patients with biliary or pancreatic benign disease. The results were compared with carcinoembryonic antigen (CEA) expression. The overall sensitivity of the CA195 assay (> 12 U/ml) ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Andicoechea A,Vizoso F,Alexandre E,Martínez A,Cruz Díez M,Riera L,Martinez E,Ruibal A

    更新日期:1999-03-01 00:00:00

  • Metastatic tumor doubling time: most important prehepatectomy predictor of survival and nonrecurrence of hepatic colorectal cancer metastasis.

    abstract::We determined the relative value of the metastatic colorectal cancer doubling time as a predictor of recurrence and survival after hepatectomy in comparison with other established predictors. Consecutive patients who underwent hepatic resection ( n = 144) for colorectal cancer liver metastases were studied retrospecti...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Tanaka K,Shimada H,Miura M,Fujii Y,Yamaguchi S,Endo I,Sekido H,Togo S,Ike H

    更新日期:2004-03-01 00:00:00

  • Pain management for unilateral orchidopexy in children: an effective regimen.

    abstract:BACKGROUND:The reported high incidence of 30-60% postoperative pain after an elective day surgical orchidopexy is undesirable. We evaluated the efficacy of our analgesic regimen for unilateral orchidopexy in preschool children performed as a day surgical procedure. METHODS:Between January 2004 and December 2006, 247 c...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Saeed A,Khan AR,Lee V,Aslam A,Brain J,Williams MP,Brennan L,Campbell R,Samuel M

    更新日期:2009-03-01 00:00:00

  • Surgical treatment of adenomas.

    abstract::Surgical treatment of adenomas may become necessary when the base of the polyp is too wide for snaring, increasing the risk of incomplete removal or perforation of the bowel wall. Suspicion of malignancy may also indicate surgery. Multiple adenomas not controlled by snare polypectomy can be treated by colectomy. The d...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Nicholls RJ

    更新日期:1991-01-01 00:00:00

  • Patterns of internal echoes in lymph nodes in the diagnosis of lung cancer metastasis.

    abstract::In 1989-90, all 37 lung cancer patients scheduled for surgery underwent transesophageal endoscopic ultrasonography (EUS) for pre-operative detection of hilar and mediastinal lymph node metastases. An electronic ultrasonic fiberscope with a linear array (EPB-503-FS, Machida-Toshiba) was used. Of 380 nodes surgically re...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Lee N,Inoue K,Yamamoto R,Kinoshita H

    更新日期:1992-09-01 00:00:00

  • Significance of serum connective tissue growth factor in patients with hepatocellular carcinoma and relationship with angiogenesis.

    abstract:BACKGROUND:Connective tissue growth factor (CTGF) expression changes variously in different human malignancies. The role of CTGF in hepatocellular carcinoma (HCC) is still not clear. The purpose of this study was to investigate the role of serum CTGF in patients with HCC and its correlation with HCC angiogenesis. METH...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Wang GB,Zhou XY,Yuan T,Xie J,Guo LP,Gao N,Wang XQ

    更新日期:2010-10-01 00:00:00