2-Methoxyisobutylisonitrile probe during parathyroid surgery: tool or gadget?

Abstract:

:The success of parathyroid surgery is determined by the identification and removal of all parathyroid tumors. Parathyroid tumors accumulate and retain 2-methoxyisobutylisonitrile (MIBI) labeled with technetium-99m. Intravenous injection of this radiopharmacon prior to parathyroid surgery allows identification of parathyroid tumors with a hand-held gamma detector. To assess the value of this technique, a case-control study was performed with 62 patient having nuclear-guided parathyroidectomy and 60 patients having conventional parathyroid explorations. The sensitivity rates of the MIBI probe in single and multiple gland disease were 84.6% and 63.0%, respectively. Rates of success, temporary and permanent hypoparathyroidism, and injury of the recurrent laryngeal nerve were similar in patients who underwent probe-guided surgery and those who had conventional surgery. In conclusion, although the MIBI probe appears to be a valuable tool in parathyroid surgery, its use has not improved the outcome of such surgery at our institution.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Bonjer HJ,Bruining HA,Pols HA,de Herder WW,Proye CA,Carnaille BM,Mohammedamin RS,Steyerberg EW,Breeman WA,Krenning EP

doi

10.1007/s002689900427

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

507-11; discussion 511-2

issue

6

eissn

0364-2313

issn

1432-2323

journal_volume

22

pub_type

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