Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population.

Abstract:

INTRODUCTION:Hypoxic stress is a feature of rapidly growing thyroid tumours. Cancer progression is thought to be driven by a small population of tumour cells possessing stem cell properties. Hypoxia-inducible factors (HIFs) are important mediators of hypoxia. Both HIF-1alpha and HIF-2alpha have been reported to be expressed in thyroid cancers. There is growing evidence that the HIF pathway plays a significant role in the maintenance of thyroid cancer stem cells (CSC). METHODOLOGY:We have isolated thyroid CSC from a papillary thyroid cancer-derived cell line (BCPAP) and an anaplastic thyroid cancer-derived cell line (SW1736) as side population (SP) cells (a putative stem cell population) and treated them with cobalt chloride (II) to induce hypoxia. RESULTS AND DISCUSSION: We observed an increase in the SP of cells within the thyroid cancer cell lines following induction of hypoxia.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Mahkamova K,Latar N,Aspinall S,Meeson A

doi

10.1007/s00268-017-4331-x

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

350-357

issue

2

eissn

0364-2313

issn

1432-2323

pii

10.1007/s00268-017-4331-x

journal_volume

42

pub_type

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