Abstract：
:Normal cellular survival is dependent on the cooperative expression of genes' signaling through a broad array of DNA patterns. Cancer, however, has an Achilles' heel. Its altered cellular survival is dependent on a limited subset of signals through mutated DNA, possibly as few as three. Identification and control of these signals through the use of RNA interference (RNAi) technology may provide a unique clinical opportunity for the management of cancer that employs genomic-proteomic profiling to provide a molecular characterization of the cancer, leading to targeted therapy customized to an individual cancer signal. Such an approach has been described as "personalized therapy." The present review identifies unique developing technology that employs RNAi as a method to target, and therefore block, signaling from mutated DNA and describes a clinical pathway toward its development in cancer therapy.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Nemunaitis J,Rao DD,Liu SH,Brunicardi FCdoi
10.1007/s00268-011-1100-0subject
Has Abstractpub_date
2011-08-01 00:00:00pages
1700-14issue
8eissn
0364-2313issn
1432-2323journal_volume
35pub_type
杂志文章,评审abstract：BACKGROUND:Central venous catheters should be positioned at the cavoatrial junction or the right atrium. If catheters are inserted to a depth derived by adding the length between the needle insertion point and the clavicular notch and the length between the clavicular notch and the carina, the catheter tip can be place...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05449-7
更新日期：2020-07-01 00:00:00
abstract：:Adenocarcinomas of the esophagogastric junction (AEG) are now recognized as a separate tumor entity with increasing incidence. The aim of the present study was to evaluate whether positron emission tomography (PET) using the glucose analog F-18-fluorodeoxyglucose (FDG) can be used for metabolic characterization of thi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-7058-9
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:Gastrointestinal (GI) tract perforation during endoscopy is a rare but severe complication. The aim of this study was to determine predictors of morbidity and mortality after iatrogenic endoscopic perforation. MATERIALS AND METHODS:All cases with iatrogenic endoscopic perforation receiving surgery at a tert...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3986-7
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Esophagectomy remains the standard treatment for resectable esophageal cancer, but the cure rate is low. Neoadjuvant therapy has been tried in attempts to prolong survival and reduce tumor recurrence. The aim of this study was to assess the surgical outcomes with and without neoadjuvant treatment for resecta...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-006-0016-6
更新日期：2006-12-01 00:00:00
abstract：:Transcutaneous laryngeal ultrasonography (TLUSG) is a promising alternative to laryngoscopy in vocal cords (VCs) assessment which might be challenging in the beginning. However, it remains unclear when an assessor can provide proficient TLUSG enough to abandon direct laryngoscopy . Eight surgical residents (SRs) witho...
journal_title：World journal of surgery
pub_type： 历史文章,杂志文章
doi：10.1007/s00268-015-3348-2
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Intraoperative parathyroid hormone assay (IOPTH) has been suggested to have value in predicting the development of postoperative hypoparathyroidism after thyroid surgery. IOPTH has been validated in identification of patients at risk of postoperative hypocalcemia requiring early onset of calcium supplementat...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-007-9405-8
更新日期：2008-05-01 00:00:00
abstract：:The most common causes of variceal bleeding are cirrhosis, schistosomiasis, and extrahepatic portal venous obstruction. The prognosis for an individual patient depends on the severity of the bleeding episode and the underlying liver function. Liver function is determined to a large extent by the underlying liver patho...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF00294397
更新日期：1994-03-01 00:00:00
abstract：INTRODUCTION:Mechanical bowel obstruction cases constitute an important place in emergency health care services. In this study, bowel obstructions caused by intra-abdominal tumors were compared with those without tumoral causes. PATIENTS AND METHODS:A total of 155 cases of mechanical bowel obstruction diagnosed were r...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0440-z
更新日期：2006-07-01 00:00:00
abstract：:The aim of this study was to investigate the epidemiologic characteristics and changing patterns of gallstone disease in Korea over a recent 20-year period. A total of 4020 gallstone patients who had undergone surgery at Seoul National University Hospital during 1981-2000 were analyzed according to periods: period I (...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-6879-x
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:Currently, there are no objective reports evaluating the quality of the South African surgical training. The aim of this study is to evaluate the current state of surgical training in South Africa from an external impartial point of view and to rate the experience of short-term supernumerary registrars and f...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05034-7
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:This study reviews the 15 year program of our Department of Pediatric Surgery for the treatment and follow-up of children born with a cleft in Benin and Togo. METHODS:We analyzed files of children born in Africa with a cleft. They were referred to us through a nongovernmental organization (NGO) between 1993...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1607-z
更新日期：2012-08-01 00:00:00
abstract：:Worldwide, traffic deaths are 500,000 per year and growing. Four nations, China, India, Russia, and the United States of America, have reached levels of 45,000-50,000 traffic deaths per year, although the nature of the problem is quite different in fully motorized countries from what it is in motorizing countries. In ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02104436
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND:Intraoperative cerebral oxygen desaturation was reported to be associated with postoperative cognitive dysfunction in elderly patients. The effect of the anesthesia method on regional cerebral oxygen saturation (rSO(2)) is still a question under debate. The purpose of this study was to compare the effects of...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-012-1676-z
更新日期：2012-10-01 00:00:00
abstract：:Acute acalculous cholecystitis (AAC) is a well known complication in severely traumatized patients. Existing data of AAC originate from retrospective analyses and episodic case reports. In a prospective study 45 polytraumatized patients admitted to our intensive care unit from January 1989 to June 1990 were clinically...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02067089
更新日期：1992-11-01 00:00:00
abstract：:Cost-benefit and cost-effectiveness analyses (CEAs) are only now beginning to be used by business, government, and policymakers to evaluate various medical treatments. The evolution of why CEAs are being demanded is reviewed. To date, a formal CEA of obesity treatments has not been published. This article outlines how...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900508
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:This study was undertaken to determine the efficacy of the clinical indications for performing staging laparoscopy for locally advanced gastric cancer to detect peritoneal metastasis or positive cytology findings. METHODS:The study included 231 patients with T4 gastric cancer without hematogenous or clinica...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1290-5
更新日期：2011-12-01 00:00:00
abstract：:The purpose of this study was to evaluate the surgical outcome of completion thyroidectomy in patients with presumed unilateral well-differentiated thyroid cancer (WDTC). The medical records of all patients having had unilateral thyroid lobectomy for WDTC, who subsequently underwent completion thyroidectomy, were revi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02067365
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:The quality of surgical performance depends on the technical skills of the surgical team as well as on non-technical skills, including teamwork. The present study evaluated the impact of familiarity among members of the surgical team on morbidity in patients undergoing elective open abdominal surgery. METHO...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2680-2
更新日期：2014-12-01 00:00:00
abstract：:Frequently, several multiple abdominal reexplorations are needed in patients with acute necrotizing hemorrhagic pancreatitis (ANP) or with persistent intraabdominal sepsis (PIAS). Residual undrained necrotic and septic foci lead to multiple organ failure. To provide wide-open drainage of the abdominal cavity, since 19...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658968
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Screening of multiple endocrine neoplasia type 1 (MEN-1) patients is widely recommended because one-fifth succumb to malignant neoplasms. However, recommendations for screening modalities and intervals are based mostly on nonprospective data. METHODS:Thirty-five of 48 MEN-1 patients were evaluated at least ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-9983-8
更新日期：2009-06-01 00:00:00
abstract：:Distinguishing cellular follicular adenomas (FA) from minimally invasive follicular carcinomas (FC) continues to plague even experienced thyroid pathologists. DNA ploidy analysis has been promoted as a means of making this differentiation; however, the finding of DNA aneuploidy in FA has caused concern that they may d...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658504
更新日期：1990-05-01 00:00:00
abstract：BACKGROUND:Typhoid fever incidence and complications, including intestinal perforation, have declined significantly in high-income countries, with mortality rates <1%. However, an estimated 10.9 million cases still occur annually, most in low- and middle-income countries. With the availability of a new typhoid conjugat...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05567-2
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze the prognostic factors associated with long-term outcome after liver resection for colorectal metastases. The retrospective analysis included 297 liver resections for colorectal metastases. METHODS:The variables considered included disease stage, differentiation grade, s...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9285-y
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The technical complexity of pancreatic resection has made it a specialized procedure performed in high-volume centers. It has been shown that patients operated on in high-volume pancreatobiliary centers have fewer complications and better survival. The purpose of this study was to share our experience with a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2644-6
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate and investigate the complications of carotid endarterectomy (CEA) and carotid artery stenting (CAS) by performing a meta-analysis based on prospective randomized controlled trials (RCTs). METHODS:We performed a search of multiple electronic databases for RCTs containing...
journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00268-008-9862-8
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:The albumin-bilirubin (ALBI) score was initially developed for assessing liver dysfunction severity and was suggested to have prognostic value in patients with hepatocellular carcinoma. We aimed to evaluate the prognostic impact of ALBI grade in patients with advanced gastric cancer (GC) after radical gastre...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4234-x
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:We assessed whether the simultaneous sequential strategy could (1) achieve additional sinus restoration for those patients who were not in sinus rhythm while coming off bypass after modified left maze procedure and (2) attain the same long-term success rates as the bi-atrial maze procedure in patients with p...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-006-0382-0
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:Small bowel obstruction (SBO) is characterized by a high rate of recurrence. In the present study, we aimed to compare the outcomes of patients managed either by conservative treatment or surgical operation for an episode of SBO. METHODS:The outcomes of all patients hospitalized at a single center for acute...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2733-6
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:A majority of patients with end-stage renal disease suffer from secondary hyperparathyroidism, which is associated with osteoporosis and cardiovascular disease. Parathyroidectomy (PTX) is often necessary despite medical treatment. However, the effect of PTX on cardio- and cerebrovascular events (CVE) remains...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05020-z
更新日期：2019-08-01 00:00:00
abstract：:The clinicopathological characteristics relevant to prognosis after surgical treatment of intrahepatic cholangiocarcinoma (ICC) remain unclear. In this study, the clinicopathological features of 19 patients with mass-forming ICC, the most common form of the disease, were reviewed to analyze prognostic determinants. Tw...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-001-0291-1
更新日期：2002-06-01 00:00:00
