Abstract：
BACKGROUND:Liver transplantation for biliary atresia is indicated whenever a Kasai portoenterostomy is considered unfeasible. However, the timing of liver transplantation in biliary atresia has not been precisely defined. Excessive shortening of hepatocellular telomeres may occur in patients with biliary atresia, and therefore, telomere length could be a predictor of hepatocellular reserve capacity. METHODS:Hepatic tissues were obtained from 20 patients with biliary atresia who underwent LT and 10 age-matched autopsied individuals (mean age, 1.7 and 1.2 years, respectively). Telomere lengths were measured by Southern blotting and quantitative fluorescence in situ hybridization using the normalized telomere-centromere ratio. The correlation between the normalized telomere-centromere ratio for the hepatocytes in biliary atresia and the pediatric end-stage liver disease score was analyzed. RESULTS:The median terminal restriction fragment length of the hepatic tissues in biliary atresia was not significantly different from that of the control (p = 0.425), whereas the median normalized telomere-centromere ratio of hepatocytes in biliary atresia was significantly smaller than that of the control (p < 0.001). Regression analysis demonstrated a negative correlation of the normalized telomere-centromere ratio with the pediatric end-stage liver disease score in biliary atresia (p < 0.001). CONCLUSIONS:Telomere length analysis using quantitative fluorescence in situ hybridization could be an objective indicator of hepatocellular reserve capacity in patients with biliary atresia, and excessive telomere shortening supports the early implementation of liver transplantation.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Sanada Y,Aida J,Kawano Y,Nakamura K,Shimomura N,Ishikawa N,Arai T,Poon SS,Yamada N,Okada N,Wakiya T,Hayashida M,Saito T,Egami S,Hishikawa S,Ihara Y,Urahashi T,Mizuta K,Yasuda Y,Kawarasaki H,Takubo Kdoi
10.1007/s00268-012-1453-zsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
908-16issue
4eissn
0364-2313issn
1432-2323journal_volume
36pub_type
杂志文章abstract：:Portal azygos disconnection, using vein ligatures and a circumferential hemostatic suture of the gastric wall at the level of the upper pole, is a simple and a rapid technique that effectively controls bleeding from esophagogastric varices. Its low mortality rate in emergency cases or poor-risk patients can be of grea...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01659042
更新日期：1989-05-01 00:00:00
abstract：:Normal cellular survival is dependent on the cooperative expression of genes' signaling through a broad array of DNA patterns. Cancer, however, has an Achilles' heel. Its altered cellular survival is dependent on a limited subset of signals through mutated DNA, possibly as few as three. Identification and control of t...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-011-1100-0
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) scoring system was developed to aid the diagnosis of necrotizing fasciitis and guide management [1]. AIM:To validate the LRINEC score and identify clinical predictors to develop a refined diagnostic scoring tool for the diagnosis of necrotizin...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05061-4
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Recurrent renal hyperparathyroidism (HPT) is a serious problem after parathyroidectomy (PTx). We evaluated the frequency of graft-dependent recurrent HPT and the clinical outcomes after removal of the autograft. METHODS:Between March 1980 and January 2009, 2660 patients underwent total PTx with forearm auto...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0412-9
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:The Acute Care Surgery (ACS) model was developed as a dedicated service for the provision of 24/7 nontrauma emergency surgical care. This systematic review investigated which components are essential in an ACS model and the state of implementation of ACS models worldwide. METHODS:A literature search was con...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-020-05536-9
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Teamwork is fundamental to effective surgery, yet there are currently no measures of teamwork to guide training, evaluate team interventions or assess the impact of teamwork on outcomes. We report the first steps in the development of an observational assessment of teamwork and preliminary findings. METHOD:...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0488-9
更新日期：2006-10-01 00:00:00
abstract：:The surgical treatment of 30 cases of vascular thoracic outlet syndrome (TOS) in 25 patients is presented. Patients included 17 women and 8 men with average age of 26.1 years. The causes of compression were cervical rib ( n = 16), soft tissue anomalies ( n = 12), and scar tissue after clavicle fracture ( n = 2). Ten s...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-6808-z
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:This study was undertaken to determine the efficacy of the clinical indications for performing staging laparoscopy for locally advanced gastric cancer to detect peritoneal metastasis or positive cytology findings. METHODS:The study included 231 patients with T4 gastric cancer without hematogenous or clinica...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1290-5
更新日期：2011-12-01 00:00:00
abstract：INTRODUCTION:The utilization of laparoscopy in colorectal surgery is increasing. However, conversion to open surgery remains relatively high. OBJECTIVE:We evaluated (1) conversion rates in laparoscopic colorectal surgery; (2) the outcomes of converted cases compared with successful laparoscopic and open colorectal ope...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-2958-z
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:With the progressive use of new diagnostic techniques, the management of penetrating abdominal stab wounds is changing. Most studies have been conducted in well-equipped trauma centers in developed countries, and there is a paucity of reports from general teaching hospitals with limited resources. We reviewe...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-1931-y
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to determine whether early oral feeding after curative resection for gastric cancer can be tolerated and whether it has an effect on recovery. METHODS:From September 2007 to January 2008, we provided early postoperative oral feeding for 35 patients who underwent curative dis...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0009-3
更新日期：2009-07-01 00:00:00
abstract：:Acute acalculous cholecystitis (AAC) is a well known complication in severely traumatized patients. Existing data of AAC originate from retrospective analyses and episodic case reports. In a prospective study 45 polytraumatized patients admitted to our intensive care unit from January 1989 to June 1990 were clinically...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02067089
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:The purpose of the present study was twofold: to summarize the characteristics of trauma patients with thoracic injury in the 2008 earthquake of Wenchuan, Sichuan, China, and to validate the accuracy of the Injury Severity Score (ISS), the New Injury Severity Score (NISS), and the Chest Injury Index (CII) in...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0427-2
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Nodal involvement of papillary thyroid carcinoma (PTC) commonly occurs in the paratracheal region and the internal jugular chain. Lymph node metastasis in the parapharyngeal space (PPS) is rare. In this report, we describe our experience and surgical outcomes of patients with PPS metastasis of PTC. METHODS:...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3321-0
更新日期：2016-02-01 00:00:00
abstract：INTRODUCTION:Percutaneous needle biopsy (PNB) is the standard of care for diagnosis of breast lesions. Rates of excisional biopsy for breast diagnosis in North America have been reported at approximately 35 %, although significant regional variation exists. A target rate of PNB for diagnosis of breast abnormalities is ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3293-0
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Parathyroid cancer is a rare endocrine tumor, and the prognostic factors for this cancer remain unclear. The standard therapy is en bloc resection of the primary tumor at the time of the initial operation. However, the clinical significance of prophylactic neck dissection (PND) in the management of parathyro...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0618-x
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the therapeutic efficacy of two surgical procedures used to treat middle thoracic esophageal squamous cell carcinoma and compare the results. METHODS:A total of 167 patients with middle thoracic esophageal squamous cell carcinoma were included in the study, including 10...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0341-7
更新日期：2010-02-01 00:00:00
abstract：:The expression CA195 in serum, defined by monoclonal antibody CC3C195 (IgM), was studied in 67 patients with pancreatic cancer and in 138 patients with biliary or pancreatic benign disease. The results were compared with carcinoembryonic antigen (CEA) expression. The overall sensitivity of the CA195 assay (> 12 U/ml) ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/pl00013182
更新日期：1999-03-01 00:00:00
abstract：:A total of 143 patients who underwent hepatic resection for hepatocellular carcinoma in our department were reviewed. The review was conducted for two periods: 1970-1982 (early period) and 1983-1990 (late period), that is, the periods before and after introduction of the hepatic surgical technique involving the use of...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01659138
更新日期：1993-09-01 00:00:00
abstract：:The surgical management of pancreatic islet cell carcinomas poses a complicated set of questions resulting from their rare occurrence and the difficulty in establishing a diagnosis in early cases or, conversely, the problems inherent in dealing with metastatic disease. However, because their biologic behavior is rathe...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01655109
更新日期：1993-07-01 00:00:00
abstract：INTRODUCTION:The follicular variant of papillary thyroid carcinoma (FVPTC) is the most common histologic subtype of papillary thyroid carcinoma (PTC). However, it is still controversial whether FVPTC should behave differently from classical PTC (CPTC). The present study aimed at evaluating any potential difference in c...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0356-7
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:The objective of the cross-sectional study reported here was to compare the quality of life of patients with an appropriate stoma site and with that of patients with an inappropriate stoma site. MATERIALS AND METHODS:Two groups of patients with permanent intestinal stomas were assessed, 174 patients with ap...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0275-0
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Despite curative resection, hepatocellular carcinoma (HCC) has a high probability of recurrence. We validated the potential role of liver resection (LR) for recurrent HCC. METHODS:Patients with intrahepatic recurrence with up to three lesions were included. We compared survival times of patients undergoing ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05225-2
更新日期：2020-01-01 00:00:00
abstract：:The aim of this study was to investigate the collagen matrix in recurrent inguinal hernias. Total ribonucleic acid (RNA) was extracted from skin fibroblasts of three groups (control group I = healthy skin; control group II = plain skin scar; recurrent inguinal hernia group = skin of recurrent inguinal hernias; each n ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-001-0239-5
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:Primary hyperparathyroidism (HPT) is often caused by a benign parathyroid tumor, adenoma; less commonly by multiglandular parathyroid disease/hyperplasia; and rarely by parathyroid carcinoma. Patients with multiple tumors require wider exploration to avoid recurrence and have increased risk for hereditary di...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-009-0022-6
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Billions of people worldwide lack access to safe affordable surgery. Surgical missions and non-governmental organisations (NGO) are vital in meeting this need, but long-term outcomes are rarely reported. Mercy Ships is a surgical NGO, and we aimed to measure disability-free survival, impact and patient satis...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3745-1
更新日期：2017-02-01 00:00:00
abstract：:Transcutaneous laryngeal ultrasonography (TLUSG) is a promising alternative to laryngoscopy in vocal cords (VCs) assessment which might be challenging in the beginning. However, it remains unclear when an assessor can provide proficient TLUSG enough to abandon direct laryngoscopy . Eight surgical residents (SRs) witho...
journal_title：World journal of surgery
pub_type： 历史文章,杂志文章
doi：10.1007/s00268-015-3348-2
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Anastomotic leakage is a serious clinical problem after colorectal resections and is associated with a significantly increased length of stay, morbidity and mortality. The aim of the present study was to evaluate the effect of changes in clinical practice on anastomotic leakage rate after colorectal resectio...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4423-7
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Artificial intelligence is touted as the future of medicine. Classical algorithms for the detection of common bile duct stones (CBD) have had poor clinical uptake due to low accuracy. This study explores the challenges of developing and implementing a machine-learning model for the prediction of CBD stones i...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05820-8
更新日期：2021-02-01 00:00:00
abstract：:Pepsinogen C is a proteolytic enzyme involved in the digestion of proteins in the stomach; it is also synthesized by a significant percentage of female breast carcinomas. In addition, it has been demonstrated that pepsinogen C is one of the few proteins induced by androgens in breast carcinoma cells. Here we evaluate ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/pl00012325
更新日期：1999-05-01 00:00:00
