Systemic chemotherapy for malignant melanoma.

Abstract:

:Malignant melanoma is notoriously resistant to chemotherapy. Standard single agents include dacarbazine and the nitrosoureas, but most series treating patients with metastatic melanoma report response rates of about 20%. Occasional patients, however, achieve long term remission, amounting to cure, after such treatment. Adjuvant studies have failed to define any systemic therapy of value after surgery for primary or regional lymph node disease. Combinations of drugs have not been shown to be superior to single agents. Cisplatin and fotemustine are among the newer agents with activity. Isolated limb perfusion with melphalan and systemic therapy with high dose alkylating agents and marrow transplantation suggest that the resistance to conventional concentrations of alkylating agents is not absolute. One strategy to improve the efficacy of alkylating agents may therefore be the modulation of cellular glutathione or glutathione-S-transferase. Biological response modifiers remain of interest, though many of the protocols with the best response rates are impractical for routine use. Many patients with asymptomatic metastatic melanoma should be observed without treatment. Outside clinical trials, it is reasonable to use single agent dacarbazine or lomustine if chemotherapy is required.

journal_name

World J Surg

journal_title

World journal of surgery

authors

Coates AS

doi

10.1007/BF02071532

keywords:

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

277-81

issue

2

eissn

0364-2313

issn

1432-2323

journal_volume

16

pub_type

杂志文章,评审
  • Splanchnic vasoregulation after major abdominal surgery in pigs.

    abstract:BACKGROUND:Unrecognized reduction of blood supply to intestinal organs is associated with significant postoperative morbidity in abdominal surgery. The aim of this study was to determine whether--in the absence of hypovolemia--intestinal hypoperfusion as a result of blood flow redistribution occurs after abdominal surg...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-010-0560-y

    authors: Brügger LE,Beldi G,Beck M,Porta F,Bracht H,Candinas D,Takala J,Jakob SM

    更新日期:2010-09-01 00:00:00

  • Pattern of Lower Intestinal Ostomies in a Low-Income Country: Case of Southeast of Niger Republic.

    abstract:BACKGROUND:Intestinal ostomies are common surgical procedures performed in visceral surgery as part of management for several gastrointestinal diseases. This study aims to report the socio-demographic characteristics, indications and prognosis of intestinal ostomies in low-income country. METHODS:This was a 4-year ret...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-017-4338-3

    authors: Adamou H,Habou O,Amadou Magagi I,Adakal O,Magagi A,Halidou M,Sani R

    更新日期:2018-06-01 00:00:00

  • Reoperation following failed fundoplication.

    abstract::Fifty patients reoperated for failed Nissen fundoplication are presented; 29 patients (group 2) were operated between 1983 and 1988 while 21 patients (group 1) were operated before 1983. In group 1, the "slipped Nissen" had been the most frequent cause of reoperation (48%). In group 2, the most frequent causes for the...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/BF01658439

    authors: Siewert JR,Isolauri J,Feussner H

    更新日期:1989-11-01 00:00:00

  • Can SAPS II predict operative mortality more accurately than POSSUM and P-POSSUM in patients with colorectal carcinoma undergoing resection?

    abstract:BACKGROUND:This study assessed the APACHE II (Acute Physiology and Chronic Health Evaluation II), SAPS II (Simplified Acute Physiology Score-II), POSSUM (Physiologic and Operative Severity Score for Enumeration of Morbidity and Mortality), and P-POSSUM (Portsmouth-POSSUM) in patients with colorectal cancer undergoing c...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-007-9321-y

    authors: Can MF,Yagci G,Tufan T,Ozturk E,Zeybek N,Cetiner S

    更新日期:2008-04-01 00:00:00

  • Waiting Too Long: The Contribution of Delayed Surgical Access to Pediatric Disease Burden in Somaliland.

    abstract:BACKGROUND:Delayed access to surgical care for congenital conditions in low- and middle-income countries is associated with increased risk of death and life-long disabilities, although the actual burden of delayed access to care is unknown. Our goal was to quantify the burden of disease related to delays to surgical ca...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-019-05239-w

    authors: Smith ER,Concepcion TL,Shrime M,Niemeier K,Mohamed M,Dahir S,Ismail EA,Poenaru D,Rice HE,Global Initiative for Children’s Surgery.

    更新日期:2020-03-01 00:00:00

  • Safety of Major Abdominal Operations in the Elderly: A Study of Geriatric-Specific Determinants of Health.

    abstract:BACKGROUND:Preoperative assessment of geriatric-specific determinants of health may enhance perioperative risk stratification among elderly patients. This study examines effects of geriatric-specific variables on postoperative outcomes in patients undergoing elective major abdominal operations. METHODS:Patients includ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-020-05515-0

    authors: Martin AN,Hoagland DL,Turrentine FE,Jones RS,Zaydfudim VM

    更新日期:2020-08-01 00:00:00

  • Feasibility of laparoscopic cholecystectomy with miniaturized instrumentation in 50 consecutive cases.

    abstract::A new technique utilizing miniaturized (2 mm) instrumentation to perform laparoscopic cholecystectomy (LC) is introduced. The safety and efficacy of this mini-LC were assessed. Fifty consecutive mini-LCs were performed using one 10-mm port and three 2-mm ports (cumulative port size 16 mm). A 2-mm fiberoptic video-lapa...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/pl00013163

    authors: Reardon PR,Kamelgard JI,Applebaum B,Rossman L,Brunicardi FC

    更新日期:1999-02-01 00:00:00

  • Role of Ki-67 proliferation index in the assessment of patients with neuroendocrine neoplasias regarding the stage of disease.

    abstract:BACKGROUND:Neuroendocrine neoplasias (NEN) of the gastroenteropancreatic (GEP) system frequently present with metastatic deposits. The proliferation marker Ki-67 is used for diagnosis and to assess the prognosis of disease. The aim of our study was to evaluate the usefulness of Ki-67 % in the assessment of NEN patients...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-014-2451-0

    authors: Miller HC,Drymousis P,Flora R,Goldin R,Spalding D,Frilling A

    更新日期:2014-06-01 00:00:00

  • Correction to: Assessment of Capacity to Meet Lancet Commission on Global Surgery Indicators in the Federal Capital Territory, Abuja, Nigeria.

    abstract::In the original article there is an error in Fig. 2. Following is the corrected figure. ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s00268-018-04886-9

    authors: Anderson JE,Ndajiwo AB,Nuhu SA,Lawal OA,Amedu JO,Ameh EA

    更新日期:2019-03-01 00:00:00

  • The influence of parathyroidectomy on restless legs syndrome in patients with renal hyperparathyroidism.

    abstract:BACKGROUND:Restless legs syndrome (RLS) is a common and poorly understood movement disorder that leads to unpleasant leg sensations. Although RLS can be idiopathic, secondary etiologies such as iron deficiency and renal failure are common. The aim of this prospective cohort study was to evaluate whether RLS is a common...

    journal_title:World journal of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00268-013-2185-4

    authors: Schneider R,Karakas E,Bartsch DK,Schlosser K

    更新日期:2013-12-01 00:00:00

  • Selective nonoperative management of kidney gunshot injuries.

    abstract:BACKGROUND:Nonoperative management (NOM) of kidney gunshot injuries as an alternative to surgical exploration is rarely reported. The aim of this study was to assess the feasibility and safety of selective NOM of such injuries. METHODS:A 4-year prospective study was conducted that included all patients admitted to a L...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-008-9888-y

    authors: Navsaria PH,Nicol AJ

    更新日期:2009-03-01 00:00:00

  • Fecal urge incontinence after stapled anopexia for prolapse and hemorrhoids: a prospective, observational study.

    abstract:BACKGROUND:Stapled anopexia was introduced as a surgical method in 1993. Long-term data with special interest in functional results and relapse symptoms are rarely presented. Urinary discomfort and problems with fecal urge incontinence are addressed as severe side effects. We present our long-term results (using data f...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-008-9818-z

    authors: Schmidt J,Dogan N,Langenbach R,Zirngibl H

    更新日期:2009-02-01 00:00:00

  • Inspection of safety and accuracy of D2 lymph node dissection in laparoscopy-assisted distal gastrectomy.

    abstract:BACKGROUND:There is a consensus on the indication of laparoscopy-assisted distal gastrectomy (LADG) for early gastric cancer that needs D1 + alpha or D1 + beta lymph node dissection. However, many gastrointestinal surgeons consider D2 lymph node dissection in LADG to be difficult, therefore, only a few medical institut...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-008-9697-3

    authors: Kawamura H,Homma S,Yokota R,Yokota K,Watarai H,Hagiwara M,Sato M,Noguchi K,Ueki S,Kondo Y

    更新日期:2008-11-01 00:00:00

  • A Systematic Review and Meta-Analysis of Sentinel Lymph Node Biopsy in Gastric Cancer, an Optimization of Imaging Protocol for Tracer Mapping.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) plays an essential role in the evaluation of lymph node (LN) metastasis status and the extent of LN dissection in gastric cancer. The aim of our study was to perform a systematic review and meta-analysis for corresponding identification rate and sensitivity of different SLNB...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-020-05900-9

    authors: Huang Y,Pan M,Chen B

    更新日期:2021-01-03 00:00:00

  • Level VI lymph node dissection does not decrease radioiodine uptake in patients undergoing radioiodine ablation for differentiated thyroid cancer.

    abstract:BACKGROUND:In patients with well-differentiated thyroid cancer, the incidence of pathologic central compartment lymph node metastases is reported to be approximately 50%. Recently level VI lymph node dissection has been advocated as a means of reducing recurrence rates in these patients, even if there are no clinically...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-012-1507-2

    authors: Yoo D,Ajmal S,Gowda S,Machan J,Monchik J,Mazzaglia P

    更新日期:2012-06-01 00:00:00

  • Fournier's gangrene: risk factors and strategies for management.

    abstract:OBJECTIVE:The prognosis of Fournier's gangrene (FG) depends on early diagnosis and management. In this study, our objective was to identify the distinct features of FG that may influence the clinical outcome. METHODS:A retrospective chart review was performed in patients with a diagnosis of FG between January 1999 and...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-0777-3

    authors: Yanar H,Taviloglu K,Ertekin C,Guloglu R,Zorba U,Cabioglu N,Baspinar I

    更新日期:2006-09-01 00:00:00

  • Nonsteroidal antiinflammatory medications: efficient and safe treatment following video-assisted pleurodesis for spontaneous pneumothorax.

    abstract:BACKGROUND:Recurrent spontaneous pneumothorax is widely treated by video-assisted thoracoscopic (VATS) bullectomy and pleurodesis. Treatment of postoperative pain with nonsteroidal antiinflammatory drugs (NSAIDs) is controversial as many surgeons believe that it reduces the efficacy of pleurodesis and increases the pne...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-011-1207-3

    authors: Ben-Nun A,Golan N,Faibishenko I,Simansky D,Soudack M

    更新日期:2011-11-01 00:00:00

  • The Scale-Up of the Global Surgical Workforce: Can Estimates be Achieved by 2030?

    abstract:BACKGROUND:The Lancet Commission on Global Surgery showed that countries with surgeon, anesthetist, and obstetrician (SAO) densities of 20-40 SAO/100,000 population were associated with improved health outcomes and recommended a global surgical workforce scale-up by 2030. Whether countries would be able to achieve such...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-019-05329-9

    authors: Daniels KM,Riesel JN,Verguet S,Meara JG,Shrime MG

    更新日期:2020-04-01 00:00:00

  • Clinicopathologic study of gastric cancer based on Dukes' classification.

    abstract::Dukes' classification is a useful staging system in patients with colorectal cancer. The aim of this study was to present clinicopathologic characteristics and survival of patients with gastric cancer based on Dukes' classification. A total of 273 patients with gastric cancer curatively treated by radical gastrectomy ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/pl00012338

    authors: Adachi Y,Suematsu T,Yasuda K,Shiromizu A,Shiraishi N,Kitano S

    更新日期:1999-05-01 00:00:00

  • A Pilot Study for a Better Visibility in the 3D Laparoscopic Right Colectomy Surgery.

    abstract:OBJECTIVE:The aim of this study was to investigate the feasibility of digital defog technique in 3D laparoscopic surgery for right colon cancer. METHODS:Fifty patients with right colon cancer were divided into digital defogging group and control group. The intraoperative image clarity, the surgeon's anxiety, the time ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-017-4402-z

    authors: Gu L,Liu PL,Zhou H,Xu Q

    更新日期:2018-06-01 00:00:00

  • Helix pomatia agglutinin binding glycoproteins in thyroid tumors.

    abstract:BACKGROUND:Binding of the lectin Helix pomatia agglutinin (HPA) has been shown to be associated with poor prognosis in many human cancers, but not in thyroid cancer. The aims of the present study were to assess alteration in cellular glycosylation, detected by HPA binding, in thyroid tumors; to determine if such altere...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-011-1196-2

    authors: Parameswaran R,Sadler G,Brooks S

    更新日期:2011-10-01 00:00:00

  • Evaluation of operative notes concerning laparoscopic cholecystectomy: are standards being met?

    abstract:BACKGROUND:Laparoscopic cholecystectomy (LC) is the most performed minimal invasive surgical procedure and has a relatively high complication rate. As complications are often revealed postoperatively, clear, accurate, and timely written operative notes are important in order to recall the procedure and start follow-up ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00268-010-0422-7

    authors: Wauben LS,Goossens RH,Lange JF

    更新日期:2010-05-01 00:00:00

  • Factors of failure for nonoperative management of blunt liver and splenic injuries.

    abstract::A review of the literature describing the management of hepatic and splenic injuries indicates that as many as 67% of exploratory celiotomies for blunt trauma are reported as nontherapeutic. Avoiding unnecessary surgery through nonoperative management offers an attractive alternative. Nonetheless, nonoperative managem...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-001-0138-9

    authors: Ochsner MG

    更新日期:2001-11-01 00:00:00

  • Number needed to treat (or harm).

    abstract::The effect of a treatment versus controls may be expressed in relative or absolute terms. For rational decision-making, absolute measures are more meaningful. The number needed to treat, the reciprocal of the absolute risk reduction, is a powerful estimate of the effect of a treatment. It is particularly useful becaus...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7916-8

    authors: Tramèr MR,Walder B

    更新日期:2005-05-01 00:00:00

  • Impact of Angiotensin Receptor Blocker Use on Overall Survival Among Patients Undergoing Resection for Pancreatic Cancer.

    abstract:BACKGROUND:Pancreatic cancer has higher concentrations of angiotensin II compared with other cancers. This study sought to assess the effect of angiotensin II receptor blockers (ARBs) on survival of patients undergoing resection using a large, nationally representative dataset. METHODS:Patients undergoing pancreatic c...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-017-4021-8

    authors: Cerullo M,Gani F,Chen SY,Canner JK,Pawlik TM

    更新日期:2017-09-01 00:00:00

  • Trauma system evaluation in developing countries: applicability of American College of Surgeons/Committee on Trauma (ACS/COT) basic criteria.

    abstract:BACKGROUND:Trauma continues to be a major health problem worldwide, particularly in the developing world, with high mortality and morbidity. Yet most developing countries lack an organized trauma system. Furthermore, developing countries do not have in place any accreditation process for trauma centers; thus, no accept...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-014-2538-7

    authors: Latifi R,Ziemba M,Leppäniemi A,Dasho E,Dogjani A,Shatri Z,Kociraj A,Oldashi F,Shosha L

    更新日期:2014-08-01 00:00:00

  • Estimation of fat absorption with the 13C-trioctanoin breath test after pancreatoduodenectomy or pancreatic head resection.

    abstract::The aim of this study was to determine if fat absorption is better after pylorus-preserving pancreatoduodenectomy (PPPD) or duodenum-preserving pancreatic head resection (DPPHR) compared with that following pancreatoduodenectomy with gastrectomy (SPD), provided the patients have similar pancreatic exocrine function. F...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s002689900156

    authors: Miyakawa S,Hayakawa M,Horiguchi A,Mizuno K,Ishihara S,Niwamoto N,Miura K

    更新日期:1996-10-01 00:00:00

  • Prospective Risk Factor Analysis for the Development of Post-operative Urinary Retention Following Ambulatory General Surgery.

    abstract:AIMS:Post-operative urinary retention (POUR) is a common cause of unplanned admission following day-case surgery and has negative effects on both patient and surgical institution. We aimed to prospectively evaluate potential risk factors for the development of POUR following day-case general surgical procedures. METHO...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-018-4697-4

    authors: Scott AJ,Mason SE,Langdon AJ,Patel B,Mayer E,Moorthy K,Purkayastha S

    更新日期:2018-12-01 00:00:00

  • Efficacy of 10% sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy: a prospective, double-blind, randomized, placebo-controlled trial.

    abstract:BACKGROUND:The aim of the present study was to evaluate the efficacy of 10 % sucralfate ointment in the reduction of acute postoperative pain after open hemorrhoidectomy. METHODS:A total of 48 patients (24 men and 24 women) between 20 and 70 years of age who underwent open hemorrhoidectomy were included in this prospe...

    journal_title:World journal of surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00268-012-1805-8

    authors: Ala S,Saeedi M,Eshghi F,Rafati M,Hejazi V,Hadianamrei R

    更新日期:2013-01-01 00:00:00

  • Robot-assisted pediatric surgery: how far can we go?

    abstract:BACKGROUND:The purpose of this study was to assess the safety and feasibility of performing robot-assisted pediatric surgery using the da Vinci Surgical System in a variety of surgical procedures. METHODS:A retrospective review of 144 robot-assisted pediatric surgical procedures performed in our institution between Ju...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-010-0431-6

    authors: Alqahtani A,Albassam A,Zamakhshary M,Shoukri M,Altokhais T,Aljazairi A,Alzahim A,Mallik M,Alshehri A

    更新日期:2010-05-01 00:00:00