Abstract：
BACKGROUND:Medullary thyroid cancer (MTC) is characterized by early regional lymph node metastasis, the presence of which represents a critical obstacle to cure. At present no molecular markers have been successfully integrated into the clinical care of sporadic MTC. The present study was designed to evaluate TP53INP1 expression in MTC and to assess its ability to guide the surgeon to the optimal extent of surgery performed with curative intent. METHODS:Thirty-eight patients with sporadic MTC were evaluated. TP53INP1 immunoexpression was studied on embedded paraffin material and on cytological smears. RESULTS:TP53INP1 was expressed in normal C cells, in C-cell hyperplasia, and in 57.9% of MTC. It was possible to identify two groups of MTC according to the proportion of TP53INP1 expressing tumor cells: group 1 from 0% to <50% and group 2 from 50% to 100% of positive cells. Patients with a decreased expression of TP53INP1 (group 1) had a lower rate of nodal metastasis (18.8% versus 63.4% in group 2; P = 0.009), with only minimal lymph node involvement per N1 patient (2.7% of positive lymph nodes versus 22.9%; P < 0.001) and better outcomes (100% of biochemical cure versus 55.5%; P < 0.001). Patients with distant metastases were only observed in group 2. Cytological samples exhibit similar results to their embedded counterparts. CONCLUSIONS:TP53INP1 immunoexpression appears to be a clinical predictor of lymph node metastasis in MTC. The evaluation of TP53INP1 expression may guide the extent of lymph node dissection in the clinically node-negative neck. These findings require prospective validation.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Taïeb D,Giusiano S,Sebag F,Marcy M,de Micco C,Palazzo FF,Dusetti NJ,Iovanna JL,Henry JF,Garcia S,Taranger-Charpin Cdoi
10.1007/s00268-010-0395-6subject
Has Abstractpub_date
2010-04-01 00:00:00pages
830-5issue
4eissn
0364-2313issn
1432-2323journal_volume
34pub_type
杂志文章abstract：BACKGROUND:The adoption of robotic systems for gastric cancer surgery has been proven feasible and safe; however, a benefit over the laparoscopic approach has not yet been well-documented. We aimed to investigate the surgical outcomes of robotic versus laparoscopic gastrectomy for gastric cancer, according to the exten...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-2998-4
更新日期：2015-07-01 00:00:00
abstract：:Mass screening for the purpose of detecting thyroid cancer at its earliest stage may not be recommended at the present time, but screening focused on certain risk groups is advocated. Familial nonmedullary thyroid carcinoma (FNMTC) is a distinct clinical entity with a high incidence of multifocality and association wi...
journal_title：World journal of surgery
pub_type： 杂志文章
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abstract：BACKGROUND:The optimal extent of lung resection and lymph nodes dissection for peripheral early-stage right middle non-small cell lung cancer (NSCLC) still remains controversial. In this study, we analyzed the patterns of lymph nodes metastasis (LNM) of patients with peripheral right middle NSCLC ≤ 3 cm, aiming to prov...
journal_title：World journal of surgery
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journal_title：World journal of surgery
pub_type： 杂志文章,多中心研究
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更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Intestinal epithelial cell apoptosis has been reported in sepsis as a mechanism of organ failure. The aim of this study was to clarify the role of apoptosis-regulating proteins (bcl-2, bax, cytochrome-c, and caspase-8) in septic rats by studying their expression in gastric and intestinal epithelial cells. M...
journal_title：World journal of surgery
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journal_title：World journal of surgery
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更新日期：2010-07-01 00:00:00
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journal_title：World journal of surgery
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journal_title：World journal of surgery
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journal_title：World journal of surgery
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
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更新日期：1998-11-01 00:00:00
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journal_title：World journal of surgery
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更新日期：2011-12-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：World journal of surgery
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journal_title：World journal of surgery
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更新日期：1998-09-01 00:00:00
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journal_title：World journal of surgery
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更新日期：2010-07-01 00:00:00
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journal_title：World journal of surgery
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更新日期：1990-03-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章
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更新日期：2007-01-01 00:00:00
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journal_title：World journal of surgery
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更新日期：2008-08-01 00:00:00
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更新日期：2005-09-01 00:00:00
