Optimal surgery for papillary thyroid carcinoma.


:There has been a long, unresolved debate regarding the operation of choice for well differentiated carcinoma of the thyroid. We therefore analyzed the feasibility, scope, sample size, and length of follow-up required to determine the optimal operation for papillary thyroid carcinoma. A statistical approach was used to design a randomized prospective trial comparing the endpoints of complications, recurrence, and cause-specific mortality. A complication comparison trial is prohibitive owing to the large population required--approximately 12,000 randomized patients. A recurrence trial appears feasible based on sample size: approximately 360 to 800 patients with a 6 to 10-year follow-up. However, recurrence detection would be severely compromised in the lobectomy arm, and a unilateral lag-time bias would occur. A cause-specific mortality trial proves to be the least objectionable, although a large sample size (n = 3100) would be required. Such a trial is critically dependent on the ability to select an appropriate endpoint. A cause-specific mortality trial proves to be the most objective and statistically valid endpoint.


World J Surg


World journal of surgery


Udelsman R,Lakatos E,Ladenson P




Has Abstract


1996-01-01 00:00:00












  • How do we predict the clinically relevant pancreatic fistula after pancreaticoduodenectomy?--an analysis in 244 consecutive patients.

    abstract:BACKGROUND:The most important problem in pancreatic fistula is whether one can distinguish clinical pancreatic fistula, grade B + C fistula by the International Study Group on Pancreatic Fistula (ISGPF), from transient pancreatic fistula (grade A), in the early period after pancreaticoduodenectomy (PD). It remains uncl...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Kawai M,Tani M,Hirono S,Ina S,Miyazawa M,Yamaue H

    更新日期:2009-12-01 00:00:00

  • Improved Outcomes of Laparoscopic Liver Resection for Hepatocellular Carcinoma Located in Posterosuperior Segments of the Liver.

    abstract:BACKGROUND:LLR is widely adapted for HCC, while LLR in PS segments is still challenging. With recent improvement of techniques and accumulation of experiences, LLR in PS segments is feasible, but studies investigating the result after the modifications are lacking. METHODS:In this single-center, retrospective study, 1...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Kwon Y,Cho JY,Han HS,Yoon YS,Lee HW,Lee JS,Lee B,Kim M

    更新日期:2021-01-13 00:00:00

  • Fishing line suture: cost-saving alternative for atraumatic intracutaneous skin closure--randomized clinical trial in Rwanda.

    abstract::Experience with the use of nylon fishing line for surgical sutures has been reported from several African countries. A recent publication suggested that fishing line and an injection needle may provide an atraumatic suture that is especially suitable for intracutaneous skin closures. This article provides further empi...

    journal_title:World journal of surgery

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Freudenberg S,Nyonde M,Mkony C,Bay F,Wilhelm T,Post S

    更新日期:2004-04-01 00:00:00

  • A new approach to accurate diagnosis of acute appendicitis.

    abstract::This study aimed (1) to develop a simple scoring system incorporating ultrasound (US) examination and clinical or laboratory predictors for increasing diagnostic accuracy in acute appendicitis (AA), and (2) to evaluate the performance of the scoring system as compared to that of previous models. Fifteen variables incl...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Tzanakis NE,Efstathiou SP,Danulidis K,Rallis GE,Tsioulos DI,Chatzivasiliou A,Peros G,Nikiteas NI

    更新日期:2005-09-01 00:00:00

  • Stent-Assisted Percutaneous Endoscopic Necrosectomy for Infected Pancreatic Necrosis: Technical Report and a Pilot Study.

    abstract:BACKGROUND AND AIMS:A variety of minimally invasive techniques have been proposed to replace open surgery for the treatment of infected pancreatic necrosis (IPN). In this study, we evaluate the feasibility and safety of the stent-assisted percutaneous endoscopic necrosectomy (SAPEN) procedure. METHODS:Data were collec...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Ke L,Mao W,Zhou J,Ye B,Li G,Zhang J,Wang P,Tong Z,Windsor J,Li W

    更新日期:2019-04-01 00:00:00

  • Cervical node metastases in early squamous cell carcinoma of the floor of the mouth: predictive value of multiple histopathologic parameters.

    abstract::A semiquantitative assessment of multiple histological parameters was applied retrospectively to 66 patients with stage I and II squamous cell carcinoma of the floor of the mouth to determine if prognostic information relative to cervical node metastases could be obtained. Three parameters relating to the tumor cell p...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Nason RW,Castillo NB,Sako K,Shedd DP

    更新日期:1990-09-01 00:00:00

  • Difference in patterns of Met expression in papillary thyroid carcinomas and nonneoplastic thyroid tissue.

    abstract::Met protein is a tyrosine kinase receptor for hepatocyte growth factor (HGF). c-Met has morphogenic, mitogenic, and motogenic properties and is overexpressed in many solid tumors. We studied c-met mRNA and protein expression in papillary thyroid carcinomas and nonneoplastic thyroid tissue. The c-met mRNA was detected ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Fluge Ø,Haugen DR,Lillehaug JR,Varhaug JE

    更新日期:2001-05-01 00:00:00

  • Primary hyperparathyroidism in younger and older patients: symptoms and outcome of surgery.

    abstract::Two-hundred and fifty patients undergoing initial exploration for primary hyperparathyroidism were analyzed for differences in clinical presentation, biochemical status, pathology, and outcome of surgery. In patients less than 60 years of age (younger patients, n = 119) the most common preoperative symptoms and signs ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Udén P,Chan A,Duh QY,Siperstein A,Clark OH

    更新日期:1992-07-01 00:00:00

  • The faltering solid organ donor pool in the United States (2001-2010).

    abstract:BACKGROUND:Organ shortage is the greatest challenge facing the field of organ transplantation today. Use of more organs of marginal quality has been advocated to address the shortage. METHOD:We examined the pattern of donation and organ use in the United States as shown in the Organ Procurement and Transplantation Net...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Saidi RF,Markmann JF,Jabbour N,Li Y,Shah SA,Cosimi AB,Bozorgzadeh A

    更新日期:2012-12-01 00:00:00

  • Incidental findings in trauma patients: dedicated communication with the primary care physician ensures adequate follow-up.

    abstract:BACKGROUND:Frequent use of computed tomography (CT) in trauma patients results in frequent detection of non-trauma-related incidental findings (IFs). Inpatient documentation and disclosure at discharge are infrequent, even when they are potentially serious. We aimed to not only identify the incidence of IFs but also to...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Yeh DD,Imam AM,Truong SH,McLaughlin EL,Klein EN,Avery LL,Velmahos GC

    更新日期:2013-09-01 00:00:00

  • Endoluminal surgery.

    abstract::The development of laparoscopic surgery has provided minimally invasive surgeons with advanced laparoscopic instrumentation and high definition imaging. The resulting surgical expertise and technology has now been extended to gastric endoluminal surgery. Laboratory and clinical investigations have been initiated for v...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Martínez-Serna T,Filipi CJ

    更新日期:1999-04-01 00:00:00

  • The Use of Three-Dimensional Printing Model in the Training of Choledochoscopy Techniques.

    abstract:AIM:To evaluate the application value of a three-dimensional (3D) printing model in the training of choledochoscopy techniques. MATERIALS AND METHODS:Imaging data from two patients with biliary dilatation were used to produce two 3D reconstruction models which were subsequently constructed into 3D printing models (No....

    journal_title:World journal of surgery

    pub_type: 杂志文章,随机对照试验


    authors: Li A,Tang R,Rong Z,Zeng J,Xiang C,Yu L,Zhao W,Dong J

    更新日期:2018-12-01 00:00:00

  • Is esophageal adenocarcinoma occurring late after antireflux surgery due to persistent postoperative reflux?

    abstract:BACKGROUND:Gastroesophageal reflux is the main risk factor for esophageal adenocarcinoma, but there is no strong support for a protective effect of antireflux surgery. We tested the hypothesis that esophageal adenocarcinoma that develops with long latency after antireflux surgery might be due to persistent postoperativ...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Lagergren J,Viklund P

    更新日期:2007-03-01 00:00:00

  • Functional Advantages of Proximal Gastrectomy with Jejunal Interposition Over Total Gastrectomy with Roux-en-Y Esophagojejunostomy for Early Gastric Cancer.

    abstract:BACKGROUND:The postoperative functional advantages of a proximal gastrectomy over a total gastrectomy remain debatable. The aim of this study was to evaluate the functional outcomes of a proximal gastrectomy with jejunal interposition (PG-JI), compared with those for a total gastrectomy with Roux-en-Y esophagojejunosto...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Ohashi M,Morita S,Fukagawa T,Oda I,Kushima R,Katai H

    更新日期:2015-11-01 00:00:00

  • Risk factors and management of local recurrence following breast conservation surgery.

    abstract::Although a number of histologic and treatment factors that individually and in combination predict for an increased risk of local recurrence after breast conserving surgery can be identified, none so obviously compromises survival that breast conservation is contraindicated because that risk factor is present. In-brea...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审


    authors: Osteen RT

    更新日期:1994-01-01 00:00:00

  • Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population.

    abstract:INTRODUCTION:Hypoxic stress is a feature of rapidly growing thyroid tumours. Cancer progression is thought to be driven by a small population of tumour cells possessing stem cell properties. Hypoxia-inducible factors (HIFs) are important mediators of hypoxia. Both HIF-1alpha and HIF-2alpha have been reported to be expr...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Mahkamova K,Latar N,Aspinall S,Meeson A

    更新日期:2018-02-01 00:00:00

  • Surgical Indications of Distal Pancreatectomy with Celiac Axis Resection for Pancreatic Body/Tail Cancer.

    abstract:BACKGROUND:The survival impact of distal pancreatectomy (DP) with celiac axis resection for locally advanced pancreatic body/tail cancer remains unclear. METHODS:A total of 16 patients underwent DP with celiac axis resection, while 76 underwent standard DP for pancreatic body/tail cancer. The indications for DP with c...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Sugiura T,Okamura Y,Ito T,Yamamoto Y,Uesaka K

    更新日期:2017-01-01 00:00:00

  • Value of fentanyl in flexible sigmoidoscopy.

    abstract::Studies have recorded significant patient discomfort during flexible sigmoidoscopy when it is performed without sedation/analgesia. This study observed whether a single dose of 50 mcg intravenous fentanyl reduces pain, improving compliance, acceptability, and completion rates. In a prospective study, 109 consecutive p...

    journal_title:World journal of surgery

    pub_type: 临床试验,杂志文章


    authors: Basu S,Krishnamurthy B,Walsh TH

    更新日期:2004-09-01 00:00:00

  • Robot-assisted gastrectomy for early gastric cancer: is it beneficial in viscerally obese patients compared to laparoscopic gastrectomy?

    abstract:BACKGROUND:The adoption of robotic systems for gastric cancer surgery has been proven feasible and safe; however, a benefit over the laparoscopic approach has not yet been well-documented. We aimed to investigate the surgical outcomes of robotic versus laparoscopic gastrectomy for gastric cancer, according to the exten...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Park JY,Ryu KW,Reim D,Eom BW,Yoon HM,Rho JY,Choi IJ,Kim YW

    更新日期:2015-07-01 00:00:00

  • ICU Risk Stratification Models Feasible for Use in Sub-Saharan Africa Show Poor Discrimination in Malawi: A Prospective Cohort Study.

    abstract:BACKGROUND:Critical illness disproportionately affects people in low-income countries (LICs). Efforts to improve critical care in LICs must account for differences in demographics and infrastructure compared to high-income settings. Part of this effort includes the development and validation of intensive care unit (ICU...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Prin M,Pan S,Kadyaudzu C,Li G,Charles A

    更新日期:2019-10-01 00:00:00

  • Fecal urge incontinence after stapled anopexia for prolapse and hemorrhoids: a prospective, observational study.

    abstract:BACKGROUND:Stapled anopexia was introduced as a surgical method in 1993. Long-term data with special interest in functional results and relapse symptoms are rarely presented. Urinary discomfort and problems with fecal urge incontinence are addressed as severe side effects. We present our long-term results (using data f...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Schmidt J,Dogan N,Langenbach R,Zirngibl H

    更新日期:2009-02-01 00:00:00

  • Rural high north: a high rate of fatal injury and prehospital death.

    abstract:BACKGROUND:Finnmark County is the northernmost county in Norway. For several decades, the rate of mortality after injury in this sparsely inhabited region has remained above the national average. Following documentation of this discrepancy for the period 1991-1995, improvements to the trauma system were implemented. Th...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Bakke HK,Wisborg T

    更新日期:2011-07-01 00:00:00

  • Stapler and nonstapler closure of the pancreatic remnant after distal pancreatectomy: multicenter retrospective analysis of 388 patients.

    abstract:BACKGROUND:The pancreatic fistula rate following distal pancreatectomy ranges widely, from 13.3 to 64.0 %. The optimal closure method of the pancreatic remnant remains controversial, especially regarding whether to use a stapler. METHODS:All patients who underwent distal pancreatectomy in five Japanese hospitals from ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,多中心研究


    authors: Ban D,Shimada K,Konishi M,Saiura A,Hashimoto M,Uesaka K

    更新日期:2012-08-01 00:00:00

  • Economic modeling of surgical disease: a measure of public health interventions.

    abstract::The measurement of the burden of disease and the interventions that address that burden can be done in various units. Reducing these measures to the common denominator of economic units (i.e., currency) enables comparison with other health entities, interventions, and even other fields. Economic assessment is complex,...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Corlew DS

    更新日期:2013-07-01 00:00:00

  • Trauma Patients with an Open Abdomen Following Damage Control Laparotomy can be Extubated Prior to Abdominal Closure.

    abstract:BACKGROUND:The open abdomen (OA) is commonly utilized as a technique during damage control laparotomy (DCL). We propose that a selected group of these OA patients can be extubated prior to abdominal closure to decrease ventilator days and risk of pneumonia. METHODS:A retrospective chart review was performed at a Level...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Sujka JA,Safcsak K,Cheatham ML,Ibrahim JA

    更新日期:2018-10-01 00:00:00

  • Intercostal Trocars Enable Easier Laparoscopic Resection of Liver Tumors in Segments 7 and 8.

    abstract:BACKGROUND:Laparoscopic resection of posterosuperior (PS) tumors of the liver is more difficult than that of anterolateral (AL) tumors, owing to the narrow surgical field in the PS location. In this retrospective cohort study, our aim was to determine if port insertion through the intercostal space would lead to improv...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Hirokawa F,Hayashi M,Asakuma M,Shimizu T,Inoue Y,Uchiyama K

    更新日期:2017-05-01 00:00:00

  • Preoperative magnetic resonance angiography as a predictive test for cerebral ischemia during carotid endarterectomy.

    abstract:BACKGROUND:To evaluate whether the preoperative magnetic resonance angiography (MRA) can predict the risk of cerebral ischemia associated with the carotid endarterectomy (CEA). METHODS:Between January 2004 and December 2010, 382 consecutive patients (mean age: 56.6 years; range: 45-78 years) were identified to have un...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Shin S,Kwon TW,Cho YP,Shin JH,Yi A,Kim H,Kim GE

    更新日期:2013-03-01 00:00:00

  • Analysis of Early and Long-Term Oncologic Outcomes After Converted Laparoscopic Resection Compared to Primary Open Surgery for Rectal Cancer.

    abstract:BACKGROUND:Laparoscopic rectal resection (LRR) for cancer is a challenging procedure, with conversion to open surgery being reported in up to 30% of cases. Since only a few studies with short follow-up have compared converted LRR and open RR (ORR), it is unclear if conversion to open surgery should be prevented by pref...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Allaix ME,Furnée E,Esposito L,Mistrangelo M,Rebecchi F,Arezzo A,Morino M

    更新日期:2018-10-01 00:00:00

  • Left Hepatectomy with Combined Resection and Reconstruction of Right Hepatic Artery for Bismuth Type I and II Perihilar Cholangiocarcinoma.

    abstract:BACKGROUND:Right hepatectomy with caudate lobectomy (RHx) is considered an appropriate procedure for Bismuth type I/II perihilar cholangiocarcinoma in terms of its anatomical and oncological aspect. However, validity of left hepatectomy with caudate lobectomy (LHx) concomitant with arterial resection and reconstruction...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Sugiura T,Okamura Y,Ito T,Yamamoto Y,Ashida R,Ohgi K,Nakagawa M,Uesaka K

    更新日期:2019-03-01 00:00:00

  • Surgery for digestive malignancies in patients with psychiatric disorders.

    abstract:BACKGROUND:The psychiatric population has been reported to be accompanied with a higher morbidity and mortality in several situations. However, little is known about the effect of co-morbid psychiatric disorders on surgical risk during major digestive surgery for malignancies. Our purpose in the present study, therefor...

    journal_title:World journal of surgery

    pub_type: 杂志文章


    authors: Aoyanagi N,Iizuka I,Watanabe M

    更新日期:2007-12-01 00:00:00