Abstract：
:We have evaluated survival and tumor-related symptoms in the presence of mesenteric lymph node and liver metastases in relation to surgical procedures in 314 patients (148 women, mean age at diagnosis 61 years; 249 with liver metastases) treated for midgut carcinoid tumors. Of the operated patients, 46% presented with severe abdominal pain and intestinal obstruction and were operated on before the diagnosis. Medical treatment (somatostatin analogs, interferon-a) was initiated in 67% and 86%, respectively. Surgical attempts included small intestine or ileocecal/right-sided colon resection with excision of mesenteric lymph node metastases. Most of the patients (n = 286) had mesenteric lymph node metastases; 33% of them had unresectable mesenteric lymph node metastases and underwent surgery without mesenteric dissection. Patients who underwent resection for the primary tumor had a longer survival than those with no resection (median survival 7.4 vs. 4.0 years; p <0.01). Patients who underwent successful excision of mesenteric metastases had a significantly longer survival than those with remaining lymph node metastases. Patients operated on for a primary tumor but with remaining lymph nodes but no liver metastases and who subsequently received interferon and somatostatin analog treatment had a median survival of 7.4 years. Resection of the primary tumor and the mesenteric lymph node metastases led to a significant reduction in tumor-related symptoms. Surgery to remove the primary intestinal tumor including mesenteric lymph node metastases is supported by the present results, even in the presence of liver metastases. Liver metastases and significant preoperative weight loss are identified as major negative prognostic factors for survival.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Hellman P,Lundström T,Ohrvall U,Eriksson B,Skogseid B,Oberg K,Tiensuu Janson E,Akerström Gdoi
10.1007/s00268-002-6630-zkeywords:
subject
Has Abstractpub_date
2002-08-01 00:00:00pages
991-7issue
8eissn
0364-2313issn
1432-2323journal_volume
26pub_type
杂志文章abstract：:Some patients are prone to persisting intraabdominal infection regardless of initial eradication of the source of infection. Our aim was to characterize patients who had to undergo relaparotomy for persisting abdominal sepsis using simple clinical parameters and to define those patients who are susceptible to benefit ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689910007
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Gastrointestinal (GI) tract perforation during endoscopy is a rare but severe complication. The aim of this study was to determine predictors of morbidity and mortality after iatrogenic endoscopic perforation. MATERIALS AND METHODS:All cases with iatrogenic endoscopic perforation receiving surgery at a tert...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3986-7
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVES:The purpose of this study was to evaluate the feedback of participants upon laparoscopic liver surgery (LLS) course on Thiel-embalmed human bodies. METHODS:From 2010 to 2017, ten LLS masterclasses have been organized by the Department of Hepatobiliary Surgery at Ghent University Hospital. A 23-question anon...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05103-x
更新日期：2019-11-01 00:00:00
abstract：BACKGROUND:The optimal extent of lung resection and lymph nodes dissection for peripheral early-stage right middle non-small cell lung cancer (NSCLC) still remains controversial. In this study, we analyzed the patterns of lymph nodes metastasis (LNM) of patients with peripheral right middle NSCLC ≤ 3 cm, aiming to prov...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-020-05647-3
更新日期：2020-10-01 00:00:00
abstract：:During laparoscopic cholecystectomy, gallbladder perforation has been reported, leading to bile leak and spillage of gallstones into the peritoneum. Because the consequences can be dangerous, conversion to laparotomy as an instant management for gallstone spillage is one of the topics of current discussion in laparosc...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-004-7588-9
更新日期：2005-04-01 00:00:00
abstract：:There is little information on the pharmacokinetics and pharmacodynamics of doxorubicin (DXR) administered during locoregional treatments of colon carcinoma under hyperthermic conditions. The aim of this study was to evaluate distribution and activity of DXR in healthy tissue and tumor tissues under hyperthermic condi...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-6804-3
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) scoring system was developed to aid the diagnosis of necrotizing fasciitis and guide management [1]. AIM:To validate the LRINEC score and identify clinical predictors to develop a refined diagnostic scoring tool for the diagnosis of necrotizin...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05061-4
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Insertion of a nasogastric tube (NGT) in an anesthetized, paralyzed, and intubated patient is difficult, and many methods have been proposed to aid in the procedure. We present a simple insertion technique. METHODS:A silicone NGT was made rigid by filling it with distilled water and freezing it. Patients we...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-009-0144-x
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Currently, there are no objective reports evaluating the quality of the South African surgical training. The aim of this study is to evaluate the current state of surgical training in South Africa from an external impartial point of view and to rate the experience of short-term supernumerary registrars and f...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05034-7
更新日期：2019-09-01 00:00:00
abstract：:Histologically differentiated adenocarcinoma satisfies one of the criteria for limited surgery for mucosal carcinoma of the stomach: however, the histology of the endoscopic biopsy specimen is often different from that of the resected specimen. The medical records of 1018 early gastric carcinomas were retrospectively ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900483
更新日期：1998-08-01 00:00:00
abstract：:Despite a slow decline in the incidence of gastric cancer over the last 90 years, we can still expect to see over 100,000 patients die of this disease each decade in England and Wales. The 5-year survival rate has not improved during this century, which is largely due to the stage at diagnosis being unchanged. There a...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF00294709
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:The appropriate surgical approach for hepatocellular carcinoma (HCC) patients of Child-Pugh class B is unclear. The aim of this study was to clarify the prognostic factors after hepatectomy in Child-Pugh class B patients and to delineate the selection criteria for hepatectomy. METHODS:One hundred fifty pati...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0929-y
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:This study aimed to evaluate the clinical relevance of hepatectomy for Barcelona Clinic Liver Cancer (BCLC) stages B and C advanced hepatocellular carcinoma (HCC). METHODS:A total of 314 patients (149 and 165 BCLC stages B and C, respectively) who underwent hepatectomy were included. Complete hepatectomy (w...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05052-5
更新日期：2019-10-01 00:00:00
abstract：:From January, 1975 to December, 1987, 241 patients with rectal cancer underwent pre-operative irradiation and surgical resection. The radiation was delivered with 25 MeV photons, 5 days per week by 2.4 grays fractions up to a total dose of 36 grays. Surgery was curative in 195 patients; 57% had abdomino-perineal resec...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF02067122
更新日期：1992-01-01 00:00:00
abstract：:To evaluate quality of life and functional results following surgery for gastric cancer we studied 104 patients with no evidence of disease at a minimum of 12 months postoperatively. Patients were treated with total gastrectomy and jejunal pouch reconstruction according to Hunt-Lawrence-Rodino (n = 59) or simple esoph...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章
doi：10.1007/BF00294722
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND:Surgical care is not uniformly available worldwide. Inequities in surgical care and access may also vary within countries, and the present study aimed to explore these disparities in Pakistan. METHODS:The National Health Survey of Pakistan was analyzed. The proportion of people with a history of abdominal s...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1732-8
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:A PubMed search of the biomedical literature was carried out to systematically review the role of laparoscopy in colonic diverticular disease. All original reports comparing elective laparoscopic, hand-assisted, and open colon resection for diverticular disease of the colon, as well as original reports evalu...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-012-1872-x
更新日期：2013-03-01 00:00:00
abstract：: ...
journal_title：World journal of surgery
pub_type： 评论,信件
doi：10.1007/s00268-018-4704-9
更新日期：2019-03-01 00:00:00
abstract：:Persistent pain after hernia repair is common, although it is usually mild. In 3% of patients it is severe, however, and has significant effects on work and social activities. The purpose of this review was to examine factors that affect pain after hernia repair. Although the type of anaesthetic used, local or general...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-005-7903-0
更新日期：2005-08-01 00:00:00
abstract：:Innovation is responsible for most advances in the field of surgery. Innovative approaches to solving clinical problems have significantly decreased morbidity and mortality for many surgical procedures, and have led to improved patient outcomes. While innovation is motivated by the surgeon's expectation that the new a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2568-1
更新日期：2014-07-01 00:00:00
abstract：:Little evidence is available regarding long-term survival of patients with gallbladder cancer that is discovered at the time of laparoscopic cholecystectomy (LC). Therefore the present study was performed to evaluate long-term outcomes of this disease. Of 1546 patients who underwent LC for benign gallbladder disease b...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7886-x
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Cardiovascular disease (CVD) and gallstones are reported to be strongly associated because both diseases are frequently part of a metabolic syndrome. Laparoscopic cholecystectomy (LC) has become the standard treatment for gallbladder disease around the world. Cardiovascular disease is considered as an absolu...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0072-9
更新日期：2009-08-01 00:00:00
abstract：BACKGROUND:Despite curative resection, hepatocellular carcinoma (HCC) has a high probability of recurrence. We validated the potential role of liver resection (LR) for recurrent HCC. METHODS:Patients with intrahepatic recurrence with up to three lesions were included. We compared survival times of patients undergoing ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-019-05225-2
更新日期：2020-01-01 00:00:00
abstract：:The major goal of wound healing biology is to determine how a wound can be induced to repair damaged tissue faster and more efficiently. Enhancement of dermal and epidermal regeneration is an extremely important goal for the treatment of many different types of wounds. Exogenous application of growth factors to the wo...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-004-2062-2
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:The pancreatic fistula rate following distal pancreatectomy ranges widely, from 13.3 to 64.0 %. The optimal closure method of the pancreatic remnant remains controversial, especially regarding whether to use a stapler. METHODS:All patients who underwent distal pancreatectomy in five Japanese hospitals from ...
journal_title：World journal of surgery
pub_type： 杂志文章,多中心研究
doi：10.1007/s00268-012-1595-z
更新日期：2012-08-01 00:00:00
abstract：INTRODUCTION:The decision to perform a relaparotomy in patients with secondary peritonitis is based on "clinical judgment" with inherent variability among surgeons. Our objective was to review the literature on prognostic variables for ongoing abdominal infection. Predictive variables for positive findings at relaparot...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-005-0333-1
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Intraoperative parathyroid hormone assay (IOPTH) has been suggested to have value in predicting the development of postoperative hypoparathyroidism after thyroid surgery. IOPTH has been validated in identification of patients at risk of postoperative hypocalcemia requiring early onset of calcium supplementat...
journal_title：World journal of surgery
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00268-007-9405-8
更新日期：2008-05-01 00:00:00
abstract：:To pursue a suitable central airway replacement, we conducted central airway reconstruction using autologous pulmonary tissue flaps lined with alloy stents in five patients after extensive tracheal resection. Preoperative and postoperative arterial blood gas analysis and pulmonary function tests were used to evaluate ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3066-9
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Pulmonary resection is the best therapeutic option for lung metastases from colorectal cancer (CRC) today. However, recurrences are frequent following pulmonary resection. We aimed to evaluate the recurrence pattern and treatment of initial pulmonary resection for metastases from CRC. METHODS:Data from 76 p...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3006-8
更新日期：2015-07-01 00:00:00
abstract：:Gastric emptying times and symptoms were recorded in 18 patients after total gastrectomy and either a 15-cm J-pouch (n = 10) or a standard esophagojejunal anastomosis (n = 8). A solid test meal labeled with 99mTc was used to compare the emptying times. The postoperative symptoms and nutritional status were also assess...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01659117
更新日期：1993-09-01 00:00:00
