当前位置： SCI文献检索 > WORLD JOURNAL OF SURGERY期刊下所有文献 > DNA Mismatch Repair Deficiency Promotes Genomic Instability in a Subset of Papillary Thyroid Cancers.

DNA Mismatch Repair Deficiency Promotes Genomic Instability in a Subset of Papillary Thyroid Cancers.

Abstract：

BACKGROUND:Efficient DNA damage repair by MutL-homolog DNA mismatch repair (MMR) enzymes, MLH1, MLH3, PMS1 and PMS2, are required to maintain thyrocyte genomic integrity. We hypothesized that persistent oxidative stress and consequent transcriptional dysregulation observed in thyroid follicles will lead to MMR deficiency and potentiate papillary thyroid tumorigenesis. METHODS:MMR gene expression was analyzed by targeted microarray in 18 papillary thyroid cancer (PTC), 9 paracarcinoma normal thyroid (PCNT) and 10 normal thyroid (NT) samples. The findings were validated by qRT-PCR, and in follicular thyroid cancers (FTC) and follicular thyroid adenomas (FTA) for comparison. FOXO transcription factor expression was also analyzed. Protein expression was assessed by immunohistochemistry. Genomic integrity was evaluated by whole-exome sequencing-derived read-depth analysis and Mann-Whitney U test. Clinical correlations were assessed using Fisher's exact and t tests. RESULTS:Microarray and qRT-PCR revealed reduced expression of all four MMR genes in PTC compared with PCNT and of PMS2 compared with NT. FTC and FTA showed upregulation in MLH1, MLH3 and PMS2. PMS2 protein expression correlated with the mRNA expression pattern. FOXO1 showed lower expression in PMS2-deficient PTCs (log2-fold change -1.72 vs. -0.55, U = 11, p < 0.05 two-tailed). Rate of LOH, a measure of genomic instability, was higher in PMS2-deficient PTCs (median 3 and 1, respectively; U = 26, p < 0.05 two-tailed). No correlation was noted between MMR deficiency and clinical characteristics. CONCLUSIONS:MMR deficiency, potentially promoted by FOXO1 suppression, may explain the etiology for PTC development in some patients. FTC and FTA retain MMR activity and are likely caused by a different tumorigenic pathway.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Javid M,Sasanakietkul T,Nicolson NG,Gibson CE,Callender GG,Korah R,Carling T

doi

10.1007/s00268-017-4299-6

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

358-366

issue

2

eissn

0364-2313

issn

1432-2323

pii

10.1007/s00268-017-4299-6

journal_volume

42

pub_type

杂志文章

相关文献

WORLD JOURNAL OF SURGERY文献大全
  • Pattern of organ failure following severe trauma.

    abstract：:Multiple organ failure (MOF) is considered to be the leading cause of death after severe trauma. Although there is extensive literature on MOF, little is known about the pattern, sequence, and onset of this clinical syndrome. The first goal of this clinical study was to define MOF; the second was to assess the typical...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s002689900067

    authors： Regel G,Grotz M,Weltner T,Sturm JA,Tscherne H

    更新日期：1996-05-01 00:00:00

  • The number of metastatic lymph nodes is a significant risk factor for bone metastasis and poor outcome after surgery for linitis plastica-type gastric carcinoma.

    abstract：BACKGROUND:Linitis plastica-type gastric carcinoma remains a disease with poor prognosis despite an aggressive surgical approach. Although a prominent pattern of disease failure is peritoneal carcinomatosis, some patients experience rapid disease progression without signs of the peritoneal disease. METHODS:Clinicopath...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-008-9672-z

    authors： Kodera Y,Ito S,Mochizuki Y,Yamamura Y,Misawa K,Ohashi N,Nakayama G,Koike M,Fujiwara M,Nakao A

    更新日期：2008-09-01 00:00:00

  • Preoperative Toll-like receptor expression in monocytes is associated with host immunological responses following gastrointestinal surgery.

    abstract：BACKGROUND:The present study was designed to evaluate the relationship between preoperative Toll-like receptor (TLR) expression in peripheral blood monocytes (PBMC) and the postoperative inflammatory cytokine secretion from PBMC, as well as the postoperative infectious complications in patients with gastrointestinal ca...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-010-0839-z

    authors： Ono S,Tsujimoto H,Hiraki S,Kinoshita M,Hase K

    更新日期：2011-02-01 00:00:00

  • Recombinant human erythropoietin and hemoglobin concentration at operation and during the postoperative period: reduced need for blood transfusions in patients undergoing colorectal surgery--prospective double-blind placebo-controlled study.

    abstract：:In a double-blind placebo-controlled study we investigated the effect of recombinant human erythropoietin (r-HuEPO), on the perioperative hemoglobin concentration and the use of blood transfusions in patients undergoing elective colorectal surgery with a preoperative hemoglobin level

    journal_title：World journal of surgery

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s002689900561

    authors： Qvist N,Boesby S,Wolff B,Hansen CP

    更新日期：1999-01-01 00:00:00

  • Intercostal Trocars Enable Easier Laparoscopic Resection of Liver Tumors in Segments 7 and 8.

    abstract：BACKGROUND:Laparoscopic resection of posterosuperior (PS) tumors of the liver is more difficult than that of anterolateral (AL) tumors, owing to the narrow surgical field in the PS location. In this retrospective cohort study, our aim was to determine if port insertion through the intercostal space would lead to improv...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-016-3867-5

    authors： Hirokawa F,Hayashi M,Asakuma M,Shimizu T,Inoue Y,Uchiyama K

    更新日期：2017-05-01 00:00:00

  • Liver volumetry plug and play: do it yourself with ImageJ.

    abstract：BACKGROUND:A small remnant liver volume is an important risk factor for posthepatectomy liver failure and can be predicted accurately by computed tomography (CT) volumetry using radiologic image analysis software. Unfortunately, this software is expensive and usually requires support by a radiologist. ImageJ is a freel...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-007-9197-x

    authors： Dello SA,van Dam RM,Slangen JJ,van de Poll MC,Bemelmans MH,Greve JW,Beets-Tan RG,Wigmore SJ,Dejong CH

    更新日期：2007-11-01 00:00:00

  • Intraoperative Near-infrared Imaging for Parathyroid Gland Identification by Auto-fluorescence: A Feasibility Study.

    abstract：BACKGROUND:Parathyroid glands (PGs) can be particularly hard to distinguish from surrounding tissue and thus can be damaged or removed during thyroidectomy. Postoperative hypoparathyroidism is the most common complication after thyroidectomy. Very recently, it has been found that the parathyroid tissue shows near-infra...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-016-3571-5

    authors： De Leeuw F,Breuskin I,Abbaci M,Casiraghi O,Mirghani H,Ben Lakhdar A,Laplace-Builhé C,Hartl D

    更新日期：2016-09-01 00:00:00

  • Open Mesh Repair for Inguinal Hernia is Safer than Laparoscopic Repair or Open Non-mesh Repair: A Nationwide Registry Study of Complications.

    abstract：BACKGROUND:Inguinal hernia repair is the most common elective procedure in general surgery. Therefore, the number of patients having complications related to inguinal hernia surgery is relatively large. The aim of this study was to compare complication profiles of inguinal open mesh (OM) hernioplasties with open non-me...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-015-3028-2

    authors： Kouhia S,Vironen J,Hakala T,Paajanen H

    更新日期：2015-08-01 00:00:00

  • Implementation Analysis of a Perioperative Patient Safety Program in Guatemala.

    abstract：BACKGROUND:The implementation of programs to improve patient safety remains challenging in low- and middle-income countries. The goal of our study was to define the barriers and facilitators to implementation of a perioperative patient safety program in Guatemala. MATERIAL AND METHODS:We conducted semi-structured inte...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-020-05495-1

    authors： Sico IP,Hall BJ,Aguilar-González A,Orozco M,Ramirez C,Baumgartner JN,Boyd D,Bolaños J,Calgua E,Lou-Meda R,Rice HE

    更新日期：2020-07-01 00:00:00

  • Preoperative Albumin-Bilirubin Grade Predicts Recurrences After Radical Gastrectomy in Patients with pT2-4 Gastric Cancer.

    abstract：BACKGROUND:The albumin-bilirubin (ALBI) score was initially developed for assessing liver dysfunction severity and was suggested to have prognostic value in patients with hepatocellular carcinoma. We aimed to evaluate the prognostic impact of ALBI grade in patients with advanced gastric cancer (GC) after radical gastre...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-017-4234-x

    authors： Kanda M,Tanaka C,Kobayashi D,Uda H,Inaoka K,Tanaka Y,Hayashi M,Iwata N,Yamada S,Fujii T,Sugimoto H,Murotani K,Fujiwara M,Kodera Y

    更新日期：2018-03-01 00:00:00

  • Detection of asymptomatic differentiated thyroid carcinoma by neck ultrasonographic screening for familial nonmedullary thyroid carcinoma.

    abstract：:Mass screening for the purpose of detecting thyroid cancer at its earliest stage may not be recommended at the present time, but screening focused on certain risk groups is advocated. Familial nonmedullary thyroid carcinoma (FNMTC) is a distinct clinical entity with a high incidence of multifocality and association wi...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-004-7676-x

    authors： Uchino S,Noguchi S,Yamashita H,Murakami T,Watanabe S,Ogawa T,Tsuno A,Shuto S

    更新日期：2004-11-01 00:00:00

  • Clinicopathologic and immunohistochemical studies of papillary thyroid microcarcinoma presenting with cervical lymphadenopathy.

    abstract：:Although most papillary thyroid microcarcinomas (PMCs) are of little clinical significance, patients with PMCs occasionally have an unfavorable outcome, especially when they present with bulky nodal metastasis or distant metastasis. We have attempted to identify "high-risk" PMCs by evaluating clinical, pathologic, and...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s002689900461

    authors： Sugitani I,Yanagisawa A,Shimizu A,Kato M,Fujimoto Y

    更新日期：1998-07-01 00:00:00

  • Association of Genetic Risk of Obesity with Postoperative Complications Using Mendelian Randomization.

    abstract：BACKGROUND:The extent to which obesity and genetics determine postoperative complications is incompletely understood. METHODS:We performed a retrospective study using two population cohorts with electronic health record (EHR) data. The first included 736,726 adults with body mass index (BMI) recorded between 1990 and ...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-019-05202-9

    authors： Robinson JR,Carroll RJ,Bastarache L,Chen Q,Mou Z,Wei WQ,Connolly JJ,Mentch F,Sleiman P,Crane PK,Hebbring SJ,Stanaway IB,Crosslin DR,Gordon AS,Rosenthal EA,Carrell D,Hayes MG,Wei W,Petukhova L,Namjou B,Zhang G,Sa

    更新日期：2020-01-01 00:00:00

  • Early Seizure Prophylaxis in Traumatic Brain Injuries Revisited: A Prospective Observational Study.

    abstract：INTRODUCTION:Pharmacological prophylaxis for early seizures following traumatic brain injury (TBI) is a recommendation in the Brain Trauma Foundation Guidelines. However, several studies have challenged the efficacy and safety of this practice, resulting in varied practice across centers around the world. The purpose o...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-017-4373-0

    authors： Khor D,Wu J,Hong Q,Benjamin E,Xiao S,Inaba K,Demetriades D

    更新日期：2018-06-01 00:00:00

  • Morbidity and Mortality of Typhoid Intestinal Perforation Among Children in Sub-Saharan Africa 1995-2019: A Scoping Review.

    abstract：BACKGROUND:Typhoid fever incidence and complications, including intestinal perforation, have declined significantly in high-income countries, with mortality rates <1%. However, an estimated 10.9 million cases still occur annually, most in low- and middle-income countries. With the availability of a new typhoid conjugat...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-020-05567-2

    authors： Birkhold M,Coulibaly Y,Coulibaly O,Dembélé P,Kim DS,Sow S,Neuzil KM

    更新日期：2020-09-01 00:00:00

  • The neglect of the global surgical workforce: experience and evidence from Uganda.

    abstract：BACKGROUND:Africa's health workforce crisis has recently been emphasized by major international organizations. As a part of this discussion, it has become apparent that the workforce required to deliver surgical services has been significantly neglected. METHODS:This paper reviews some of the reasons for this relative...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-008-9473-4

    authors： Ozgediz D,Galukande M,Mabweijano J,Kijjambu S,Mijumbi C,Dubowitz G,Kaggwa S,Luboga S

    更新日期：2008-06-01 00:00:00

  • Early experience with the Nuss minimally invasive correction of pectus excavatum in adults.

    abstract：:Nuss described a minimally invasive technique for correcting pectus excavatum in children. A curved stainless-steel bar is inserted behind the sternum through the chest cavity with the convex surface face down, then rotated 180 degrees to elevate the sternum and correct the deformity. The procedure gained wide accepta...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-002-6519-x

    authors： Coln D,Gunning T,Ramsay M,Swygert T,Vera R

    更新日期：2002-10-01 00:00:00

  • Delayed Laparoscopic Cholecystectomy for Acute Calculous Cholecystitis: Is it Time for a Change?

    abstract：BACKGROUND:Our aim was to evaluate the advantages and limitations of delayed laparoscopic cholecystectomy (LC) in a tertiary center. MATERIALS AND METHODS:A retrospective analysis of all patients admitted to our institution with acute calculous cholecystitis (ACC) between January 2003 and December of 2012 was performe...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-017-3928-4

    authors： Yuval JB,Mizrahi I,Mazeh H,Weiss DJ,Almogy G,Bala M,Kuchuk E,Siam B,Simanovsky N,Eid A,Pikarsky AJ

    更新日期：2017-07-01 00:00:00

  • Liver Resection Versus Embolization for Recurrent Hepatocellular Carcinoma.

    abstract：BACKGROUND:Despite curative resection, hepatocellular carcinoma (HCC) has a high probability of recurrence. We validated the potential role of liver resection (LR) for recurrent HCC. METHODS:Patients with intrahepatic recurrence with up to three lesions were included. We compared survival times of patients undergoing ...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-019-05225-2

    authors： Midorikawa Y,Takayama T,Moriguchi M,Yagi R,Yamagishi S,Nakayama H,Aramaki O,Yamazaki S,Tsuji S,Higaki T

    更新日期：2020-01-01 00:00:00

  • Risk factors for conversion of laparoscopic colorectal surgery to open surgery: does conversion worsen outcome?

    abstract：INTRODUCTION:The utilization of laparoscopy in colorectal surgery is increasing. However, conversion to open surgery remains relatively high. OBJECTIVE:We evaluated (1) conversion rates in laparoscopic colorectal surgery; (2) the outcomes of converted cases compared with successful laparoscopic and open colorectal ope...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-015-2958-z

    authors： Masoomi H,Moghadamyeghaneh Z,Mills S,Carmichael JC,Pigazzi A,Stamos MJ

    更新日期：2015-05-01 00:00:00

  • Effects of early oral feeding on surgical outcomes and recovery after curative surgery for gastric cancer: pilot study results.

    abstract：BACKGROUND:The aim of the present study was to determine whether early oral feeding after curative resection for gastric cancer can be tolerated and whether it has an effect on recovery. METHODS:From September 2007 to January 2008, we provided early postoperative oral feeding for 35 patients who underwent curative dis...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-009-0009-3

    authors： Hur H,Si Y,Kang WK,Kim W,Jeon HM

    更新日期：2009-07-01 00:00:00

  • The Impact of Evidence in Surgery of the Musculoskeletal System.

    abstract：:There have been a growing number of landmark randomized controlled trials published in the orthopedic literature over the past decade. These large-scale trials have had a substantial impact on informing clinical orthopedic practice globally. This review highlights a selected sample of such pivotal trials, across the s...

    journal_title：World journal of surgery

    pub_type： 杂志文章,评审

    doi：10.1007/s00268-019-04955-7

    authors： Akhter S,Mundi R,Bhandari M

    更新日期：2020-04-01 00:00:00

  • Introduction of an acute surgical unit: comparison of performance indicators and outcomes for operative management of acute appendicitis.

    abstract：BACKGROUND:The Acute Surgical Unit (ASU) is a recent change in management of acute general surgical patients in hospitals worldwide. In contrast to traditional management of acute surgical presentations by a rotating on-call system, ASUs are shown to deliver improved efficiency and patient outcomes. This study investig...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-014-2497-z

    authors： Lancashire JF,Steele M,Parker D,Puhalla H

    更新日期：2014-08-01 00:00:00

  • Barriers to Women Entering Surgical Careers: A Global Study into Medical Student Perceptions.

    abstract：BACKGROUND:Barriers to female surgeons entering the field are well documented in Australia, the USA and the UK, but how generalizable these problems are to other regions remains unknown. METHODS:A cross-sectional survey was developed by the International Federation of Medical Students' Associations (IFMSA)'s Global Su...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-019-05199-1

    authors： Marks IH,Diaz A,Keem M,Ladi-Seyedian SS,Philipo GS,Munir H,Pomerani TI,Sughayer HM,Peter N,Lavy C,Chang DC

    更新日期：2020-01-01 00:00:00

  • Helicopter evacuation of trauma victims in Los Angeles: does it improve survival?

    abstract：BACKGROUND:The purpose of this study was to investigate the relationship between the method of transport after injury and survival among trauma patients admitted to a Level 1 trauma facility in Los Angeles, California. METHODS:The trauma registry of LAC+USC Medical Center was reviewed to identify all injured patients ...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-009-0185-1

    authors： Talving P,Teixeira PG,Barmparas G,DuBose J,Inaba K,Lam L,Demetriades D

    更新日期：2009-11-01 00:00:00

  • Clinical Relevance of Reductive Hepatectomy for Barcelona Clinic Liver Cancer Stages B and C Advanced Hepatocellular Carcinoma: A Single-Center Experience of 102 Patients.

    abstract：BACKGROUND:This study aimed to evaluate the clinical relevance of hepatectomy for Barcelona Clinic Liver Cancer (BCLC) stages B and C advanced hepatocellular carcinoma (HCC). METHODS:A total of 314 patients (149 and 165 BCLC stages B and C, respectively) who underwent hepatectomy were included. Complete hepatectomy (w...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-019-05052-5

    authors： Komatsu S,Kido M,Tanaka M,Kuramitsu K,Tsugawa D,Awazu M,Gon H,Toyama H,Ueno K,Fukumoto T

    更新日期：2019-10-01 00:00:00

  • Is nasogastric or nasojejunal decompression necessary after gastrectomy? A prospective randomized trial.

    abstract：BACKGROUND:Nasogastric decompression has been routinely used in most major abdominal operations to prevent the consequences of postoperative ileus. The aim of the present study was to assess the necessity for routine prophylactic nasogastric or nasojejunal decompression after gastrectomy. METHODS:A prospective randomi...

    journal_title：World journal of surgery

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00268-006-0430-9

    authors： Carrère N,Seulin P,Julio CH,Bloom E,Gouzi JL,Pradère B

    更新日期：2007-01-01 00:00:00

  • Intraoperative Neuromonitoring of Recurrent Laryngeal Nerve During Thyroidectomy with Adhesive Skin Electrodes.

    abstract：BACKGROUND:Alternative methods to overcome limitations of electromyogram (EMG) tube applied for intraoperative neuromonitoring (IONM) of recurrent laryngeal nerve (RLN) during thyroidectomy have been introduced. In this study, we evaluated the feasibility of adhesive skin electrodes for IONM of RLN in patients who unde...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-019-05208-3

    authors： Lee HS,Oh J,Kim SW,Jeong YW,Wu CW,Chiang FY,Lee KD

    更新日期：2020-01-01 00:00:00

  • Laparoscopic Versus Open Cholecystectomy: A Cost-Effectiveness Analysis at Rwanda Military Hospital.

    abstract：BACKGROUND:Laparoscopic cholecystectomy is first-line treatment for uncomplicated gallstone disease in high-income countries due to benefits such as shorter hospital stays, reduced morbidity, more rapid return to work, and lower mortality as well-being considered cost-effective. However, there persists a lack of uptake...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-016-3851-0

    authors： Silverstein A,Costas-Chavarri A,Gakwaya MR,Lule J,Mukhopadhyay S,Meara JG,Shrime MG

    更新日期：2017-05-01 00:00:00

  • Increased platelet counts after transthoracic en bloc resection for esophageal cancer is associated with significantly improved survival.

    abstract：BACKGROUND:We analyzed perioperative platelet counts as a potential clinical marker for survival after transthoracic en bloc resection for esophageal cancer. Recent data described preoperative thrombocytosis in malignancies to be associated with poor prognosis. METHODS:A retrospective analysis from a prospective datab...

    journal_title：World journal of surgery

    pub_type： 杂志文章

    doi：10.1007/s00268-010-0707-x

    authors： Ling FC,Vallböhmer D,Hoelscher AH,Schmidt D,Bollschweiler E,Schneider PM

    更新日期：2010-11-01 00:00:00