Abstract：
BACKGROUND:Pancreatic cancer has higher concentrations of angiotensin II compared with other cancers. This study sought to assess the effect of angiotensin II receptor blockers (ARBs) on survival of patients undergoing resection using a large, nationally representative dataset. METHODS:Patients undergoing pancreatic cancer resection were identified in the Truven Health MarketScan database. Multivariable Cox proportional hazards regression was used to assess the effect of ARB use on overall survival. RESULTS:A total of 4299 patients were identified, among whom 479 (11.1%) filled a prescription for an ARB. Mean patient age was 54.5 years (SD = 8.6 years); 2187 (51.1%) were female. Exactly 49.4% (n = 2125) of patients had a Charlson comorbidity index >2 at the time of surgery (n = 2125, 49.4%) and 59.6% (n = 2563) underwent a pancreaticoduodenectomy. Kaplan-Meier estimates of survival at 1, 2, and 4 years were 62.8% (95% CI: 61.3-64.2%), 38.2% (95% CI: 36.6-39.8%), and 19.0% (95% CI: 17.1-21.0%), respectively. On multivariable analysis, ARB use was associated with a 24% decreased risk of death over the 5-year period in which patients were under observation (HR = 0.76, 95% CI: 0.67-0.87, p < 0.001). CONCLUSIONS:ARB use was associated with improved survival in patients undergoing resection of pancreatic cancer. Further research is required into the differential effect of ARBs in the treatment of pancreatic cancer.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Cerullo M,Gani F,Chen SY,Canner JK,Pawlik TMdoi
10.1007/s00268-017-4021-8subject
Has Abstractpub_date
2017-09-01 00:00:00pages
2361-2370issue
9eissn
0364-2313issn
1432-2323pii
10.1007/s00268-017-4021-8journal_volume
41pub_type
杂志文章abstract：BACKGROUND:Esophageal achalasia is characterized by the absence of esophageal peristalsis and by a dysfunctional lower esophageal sphincter (LES). Descriptions of clinical, radiological, and manometric findings in patients with achalasia usually have been based on small numbers of patients. This study was designed to d...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9656-z
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:We analyzed perioperative platelet counts as a potential clinical marker for survival after transthoracic en bloc resection for esophageal cancer. Recent data described preoperative thrombocytosis in malignancies to be associated with poor prognosis. METHODS:A retrospective analysis from a prospective datab...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0707-x
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:We assessed whether the simultaneous sequential strategy could (1) achieve additional sinus restoration for those patients who were not in sinus rhythm while coming off bypass after modified left maze procedure and (2) attain the same long-term success rates as the bi-atrial maze procedure in patients with p...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-006-0382-0
更新日期：2006-10-01 00:00:00
abstract：BACKGROUND:There is no consensus opinion on a definitive surgical management option for ranulas to curtail recurrence, largely from the existing gap in knowledge on the pathophysiologic basis. AIM:To highlight the current scientific basis of ranula development that informed the preferred surgical approach. DESIGN:Ret...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3901-2
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:We aimed to describe the pattern of solid organ injuries (SOIs) and analyze the characteristics, management and outcomes based on the multiplicity of SOIs. METHODS:A retrospective study in a Level 1 trauma center was conducted and included patients admitted with blunt abdominal trauma between 2011 and 2014....
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4087-3
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Hepatic resection for hepatocellular carcinoma (HCC) patients with liver cirrhosis and severe hypersplenic thrombocytopenia is risky and controversial. METHODS:From 1989 to 2005, 341 patients underwent hepatic resection for HCC in our hospital. Of these, 15 patients were concomitant with severe thrombocytop...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9442-3
更新日期：2008-06-01 00:00:00
abstract：:Malignant melanoma is notoriously resistant to chemotherapy. Standard single agents include dacarbazine and the nitrosoureas, but most series treating patients with metastatic melanoma report response rates of about 20%. Occasional patients, however, achieve long term remission, amounting to cure, after such treatment...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02071532
更新日期：1992-03-01 00:00:00
abstract：:Dissemination of new surgical knowledge, skills, and techniques across the wide spectrum of practicing surgeons in the community is often difficult and slow. This is even more problematic in countries such as Canada, where geographic distances separate a large portion of community surgeons from the large teaching cent...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9076-5
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:The aim of this work was to study the impact of anemia on surgical outcomes and the impact of instituting appropriate workup and treatment of anemia on surgical outcomes. METHODS:We conducted a case-control retrospective chart review of all hernia repair, hydrocele repair, and hysterectomy cases at the SEAR...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1615-z
更新日期：2012-09-01 00:00:00
abstract：INTRODUCTION:Large-bowel obstruction and perforation are still frequently occurring entities for the acute care surgeon. In these cases, Hartmann's procedure is the most commonly used surgical technique. However, recent papers demonstrate that colon resection and primary anastomosis (RPA) in the emergency setting is a ...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章
doi：10.1007/s00268-012-1513-4
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Acute appendicitis is the most common reason for abdominal surgery in young adults and children. Open appendectomy is still the treatment often chosen because it is simple, safe, and effective. Our aim was to study whether cosmetic results of appendectomy wounds are better after using continuous absorbable i...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-013-2396-8
更新日期：2014-05-01 00:00:00
abstract：:Medieval contracts for medical treatment are, without doubt, evidence of proper and adequate insight into the quality of operations performed centuries ago. Historical archives in Dalmatian cities have preserved a certain number of such contracts. Their contents assist in better understanding our historical heritage. ...
journal_title：World journal of surgery
pub_type： 历史文章,杂志文章
doi：10.1007/s002680010176
更新日期：2000-08-01 00:00:00
abstract：BACKGROUND:Nipple-sparing mastectomy (NSM) has gained widespread popularity in recent years. Nonetheless, patient selection, technical consideration and oncological safety of its extension to breast cancer treatment remain uncertain. Few publications have reviewed the application of NSM in Asian populations. METHODS:W...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4197-y
更新日期：2018-05-01 00:00:00
abstract：INTRODUCTION:In recent years, surgical providers and advocates have engaged in a growing effort to establish metrics to estimate capacity for surgical services as well the burden of surgical diseases in resource-limited settings. The burden of disease (BoD) studies have established the disability-adjusted life year (DA...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2182-7
更新日期：2013-11-01 00:00:00
abstract：:A wide range of clinical symptoms and signs are observed with venous thrombosis. Nonetheless, clinical diagnosis has been found to be unreliable and accurate diagnostic methods must be used before potent therapy such as anticoagulation is instituted, since the complications of treatment themselves can be life-threaten...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01658825
更新日期：1990-09-01 00:00:00
abstract：BACKGROUND:Liver abscess after orthotopic liver transplantation (OLT) is a rare, life-threatening complication. The aim of this study is to analyze the incidence, risk factors, clinical manifestations, treatment and outcomes of liver abscesses after OLT. METHODS:We perform a retrospective review of the patients who de...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4622-x
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Classification of the open abdomen (OA) status is essential for clinical studies on the subject and may help to improve OA therapy. This is a validity and reliability analysis of the OA classification proposed by the World Society of the Abdominal Compartment Syndrome in 2013. METHODS:Prospective data on 11...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2716-7
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND:Gallbladder (GB) cancer may be discovered incidentally by histopathologic examination following simple cholecystectomy. Incidental GB cancer > or =T2 or > or =N1 needs a second radical resection. It is a matter of concern whether the prognosis may be worse in patients with T2GB cancer who undergo a second ra...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0522-4
更新日期：2010-07-01 00:00:00
abstract：:During the past four decades, especially in recent years, various active adjuvant therapies combined with surgery have improved the outcome in cases of cancer of the esophagus. However, no optimum adjuvant therapy has been determined. From 1981 to 1992, 341 patients with regional and distant node metastasis who underw...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF00316819
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:The burden of emergency general surgery conditions is high in sub-Saharan Africa, and poor access to surgical care leads to poor patient outcomes. We examined the trends in mortality in patients presenting with an acute abdomen to a referral hospital. METHODS:A retrospective analysis of the prospectively co...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05468-4
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:A substantial number of people are suffering from gastroesophageal reflux disease (GERD). The indication for surgical treatment is the failure of medical treatment in patients with objectively verified GERD. The use of PPIs has been noted to increase with the length of follow-up after fundoplication, raising...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3924-8
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:Hepatic trisectionectomy is a challenge for surgeons. We describe a technique by combination of the Glisson pedicle method and anterior approach to perform hepatic trisectionectomy. METHODS:In this technique, the Glisson pedicles are isolated above the hilar plate without hilar dissection. After dividing th...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2579-y
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Recurrent laryngeal nerve palsy (RLNP) is one of the most common complications after thyroidectomy. We aim to evaluate the role of intraoperative corticosteroids in preventing or treating postoperative RLNP. MATERIALS AND METHODS:We conducted a prospective study of 295 patients who underwent either total lo...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0399-9
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:The fields of surgery and trauma care have largely been neglected in the global health discussion. As a result the idea that surgery is not safe or cost effective in resource-limited settings has gone unchallenged. The SIGN Online Surgical Database (SOSD) is now one of the largest databases on trauma surgery...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1817-4
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:The change in the route of food passage after pancreaticoduodenectomy (PD) is quite similar to the change after gastric bypass surgery; both procedures bypass the duodenum and directly connect to the distal jejunum. Moreover, both procedures result in resolution of type 2 diabetes mellitus. Therefore, more d...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3157-7
更新日期：2015-11-01 00:00:00
abstract：INTRODUCTION TO THE PROBLEM:Though declining in the recent decades, high-energy musculoskeletal trauma remains a major contributor to the burden of disease in high-income countries (HICs). However, due to limitations in the available body of the literature, evaluation of this burden is challenging. The purpose of this ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-018-4742-3
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Although ultrasonographic (US) evaluation is currently recommended for the workup of all palpable thyroid nodules, little guidance exists regarding the manner in which US data are to be used. Herein, we examine the available evidence and recommend how US can be used most effectively to predict malignancy. We...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-008-9494-z
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:The 6th edition TNM staging (TNM-6) for hepatocellular carcinoma (HCC) has been recommended. However, its superiority, in contrast to the previous 5th edition (TNM-5), has not been fully recognized. Besides, tumor differentiation was not included. The current study was designed to compare the value of these ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9615-8
更新日期：2008-08-01 00:00:00
abstract：:From January, 1972 to June, 1989, 51 patients with liver hemangiomas (32 females and 19 males, mean age 35 years) were evaluated for surgical treatment. Diameters of the masses were 5 cm to 20 cm (median 8.5 cm). Nine of the patients had already been treated for cancer. Twenty-two (43.1%) of the 51 patients were sympt...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02104457
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND:Variously described as Courvoisier's law, sign, or even gallbladder, this eponymous "law" has been taught to medical students since the publication of Courvoisier's treatise in 1890. METHODS:We reviewed Courvoisier's original "law," the modern misconceptions surrounding it, and the contemporary evidence sup...
journal_title：World journal of surgery
pub_type： 传,历史文章,杂志文章
doi：10.1007/s00268-008-9908-y
更新日期：2009-04-01 00:00:00
