Abstract：
BACKGROUND:A majority of patients with small intestinal neuroendocrine tumors (SI-NETs) present with or develop liver metastases (LM). A number of treatments for LM are used clinically, including liver transplantation (LTx). Indications for LTx are under debate; young age(<65 years), absence of extrahepatic disease, resected primary tumor and limited extent of LM have been suggested as inclusion criteria for LTx with the aim to optimize outcome. MATERIALS AND METHODS:From our series of 672 patients with SI-NET treated at the University Hospital in Uppsala between 1985 and 2012, we identified 78 patients according to the following criteria: <65 years of age, locoregional surgery (LRS) of the primary tumor and mesenteric metastases successfully performed, LM present but no extrahepatic disease. Baseline was chosen as the first date the following points were met: First visit to our center,LRS performed, LM present. The patients underwent treatment according to the standard clinical protocols at our center, and during this time period we did not perform or refer any SI-NET patients for LTx. Kaplan-Meier survival analyses were performed in three different groups based on hypothetical criteria for LTx. RESULTS:Five-year overall survival rates for patients <65 years (n = 78) and <55 years (n = 36) of age were 84 ± 8 and 92 ± 9 %, respectively. For patients fulfilling the Milan criteria (n = 33) the 5-year survival was 97 ± 6 %. CONCLUSIONS:Most young patients (<65 years) with SINET and LM have a favorable survival with standardized multimodality treatment. Indeed, most survival figures reported after LTx of NET do not surpass these figures.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Norlén O,Daskalakis K,Öberg K,Åkerström G,Stålberg P,Hellman Pdoi
10.1007/s00268-013-2331-zsubject
Has Abstractpub_date
2014-03-01 00:00:00pages
742-7issue
3eissn
0364-2313issn
1432-2323journal_volume
38pub_type
杂志文章abstract：BACKGROUND:Chagas disease is a serious public health issue in South and Central America due to its high prevalence, morbidity, and mortality. The esophageal form of the disease leads to achalasia and consequent megaesophagus. In advanced or recurrent cases of megaesophagus, there is no consensus for which of three esta...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2445-3
更新日期：2014-06-01 00:00:00
abstract：:In 141 patients with chronic pancreatitis and an inflammatory enlargement of the head of the pancreas, a duodenum-preserving resection of the head of the pancreas was performed within a 16-year period. The hospital mortality was 0.7%; the late mortality was 5%. Seventy-seven percent of the patients were completely fre...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01670550
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:Advanced Trauma Life Support (ATLS®) is one of the world's best-known training programs for medical providers. Revisions of the ATLS manual have been evidence based for a number of years. In 2011, a level 3 (S3) evidence- and consensus-based guideline on the treatment of patients with severe and multiple injuri...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3063-z
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Heterotopic pancreas (HP) in the stomach can be difficult to diagnose and there are many treatment options. The aim of this article is to review the contemporary diagnosis of and treatment options for HP in the stomach. METHODS:We undertook a retrospective review of patients with the diagnosis heterotopic p...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0669-6
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Parathyroid cancer is rare. Differentiating parathyroid carcinoma from degenerative changes at histopathology can be difficult and studies investigating the value of single immunohistochemical markers have had variable results. In this study we aimed to investigate whether a panel of immunohistochemistry mar...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2700-2
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate and investigate the complications of carotid endarterectomy (CEA) and carotid artery stenting (CAS) by performing a meta-analysis based on prospective randomized controlled trials (RCTs). METHODS:We performed a search of multiple electronic databases for RCTs containing...
journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00268-008-9862-8
更新日期：2009-03-01 00:00:00
abstract：:A randomized, double-blind multicenter trial was performed to compare the safety and efficacy of a new low-molecular-weight heparin (LMWH) (LU 47311, Clivarine) and standard unfractionated heparin for the prophylaxis of postoperative venous thromboembolism. Altogether 1351 patients scheduled to undergo abdominal surge...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/s002689900185
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Enhanced Recovery After Surgery (ERAS®) Society guidelines integrate evidence-based practices into multimodal care pathways that have improved outcomes in multiple adult surgical specialties. There are currently no pediatric ERAS® Society guidelines. We created an ERAS® guideline designed to enhance quality ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05530-1
更新日期：2020-08-01 00:00:00
abstract：:Precise localization of cervical node metastasis of papillary thyroid carcinoma is rarely described. The aim of this retrospective study was to map their cervical involvement. Between 1974 and 1996 a series of 119 patients had total thyroidectomy with bilateral cervical lymph node dissection. Patients who had secondar...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900609
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND:We analyzed perioperative platelet counts as a potential clinical marker for survival after transthoracic en bloc resection for esophageal cancer. Recent data described preoperative thrombocytosis in malignancies to be associated with poor prognosis. METHODS:A retrospective analysis from a prospective datab...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0707-x
更新日期：2010-11-01 00:00:00
abstract：:Lower esophageal sphincter pressure has been assessed pre-operatively, intra-operatively,and more than 6 months postoperatively in 34 patients having antireflux surgery for gastro-esophageal reflux disease. The sphincter pressures associated with the outcome in relation to pH measured reflux and the symptoms of recurr...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02071543
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND:The aim of this study was to analyze the prognostic factors associated with long-term outcome after liver resection for colorectal metastases. The retrospective analysis included 297 liver resections for colorectal metastases. METHODS:The variables considered included disease stage, differentiation grade, s...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9285-y
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The extent to which obesity and genetics determine postoperative complications is incompletely understood. METHODS:We performed a retrospective study using two population cohorts with electronic health record (EHR) data. The first included 736,726 adults with body mass index (BMI) recorded between 1990 and ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05202-9
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Gastroesophageal reflux disease (GERD) may present with heartburn, regurgitation, dysphagia, chronic cough, laryngitis, or even asthma. The clinical presentation of GERD is therefore varied and poses certain challenges to the physician, especially given the limitations of the diagnostic testing. DISCUSSIO...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-017-3953-3
更新日期：2017-07-01 00:00:00
abstract：:Radiologically demonstrable pancreatic endocrine tumors are a frequent requirement for exploration in patients with multiple endocrine neoplasia type I (MEN-I). Such delayed intervention is accompanied by a 30% to 50% incidence of pancreatic endocrine metastases. This study explores biochemical tumor markers and opera...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900451
更新日期：1998-07-01 00:00:00
abstract：:In 1947, a patient with metastatic islet cell tumor was treated for intractable ulcer disease at the University of Chicago Medical Center. Eight years later, in retrospect, it was recognized that he and another patient had the Zollinger-Ellison syndrome (ZE). From 1947 until the present, 30 patients with the ZE syndro...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658530
更新日期：1990-05-01 00:00:00
abstract：:The aim of this study was to clarify the role of ganglion cells in the development and recurrence of sigmoid volvulus. We analyzed 9 samples obtained from 9 patients who had undergone sigmoidectomy for sigmoid volvulus, and, for comparison, 18 samples from 18 patients who had undergone sigmoidectomy or low anterior re...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7462-9
更新日期：2005-01-01 00:00:00
abstract：:Met protein is a tyrosine kinase receptor for hepatocyte growth factor (HGF). c-Met has morphogenic, mitogenic, and motogenic properties and is overexpressed in many solid tumors. We studied c-met mRNA and protein expression in papillary thyroid carcinomas and nonneoplastic thyroid tissue. The c-met mRNA was detected ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002680020167
更新日期：2001-05-01 00:00:00
abstract：:The release of the neuronal protein S-100B into the circulation has been suggested as an early indication of cellular brain damage. The objective of this prospective pilot study was to determine S-100B serum levels in patients undergoing cross-clamping during carotid endarterectomy (CEA) and to correlate the results w...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6547-6
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to evaluate the influence of donor age on liver regeneration and surgical outcomes in recipients and donors. PATIENTS AND METHODS:Among 101 cases of adult-to-adult living donor liver transplantation (LDLT) between March 2002 and March 2011, according to donor age: younger (Y...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1496-1
更新日期：2012-05-01 00:00:00
abstract：:Although palpable axillary lymphadenopathy is most often related to benign disorders, it may be a harbinger of an underlying advanced malignancy. Fewer than 1% of patients diagnosed with breast cancer initially present with axillary metastases as their only clinical manifestation. This study represents the Mayo Clinic...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7290-y
更新日期：2004-06-01 00:00:00
abstract：:A mathematic model is created to determine the economic cost per year of anticipated prolongation of life that would result from a program of abdominal ultrasonographic (US) screening for abdominal aortic aneurysm. The protocol involves US screening at age 60, 67, and 74 years with additional annual follow-up US and e...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01659032
更新日期：1989-05-01 00:00:00
abstract：:Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer. It can be diagnosed based on a clinical or pathologic basis. We evaluated the usefulness of (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) scans for diagnosing and staging IBC. We retrospectively reviewed t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-6893-z
更新日期：2003-10-01 00:00:00
abstract：:The imaging characteristics of diagnostic ultrasound (US) are determined by the ultrasonic properties of tissue. The velocity of propagation of US and the attenuation are the 2 most important parameters. These determine the frequency with which the tissues may be imaged, which in turn sets a fundamental limit on the a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689910026
更新日期：2000-02-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-005-7778-0
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:It is generally believed that the accompanying conditions in patients with inflammatory bowel disease (IBD) are associated with a high incidence of surgical site infection (SSI), and sometimes these patients are classified as compromised hosts without definitive clinical evidence. The aim of this study was t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-9934-4
更新日期：2009-05-01 00:00:00
abstract：:Local recurrence in differentiated and medullary thyroid carcinoma develops frequently from metastatic infiltration of cervical lymph nodes. Despite an aggressive surgical approach, postoperative calcitonin levels as biochemical evidence for residual cancer cells remain often elevated in patients with medullary thyroi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-001-0197-y
更新日期：2002-02-01 00:00:00
abstract：:Left untreated, aneurysmal disease of the abdominal aorta is a highly lethal condition. Standard transabdominal repair of aortic aneurysm, although successful and durable, continues to be plagued by significant morbidity, mortality, and cost. Placement of an endovascular graft through a femoral arteriotomy is a new te...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002689900101
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:The stapled hemorrhoidopexy is reported to have a low recurrence while treating the major hemorrhoidal symptoms of bleeding and prolapse. The aim of this study is to obtain long-term results on the outcome of the stapled hemorrhoidopexy. METHODS:All patients with a hemorrhoidal disease grade III, who underw...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05065-0
更新日期：2019-10-01 00:00:00
abstract：:This study aimed to investigate the effects and timing of local anesthesia during laparoscopic surgery in terms of postoperative pain, nausea, and the need for opioids and antiemetics. This prospective study was carried out on 142 patients who underwent laparoscopic cholecystectomy. Peroperative local anesthesia was n...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7350-3
更新日期：2004-08-01 00:00:00
