Abstract：
:Squamous cell carcinoma of the anus (SCCA) is a rare disease in the average population but is an increasing concern among immunocompromised individuals, such as the HIV-seropositive. Coinfection with human papillomavirus (HPV) in this population is common. HPV infection is difficult to clear with a compromised immune system, which results in a greater risk of tumor development and a more aggressive progression of the disease. The recent approval of a prophylactic HPV vaccine for cervical cancer has sparked an interest in a search for improved immunotherapeutic multimodality therapies to combat anogenital tumors associated with the virus. In this review, we discuss the known mechanisms of action of HIV-associated SCCA, examine the current treatments for the disease, and focus on the potential of an immunotherapeutic vaccine approach for both prophylactic and therapeutic application.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Marin-Muller C,Li M,Chen C,Yao Qdoi
10.1007/s00268-008-9835-ysubject
Has Abstractpub_date
2009-04-01 00:00:00pages
653-60issue
4eissn
0364-2313issn
1432-2323journal_volume
33pub_type
杂志文章,评审abstract：BACKGROUND:When needle core biopsies (NCBs) of the breast reveal fibroepithelial lesions (FELs), excision is often performed to rule out a phyllodes tumor (PT), despite low malignancy rates. Consequently, the natural history of observed FELs is not well described. We analyzed the malignancy risk in excised FELs and the...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05385-6
更新日期：2020-05-01 00:00:00
abstract：:Surgical education in the United Kingdom has evolved to meet the need of the National Health Service (NHS) for a relatively small body of consultants practicing autonomously and carrying ultimate clinical responsibility for their patients. This form of specialist practice is markedly different from that found in most ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF00298916
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND:Intense disease surveillance and frequent lymph node metastases (LNMs) in papillary thyroid cancer (PTC) have resulted in increased locoregional recurrences. We examined the safety and efficacy of an optimized surgical approach including preoperative ultrasonography (US), bilateral thyroidectomy, routine com...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0307-9
更新日期：2010-06-01 00:00:00
abstract：:Octenidine HCl is new topical antiseptic solution for wounds and abdominal washing that has been found to be highly effective for inactivating scolices in an in vitro study. However, the effects of octenidine HCl on the liver are not yet known. The aim of this study was to determine if there are any histopathologic ch...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9022-6
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:The purposes of this study were to determine clinical presentations and surgical outcomes of perforated peptic ulcer (PPU), and to evaluate the accuracy of the Boey scoring system in predicting mortality and morbidity. METHODS:We carried out a retrospective study of patients undergoing emergency surgery for...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9796-1
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:The objective of this study was to compare the prevalence of Helicobacter pylori (HP) seropositivity in patients undergoing bariatric surgery with that of the general population. METHODS:H. pylori serologies, tested by ELISA, were collected on 240 morbidly obese patients seen at the Cleveland Clinic Florida...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9608-7
更新日期：2008-09-01 00:00:00
abstract：INTRODUCTION:An increasing body of evidence is being published about single-incision laparoscopic cholecystectomy (SILC), but there are no well-powered trials with an adequate evaluation of post-operative pain. This randomized trial compares SILC against four-port laparoscopic cholecystectomy (LC) with post-operative p...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-014-2903-6
更新日期：2015-04-01 00:00:00
abstract：:Surgical resection remains the therapy of choice for the treatment of potentially curable gastrointestinal tract (GI) malignancies. Many of these tumors are incurable at the time of diagnosis and therapy should be directed towards palliation with the intent of minimizing pain, bleeding, obstruction, and potential morb...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02067061
更新日期：1992-11-01 00:00:00
abstract：:The most common causes of variceal bleeding are cirrhosis, schistosomiasis, and extrahepatic portal venous obstruction. The prognosis for an individual patient depends on the severity of the bleeding episode and the underlying liver function. Liver function is determined to a large extent by the underlying liver patho...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF00294397
更新日期：1994-03-01 00:00:00
abstract：:Cancers of the distal rectum (less than 7.5 cm from the anal verge) that are freely mobile, moderately well or well differentiated, less than 4 cm in size, limited to the bowel wall, and without evidence of metastasis should be considered candidates for treatment with electrocoagulation for cure. Tumor cell ploidy and...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02104447
更新日期：1992-05-01 00:00:00
abstract：BACKGROUND:Every day thousands of surgeons and patients negotiate their way through the complex process of decision-making about operative treatments. We conducted a series of qualitative studies, asking patients and surgeons to describe their experience and beliefs about informed decision-making and consent. This stud...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0021-7
更新日期：2009-07-01 00:00:00
abstract：:Medical errors from communication failures are enormous during the perioperative period of cardiac surgical patients. As caregivers change shifts or surgical patients change location within the hospital, key information is lost or misconstrued. After a baseline cognitive study of information need and caregiver workflo...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0319-5
更新日期：2010-04-01 00:00:00
abstract：:Among 26 patients with gallbladder carcinoma, 11 resected cases were studied retrospectively with respect to the preoperative imaging techniques and the operative procedures employed. Ultrasonography, endoscopic ultrasonography, and computed tomography were valuable in detecting gallbladder carcinoma preoperatively wh...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01658723
更新日期：1991-05-01 00:00:00
abstract：:The geographic distribution of duodenal ulcer and its characteristics in rural areas of high incidence in developing countries are reviewed. The choice of surgical procedures is discussed in light of the bulky diet and nutritional problems of these countries. A vagotomy procedure is advised for duodenal ulcer and a B...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01654731
更新日期：1977-01-01 00:00:00
abstract：:The aim of this study was to investigate the collagen matrix in recurrent inguinal hernias. Total ribonucleic acid (RNA) was extracted from skin fibroblasts of three groups (control group I = healthy skin; control group II = plain skin scar; recurrent inguinal hernia group = skin of recurrent inguinal hernias; each n ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-001-0239-5
更新日期：2002-04-01 00:00:00
abstract：BACKGROUND:There is no consensus opinion on a definitive surgical management option for ranulas to curtail recurrence, largely from the existing gap in knowledge on the pathophysiologic basis. AIM:To highlight the current scientific basis of ranula development that informed the preferred surgical approach. DESIGN:Ret...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3901-2
更新日期：2017-06-01 00:00:00
abstract：:Surgery is the most effective therapeutic intervention available for the treatment of breast cancer. It has been responsible for obtaining local control and long-term disease-free intervals in more patients over the past century than any other treatment modality. Trends toward earlier stage at diagnosis are likely to ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-001-0010-y
更新日期：2001-06-01 00:00:00
abstract：:Gastric cancer is a disease in which the main treatment is surgical extirpation. The modifications introduced in the surgical treatment over the last decades were accompanied by a clear increase of survival, which reaches global values of 61% at 5 years in Japan. One of the reasons that contribute to this improvement ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-001-0228-8
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:Treating large and extensive pilonidal sinus disease is a challenging task. Long-term reports on flaps suitable for coverage of large, wide, local-excision defects are sparse. We prospectively evaluated data with a minimum 1-year follow-up of the use of a single-sided, innervated, superior gluteal artery per...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1639-4
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Better prognostic markers are needed for pancreatic endocrine tumors. Survivin is an apoptosis inhibitor that is suggested to have a negative prognostic impact in several tumor types. Contradictory data exist, especially regarding the significance of a nuclear versus cytoplasmic location of survivin. The pro...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1345-7
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Sentinel lymph node biopsy (SLNB) plays an essential role in the evaluation of lymph node (LN) metastasis status and the extent of LN dissection in gastric cancer. The aim of our study was to perform a systematic review and meta-analysis for corresponding identification rate and sensitivity of different SLNB...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-020-05900-9
更新日期：2021-01-03 00:00:00
abstract：:This study aims to examine the frequency of the pheochromocytoma (pheo), defined as a "benign, intra-adrenal, hypertensive, sporadic, unilateral tumor." Three large series amounting to 310 subphrenic chromaffin tumors operated over periods of 17, 23, and 41 years, respectively, have been reviewed. Among those combined...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00353738
更新日期：1994-07-01 00:00:00
abstract：:The treatment results of mycobacterial cervical lymphadenitis in 69 patients between 1990 and 1993 are reviewed. All patients underwent surgical procedures consisting of total excision or selective nodal dissection for lymphadenopathies and curettage for fluctuant cases, followed by antituberculous chemotherapy applie...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900265
更新日期：1997-06-01 00:00:00
abstract：:Inflammation is an essential component of the first phase of anastomotic wound healing, and it is suppressed by corticosteroids. The anti-inflammatory effect of corticosteroids is largely responsible for the impairment of wound healing in bowel anastomosis. It has been reported that local application of granulocyte-ma...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6505-3
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:Intra-abdominal adhesions constitute between 49% and 74% of the causes of small bowel obstruction. Traditionally, laparotomy and open adhesiolysis have been the treatment for patients who have failed conservative measures or when clinical and physiologic derangements suggest toxemia and/or ischemia. With the...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-005-7778-0
更新日期：2006-04-01 00:00:00
abstract：:Enteral nutrition (EN) and total parenteral nutrition (TPN) may provide life-sustaining therapy for surgical patients. The duration of nutritional therapy (enteral or parenteral) implies distinct access routes. We review the main aspects related to access routes for nutrient delivery. The enteral route, whenever feasi...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002680010264
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:The histone deacetylase (HDAC) inhibitors have emerged as the useful reagents that epigenetically modulate the expression of various genes. In the present study, the effects of HDAC inhibitors on the expression of inflammation-related genes and lung injury during sepsis were investigated. METHODS:Mice were ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0493-5
更新日期：2010-07-01 00:00:00
abstract：:Central pancreatectomy is an uncommonly performed procedure that may be particularly useful for the removal of benign and low malignant potential lesions in the neck and body of the pancreas. This procedure may have fewer major complications and better preserve endocrine and exocrine function than the more commonly pe...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-6848-4
更新日期：2003-05-01 00:00:00
abstract：:It is difficult to evaluate precisely the effects of one individual on an entire discipline such as surgery. Indeed, it is impossible to do so when such a discipline spans so vast a country as the United States of America. Nevertheless, as a mountain peak can be seen from afar, so may one perceive the influence of man...
journal_title：World journal of surgery
pub_type： 传,历史文章,杂志文章
doi：10.1007/s002689900357
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Some patients complain of long-lasting voice symptoms after thyroid surgery without objective vocal fold pathology. We assessed the factors that may influence voice symptoms more than 12 months after thyroidectomy. METHODS:We performed a retrospective analysis of 68 patients from July 2010 to May 2012. The ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4438-0
更新日期：2018-07-01 00:00:00
