Abstract：
BACKGROUND:Liver abscess after orthotopic liver transplantation (OLT) is a rare, life-threatening complication. The aim of this study is to analyze the incidence, risk factors, clinical manifestations, treatment and outcomes of liver abscesses after OLT. METHODS:We perform a retrospective review of the patients who developed one or more liver abscesses among a series of 984 patients who underwent OLT between January 2000 and December 2016. RESULTS:Fourteen patients (1.5%) developed 18 episodes of liver abscesses, and the median time from OLT to the diagnosis of liver abscess was 39.7 months. Major predisposing factors were biliary strictures in 11 patients, hepatic artery thrombosis in 8, re-OLT in 3, choledochojejunostomy in 2, living donor OLT in 2, donor after cardiac death in 1, split liver in 1, and liver biopsy in 1. All patients were managed by intravenous antibiotics; percutaneous drainage was performed in 10 patients, while 2 patients underwent re-OLT. The mortality rate related to liver abscesses was 21.4%. The mean hospital stay was 30 ± 19 days, and during a mean follow-up of 93 ± 78 months, three other patients died. CONCLUSIONS:Liver abscesses must be managed with antibiotic therapy and percutaneous drainage, but when these conservative measures fail (persistent abscess and sepsis), a re-OLT must be performed in order to prevent the high mortality associated with this severe complication.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Justo I,Jiménez-Romero C,Manrique A,Caso O,Calvo J,Cambra F,Marcacuzco Adoi
10.1007/s00268-018-4622-xsubject
Has Abstractpub_date
2018-10-01 00:00:00pages
3341-3349issue
10eissn
0364-2313issn
1432-2323pii
10.1007/s00268-018-4622-xjournal_volume
42pub_type
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journal_title：World journal of surgery
pub_type： 杂志文章
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journal_title：World journal of surgery
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journal_title：World journal of surgery
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journal_title：World journal of surgery
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journal_title：World journal of surgery
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journal_title：World journal of surgery
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journal_title：World journal of surgery
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journal_title：World journal of surgery
pub_type： 杂志文章
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journal_title：World journal of surgery
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journal_title：World journal of surgery
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02393566
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journal_title：World journal of surgery
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