Abstract:
:The surgical management of pancreatic islet cell carcinomas poses a complicated set of questions resulting from their rare occurrence and the difficulty in establishing a diagnosis in early cases or, conversely, the problems inherent in dealing with metastatic disease. However, because their biologic behavior is rather indolent, a real opportunity exists not only for cure but also for meaningful palliation. These goals apply both to the tumor itself and the effects of the hormones they may secrete. The challenge facing the multidisciplinary management team in general, and the surgeon specifically, is to achieve the optimal combination of surgical resection and other treatment options. While the precept of aggressive excision applies to most islet cell carcinomas, it is not universally applicable. In contrast to other islet cell tumors, insulinomas are overwhelmingly benign, and are well treated by enucleation or limited pancreatic resection. Although based on relatively few cases, cytoreductive surgery seems beneficial for malignant insulinomas. Advances that have occurred over the past decade in Zollinger-Ellison syndrome have markedly altered surgical management. Medication which reliably prevents ulcer formation has permitted the surgical perspective to be redirected from end organ ablation to curative tumor excision. Multicentricity and metastases, however, limit the extent to which cure can actually be achieved. Patients with vasoactive intestinal peptide-producing tumors and glucagonomas are very rare, and when possible, should undergo tumor resection to correct the severe hormonally caused metabolic derangements. Increasingly recognized are islet cell carcinomas that do not produce clinical syndromes. They may be confused with ductal carcinomas, but when resected, lead to distinctly superior survival rates among patients.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Grant CSdoi
10.1007/BF01655109subject
Has Abstractpub_date
1993-07-01 00:00:00pages
498-503issue
4eissn
0364-2313issn
1432-2323journal_volume
17pub_type
杂志文章abstract:BACKGROUND:Seroma formation is a frequent postoperative complication following open ventral hernia repair (OVHR), especially in cases requiring wide subcutaneous dissection (WSD). The aim of this study was to evaluate the effectiveness of a new low-thrombin fibrin sealant for seroma prevention. METHODS:A total of 60 c...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2691-z
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Thymic epithelial tumors are characterized by slow growth and variable malignant behavior. We present our experience on the surgical management of these tumors. MATERIALS AND METHODS:We conducted a retrospective analysis of patients with thymomas undergoing modified maximal thymectomy over a period of 16 ye...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0097-0
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:There have been no reports on the impact of preoperative biliary MRSA infection on the outcome of major hepatectomy. The aim of this study was to review the surgical outcome of patients who underwent hepatobiliary resection after biliary drainage and to evaluate the impact of preoperative biliary MRSA infect...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-0990-1
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Primary hyperparathyroidism (PHPT) is a common endocrine disorder that predominantly affects patients >60 and is increasing in prevalence. Identifying risk factors for poor outcomes after parathyroidectomy in older adults will help tailor operative decision making. The impact of frailty on surgical outcomes ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4629-3
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:The majority of small bowel obstructions (SBO) are the result of adhesions caused by a previous abdominal operation. On rare occasions, adhesional SBO occurs in the absence of such an operation. Our objective was to describe the management, findings, and outcomes of unexplained adhesional SBO (UA-SBO) and ex...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0200-6
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:The present study was designed to evaluate the relationship between preoperative Toll-like receptor (TLR) expression in peripheral blood monocytes (PBMC) and the postoperative inflammatory cytokine secretion from PBMC, as well as the postoperative infectious complications in patients with gastrointestinal ca...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0839-z
更新日期:2011-02-01 00:00:00
abstract::A semiquantitative assessment of multiple histological parameters was applied retrospectively to 66 patients with stage I and II squamous cell carcinoma of the floor of the mouth to determine if prognostic information relative to cervical node metastases could be obtained. Three parameters relating to the tumor cell p...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01658802
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:There is emerging evidence indicating that distractions in the operating room (OR) are prevalent. Studies have shown a negative impact of distractions, but they have been conducted mostly with residents in simulated environments. We tested the hypothesis that intraoperative distractions are associated with d...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2315-z
更新日期:2014-04-01 00:00:00
abstract::Calcium oxalate is a major component of renal stones, and its urinary concentration plays an important role in stone formation. Even a small increase in urinary oxalate has a significant impact on calcium oxalate saturation. Although primary hyperoxaluria is relatively uncommon, patients with calcium oxalate stones ha...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s002680010193
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:Thoracoscopic repair of esophageal atresia is considered to be one of the more advanced pediatric surgical procedures, and it undoubtedly has a learning curve. This is a single-center study that was designed to determine the learning curve of thoracoscopic repair of esophageal atresia. METHODS:The study inv...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1651-8
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION:In India, half of the annual 200,000 road traffic deaths occur in hospitals, but the exact in-hospital trauma mortality rate remains unknown. A research consortium of universities, with a mandate to reduce trauma mortality, measured the baseline 30-day in-hospital mortality rate. METHODS:Between September...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s00268-016-3452-y
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To evaluate comparative outcomes of laparoscopic transcystic (TC) and transductal (TD) common bile duct (CBD) exploration. METHODS:We systematically searched MEDLINE, EMBASE, CINAHL, CENTRAL, the World Health Organization International Clinical Trials Registry, ClinicalTrials.gov, ISRCTN Register, and biblio...
journal_title:World journal of surgery
pub_type: 杂志文章,meta分析
doi:10.1007/s00268-019-05005-y
更新日期:2019-08-01 00:00:00
abstract::In a prospective multicenter study, 186 patients with squamous cell esophageal carcinoma, who after evaluation were considered suitable for surgery, were randomized to 4 treatment groups: Group 1, surgery alone; Group 2, pre-operative chemotherapy (cisplatin and bleomycin) and surgery; Group 3, pre-operative irradiati...
journal_title:World journal of surgery
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/BF02067069
更新日期:1992-11-01 00:00:00
abstract::Worldwide, traffic deaths are 500,000 per year and growing. Four nations, China, India, Russia, and the United States of America, have reached levels of 45,000-50,000 traffic deaths per year, although the nature of the problem is quite different in fully motorized countries from what it is in motorizing countries. In ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF02104436
更新日期:1992-05-01 00:00:00
abstract::The surgical treatment of 30 cases of vascular thoracic outlet syndrome (TOS) in 25 patients is presented. Patients included 17 women and 8 men with average age of 26.1 years. The causes of compression were cervical rib ( n = 16), soft tissue anomalies ( n = 12), and scar tissue after clavicle fracture ( n = 2). Ten s...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-003-6808-z
更新日期:2003-05-01 00:00:00
abstract::The surgical morbidity, mortality, and effectiveness of a modified nonshunting operation that includes splenic artery division instead of splenectomy, devascularization, and esophageal transection (SAD group) were evaluated. Eighteen cirrhotic patients with varices who underwent this modified procedure were compared w...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00299180
更新日期:1995-05-01 00:00:00
abstract::A review of the literature describing the management of hepatic and splenic injuries indicates that as many as 67% of exploratory celiotomies for blunt trauma are reported as nontherapeutic. Avoiding unnecessary surgery through nonoperative management offers an attractive alternative. Nonetheless, nonoperative managem...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-001-0138-9
更新日期:2001-11-01 00:00:00
abstract::Most adrenal incidentalomas are nonfunctioning cortical adenomas that do not require surgery. Operative treatment is indicated if the incidentaloma has malignant features as seen during the radiologic workup, is hormonally active, or grows during follow-up. A conservative attitude is justified in asymptomatic patients...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689910095
更新日期:2000-05-01 00:00:00
abstract::Fourteen patients with liver tumor malignancy and sixteen patients with malignant melanoma localized to one limb were studied regarding leukocyte activation with the release of polymorphonuclear neutrophilic (PMN) elastase and of neopterin and formation of cytokines (TNF-alpha and IL-6) during the surgical treatment. ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00299787
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:The goal of the present study was to evaluate the effects of preoperative oral carbohydrate supplementation (OCH) on the postoperative metabolic stress response of patients undergoing elective abdominal surgery. METHODS:The study was designed as a controlled, prospective, cohort study including 38 patients ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1590-4
更新日期:2012-08-01 00:00:00
abstract::The effects of pneumoperitoneum on the lower esophageal sphincter (LES) were evaluated during laparoscopic operation for esophageal achalasia. Intraoperative manometry was performed in three patients who underwent laparoscopic cardiomyectomy with Dor's fundoplication and five patients who underwent laparoscopic cholec...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900146
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:The World Health Organization Surgical Safety Checklist (SSC) has been widely implemented in an effort to decrease surgical adverse events. METHOD:This systematic literature review examined the effects of the SSC on postoperative outcomes. The review included 25 studies: two randomised controlled trials, 13...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-016-3519-9
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Pancreaticodudenectomy (PD) is a high-risk, technically demanding operation associated with substantial perioperative morbidity and mortality. This review is intended to evaluate the perioperative outcomes of PD done in a single gastrointestinal surgery unit of a university teaching hospital. PATIENTS AND M...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0589-y
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Hernia is especially prevalent in developing countries where the population is obliged to undertake strenuous work in order to survive, and International Cooperation Programmes are helping to solve this problem. However, the quality of surgical interventions is unknown. The objective of the present study was...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1768-9
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The role of neutrophil-to-lymphocyte ratio (NLR) and preoperative prediction model in gastric cancer is controversial, while postoperative prognostic models are available. This study investigated NLR as a preoperative prognostic indicator in gastric cancer. METHODS:We reviewed patients with primary gastric ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4510-4
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Delayed recovery of gastrointestinal (GI) motility is a common complication following surgery. TZP-101/ulimorelin is a macrocyclic peptidomimetic ghrelin receptor agonist with GI promotility effects that significantly accelerates time to recovery of GI motility compared to placebo following partial colectomy...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00268-011-1335-9
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The long-term course after peptic ulcer perforation is unclear, but because the ulcer population is generally older and has concomitant disease, the long-term prognosis may be expected to be poor. METHODS:In a study based on prospective data collection, all patients with peptic ulcer perforation treated at ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9370-2
更新日期:2008-03-01 00:00:00
abstract::Nuss described a minimally invasive technique for correcting pectus excavatum in children. A curved stainless-steel bar is inserted behind the sternum through the chest cavity with the convex surface face down, then rotated 180 degrees to elevate the sternum and correct the deformity. The procedure gained wide accepta...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-002-6519-x
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Surgical disease burden falls disproportionately on individuals in low- and middle-income countries. These populations are also the least likely to have access to surgical care. Understanding the barriers to access in these populations is therefore necessary to meet the global surgical need. METHODS:Using g...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-016-3765-x
更新日期:2017-03-01 00:00:00
abstract::This paper reviews aspects of head injury management and research in the United Kingdom (UK). We discuss evidence about the scale and etiology of head injury in Britain and how this information has supported a triage-based approach, incorporating risk analysis. A Cohesive organization based upon nationally accepted, y...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-001-0084-6
更新日期:2001-09-01 00:00:00