Abstract:
INTRODUCTION:Response rates to systemic chemotherapy for patients who have failed irinotecan-based chemotherapy for liver-dominant metastatic colorectal cancer range between 10 and 18 % with overall survival between 7 and 9 months. The aim of this study was to assess the efficacy and safety of hepatic arterial irinotecan therapy in patients with hepatic-dominant metastatic colorectal cancer who had failed systemic irinotecan. METHODS:This was a multi-institutional, multi-national, analysis of patients who received DEBIRI in the setting of unresectable liver-dominant metastatic colorectal cancer. Patients had received between 1 and 4 lines of prior chemotherapy, the majority of which included systemic irinotecan. Primary endpoints were toxicity profile and tumor response rate. RESULTS:296 patients with unresectable liver metastases who had undergone 666 DEBIRI treatments were reviewed. 192 treatments were performed in patients who had received prior systemic irinotecan. 222 treatments were performed in irinotecan-naïve patients. The median number of DEBIRI treatments was 1 (range 1-8); median treatment dose was 100 mg (range 50-200 mg), with total hepatic treatment of approximately 100 mg (range 20/30-200/300 mg). All-grade adverse events occurred in 18 % of patients receiving prior systemic irinotecan compared with 15 % of patients receiving no prior systemic irinotecan (including chemo-naïve patients). Response rates in patients with prior systemic irinotecan were 44 % at 3 months, 43 % at 6 months, and 44 % at 12 months, compared with 45, 40, and 35 % during the same time point in patients without prior systemic irinotecan. All-grade adverse events occurred in 10, 20, 10, and 37 % of patients receiving 0, 1, 2, and 3+ lines of systemic chemotherapy, respectively. Overall survival was 90 %, 93 %, 90 %, 90 % at 6 months and 76 %, 71 %, 77 %, 87 % at 12 months in patients undergoing DEBIRI therapy after receiving 0, 1, 2, and 3+ lines of systemic chemotherapy, respectively. CONCLUSIONS:The safety and efficacy of hepatic arterial drug-eluting irinotecan bead (DEBIRI) therapy are not affected by non-response to prior systemic irinotecan. While DEBIRI complete response rates are greatest and overall adverse events are least in chemotherapy-naïve individuals, it retains its respectable efficacy and low rate of serious adverse events even in the setting of previous administration of systemic chemotherapy.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Bhutiani N,Akinwande O,Martin RC 2nddoi
10.1007/s00268-015-3386-9subject
Has Abstractpub_date
2016-05-01 00:00:00pages
1178-90issue
5eissn
0364-2313issn
1432-2323pii
10.1007/s00268-015-3386-9journal_volume
40pub_type
杂志文章,多中心研究abstract:INTRODUCTION:Hypoxic stress is a feature of rapidly growing thyroid tumours. Cancer progression is thought to be driven by a small population of tumour cells possessing stem cell properties. Hypoxia-inducible factors (HIFs) are important mediators of hypoxia. Both HIF-1alpha and HIF-2alpha have been reported to be expr...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4331-x
更新日期:2018-02-01 00:00:00
abstract::The measurement of the burden of disease and the interventions that address that burden can be done in various units. Reducing these measures to the common denominator of economic units (i.e., currency) enables comparison with other health entities, interventions, and even other fields. Economic assessment is complex,...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1796-5
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:This study was designed to assess the chronological change in health-related quality of life (HRQOL) following robot-assisted distal gastrectomy (RADG) for early gastric cancer (EGC) and to compare the HRQOL of the patients undergoing RADG with that of the general population. METHODS:Patients undergoing RADG f...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2390-1
更新日期:2014-05-01 00:00:00
abstract::Intraabdominal bleeding, the most life-threatening complication following pancreaticoduodenectomy (PD), most often is associated with failure of a pancreaticojejunostomy anastomosis or with intraabdominal infection. We investigated whether placement of an omental flap around the splanchnic vessels in PD could reduce t...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-7900-3
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:The Severe Acute Respiratory Syndrome Coronavirus 2 pandemic has exposed surgeons to hazardous working conditions, imposing the need for personal protective equipment (PPE) use during surgery. The use of such equipment may affect their non-technical skills, augment fatigue, and affect performance. This study...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05648-2
更新日期:2020-09-01 00:00:00
abstract::In 1947, a patient with metastatic islet cell tumor was treated for intractable ulcer disease at the University of Chicago Medical Center. Eight years later, in retrospect, it was recognized that he and another patient had the Zollinger-Ellison syndrome (ZE). From 1947 until the present, 30 patients with the ZE syndro...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01658530
更新日期:1990-05-01 00:00:00
abstract::The most common causes of variceal bleeding are cirrhosis, schistosomiasis, and extrahepatic portal venous obstruction. The prognosis for an individual patient depends on the severity of the bleeding episode and the underlying liver function. Liver function is determined to a large extent by the underlying liver patho...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF00294397
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the short- and long-term outcomes of malnourished gastric cancer patients who underwent laparoscopic or open radical gastrectomy. BACKGROUND:Preoperative malnutrition is an independent risk factor for postoperative mortality and morbidity in major gastrointestinal surgery...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4138-9
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) scoring system was developed to aid the diagnosis of necrotizing fasciitis and guide management [1]. AIM:To validate the LRINEC score and identify clinical predictors to develop a refined diagnostic scoring tool for the diagnosis of necrotizin...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05061-4
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Exact tissue identification during parathyroidectomy is essential to successfully cure hyperparathyroidism. PTH level determination from tissue aspirates has been advocated as a "biochemical frozen section" for parathyroid tissue identification. We investigated the sensitivity and specificity of this method ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0351-5
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Gallbladder (GB) cancer may be discovered incidentally by histopathologic examination following simple cholecystectomy. Incidental GB cancer > or =T2 or > or =N1 needs a second radical resection. It is a matter of concern whether the prognosis may be worse in patients with T2GB cancer who undergo a second ra...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0522-4
更新日期:2010-07-01 00:00:00
abstract::Uncontrolled bleeding from the cystic artery and its branches is a serious problem that may increase the risk of intraoperative lesions to vital vascular and biliary structures. On laparoscopic visualization anatomic relations are seen differently than during conventional surgery, so proper knowledge of the hepatobili...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/pl00012372
更新日期:1999-07-01 00:00:00
abstract::The surgical treatment of groin hernias continues to undergo technical modifications. The introduction of minimally invasive surgery had added a possible new dimension, replacing an inguinal approach by laparoscopy. Conceived some 15 years ago, the thesis was subjected to a clinical trial where coincidental abdominal ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01655704
更新日期:1993-01-01 00:00:00
abstract::Histologically differentiated adenocarcinoma satisfies one of the criteria for limited surgery for mucosal carcinoma of the stomach: however, the histology of the endoscopic biopsy specimen is often different from that of the resected specimen. The medical records of 1018 early gastric carcinomas were retrospectively ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900483
更新日期:1998-08-01 00:00:00
abstract::Surgical innovation relies on patient safety and quality of life, which require a drastic iatrogenic impact reduction. A parallel development toward less invasive approaches has occurred in the field of surgery, interventional radiology, and endoscopy. Minimally invasive techniques provide unquestionable benefits to p...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2879-2
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION:The follicular variant of papillary thyroid carcinoma (FVPTC) is the most common histologic subtype of papillary thyroid carcinoma (PTC). However, it is still controversial whether FVPTC should behave differently from classical PTC (CPTC). The present study aimed at evaluating any potential difference in c...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-0356-7
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Beginning in 2004, a standardized medial-to-lateral approach was adopted in laparoscopic colorectal resection (LapCR) in our institution. The present study aimed to compare the outcomes of patients operated on by this approach with those who were operated on prior to the adoption of this technique. METHODS:...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0173-5
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:The aim of the study was to compare the changes in health-related quality of life (QOL) after lung surgery between young and old patients. METHODS:We performed a prospective, population-based, cohort study to investigate health-related QOL before and 6 months after lung surgery. We used the validated instru...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0430-7
更新日期:2010-04-01 00:00:00
abstract::Congenital diaphragmatic hernia (CDH) is one of the most common causes of neonatal morbidity and mortality. The clinical spectrum of CDH ranges from minimally affected infants who do well with modern neonatal care to severely affected infants who die despite all interventions. Two decades of research have led to advan...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-002-6739-0
更新日期:2003-01-01 00:00:00
abstract::In 1989-90, all 37 lung cancer patients scheduled for surgery underwent transesophageal endoscopic ultrasonography (EUS) for pre-operative detection of hilar and mediastinal lymph node metastases. An electronic ultrasonic fiberscope with a linear array (EPB-503-FS, Machida-Toshiba) was used. Of 380 nodes surgically re...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF02067013
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND:Construction of a gastric tube that is well perfused with blood during esophagectomy is the most important factor in avoiding anastomotic leakage. We clarified the hemodynamics of the reconstructed gastric tube with indocyanine green (ICG) fluorescence. METHODS:In 20 patients undergoing gastric tube reconst...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2237-9
更新日期:2014-01-01 00:00:00
abstract::Papillary thyroid carcinoma is a frequent thyroid cancer. Many factors have been reported to be of prognostic importance, but the significance of biologic factors suggesting aggressiveness and proliferating activity has not been sufficiently documented. Conventional prognostic factors such as age, extrathyroidal invas...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900551
更新日期:1998-12-01 00:00:00
abstract::The aim of this study was to investigate the epidemiologic characteristics and changing patterns of gallstone disease in Korea over a recent 20-year period. A total of 4020 gallstone patients who had undergone surgery at Seoul National University Hospital during 1981-2000 were analyzed according to periods: period I (...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-003-6879-x
更新日期:2004-02-01 00:00:00
abstract::At the time of laparotomy, peritoneal washings were collected from 155 gastric cancer patients and the levels of carcinoembryonic antigen (CEA) determined. The CEA levels in peritoneal washings were statistically independent of those in sera and could more reliably predict the presence of peritoneal metastasis than a ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00316997
更新日期:1995-01-01 00:00:00
abstract::This prospective study addresses the rate of male genital dysfunction following total mesorectal excision (TME) for rectal carcinoma using the anterior extramesorectal plane and its correlation with early urinary function, pelvic autonomic nerve preservation (PANP), and intraoperative neurostimulation (INS). A consecu...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9008-4
更新日期:2007-06-01 00:00:00
abstract:BACKGROUND:The pancreatic fistula rate following distal pancreatectomy ranges widely, from 13.3 to 64.0 %. The optimal closure method of the pancreatic remnant remains controversial, especially regarding whether to use a stapler. METHODS:All patients who underwent distal pancreatectomy in five Japanese hospitals from ...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s00268-012-1595-z
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:There is no standardized treatment for patients with chemo-resistant or recurrent advanced ovarian cancer. Locoregional treatments combining cytoreductive surgery and intraperitoneal chemohyperthermia (HIPEC) may improve survival for locoregional disease. PATIENTS AND METHODS:A prospective single center study ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9146-8
更新日期:2007-09-01 00:00:00
abstract::Experience with screening for colorectal cancer has been disappointing. Prevention of this disease seems to be a more beneficial research direction. Although radical surgery presents the best treatment option, it is nonetheless an inadequate strategy by itself. A new dose intensive approach would temporally combine su...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF01789207
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Reported results of incisional hernia repair are poor with high recurrence rates unless prosthetic mesh is used. Mesh gives improved results, but certain techniques are associated with a high incidence of infections, fistulas, and seromas. This study reports the results of a consecutive series of incisional ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9118-z
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The extent to which obesity and genetics determine postoperative complications is incompletely understood. METHODS:We performed a retrospective study using two population cohorts with electronic health record (EHR) data. The first included 736,726 adults with body mass index (BMI) recorded between 1990 and ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05202-9
更新日期:2020-01-01 00:00:00