Optimal surgery for papillary thyroid carcinoma.


:There has been a long, unresolved debate regarding the operation of choice for well differentiated carcinoma of the thyroid. We therefore analyzed the feasibility, scope, sample size, and length of follow-up required to determine the optimal operation for papillary thyroid carcinoma. A statistical approach was used to design a randomized prospective trial comparing the endpoints of complications, recurrence, and cause-specific mortality. A complication comparison trial is prohibitive owing to the large population required--approximately 12,000 randomized patients. A recurrence trial appears feasible based on sample size: approximately 360 to 800 patients with a 6 to 10-year follow-up. However, recurrence detection would be severely compromised in the lobectomy arm, and a unilateral lag-time bias would occur. A cause-specific mortality trial proves to be the least objectionable, although a large sample size (n = 3100) would be required. Such a trial is critically dependent on the ability to select an appropriate endpoint. A cause-specific mortality trial proves to be the most objective and statistically valid endpoint.


World J Surg


World journal of surgery


Udelsman R,Lakatos E,Ladenson P




Has Abstract


1996-01-01 00:00:00












  • Fast-track surgery improves postoperative clinical recovery and immunity after elective surgery for colorectal carcinoma: randomized controlled clinical trial.

    abstract:BACKGROUND:Few clinical studies or randomized clinical trial results have reported the impact of fast-track surgery on human immunity. This study aimed to investigate the clinical and immune impact of fast-track surgery in colorectal cancer patients undergoing elective open surgery. METHODS:A controlled randomized cli...

    journal_title:World journal of surgery

    pub_type: 杂志文章,随机对照试验


    authors: Yang D,He W,Zhang S,Chen H,Zhang C,He Y

    更新日期:2012-08-01 00:00:00

  • New surgical strategy for gastroduodenal ulcer: laparoscopic approach.

    abstract::Although peptic gastroduodenal ulcers are rarely treated surgically today, when surgery is required a laparoscopic approach is possible with its well known advantages. The most widely used technique is vagotomy by various modalities. Training in laparoscopy requires good instrumentation to avoid complications. Vagotom...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Dubois F

    更新日期:2000-03-01 00:00:00

  • The surgeon and human immunodeficiency virus.

    abstract::The moral dilemmas faced by surgeons worldwide who treat patients infected with the human immunodeficiency virus (HIV) can be viewed against the background of experience in sub-Saharan countries, where the community prevalence is in excess of 25% (90% of hospital inpatients). When seeking consent for an HIV test befor...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Mielke J,Kalangu KK

    更新日期:2003-08-01 00:00:00

  • Moving from data collection to application: a systematic literature review of surgical capacity assessments and their applications.

    abstract:BACKGROUND:Over the past decade, assessments of surgical capacity in low- and middle-income countries (LMICs) have contributed to our understanding of barriers to the delivery of surgical services in a number of countries. It is yet unclear, however, how the findings of these assessments have been applied and built upo...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Carlson LC,Lin JA,Ameh EA,Mulwafu W,Donkor P,Derbew M,Rodas E,Mkandawire NC,Dhanaraj M,Yangni-Angate H,Sani R,Labib M,Barbero R,Clarke D,Smith MD,Sherman L,Mutyaba FA,Alexander P,Hadley LG,VanRooyen MJ,Kushner AL

    更新日期:2015-04-01 00:00:00

  • Preoperative Albumin-Bilirubin Grade Predicts Recurrences After Radical Gastrectomy in Patients with pT2-4 Gastric Cancer.

    abstract:BACKGROUND:The albumin-bilirubin (ALBI) score was initially developed for assessing liver dysfunction severity and was suggested to have prognostic value in patients with hepatocellular carcinoma. We aimed to evaluate the prognostic impact of ALBI grade in patients with advanced gastric cancer (GC) after radical gastre...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Kanda M,Tanaka C,Kobayashi D,Uda H,Inaoka K,Tanaka Y,Hayashi M,Iwata N,Yamada S,Fujii T,Sugimoto H,Murotani K,Fujiwara M,Kodera Y

    更新日期:2018-03-01 00:00:00

  • Impact of Preoperative Exclusive Enteral Nutrition on Postoperative Complications and Recurrence After Bowel Resection in Patients with Active Crohn's Disease.

    abstract:BACKGROUND:The impact of preoperative enteral nutrition (EN) on postoperative complications and recurrence in Crohn's disease (CD) has not been investigated to date. The purpose of the present study was to determine the effect of preoperative exclusive EN on postoperative complications and recurrence after bowel resect...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Wang H,Zuo L,Zhao J,Dong J,Li Y,Gu L,Gong J,Liu Q,Zhu W

    更新日期:2016-08-01 00:00:00

  • Effect of the use of vital dye, lymphoscintigraphy, or a combination for axillary lymphatic mapping and sentinel node biopsy in breast cancer.

    abstract::Axillary dissection in patients with breast cancer is associated with significant morbidity. Because 85% of the patients with a cancer < or = 1 cm have negative axillary nodal status, axillary dissection in these patients is only a staging procedure. A study of the sentinel lymph node (SLN) biopsy has been developed t...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: d'Eredita G,Serio G,Mele M,Giardina C,Martellotta M,Ferrarese F

    更新日期:2002-05-01 00:00:00

  • Screening of patients with multiple endocrine neoplasia type 1 (MEN-1): a critical analysis of its value.

    abstract:BACKGROUND:Screening of multiple endocrine neoplasia type 1 (MEN-1) patients is widely recommended because one-fifth succumb to malignant neoplasms. However, recommendations for screening modalities and intervals are based mostly on nonprospective data. METHODS:Thirty-five of 48 MEN-1 patients were evaluated at least ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Waldmann J,Fendrich V,Habbe N,Bartsch DK,Slater EP,Kann PH,Rothmund M,Langer P

    更新日期:2009-06-01 00:00:00

  • A new knot technique for vessel ligatures.

    abstract::A new technique for ligating vessels and similar structures that offers more security is described. The aim of the study was to test whether this hypothesis was correct. Six different types of knots, including the one described in this article were compared by a strength-testing study. The knots were tied on a silicon...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Botet X,Surinyach S,Molinas J

    更新日期:2005-10-01 00:00:00

  • Molecular genetics of parathyroid disease.

    abstract:BACKGROUND:Primary hyperparathyroidism (HPT) is often caused by a benign parathyroid tumor, adenoma; less commonly by multiglandular parathyroid disease/hyperplasia; and rarely by parathyroid carcinoma. Patients with multiple tumors require wider exploration to avoid recurrence and have increased risk for hereditary di...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Westin G,Björklund P,Akerström G

    更新日期:2009-11-01 00:00:00

  • Early experience with the bioabsorbable anal fistula plug.

    abstract:PURPOSE:Management of anal fistula represents a balance between curing the condition and maintaining anal continence. Recent reports of the results of the porcine anal fistula plug have demonstrated excellent fistula healing rates without reporting significant complications. METHODS:The outcome of patients who underwe...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Lawes DA,Efron JE,Abbas M,Heppell J,Young-Fadok TM

    更新日期:2008-06-01 00:00:00

  • Cost-benefit analysis for the treatment of severe obesity.

    abstract::Cost-benefit and cost-effectiveness analyses (CEAs) are only now beginning to be used by business, government, and policymakers to evaluate various medical treatments. The evolution of why CEAs are being demanded is reviewed. To date, a formal CEA of obesity treatments has not been published. This article outlines how...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Martin LF,White S,Lindstrom W Jr

    更新日期:1998-09-01 00:00:00

  • Long-term result of total versus partial fundoplication after esophagomyotomy for primary esophageal motor disorders.

    abstract:BACKGROUND:The selection of the type of fundoplication or the necessity for an added fundoplication after esophagomyotomy (Heller's operation) for the treatment of achalasia remains controversial. The present retrospective study was designed to compare the long-term results of total and partial fundoplication on the my...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Zhu ZJ,Chen LQ,Duranceau A

    更新日期:2008-03-01 00:00:00

  • Efficacy and safety of Seprafilm for preventing postoperative abdominal adhesion: systematic review and meta-analysis.

    abstract:BACKGROUND:There is no clear consensus on the efficacy and safety of hyaluronate-carboxymethylcellulose membrane (Seprafilm) for preventing postoperative abdominal adhesion. This study is a meta-analysis of the available evidence. METHODS:A search of the MEDLINE, EMBASE, and the Cochrane Library identified eight studi...

    journal_title:World journal of surgery

    pub_type: 杂志文章,meta分析,评审


    authors: Zeng Q,Yu Z,You J,Zhang Q

    更新日期:2007-11-01 00:00:00

  • Indication for liver transplantation in young patients with small intestinal NETs is rare?

    abstract:BACKGROUND:A majority of patients with small intestinal neuroendocrine tumors (SI-NETs) present with or develop liver metastases (LM). A number of treatments for LM are used clinically, including liver transplantation (LTx). Indications for LTx are under debate; young age(<65 years), absence of extrahepatic disease, re...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Norlén O,Daskalakis K,Öberg K,Åkerström G,Stålberg P,Hellman P

    更新日期:2014-03-01 00:00:00

  • Anastomotic Recurrence After Curative Resection for Colorectal Cancer.

    abstract:BACKGROUND:A precise understanding of anastomotic recurrence (AR) permits efficient surveillance and treatment strategies. This study aimed to evaluate the clinicopathologic characteristics of patients with AR undergoing curative resection for colorectal cancer (CRC), compare colonic with rectal tumors and investigate ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Jung WB,Yu CS,Lim SB,Park IJ,Yoon YS,Kim JC

    更新日期:2017-01-01 00:00:00

  • Preoperative biliary MRSA infection in patients undergoing hepatobiliary resection with cholangiojejunostomy: incidence, antibiotic treatment, and surgical outcome.

    abstract:BACKGROUND:There have been no reports on the impact of preoperative biliary MRSA infection on the outcome of major hepatectomy. The aim of this study was to review the surgical outcome of patients who underwent hepatobiliary resection after biliary drainage and to evaluate the impact of preoperative biliary MRSA infect...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Takara D,Sugawara G,Ebata T,Yokoyama Y,Igami T,Nagino M

    更新日期:2011-04-01 00:00:00

  • Pathogenesis of pain in chronic pancreatitis: ongoing enigma.

    abstract::The pathogenesis of pain in chronic pancreatitis remains an enigma. The cause of pain is almost certainly multifactorial and may vary at different stages of the disease process. These factors may include the release of excessive oxygen-derived free radicals, tissue hypoxia and acidosis, inflammatory infiltration with ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Bornman PC,Marks IN,Girdwood AW,Berberat PO,Gulbinas A,Büchler MW

    更新日期:2003-11-01 00:00:00

  • Limited tumor involvement found at multiple endocrine neoplasia type I pancreatic exploration: can it be predicted by preoperative tumor localization?

    abstract::Radiologically demonstrable pancreatic endocrine tumors are a frequent requirement for exploration in patients with multiple endocrine neoplasia type I (MEN-I). Such delayed intervention is accompanied by a 30% to 50% incidence of pancreatic endocrine metastases. This study explores biochemical tumor markers and opera...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Skogseid B,Oberg K,Akerström G,Eriksson B,Westlin JE,Janson ET,Eklöf H,Elvin A,Juhlin C,Rastad J

    更新日期:1998-07-01 00:00:00

  • Pancreaticoduodenal resection for malignancy in a low-volume center: long-term outcomes from a developing country.

    abstract:BACKGROUND:The technical complexity of pancreatic resection has made it a specialized procedure performed in high-volume centers. It has been shown that patients operated on in high-volume pancreatobiliary centers have fewer complications and better survival. The purpose of this study was to share our experience with a...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Bhatti AB,Yusuf MA,Kazmi SA,Syed AA

    更新日期:2014-10-01 00:00:00

  • Necrotizing lesions of soft tissues: a review.

    abstract::Necrotizing lesions of the soft tissues are grave entities not infrequently seen in daily surgical practice. They may occur with epidemic proportions after natural disasters, representing a serious challenge to the surgeon since they are characteristically associated with high mortality rates unless an early diagnosis...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Patiño JF,Castro D

    更新日期:1991-03-01 00:00:00

  • Tumor size  ≥50 mm as an Independent Prognostic Factor for Patients with Stage II or III Gastric Cancer After Postoperative S-1 Monotherapy: Analysis of a Multi-institution Dataset.

    abstract:BACKGROUND:Little is known about the changes in prognostic factors after adjuvant S-1 monotherapy has become widespread as a standard of care for patients with gastric cancer (GC) in East Asia. The present study compared prognostic factors of patients with stage II/III GC treated with or without S-1 adjuvant to formula...

    journal_title:World journal of surgery

    pub_type: 杂志文章,多中心研究


    authors: Tsutsuyama M,Kanda M,Ito S,Mochizuki Y,Teramoto H,Ishigure K,Murai T,Asada T,Ishiyama A,Matsushita H,Tanaka C,Kobayashi D,Fujiwara M,Murotani K,Kodera Y

    更新日期:2020-01-01 00:00:00

  • Risk factors for lymph node metastasis in submucosal invasive colorectal cancer.

    abstract:BACKGROUND:Recent studies have shown a 7-15% lymph node (LN) metastasis rate in submucosal invasive colorectal cancer (SICC). Identifying risk factors for LN metastasis is crucial in selecting therapeutic modalities for SICC. We assessed the possibility of and the risk factors for LN metastasis in SICC. METHODS:We per...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Choi PW,Yu CS,Jang SJ,Jung SH,Kim HC,Kim JC

    更新日期:2008-09-01 00:00:00

  • Prognostic Significance of Muscle Attenuation in Pancreatic Cancer Patients Treated with Neoadjuvant Chemoradiotherapy.

    abstract:BACKGROUND:Emerging evidences have gradually revealed the skeletal muscle attenuation (MA) was not only reflected the accumulation of lipids in skeletal muscle but also associated with physiological and pathological states. The aim of this study was to evaluate the impact of MA on the prognosis of pancreatic cancer pat...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Akahori T,Sho M,Kinoshita S,Nagai M,Nishiwada S,Tanaka T,Tamamoto T,Ohbayashi C,Hasegawa M,Kichikawa K,Nakajima Y

    更新日期:2015-12-01 00:00:00

  • Early predictor of mortality due to irreversible posthepatectomy liver failure in patients with hepatocellular carcinoma.

    abstract:BACKGROUND:Although mortality after liver resection has declined, posthepatectomy liver failure (PHLF) remains a major cause of operative mortality. To date there is not consensus on a definition for PHLF. However, there have been many efforts to define PHLF causing operative mortality. In the present study we sought t...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Kim SH,Kang DR,Lee JG,Kim DY,Ahn SH,Han KH,Chon CY,Kim KS

    更新日期:2013-05-01 00:00:00

  • Patterns and treatment of recurrence following pulmonary resection for colorectal metastases.

    abstract:BACKGROUND:Pulmonary resection is the best therapeutic option for lung metastases from colorectal cancer (CRC) today. However, recurrences are frequent following pulmonary resection. We aimed to evaluate the recurrence pattern and treatment of initial pulmonary resection for metastases from CRC. METHODS:Data from 76 p...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Yokota M,Kobayashi A,Nomura S,Nishizawa Y,Ito M,Nagai K,Saito N

    更新日期:2015-07-01 00:00:00

  • Helicopter evacuation of trauma victims in Los Angeles: does it improve survival?

    abstract:BACKGROUND:The purpose of this study was to investigate the relationship between the method of transport after injury and survival among trauma patients admitted to a Level 1 trauma facility in Los Angeles, California. METHODS:The trauma registry of LAC+USC Medical Center was reviewed to identify all injured patients ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Talving P,Teixeira PG,Barmparas G,DuBose J,Inaba K,Lam L,Demetriades D

    更新日期:2009-11-01 00:00:00

  • Factors of failure for nonoperative management of blunt liver and splenic injuries.

    abstract::A review of the literature describing the management of hepatic and splenic injuries indicates that as many as 67% of exploratory celiotomies for blunt trauma are reported as nontherapeutic. Avoiding unnecessary surgery through nonoperative management offers an attractive alternative. Nonetheless, nonoperative managem...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Ochsner MG

    更新日期:2001-11-01 00:00:00

  • Comparative analysis between clinical outcomes of primary radical resection and second completion radical resection for T2 gallbladder cancer: single-center experience.

    abstract:BACKGROUND:Gallbladder (GB) cancer may be discovered incidentally by histopathologic examination following simple cholecystectomy. Incidental GB cancer > or =T2 or > or =N1 needs a second radical resection. It is a matter of concern whether the prognosis may be worse in patients with T2GB cancer who undergo a second ra...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Cho SY,Park SJ,Kim SH,Han SS,Kim YK,Lee KW

    更新日期:2010-07-01 00:00:00

  • Simulation for team training and assessment: case studies of online training with virtual worlds.

    abstract::Individuals in clinical training programs concerned with critical medical care must learn to manage clinical cases effectively as a member of a team. However, practice on live patients is often unpredictable and frequently repetitive. The widely substituted alternative for real patients-high-fidelity, manikin-based si...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: LeRoy Heinrichs W,Youngblood P,Harter PM,Dev P

    更新日期:2008-02-01 00:00:00