Effect of sirolimus in the prevention of adhesions around intraabdominal prosthetic graft.

Abstract:

BACKGROUND:Adhesions due to the reactions caused by the grafts used in primary vascular operations can lead to various problems when a secondary operation is necessary. These problems include bleeding, injuries to neighboring organs, and complications occurring due to a prolonged operation. We investigated the effects of sirolimus, which has antiproliferative features, on vascular adhesions. METHODS:The abdominal aorta of rats was explored and abrasions applied. Following the fixation of a polytetrafluoroethylene (PTFE) graft on the abdominal aorta, sirolimus (rapamycin) is applied (in powdered form) onto the grafts of the study group. Eight weeks later a laparotomy was repeated and any adhesions were evaluated. RESULTS:In the study group the adhesions were determined to be fewer in number and milder in severity. Severe cases of adhesion were determined in the control group. CONCLUSIONS:Therefore, sirolimus applied around the prosthesis in vascular operations was determined to be effective at preventing possible adhesions.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Kanko M,Ozbudak E,Ozerdem A,Aksoy A,Kilic M,Berki KT

doi

10.1007/s00268-005-0750-1

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

1648-52

issue

9

eissn

0364-2313

issn

1432-2323

journal_volume

30

pub_type

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