Abstract:
BACKGROUND:The aim of the present study was to evaluate the influence of donor age on liver regeneration and surgical outcomes in recipients and donors. PATIENTS AND METHODS:Among 101 cases of adult-to-adult living donor liver transplantation (LDLT) between March 2002 and March 2011, according to donor age: younger (Y) <50 years of age or older (O) ≥ 50 years of age, the donors and recipients using right (R) or left (L) graft were divided into groups Y/R (n = 51) and O/R (n = 17), and groups Y/L (n = 26) and O/L (n = 7), respectively. Remnant liver volume (RemLV) and graft liver volume (GLV) were estimated by computed tomography (CT) volumetry. A disintegrin and metalloprotease with thrombospondin type I domain 13 (ADAMTS13) activities and von Willebrand factor (vWF) antigen levels were measured as factors reflecting thrombotic microangiopathy. RESULTS:Among the donors, RemLV/total liver volume (TLV) was lower in group O/R than in group Y/R, although there were no significant differences by t-test with the Bonferroni correction (rough p value = 0.02 at 6 months and rough p value > 0.05 at 1, 3, and 12 months). Donor age (≥ 50 years) was independently correlated with impaired remnant liver regeneration at 6 months in right lobe LDLT (p = 0.04). Among the recipients, GLV/standard liver volume (SLV) was lower during the first month, although there were no significant differences between the two groups by t-test with the Bonferroni correction (rough p value = 0.03 at 1 week and rough p value >0.05 at 2 weeks and 1 and 3 months). Donor age (≥ 50 years) was independently correlated with impaired graft liver regeneration at 1 week in both right and left lobe LDLT (p < 0.05). ADAMTS13 activities were lower in group O/R than in group Y/R, although there were no significant differences by t-test with the Bonferroni correction (rough p value = 0.049 on postoperative days (POD) 1 and 28 and rough p value >0.05 on POD 7 and 14). vWF/ADAMTW13 ratios were higher on POD 14, although there were no significant differences between the two groups by t-test with the Bonferroni correction (rough p value = 0.044 on POD 14 and rough p value >0.05 on POD 1, 7, 14, and 28). CONCLUSIONS:The surgical outcomes using older donor livers for LDLT were comparable to those using younger donor livers. When using older donor livers, however, we should pay attention to the liver volume for recipients as well as donors, because older donor livers might have impaired regenerative ability.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Tanemura A,Mizuno S,Wada H,Yamada T,Nobori T,Isaji Sdoi
10.1007/s00268-012-1496-1subject
Has Abstractpub_date
2012-05-01 00:00:00pages
1102-11issue
5eissn
0364-2313issn
1432-2323journal_volume
36pub_type
杂志文章abstract:BACKGROUND:The International Study Group on Pancreatic Fistula (ISGPF) classification scheme has become a useful system for characterizing the clinical impact of pancreatic fistula. We sought to identify predictive factors that predispose patients to fistula, specifically those with clinical relevance (grades B/C), and...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9388-5
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Patients with HIV/AIDS on antiretroviral therapy (ART) live longer and now require surgery for indications similar to those described for the general population. They have been previously reported to carry higher mortality and complication rates, especially septic complications. The aim of this study was to ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-2994-8
更新日期:2015-07-01 00:00:00
abstract::Spontaneous pneumothorax (SP) is commonly observed in young, tall, thin subjects without apparent underlying lung disease and in the elderly with chronic emphysematous lung disease. We present our experience in treating SP during the last decade. From December 1986 to November 1996 a total of 417 consecutive patients ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900473
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:The treatment of acute limb ischemia (ALI) has barely changed over the last years. However, the progressive implementation of anticoagulants, antiplatelet agents or statins within the population might have modified the profile and prognosis of patients suffering an ALI. The aim of this study was to evaluate ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4511-3
更新日期:2018-08-01 00:00:00
abstract::The success of parathyroid surgery is determined by the identification and removal of all parathyroid tumors. Parathyroid tumors accumulate and retain 2-methoxyisobutylisonitrile (MIBI) labeled with technetium-99m. Intravenous injection of this radiopharmacon prior to parathyroid surgery allows identification of parat...
journal_title:World journal of surgery
pub_type: 临床试验,杂志文章
doi:10.1007/s002689900427
更新日期:1998-06-01 00:00:00
abstract::Endoscopic sphincterotomy (EST) is an established method for treatment of retained or recurrent common bile duct (CBD) calculi after cholecystectomy. Present experience shows that few patients have recurrent biliary tract complications, but follow-up periods are most often short. EST was performed in 147 patients with...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900043
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Chronic pilonidal disease is a debilitating condition that typically affects young adults. There is a wide variety of available therapeutic strategies reflecting the inconsistent outcomes attributed to the various operative approaches. The majority involve excision of the sinus tract followed by either prima...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1138-z
更新日期:2011-08-01 00:00:00
abstract::This article surveys in an interdisciplinary fashion the evolution of ancient Greek medicine and traumatology in particular. In sounding out the key methods and themes of Greek medicine, we cite a range of medical treatises and correlate them to the rich evidence of ancient Greek art (iconography), which often is expl...
journal_title:World journal of surgery
pub_type: 历史文章,杂志文章
doi:10.1007/s00268-003-6931-x
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:We hypothesized that a dedicated collaborative transdisciplinary Geriatric Surgery Service (GSS) will improve care for elderly colorectal surgery patients. METHODS:Patients older than 75 years of age who underwent major colorectal surgery were included in this study. The Geriatric Surgery Service employed a...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1112-9
更新日期:2011-07-01 00:00:00
abstract::The present prospective clinical study was carried out to investigate the effect of age on mortality, morbidity, and readmission rates after coronary artery bypass grafting (CABG). Data on 1131 consecutive CABG patients were collected in a surgical center and in all 18 secondary referral hospitals up to 3 months after...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-003-7033-5
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:Adenocarcinoma of the small bowel is relatively less common than malignancies of the esophagus, stomach, and colorectum. In small bowel adenocarcinoma, various prognostic factors influence the disease-free status and overall survival rates. MATERIALS AND METHODS:Eighty patients who were diagnosed with small...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-7898-6
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) scoring system was developed to aid the diagnosis of necrotizing fasciitis and guide management [1]. AIM:To validate the LRINEC score and identify clinical predictors to develop a refined diagnostic scoring tool for the diagnosis of necrotizin...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05061-4
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Spleen-preserving procedures deserve every effort by surgeons to reduce the risk of overwhelming postsplenectomy infection. Partial splenectomy at hospitals with restricted sources remains technically demanding. We describe our method of partial splenectomy for benign splenic cysts with the aid of a Lin clam...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9240-y
更新日期:2007-11-01 00:00:00
abstract::Whether for hepatic trauma or transplantation, a surgeon's knowledge of hepatic anatomy commonly determines a patient's outcome. The first medically relevant anatomic studies of the liver emerged with the endeavors of Herophilus and Erasistratus between 310 and 280 bc. Yet it was not until after the development of ane...
journal_title:World journal of surgery
pub_type: 传,历史文章,杂志文章
doi:10.1007/s002689900238
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Complications are important indicators of immediate postoperative outcomes. The Clavien-Dindo classification (CDC) is a widely used index for the classification of surgical complications. More recently, the comprehensive complication index (CCI) has also been introduced for classifying postoperative complica...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05859-7
更新日期:2021-03-01 00:00:00
abstract:BACKGROUND:Surgery is the best treatment for primary GIST and may be curative, but resection extension/completeness impact on the prognosis remains controversial. The authors aim was to evaluate the clinicopathological (CP) parameters and surgical margins status influence on GIST patients' outcome. MATERIALS AND METHO...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9704-8
更新日期:2008-11-01 00:00:00
abstract::Although HLA matching can improve organ graft survival, well matched grafts fail and poorly matched ones survive. Recently evidence has been found that perinatal exposure to noninherited antigens (NIMAs) has a lifelong impact on the immune repertoire of the individual. The state of the art of the influence of NIMAs on...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s002680010132
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Pain syndromes of somatic and neuropathic origin are considered to be the main causes of chronic pain after open inguinal hernia repair. Nerve-identification during open hernia repair is suggested to be associated with less postoperative chronic pain. The aim of this study was to define clinically relevant s...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-006-0376-y
更新日期:2007-02-01 00:00:00
abstract::From the earliest description of dysphagia relieved by dilatation with a whalebone in 1674 we have witnessed the evolution of esophageal function testing from the conventional manometry to the high-resolution manometry (HRM) and esophageal topography pressure plotting that have led to the revised Chicago classificatio...
journal_title:World journal of surgery
pub_type: 历史文章,杂志文章
doi:10.1007/s00268-014-2939-7
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Little is known about the changes in prognostic factors after adjuvant S-1 monotherapy has become widespread as a standard of care for patients with gastric cancer (GC) in East Asia. The present study compared prognostic factors of patients with stage II/III GC treated with or without S-1 adjuvant to formula...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s00268-019-05198-2
更新日期:2020-01-01 00:00:00
abstract::Primary hyperparathyroidism was investigated using the presence of basic fibroblast growth factor (bFGF) from the immunohistochemical viewpoint with an anti-bFGF antibody in hyperplastic parathyroid glands of patients with multiple endocrine neoplasia type I (MEN-I) and of patients with non-MEN. The results correspond...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00299109
更新日期:1994-11-01 00:00:00
abstract::From 1978 to 1989, 164 patients underwent hepatic resection for hepatocellular carcinoma at our institution. The carcinoma was resected completely in 149 patients. Sixteen patients were excluded from this study because it was not known whether they were recurrent or disease free, or because death occurred as a result ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01659099
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Frequent use of computed tomography (CT) in trauma patients results in frequent detection of non-trauma-related incidental findings (IFs). Inpatient documentation and disclosure at discharge are infrequent, even when they are potentially serious. We aimed to not only identify the incidence of IFs but also to...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2092-8
更新日期:2013-09-01 00:00:00
abstract::Malnutrition in its various forms is without doubt the commonest disease. Acute malnutrition resulting from a total lack of ingestion clearly shows that not only are water and electrolytes a priority for survival but also energy reserves. It also shows that the maximum wasting that the lean body mass can withstand is ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/pl00012343
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Single-incision laparoscopic colorectal surgery (SILS) suggests a promising alternative to conventional laparoscopic surgery. In this report we describe our initial experience with SILS for both right hemicolectomies and anterior resections. METHODS:Between June 2009 and May 2010, SILS was performed for 32 ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-0989-7
更新日期:2011-04-01 00:00:00
abstract::Recent collective reviews have outlined when and how surgeons should treat patients with bile duct injuries after laparoscopic cholecystectomy (LC). However, little is described about other injuries combined with bile duct injuries, for example, hepatic arterial injury and secondary biliary cirrhosis. Fifteen patients...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-001-0120-6
更新日期:2001-10-01 00:00:00
abstract::Thoracic and thoracoabdominal penetrating wounds are frequently encountered in urban medical centers in the United States. This study was undertaken to determine the clinical characteristics and in hospital outcome of these injuries. This was a longitudinal, nonblinded study using the established standard of care of p...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF03215862
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Video-assisted thoracoscopic surgery (VATS) is a new area of exploration and evolution in thoracic minimal invasive surgery. The uniportal VATS approach has become popular during lung resection for small nodules and ground glass lesions. Our objective is to investigate the efficacy, availability and safety o...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05781-y
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:The aim of this trial was to compare the Enhanced Recovery After Surgery (ERAS) program with conventional perioperative management in patients who underwent radical resection for colorectal cancer. METHODS:A combination of evidence-based and consensus methodology was used to develop the ERAS protocol. Five ...
journal_title:World journal of surgery
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00268-011-1348-4
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Critical illness disproportionately affects people in low-income countries (LICs). Efforts to improve critical care in LICs must account for differences in demographics and infrastructure compared to high-income settings. Part of this effort includes the development and validation of intensive care unit (ICU...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05078-9
更新日期:2019-10-01 00:00:00