Abstract：
BACKGROUND:The present study was designed to evaluate the impact of the tyrosine kinase ligands VEGF-A/C/D, PDGF-A/B on tumor dissemination and survival in gastric cancer. This is the first study analyzing all these parameters in a homogeneous patient population undergoing surgery. METHODS:The expression pattern of VEGF-A/C/D and PDGF-A/B was analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) in 69 samples of human gastric adenocarcinoma and correlated with tumor stage and survival. RESULTS:Expression of the ligand VEGF-D significantly correlated with distant metastatic disease (P=0.00001) but not with patient survival. However, VEGF-A inversely correlated with M1 and grading, PDGF-A inversely correlated with pT and pN category. In contrast, VEGF-C and PDGF-B did not have an impact on clinicopathological parameters. CONCLUSIONS:The ligand VEGF-D, rather than the other ligands or tyrosine kinase receptors analyzed, is associated with progressive disease in gastric cancer patients undergoing surgery. The VEGF-D ligand might be a helpful marker indicating disseminated disease, and targeting VEGF-D may be a potential therapeutic strategy, although limitations imposed by the selected sample population have to be considered critically.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Schimanski CC,Schlaegel F,Jordan M,Moehler M,Sgourakis G,Drescher DG,Galle PR,Lang H,Gockel Idoi
10.1007/s00268-011-1041-7subject
Has Abstractpub_date
2011-05-01 00:00:00pages
1010-6issue
5eissn
0364-2313issn
1432-2323journal_volume
35pub_type
杂志文章abstract：BACKGROUND:The optimal surgical approach for patients with primary hyperparathyroidism (pHPT) and multiple endocrine neoplasia 1 (MEN1) is controversial. We sought to determine the optimal type of surgery for pHPT in MEN1. METHODS:We collected data on clinical presentation, surgery, and follow-up for MEN1 patients wit...
journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00268-011-1068-9
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Postoperative outcome prediction in elderly is based on preoperative physical status but its predictive value is uncertain. The goal was to evaluate the value of risk assessment performed perioperatively in predicting outcome in case of admission to an intensive care unit (ICU). METHODS:A total of 108 posts...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05742-5
更新日期：2020-12-01 00:00:00
abstract：:Studies of large series of melanoma patients indicated that the average incidence of developing a recurrence during follow-up was 40%. The most frequent first sites of these recurrences were the regional lymph nodes. We hypothesized that the sentinel node (SN) procedure may change the pattern of recurrence by reducing...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6197-8
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:Solitary fibrous tumor of the pleura (SFTP) represents a clinical entity rarely encountered, especially in giant forms. Complete surgical resection for giant tumor of pleura is a challenge. The aim of this article is to present five new cases of giant SFTP, and to discuss their clinical characteristics and t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0715-x
更新日期：2010-11-01 00:00:00
abstract：:Papillary thyroid carcinoma is a frequent thyroid cancer. Many factors have been reported to be of prognostic importance, but the significance of biologic factors suggesting aggressiveness and proliferating activity has not been sufficiently documented. Conventional prognostic factors such as age, extrathyroidal invas...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900551
更新日期：1998-12-01 00:00:00
abstract：:The treatment results of mycobacterial cervical lymphadenitis in 69 patients between 1990 and 1993 are reviewed. All patients underwent surgical procedures consisting of total excision or selective nodal dissection for lymphadenopathies and curettage for fluctuant cases, followed by antituberculous chemotherapy applie...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900265
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND:Scarce data are available on the characteristics of postoperative organ failure (POF) and mortality after gastrectomy. We aimed to describe the causes of organ failure and mortality related to gastrectomy for gastric cancer and to identify patients with POF who are at a risk of failure to rescue (FTR). METH...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05382-9
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Due to advances in operative methods and perioperative care, mortality and morbidity following major hepatic resection have decreased substantially, making long-term quality of life (QoL) an increasingly prominent issue. We evaluated whether postoperative diagnosis was associated with long-term QoL and healt...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0032-4
更新日期：2009-07-01 00:00:00
abstract：:Variceal bleeding remains an important complication in extrahepatic portal vein thrombosis (EPVT). As for portal hypertension due to other etiologies, an elective treatment to decrease the risk of subsequent rebleeding is warranted. The results of the Sugiura-Futagawa procedure (SP) in 38 patients with variceal bleedi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00294409
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:Papillary thyroid carcinoma (PTC) frequently recurs to the lymph nodes, which may not be fatal immediately but is a stressor for physicians and patients. Recurrence to the distant organs, although less frequent, is often life-threatening, and the lung and bone are organs to which PTC is likely to recur. In t...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1423-5
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:The present study evaluated outcomes of patients undergoing proximal diversion using either a loop ileostomy or loop colostomy following distal colorectal resection for malignant and non-malignant disease. METHODS:A literature search of the Medline, Ovid, Embase and Cochrane databases was performed to ident...
journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00268-006-0218-y
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND:Complications are important indicators of immediate postoperative outcomes. The Clavien-Dindo classification (CDC) is a widely used index for the classification of surgical complications. More recently, the comprehensive complication index (CCI) has also been introduced for classifying postoperative complica...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05859-7
更新日期：2021-03-01 00:00:00
abstract：:Extracorporeal life support has evolved considerably over the past two decades. Once considered as salvage or experimental therapy in adults, extracorporeal membrane oxygenation (ECMO) is evolving into a mainstream treatment for adult critical care. This is especially true in trauma and high-risk surgical patients, wh...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-016-3586-y
更新日期：2017-05-01 00:00:00
abstract：:We have evaluated survival and tumor-related symptoms in the presence of mesenteric lymph node and liver metastases in relation to surgical procedures in 314 patients (148 women, mean age at diagnosis 61 years; 249 with liver metastases) treated for midgut carcinoid tumors. Of the operated patients, 46% presented with...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6630-z
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND:Linitis plastica-type gastric carcinoma remains a disease with poor prognosis despite an aggressive surgical approach. Although a prominent pattern of disease failure is peritoneal carcinomatosis, some patients experience rapid disease progression without signs of the peritoneal disease. METHODS:Clinicopath...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9672-z
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Anal manometry is a useful tool for testing the effectiveness of surgical treatment. However, most techniques for anal pressure measurement are not easily available because of high cost. The aim of the present study was to introduce an easy and reproducible method for measuring anal pressures in testing the ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-006-0365-1
更新日期：2007-02-01 00:00:00
abstract：:Hepatoblastoma is a rare pediatric malignancy that frequently appears in an advanced unresectable stage. Improved resectability and survival rate have been reported with the help of neoadjuvant chemotherapy. Between January 1987 and June 1995 a series of 20 patients were managed with a diagnosis of hepatoblastoma. The...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002680020052
更新日期：2001-02-01 00:00:00
abstract：INTRODUCTION:Acute intestinal ischemia is in most cases a lethal condition with a low survival rate. Risk factors of perioperative mortality are poorly defined. The aim of this study was to define risk factors that predict an adverse outcome of acute mesenteric ischemia (AMI). METHODS:A total of 132 consecutive patien...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0560-5
更新日期：2006-08-01 00:00:00
abstract：:Lower esophageal sphincter pressure has been assessed pre-operatively, intra-operatively,and more than 6 months postoperatively in 34 patients having antireflux surgery for gastro-esophageal reflux disease. The sphincter pressures associated with the outcome in relation to pH measured reflux and the symptoms of recurr...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02071543
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND:The European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Cancer (QLQ-C30) and the site-specific module for gastric cancer (QLQ-STO22) have seldom been used to measure the postoperative health-related quality of life (HRQOL) in Japanese gastric cancer patients. The ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0860-2
更新日期：2011-02-01 00:00:00
abstract：:Uncontrolled bleeding from the cystic artery and its branches is a serious problem that may increase the risk of intraoperative lesions to vital vascular and biliary structures. On laparoscopic visualization anatomic relations are seen differently than during conventional surgery, so proper knowledge of the hepatobili...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/pl00012372
更新日期：1999-07-01 00:00:00
abstract：:Tamoxifen is being used successfully in breast cancer patients as adjuvant hormonal therapy. The aim of this retrospective cohort study is to evaluate the impact of tamoxifen on gallstone formation in postmenopausal breast cancer patients. A total of 3165 patients who were treated for invasive breast cancer between 19...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6468-4
更新日期：2003-04-01 00:00:00
abstract：:Postoperative complications in patients with obstructive jaundice remain increased when associated with endotoxemia and the inflammatory response due to gut barrier failure. Administration of glutamine has been proposed to maintain the integrity of the gut mucosa and thus reduce bacterial translocation (BT), but the e...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7721-4
更新日期：2005-10-01 00:00:00
abstract：:The aim of this study was to identify the risk factors for bacterial translocation and to determine the clinical significance of bacterial translocation in patients with colorectal cancer. Mesenteric lymph node sampling was performed to identify the presence of bacterial translocation in 75 patients with colorectal ca...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7576-0
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND:The estimation of physiologic ability and surgical stress (E-PASS) has been used to produce a numerical estimate of expected mortality and morbidity after elective gastrointestinal surgery. The aim of this study was to validate E-PASS in a selected cohort of patients requiring liver resections (LR). METHODS...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-9989-2
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:Advanced Trauma Life Support (ATLS®) is one of the world's best-known training programs for medical providers. Revisions of the ATLS manual have been evidence based for a number of years. In 2011, a level 3 (S3) evidence- and consensus-based guideline on the treatment of patients with severe and multiple injuri...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3063-z
更新日期：2015-08-01 00:00:00
abstract：:Malignant melanoma is notoriously resistant to chemotherapy. Standard single agents include dacarbazine and the nitrosoureas, but most series treating patients with metastatic melanoma report response rates of about 20%. Occasional patients, however, achieve long term remission, amounting to cure, after such treatment...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02071532
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND:It is now generally believed that regulatory T cells (Tregs) play an important role in peripheral tolerance, and a defect in Tregs is considered one of the most important factors in the induction of various kinds of autoimmune disease including ulcerative colitis (UC). Here, we examined the change in frequen...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0301-9
更新日期：2006-04-01 00:00:00
abstract：:The pathogenesis of pain in chronic pancreatitis remains an enigma. The cause of pain is almost certainly multifactorial and may vary at different stages of the disease process. These factors may include the release of excessive oxygen-derived free radicals, tissue hypoxia and acidosis, inflammatory infiltration with ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-003-7235-x
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND AND AIM:Previous studies have shown that microscopic vessel invasion (MVI) occurs in hepatocellular carcinoma (HCC) with a treatment history due to its poorer malignant behavior in comparison with primary HCC. The aim of the present study was to determine the predictors of MVI and overall survival in HCC pat...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4658-y
更新日期：2018-11-01 00:00:00
