Abstract:
:In a double-blind placebo-controlled study we investigated the effect of recombinant human erythropoietin (r-HuEPO), on the perioperative hemoglobin concentration and the use of blood transfusions in patients undergoing elective colorectal surgery with a preoperative hemoglobin level =8.5 mmol/L. Altogether 100 were included, and 81 patients could be evaluated. A total of 38 patients received r-HuEPO in a dose of 300 IU/kg body weight on day 4 before surgery and 150 IU/kg daily for the following 7 days; 43 patients received placebo. In addition, all patients received daily doses of 200 mg iron orally for 4 days before surgery. There were no differences between the two groups with regard to sex, height, weight, serum electrolytes, and liver function tests at study entry. The preentry hemoglobin concentration was similar in the two groups, with a median value of 7.9 (range 5.3-8.5) mmol/L in the erythropoietin group and 7.6 (5.1-8.5) mmol/L in the placebo group. On the day of surgery the median hemoglobin concentration was 7.8 (5. 3-9.2) mmol/L in the erythropoietin group and 7.2 (4.6-8.5) mmol/L in the placebo group (p < 0.05). On postoperative days 3 and 7 the values were 7.2 (5.3-8.2) and 7.5 (5.4-9.4) mmol/L, respectively, in the erythropoietin group compared to 6.7 (5.2-7.8) and 6.9 (5.1-8.6) mmol/L in the placebo group (p < 0.01). At discharge the hemoglobin concentration was 7.8 (5.9-8.8) mmol/L in the erythropoietin group and 7.2 (5.4-8.6) mmol/L in the placebo group (p < 0.002). The blood loss during operation was similar in the two groups. In the erythropoietin group the median value was 280 ml (range 25-2000 ml), with the lower and upper quartiles 150 and 500 ml, respectively. In the placebo group the blood loss was median 300 ml (range 50-1800 ml), with the lower and upper quartiles 200 and 750 ml, respectively. The number of blood transfusions given was significantly lower in the erythropoietin group, with a mean of 0.3 (range 0-6) units compared to 1.6 (0-9) units in the control group (p < 0.05). In conclusion, the hemoglobin concentration at the time of surgery and during the week following surgery was significantly higher in the group of patients receiving r-HuEPO perioperatively compared to the placebo group together with a significant lower use of blood transfusions in the r-HuEPO group. However, the clinical implications of these findings has yet to be proven.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Qvist N,Boesby S,Wolff B,Hansen CPdoi
10.1007/s002689900561subject
Has Abstractpub_date
1999-01-01 00:00:00pages
30-5issue
1eissn
0364-2313issn
1432-2323journal_volume
23pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:The prognosis of intrahepatic cholangiocarcinoma (ICC) remains poor despite improvements in treatment and post-operative clinical management. We review our experiences and evaluate our current surgical approaches by comparing patients from two consecutive treatment periods. METHODS:One hundred forty-four pa...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-016-3583-1
更新日期:2016-09-01 00:00:00
abstract::Adenocarcinomas of the esophagogastric junction (AEG) are now recognized as a separate tumor entity with increasing incidence. The aim of the present study was to evaluate whether positron emission tomography (PET) using the glucose analog F-18-fluorodeoxyglucose (FDG) can be used for metabolic characterization of thi...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-003-7058-9
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to describe the perioperative and long-term results of carotid endarterectomy (CEA) in patients aged 60 or less and compare them to patients of more advanced age in a retrospective single-centre case-control study. METHODS:From January 1996 to December 2014, 5893 consecutive CEAs wer...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4133-1
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Surgical care is not uniformly available worldwide. Inequities in surgical care and access may also vary within countries, and the present study aimed to explore these disparities in Pakistan. METHODS:The National Health Survey of Pakistan was analyzed. The proportion of people with a history of abdominal s...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1732-8
更新日期:2013-07-01 00:00:00
abstract:PURPOSE:This study was designed to assess the chronological change in health-related quality of life (HRQOL) following robot-assisted distal gastrectomy (RADG) for early gastric cancer (EGC) and to compare the HRQOL of the patients undergoing RADG with that of the general population. METHODS:Patients undergoing RADG f...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2390-1
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Loop ileostomy reduces the rates of morbidity due to colorectal anastomotic dehiscence. For its part, ileostomy closure is associated with low mortality (0-4%) but substantial morbidity (11-37%). Incisional surgical site infection (SSI) is one of the most frequent complications (2-40%). METHODS:A single-cen...
journal_title:World journal of surgery
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00268-019-04972-6
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Acute appendicitis is the most common abdominal emergency in clinical surgery. This study was designed to compare the diagnostic value of the Pediatric Appendicitis Score (PAS) with that of the Alvarado score based on different time points in children with right lower quadrant (RLQ) abdominal pain. METHODS:...
journal_title:World journal of surgery
pub_type: 临床试验,杂志文章
doi:10.1007/s00268-011-1310-5
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:This prospective, non-randomized, comparative study evaluated morbidity of chemotherapy administration via a totally implantable venous access device (TIVAD) versus peripheral intravenous access (PIVA), and satisfaction in breast cancer patients in a limited-resource setting. METHODS:Consecutive patients re...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2378-x
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Little is known about the changes in prognostic factors after adjuvant S-1 monotherapy has become widespread as a standard of care for patients with gastric cancer (GC) in East Asia. The present study compared prognostic factors of patients with stage II/III GC treated with or without S-1 adjuvant to formula...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s00268-019-05198-2
更新日期:2020-01-01 00:00:00
abstract::Leiomyomas and leiomyosarcomas are derived from smooth muscle tissues. Smooth muscle cells also surround the blood vessels that supply the alimentary tract. These cells have at times been said to contribute to the formation of smooth muscle tumors in the alimentary canal. With such an abundance of smooth muscle, there...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689910063
更新日期:2000-04-01 00:00:00
abstract::The phrase "outcomes studies" is usually used to describe those studies where outcome is assessed in large cohorts of patients, often using data from administrative databases. They are used to determine the role and impact of variations in the structure and process of health care delivery play in routine practice. Opt...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s002689900651
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:There is emerging evidence indicating that distractions in the operating room (OR) are prevalent. Studies have shown a negative impact of distractions, but they have been conducted mostly with residents in simulated environments. We tested the hypothesis that intraoperative distractions are associated with d...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2315-z
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:The use of pulmonary artery catheter (PAC) is controversial. The purpose of this study was to document the changing pattern of PAC use and to determine its effect on outcome. METHODS:The use of PAC was analyzed in patients ≥16 years old admitted to the surgical intensive care unit (SICU) over a 9-year period...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1149-9
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Uncomplicated acute appendicitis has been managed traditionally by early appendicectomy. However, recently, there has been increasing interest in the potential for primary treatment with antibiotics, with studies finding this to be associated with fewer complications than appendicectomy. The aim of this stud...
journal_title:World journal of surgery
pub_type: 杂志文章,meta分析
doi:10.1007/s00268-016-3561-7
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Increasing numbers of patients are treated by robotic distal gastrectomy (RDG); however, it remains unclear whether RDG is clinically comparable with conventional laparoscopic distal gastrectomy (LDG). This study aimed to clarify the feasibility of RDG from safety aspects. METHODS:The study included 109 cT1...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4345-4
更新日期:2018-06-01 00:00:00
abstract::Node dissection for melanoma remains the most important therapeutic decision for the optimal management of the patient with melanoma. In Australia and in some parts of the United States, the majority of patients with intermediate thickness melanoma (1.6-4.00 mm) will undergo elective lymph node dissection. In Europe, ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:
更新日期:1992-03-01 00:00:00
abstract::Sixty-one patients who were diagnosed with mucosal gastric cancer have been successfully treated with two laparoscopic techniques at our institute from March 1992 to March 1997. One is laparoscopic wedge resection of the stomach using a lesion-lifting method for lesions of the anterior wall, the lesser curvature, and ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/pl00013167
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:The decision to proceed to simple underwater seal drainage or apply active suction to the underwater seal after lung resection is mostly based on surgeon preference. The purpose of this study was to test whether routine application of active suction is necessary after lobectomy. PATIENTS AND METHODS:This wa...
journal_title:World journal of surgery
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00268-008-9741-3
更新日期:2008-11-01 00:00:00
abstract::In some patients, bile ducts of segments 2 and 3 (B2 and B3) run caudally to the umbilical portion of the left portal vein (UP)--an infraportal course. We aimed to evaluate the frequency and clinical implications of this variation. Between January 1992 and October 2000, 108 patients underwent resection for hilar chola...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-002-6544-9
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:The present study was designed to evaluate the impact of the tyrosine kinase ligands VEGF-A/C/D, PDGF-A/B on tumor dissemination and survival in gastric cancer. This is the first study analyzing all these parameters in a homogeneous patient population undergoing surgery. METHODS:The expression pattern of VE...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1041-7
更新日期:2011-05-01 00:00:00
abstract::Although emergency department thoracotomy (EDT) is often considered a controversial "last chance" method of resuscitation, we hypothesized that EDT performed in a busy urban Level I trauma center has significant salvage rates despite the absence of traditional survival predictors. A retrospective review revealed that ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9392-9
更新日期:2008-04-01 00:00:00
abstract::The first laparoscopic Nissen fundoplication was performed 20 years ago. Surgical management of gastroesophageal reflux disease (GERD) should be offered only to appropriately studied and selected patients, with the ultimate aim of improving the well-being of the individual, the "quality of life." The choice of fundopl...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-011-1050-6
更新日期:2011-07-01 00:00:00
abstract:INTRODUCTION:Percutaneous needle biopsy (PNB) is the standard of care for diagnosis of breast lesions. Rates of excisional biopsy for breast diagnosis in North America have been reported at approximately 35 %, although significant regional variation exists. A target rate of PNB for diagnosis of breast abnormalities is ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-3293-0
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Intraoperative identification of the difficult-to-spot parathyroid gland is critical during surgery for thyroid and parathyroid disease. Recently, intrinsic fluorescence of the parathyroid gland was identified, and a new method was developed for intraoperative detection of the parathyroid with an original fl...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-3903-0
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:In the last decade, robotic video-assisted thoracic surgery (R-VATS) has grown significantly and consolidated as an alternative to video-assisted thoracic surgery. The objective of this study is to present the implementation as well as the experience with R-VATS accumulated by 2 Brazilian groups. We also com...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05086-9
更新日期:2019-11-01 00:00:00
abstract:INTRODUCTION:Parastomal hernia (PH) is a frequent complication after end-colostomy formation. PH may negatively influence the quality of life in end-colostomy patients. Our study investigates the quality of life and body image (BI) in patients with an end-colostomy. METHODS:We conducted a cross-sectional study of end-...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-3107-4
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Resection of hepatocellular carcinoma (HCC) located in the right liver often requires hepatic mobilization. However, exposure of the HCC may be restricted when using the conventional abdominal approach (AA). In such cases, a thoracoabdominal approach (TA) can provide a good operating field. Although several ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1023-9
更新日期:2011-05-01 00:00:00
abstract::The present study documents the indications and results of endoscopic sphincterotomy (ES) performed over 7 years in a surgical endoscopy unit. Potential improvement of results over this time period was analyzed. ES was associated with rare but undesirable morbidity and mortality. Specific improvement of results over t...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900195
更新日期:1997-01-01 00:00:00
abstract::A semiquantitative assessment of multiple histological parameters was applied retrospectively to 66 patients with stage I and II squamous cell carcinoma of the floor of the mouth to determine if prognostic information relative to cervical node metastases could be obtained. Three parameters relating to the tumor cell p...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01658802
更新日期:1990-09-01 00:00:00
abstract::This study investigated whether cytokines and colony-stimulating factors can predict prognosis in patients with postoperative multiple organ failure (MOF). We evaluated 14 patients with postoperative MOF who underwent operation for cardiovascular disease. Seven patients recovered from MOF (survivors) and seven did not...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900520
更新日期:1998-10-01 00:00:00