Therapeutic splenectomy in immune thrombocytopenic purpura.

Abstract:

:The effects of splenectomy in 41 patients managed from 1982 to 1995 at Sher-i-Kashmir Institute of Medical Sciences, Srinagar (Jammu and Kashmir), India, were studied. Immune thrombocytopenic purpura (ITP) was the main indication for therapeutic splenectomy among all the hematologic disorders. The mean age was 30 years (range 7-64), and the male to female ratio was 1.05:1. The mean platelet count in the preoperative period was 31,751/mm(3) (range 4000-85,000). All patients presented with thrombocytopenia, i.e., platelet count of <100,000/mm(3). In addition, 5 patients presented with anemia, i.e., Hb <10 g%. Among the patients with thrombocytopenia, 30 patients presented with counts <50,000/mm(3) and 11 patients presented with counts between 50,000-100,000/mm(3). None of the patients presented with leukopenia. The morbidity observed was 15% and mortality was 2%. The response to splenectomy was complete for thrombocytopenia in 3 patients and partial in 5 patients; 4 patients failed to show any response. In anemic patients, 4 patients showed complete response and 1 patient showed no response. The prognosis was excellent in patients with platelet count >50,000/mm(3), age <50 years, no concomitant disease, and disease of shorter duration.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Wani NA,Parray FQ

doi

10.1007/s002689910017

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

92-4

issue

1

eissn

0364-2313

issn

1432-2323

pii

10.1007/s002689910017

journal_volume

24

pub_type

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