Abstract:
BACKGROUND:Typhoid fever incidence and complications, including intestinal perforation, have declined significantly in high-income countries, with mortality rates <1%. However, an estimated 10.9 million cases still occur annually, most in low- and middle-income countries. With the availability of a new typhoid conjugate vaccine licensed for children and recommended by the World Health Organization, understanding severe complications, including associated mortality rates, is essential to inform country-level decisions on introduction of this vaccine. This scoping review summarizes over 20 years of the literature on typhoid intestinal perforation in sub-Saharan Africa. METHODS:We searched EMBASE, PubMed, Medline, and Cochrane databases for studies reporting mortality rates due to typhoid intestinal perforation in children, under 18 years old, in sub-Saharan Africa published from January 1995 through June 2019. RESULTS:Twenty-four papers from six countries were included. Reported mortality rates ranged from 4.6-75%, with 16 of the 24 studies between 11 and 30%. Thirteen papers included postoperative morbidity rates, ranging from 16-100%. The most documented complications included surgical site infections, intra-abdominal abscesses, and enterocutaneous fistulas. High mortality rates can be attributed to late presentation to tertiary centers, sepsis and electrolyte abnormalities requiring preoperative resuscitation, prolonged perforation-to-surgery interval, and lack of access to critical care or an intensive care unit postoperatively. CONCLUSIONS:Current estimates of mortality related to typhoid intestinal perforation among children in sub-Saharan Africa remain unacceptably high. Prevention of typhoid fever is essential to reduce mortality, with the ultimate goal of a comprehensive approach that utilizes vaccination, improvements in water, sanitation, and hygiene, and greater access to surgical care.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Birkhold M,Coulibaly Y,Coulibaly O,Dembélé P,Kim DS,Sow S,Neuzil KMdoi
10.1007/s00268-020-05567-2subject
Has Abstractpub_date
2020-09-01 00:00:00pages
2892-2902issue
9eissn
0364-2313issn
1432-2323pii
10.1007/s00268-020-05567-2journal_volume
44pub_type
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journal_title:World journal of surgery
pub_type: 杂志文章,评审
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journal_title:World journal of surgery
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pub_type: 社论,评审
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journal_title:World journal of surgery
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更新日期:2009-03-01 00:00:00
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journal_title:World journal of surgery
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更新日期:2011-03-01 00:00:00
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doi:10.1007/s00268-005-7955-1
更新日期:2005-11-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01675641
更新日期:1991-07-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0021-7
更新日期:2009-07-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002680020052
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journal_title:World journal of surgery
pub_type: 杂志文章,评审
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journal_title:World journal of surgery
pub_type: 杂志文章,评审
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journal_title:World journal of surgery
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更新日期:2016-02-01 00:00:00
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更新日期:2018-11-01 00:00:00
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