Abstract：
:We sought to determine whether early eschar excision en masse (EEE) at one operation would be effective in the prevention and treatment of postburn organ dysfunction (OD) and multiple organ dysfunction syndrome (MODS). A total of 60 patients, with total body surface burned area over 35% and a third degree burn area over 20% were studied and divided into two groups, the EEE group (35 cases) and the group treated with repeated escharectomies by stages (repeated escharectomy group, 25 cases). Other than the different operations undertaken, the patients in both groups received identical conventional treatment. Before, during, and after operation the hemodynamic and blood gas indices, plasma levels of endotoxin and tumor necrosis factor (TNF), and the injurious effects of burn patients' sera on endothelial cells in vitro were determined in patients of the EEE group. The incidence of OD and MODS was decreased significantly (11.4%) in patients of the EEE group, and the cure rate increased greatly (85.7%). The cardiac output dropped to 77.8% of its preoperative level at the end of escharectomy but began to rise at 2 hours and returned to its baseline levels at 24 hours after operation. Plasma levels of endotoxin and TNF and levels of lactic dehydrogenase and 6-keto-prostaglandin F(1|ga) in the endothelial cell culture media were all reduced profoundly. The cultured endothelial cells maintained their original morphology. The findings substantiate the hypothesis that eschar excision en masse at one operation is feasible and effective in preventing and treating early postburn OD and MODS, mainly by alleviating systemic inflammatory response syndrome and endothelial cell injury.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Huang Y,Yang Z,Chen F,Crowther RS,Li Adoi
10.1007/s002689900661keywords:
subject
Has Abstractpub_date
1999-12-01 00:00:00pages
1272-8; discussion 1278issue
12eissn
0364-2313issn
1432-2323pii
5122journal_volume
23pub_type
杂志文章abstract：:This study investigated whether cytokines and colony-stimulating factors can predict prognosis in patients with postoperative multiple organ failure (MOF). We evaluated 14 patients with postoperative MOF who underwent operation for cardiovascular disease. Seven patients recovered from MOF (survivors) and seven did not...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900520
更新日期：1998-10-01 00:00:00
abstract：:The authors' affiliations are updated as reflected here. ...
journal_title：World journal of surgery
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00268-020-05519-w
更新日期：2020-08-01 00:00:00
abstract：:Mass screening for the purpose of detecting thyroid cancer at its earliest stage may not be recommended at the present time, but screening focused on certain risk groups is advocated. Familial nonmedullary thyroid carcinoma (FNMTC) is a distinct clinical entity with a high incidence of multifocality and association wi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7676-x
更新日期：2004-11-01 00:00:00
abstract：:The development of microsurgical techniques has supplied plastic surgery with a new chance to transfer tissue to nearly any recipient site of the body. Classical methods still have their value but also their limits in many circumstances. Free tissue transfer has proved its advantages, especially in covering defects in...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01670525
更新日期：1990-11-01 00:00:00
abstract：BACKGROUND:New medical therapies available to ulcerative colitis (UC) patients have influenced operative mortality for patients requiring colectomy. We sought to examine trends in treatment and outcome for UC patients treated surgically. METHODS:A review of 36,447 UC patients from the Nationwide Inpatient Sample was p...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0910-9
更新日期：2011-03-01 00:00:00
abstract：INTRODUCTION:Large-bowel obstruction and perforation are still frequently occurring entities for the acute care surgeon. In these cases, Hartmann's procedure is the most commonly used surgical technique. However, recent papers demonstrate that colon resection and primary anastomosis (RPA) in the emergency setting is a ...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章
doi：10.1007/s00268-012-1513-4
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Gastroesophageal reflux is the main risk factor for esophageal adenocarcinoma, but there is no strong support for a protective effect of antireflux surgery. We tested the hypothesis that esophageal adenocarcinoma that develops with long latency after antireflux surgery might be due to persistent postoperativ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-006-0386-9
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:In the last decade, robotic video-assisted thoracic surgery (R-VATS) has grown significantly and consolidated as an alternative to video-assisted thoracic surgery. The objective of this study is to present the implementation as well as the experience with R-VATS accumulated by 2 Brazilian groups. We also com...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05086-9
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:Minimally invasive radio-guided parathyroidectomy (MIRP) has been embraced as an acceptable therapeutic approach to primary hyperparathyroidism. Preoperative sestamibi scanning has facilitated this technique. Here we evaluate the addition of a rapid intraoperative parathyroid hormone (iPTH) assay for patient...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0293-5
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Schistosomiasis is a waterborne trematode with numerous subtypes affecting different areas of the body. Rob Ferreira Hospital is located in an endemic area for schistosomiasis in the Lowveld region of South Africa. We set out to determine the prevalence of Sch istosoma in appendicitis. METHODS:From 2009 to ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-2954-3
更新日期：2015-05-01 00:00:00
abstract：:We determined the relative value of the metastatic colorectal cancer doubling time as a predictor of recurrence and survival after hepatectomy in comparison with other established predictors. Consecutive patients who underwent hepatic resection ( n = 144) for colorectal cancer liver metastases were studied retrospecti...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-7088-3
更新日期：2004-03-01 00:00:00
abstract：:Postoperative complications in patients with obstructive jaundice remain increased when associated with endotoxemia and the inflammatory response due to gut barrier failure. Administration of glutamine has been proposed to maintain the integrity of the gut mucosa and thus reduce bacterial translocation (BT), but the e...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7721-4
更新日期：2005-10-01 00:00:00
abstract：:Patients with obstructive jaundice (OJ) that requires surgery often have malnutrition associated with increased perioperative morbidity. This study investigated the factors influencing nutritional derangements in these patients. A series of 46 OJ patients were investigated prospectively (28 malignant tumors, 18 benign...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002680020043
更新日期：2001-04-01 00:00:00
abstract：BACKGROUND:The Institute of Medicine has identified atrial fibrillation (AF) among national priorities for research. We examine the incidence of AF and its association with outcomes of patients undergoing abdominal surgery. METHODS:Patients ≥ 55 years who underwent abdominal surgery captured in a State Inpatient Datab...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2777-7
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with poor prognosis, as a majority of patients present with advanced disease. Current adjuvant strategies for metastatic patients include mitotane or other cytotoxic agents and carry a significant morbidity as well as a low (<10 %) 5-year sur...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2532-0
更新日期：2014-06-01 00:00:00
abstract：:Whether for hepatic trauma or transplantation, a surgeon's knowledge of hepatic anatomy commonly determines a patient's outcome. The first medically relevant anatomic studies of the liver emerged with the endeavors of Herophilus and Erasistratus between 310 and 280 bc. Yet it was not until after the development of ane...
journal_title：World journal of surgery
pub_type： 传,历史文章,杂志文章
doi：10.1007/s002689900238
更新日期：1997-03-01 00:00:00
abstract：BACKGROUND:Fast-track surgery (FTS) is a promising program for surgical patients and has been applied to several surgical diseases. FTS is much superior to conventional perioperative care. Our aim was to evaluate and compare the safety and efficacy of FTS and conventional perioperative care for patients undergoing gast...
journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00268-014-2690-0
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:The importance of safe anesthesia for the best possible surgical outcomes in every patient is not disputed in high resource settings. Low-income countries lag far behind in the provision of, and training for, safe anesthesia practice. Too little is known about numbers and types of providers in a majority of ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2775-9
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Measurement of the parathyroid hormone (PTH) level following total thyroidectomy (TTx) may allow prediction of postoperative hypocalcemia. We present an algorithmic method of managing hypocalcemia pre-emptively, based on the PTH level 1 h after operation. MATERIALS AND METHODS:We examined 423 consecutive pa...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0348-0
更新日期：2010-03-01 00:00:00
abstract：:This retrospective study reports our experience managing 78 patients with adenocarcinoma of the esophagus and gastroesophageal junction operated between January 1982 and December 1996. Altogether 18 patients presented with stage I and II disease, and 60 patients had stage III and IV disease at presentation; 56 patient...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/pl00013179
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:Trauma in the elderly (≥ 55 years) accounts for a significant proportion of admissions to trauma centers. Our understanding of the epidemiology and outcomes associated with penetrating injury in this age segment of the population, however, is severely limited. The aim of the present study therefore was to in...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0920-7
更新日期：2011-03-01 00:00:00
abstract：:The aim of this study was to clarify the role of ganglion cells in the development and recurrence of sigmoid volvulus. We analyzed 9 samples obtained from 9 patients who had undergone sigmoidectomy for sigmoid volvulus, and, for comparison, 18 samples from 18 patients who had undergone sigmoidectomy or low anterior re...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7462-9
更新日期：2005-01-01 00:00:00
abstract：:Surgical resection is the treatment of choice for patients with stage I and stage II non-small-cell lung cancer (NSCLC--squamous cell, adenocarcinoma, and large-cell carcinoma). Distant recurrence is an important cause of death after complete surgical resection, occurring in 30-60% of patients. Postoperative adjuvant ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01659083
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:Neuroendocrine neoplasia (NEN) with unknown primary site (NEN-CUP tumors) may have a poor prognosis. We evaluated the clinical presentation, therapy, outcome, and risk factors for adverse outcomes in patients who had these tumors. METHODS:In 243 patients who had NEN, a retrospective review was performed in ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-2963-2
更新日期：2015-06-01 00:00:00
abstract：:In the original article, Mehreen K. Bhettani's last name and Mubarik Rehman's first name are misspelled. ...
journal_title：World journal of surgery
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00268-019-05334-y
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Few studies have focused on the risk factors for failure to achieve fascial closure after use of negative-pressure wound therapy (NPWT) in an open abdomen (OA). We aimed at analyzing possible risk factors for failure of fascial closure and the risk of fistulas after nontrauma lower gastrointestinal (GI) trac...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2360-7
更新日期：2014-04-01 00:00:00
abstract：:There has been a long, unresolved debate regarding the operation of choice for well differentiated carcinoma of the thyroid. We therefore analyzed the feasibility, scope, sample size, and length of follow-up required to determine the optimal operation for papillary thyroid carcinoma. A statistical approach was used to...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002689900016
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:There is emerging evidence indicating that distractions in the operating room (OR) are prevalent. Studies have shown a negative impact of distractions, but they have been conducted mostly with residents in simulated environments. We tested the hypothesis that intraoperative distractions are associated with d...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2315-z
更新日期：2014-04-01 00:00:00
abstract：:Hereditary breast cancers, mainly due to BRCA1 and BRCA2 mutations, account for only 5-10% of this disease. The threshold for genetic testing is a 10% likelihood of detecting a mutation, as determined by validated models such as BOADICEA and Manchester Scoring System. A 90-95% reduction in breast cancer risk can be ac...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-018-04897-6
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:The skin is closed in open appendectomy traditionally with few interrupted nonabsorbable sutures. The use of this old method is based on a suggestion that this technique decreases wound infections. In pediatric surgery, skin closure with running intradermal absorbable sutures has been found to be as safe as ...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-012-1664-3
更新日期：2012-10-01 00:00:00
