Abstract:
:Malignant melanoma is notoriously resistant to chemotherapy. Standard single agents include dacarbazine and the nitrosoureas, but most series treating patients with metastatic melanoma report response rates of about 20%. Occasional patients, however, achieve long term remission, amounting to cure, after such treatment. Adjuvant studies have failed to define any systemic therapy of value after surgery for primary or regional lymph node disease. Combinations of drugs have not been shown to be superior to single agents. Cisplatin and fotemustine are among the newer agents with activity. Isolated limb perfusion with melphalan and systemic therapy with high dose alkylating agents and marrow transplantation suggest that the resistance to conventional concentrations of alkylating agents is not absolute. One strategy to improve the efficacy of alkylating agents may therefore be the modulation of cellular glutathione or glutathione-S-transferase. Biological response modifiers remain of interest, though many of the protocols with the best response rates are impractical for routine use. Many patients with asymptomatic metastatic melanoma should be observed without treatment. Outside clinical trials, it is reasonable to use single agent dacarbazine or lomustine if chemotherapy is required.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Coates ASdoi
10.1007/BF02071532keywords:
subject
Has Abstractpub_date
1992-03-01 00:00:00pages
277-81issue
2eissn
0364-2313issn
1432-2323journal_volume
16pub_type
杂志文章,评审abstract:BACKGROUND:Unrecognized reduction of blood supply to intestinal organs is associated with significant postoperative morbidity in abdominal surgery. The aim of this study was to determine whether--in the absence of hypovolemia--intestinal hypoperfusion as a result of blood flow redistribution occurs after abdominal surg...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0560-y
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Intestinal ostomies are common surgical procedures performed in visceral surgery as part of management for several gastrointestinal diseases. This study aims to report the socio-demographic characteristics, indications and prognosis of intestinal ostomies in low-income country. METHODS:This was a 4-year ret...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4338-3
更新日期:2018-06-01 00:00:00
abstract::Fifty patients reoperated for failed Nissen fundoplication are presented; 29 patients (group 2) were operated between 1983 and 1988 while 21 patients (group 1) were operated before 1983. In group 1, the "slipped Nissen" had been the most frequent cause of reoperation (48%). In group 2, the most frequent causes for the...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01658439
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:This study assessed the APACHE II (Acute Physiology and Chronic Health Evaluation II), SAPS II (Simplified Acute Physiology Score-II), POSSUM (Physiologic and Operative Severity Score for Enumeration of Morbidity and Mortality), and P-POSSUM (Portsmouth-POSSUM) in patients with colorectal cancer undergoing c...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9321-y
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Delayed access to surgical care for congenital conditions in low- and middle-income countries is associated with increased risk of death and life-long disabilities, although the actual burden of delayed access to care is unknown. Our goal was to quantify the burden of disease related to delays to surgical ca...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05239-w
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Preoperative assessment of geriatric-specific determinants of health may enhance perioperative risk stratification among elderly patients. This study examines effects of geriatric-specific variables on postoperative outcomes in patients undergoing elective major abdominal operations. METHODS:Patients includ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05515-0
更新日期:2020-08-01 00:00:00
abstract::A new technique utilizing miniaturized (2 mm) instrumentation to perform laparoscopic cholecystectomy (LC) is introduced. The safety and efficacy of this mini-LC were assessed. Fifty consecutive mini-LCs were performed using one 10-mm port and three 2-mm ports (cumulative port size 16 mm). A 2-mm fiberoptic video-lapa...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/pl00013163
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Neuroendocrine neoplasias (NEN) of the gastroenteropancreatic (GEP) system frequently present with metastatic deposits. The proliferation marker Ki-67 is used for diagnosis and to assess the prognosis of disease. The aim of our study was to evaluate the usefulness of Ki-67 % in the assessment of NEN patients...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2451-0
更新日期:2014-06-01 00:00:00
abstract::In the original article there is an error in Fig. 2. Following is the corrected figure. ...
journal_title:World journal of surgery
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00268-018-04886-9
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Restless legs syndrome (RLS) is a common and poorly understood movement disorder that leads to unpleasant leg sensations. Although RLS can be idiopathic, secondary etiologies such as iron deficiency and renal failure are common. The aim of this prospective cohort study was to evaluate whether RLS is a common...
journal_title:World journal of surgery
pub_type: 临床试验,杂志文章
doi:10.1007/s00268-013-2185-4
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Nonoperative management (NOM) of kidney gunshot injuries as an alternative to surgical exploration is rarely reported. The aim of this study was to assess the feasibility and safety of selective NOM of such injuries. METHODS:A 4-year prospective study was conducted that included all patients admitted to a L...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9888-y
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Stapled anopexia was introduced as a surgical method in 1993. Long-term data with special interest in functional results and relapse symptoms are rarely presented. Urinary discomfort and problems with fecal urge incontinence are addressed as severe side effects. We present our long-term results (using data f...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9818-z
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:There is a consensus on the indication of laparoscopy-assisted distal gastrectomy (LADG) for early gastric cancer that needs D1 + alpha or D1 + beta lymph node dissection. However, many gastrointestinal surgeons consider D2 lymph node dissection in LADG to be difficult, therefore, only a few medical institut...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9697-3
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) plays an essential role in the evaluation of lymph node (LN) metastasis status and the extent of LN dissection in gastric cancer. The aim of our study was to perform a systematic review and meta-analysis for corresponding identification rate and sensitivity of different SLNB...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-020-05900-9
更新日期:2021-01-03 00:00:00
abstract:BACKGROUND:In patients with well-differentiated thyroid cancer, the incidence of pathologic central compartment lymph node metastases is reported to be approximately 50%. Recently level VI lymph node dissection has been advocated as a means of reducing recurrence rates in these patients, even if there are no clinically...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1507-2
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:The prognosis of Fournier's gangrene (FG) depends on early diagnosis and management. In this study, our objective was to identify the distinct features of FG that may influence the clinical outcome. METHODS:A retrospective chart review was performed in patients with a diagnosis of FG between January 1999 and...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-0777-3
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Recurrent spontaneous pneumothorax is widely treated by video-assisted thoracoscopic (VATS) bullectomy and pleurodesis. Treatment of postoperative pain with nonsteroidal antiinflammatory drugs (NSAIDs) is controversial as many surgeons believe that it reduces the efficacy of pleurodesis and increases the pne...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1207-3
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:The Lancet Commission on Global Surgery showed that countries with surgeon, anesthetist, and obstetrician (SAO) densities of 20-40 SAO/100,000 population were associated with improved health outcomes and recommended a global surgical workforce scale-up by 2030. Whether countries would be able to achieve such...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05329-9
更新日期:2020-04-01 00:00:00
abstract::Dukes' classification is a useful staging system in patients with colorectal cancer. The aim of this study was to present clinicopathologic characteristics and survival of patients with gastric cancer based on Dukes' classification. A total of 273 patients with gastric cancer curatively treated by radical gastrectomy ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/pl00012338
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to investigate the feasibility of digital defog technique in 3D laparoscopic surgery for right colon cancer. METHODS:Fifty patients with right colon cancer were divided into digital defogging group and control group. The intraoperative image clarity, the surgeon's anxiety, the time ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4402-z
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Binding of the lectin Helix pomatia agglutinin (HPA) has been shown to be associated with poor prognosis in many human cancers, but not in thyroid cancer. The aims of the present study were to assess alteration in cellular glycosylation, detected by HPA binding, in thyroid tumors; to determine if such altere...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1196-2
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Laparoscopic cholecystectomy (LC) is the most performed minimal invasive surgical procedure and has a relatively high complication rate. As complications are often revealed postoperatively, clear, accurate, and timely written operative notes are important in order to recall the procedure and start follow-up ...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s00268-010-0422-7
更新日期:2010-05-01 00:00:00
abstract::A review of the literature describing the management of hepatic and splenic injuries indicates that as many as 67% of exploratory celiotomies for blunt trauma are reported as nontherapeutic. Avoiding unnecessary surgery through nonoperative management offers an attractive alternative. Nonetheless, nonoperative managem...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-001-0138-9
更新日期:2001-11-01 00:00:00
abstract::The effect of a treatment versus controls may be expressed in relative or absolute terms. For rational decision-making, absolute measures are more meaningful. The number needed to treat, the reciprocal of the absolute risk reduction, is a powerful estimate of the effect of a treatment. It is particularly useful becaus...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-7916-8
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Pancreatic cancer has higher concentrations of angiotensin II compared with other cancers. This study sought to assess the effect of angiotensin II receptor blockers (ARBs) on survival of patients undergoing resection using a large, nationally representative dataset. METHODS:Patients undergoing pancreatic c...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-017-4021-8
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Trauma continues to be a major health problem worldwide, particularly in the developing world, with high mortality and morbidity. Yet most developing countries lack an organized trauma system. Furthermore, developing countries do not have in place any accreditation process for trauma centers; thus, no accept...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2538-7
更新日期:2014-08-01 00:00:00
abstract::The aim of this study was to determine if fat absorption is better after pylorus-preserving pancreatoduodenectomy (PPPD) or duodenum-preserving pancreatic head resection (DPPHR) compared with that following pancreatoduodenectomy with gastrectomy (SPD), provided the patients have similar pancreatic exocrine function. F...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900156
更新日期:1996-10-01 00:00:00
abstract:AIMS:Post-operative urinary retention (POUR) is a common cause of unplanned admission following day-case surgery and has negative effects on both patient and surgical institution. We aimed to prospectively evaluate potential risk factors for the development of POUR following day-case general surgical procedures. METHO...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4697-4
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to evaluate the efficacy of 10 % sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy. METHODS:A total of 48 patients (24 men and 24 women) between 20 and 70 years of age who underwent open hemorrhoidectomy were included in this prospe...
journal_title:World journal of surgery
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00268-012-1805-8
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to assess the safety and feasibility of performing robot-assisted pediatric surgery using the da Vinci Surgical System in a variety of surgical procedures. METHODS:A retrospective review of 144 robot-assisted pediatric surgical procedures performed in our institution between Ju...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0431-6
更新日期:2010-05-01 00:00:00