Abstract：
:Genital manifestations of lymphatic filariasis (genital LF) are a significant cause of disfigurement and disability in the developing world. Surgery is the standard treatment; however, definitive publications are lacking and best practice remains unclear. An exhaustive search strategy using keyword and subject headings was applied to Medline, EMBASE, Web of Science, CINAHL, and Scopus. Additionally citation lists, Google and Google Scholar, archives of relevant journals and websites were searched systematically. Studies with data on one or more human patient(s) who underwent surgery for genital LF were included. Articles were screened and data extracted by the first author with data verification by the second author. Fifty-seven studies were included: 18 series of ablative surgery, four series of non-ablative surgery and 35 case reports. Poor study quality, heterogeneous case definitions, lack of severity grading and limited follow-up precluded meta-analysis. Two series of simple hydrocelectomies performed in resource-limited settings reported early complication rates of 3.0-3.5 % using eversion and 5-7 % using excision, with recurrence of 7 % and 3-5 %, respectively. Complications were minimal for single-surgeon series and greater (12-18 %) when scrotal reconstruction was performed. There is little useful evidence for lymphatic bypass procedures in genital LF. Under-recognition of atypical manifestation of genital LF leads to potentially unnecessary surgeries. Surgery for genital LF is safe in resource-limited settings; however, more well-designed studies with better follow-up are needed. Research priorities include validation of case definitions and severity grading systems, and solutions to improve post-operative follow-up in resource-limited settings.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Lim KH,Speare R,Thomas G,Graves Pdoi
10.1007/s00268-015-3220-4subject
Has Abstractpub_date
2015-12-01 00:00:00pages
2885-99issue
12eissn
0364-2313issn
1432-2323pii
10.1007/s00268-015-3220-4journal_volume
39pub_type
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journal_title：World journal of surgery
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journal_title：World journal of surgery
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2004-05-01 00:00:00
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更新日期：2011-09-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章
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journal_title：World journal of surgery
pub_type： 杂志文章
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更新日期：2009-06-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章,评审
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更新日期：1990-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章,meta分析,评审
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更新日期：2014-12-01 00:00:00
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journal_title：World journal of surgery
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pub_type： 杂志文章
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journal_title：World journal of surgery
pub_type： 杂志文章,已发布勘误
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更新日期：2020-08-01 00:00:00
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journal_title：World journal of surgery
pub_type： 杂志文章
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journal_title：World journal of surgery
pub_type： 杂志文章
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journal_title：World journal of surgery
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更新日期：2007-06-01 00:00:00
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journal_title：World journal of surgery
pub_type： 历史文章,杂志文章
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pub_type： 杂志文章
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journal_title：World journal of surgery
pub_type： 杂志文章
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