Abstract:
PURPOSE:There is no standardized treatment for patients with chemo-resistant or recurrent advanced ovarian cancer. Locoregional treatments combining cytoreductive surgery and intraperitoneal chemohyperthermia (HIPEC) may improve survival for locoregional disease. PATIENTS AND METHODS:A prospective single center study of 81 patients with recurrent or chemo-resistant peritoneal carcinomatosis from ovarian cancer was performed. Patients were treated by maximal cytoreductive surgery combined with HIPEC (with cisplatinum at 20 mg/m(2)/L). A total of 47 patients were included for their third, fourth, fifth, sixth, or seventh surgical look. Altogether, 54 patients presented with extensive carcinomatosis (malignant nodules of >5 mm). RESULTS:Complete macroscopic resection (CCR-0) was achieved in 45 patients. Mortality and morbidity rates were 2.5% and 13.6%, respectively. With a median follow-up of 47.1 months, the overall and disease-free median survivals were 28.4 and 19.2 months, respectively. Carcinomatosis extent and completeness of cytoreduction (p = 0.02 and p <0.001, respectively) were identified as independent prognostic factors. For CCR-0 patients, overall and disease-free survivals were 54.9 and 26.9 months, respectively. CONCLUSION:Salvage therapy combining optimal cytoreductive surgery and HIPEC may achieve long-term survival in selected patients with recurrent or chemo-resistant ovarian cancer. This strategy may be most effective in patients with limited carcinomatosis or when cytoreductive surgery provides sufficient downstaging.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Cotte E,Glehen O,Mohamed F,Lamy F,Falandry C,Golfier F,Gilly FNdoi
10.1007/s00268-007-9146-8subject
Has Abstractpub_date
2007-09-01 00:00:00pages
1813-20issue
9eissn
0364-2313issn
1432-2323journal_volume
31pub_type
杂志文章abstract::Intraabdominal bleeding, the most life-threatening complication following pancreaticoduodenectomy (PD), most often is associated with failure of a pancreaticojejunostomy anastomosis or with intraabdominal infection. We investigated whether placement of an omental flap around the splanchnic vessels in PD could reduce t...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-7900-3
更新日期:2005-09-01 00:00:00
abstract::During the course of tumor progression the differentiated morphologic and functional characteristics of differentiated thyroid carcinomas (DTC) disappear. This corresponds to more aggressive growth, metastatic spread, and loss of iodine uptake. Experimental data give strong evidence that differentiated functions of io...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900436
更新日期:1998-06-01 00:00:00
abstract::Radiation-induced proctitis with hemorrhage is not a common complication of radiotherapy to the pelvis for carcinoma. In the most severe forms, massive hemorrhage may necessitate repeated transfusions and inpatient treatment. In severe cases medical treatment has not been proved effective. Surgery may lead to serious ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900166
更新日期:1996-10-01 00:00:00
abstract::Fourteen patients with liver tumor malignancy and sixteen patients with malignant melanoma localized to one limb were studied regarding leukocyte activation with the release of polymorphonuclear neutrophilic (PMN) elastase and of neopterin and formation of cytokines (TNF-alpha and IL-6) during the surgical treatment. ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00299787
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:The postoperative functional advantages of a proximal gastrectomy over a total gastrectomy remain debatable. The aim of this study was to evaluate the functional outcomes of a proximal gastrectomy with jejunal interposition (PG-JI), compared with those for a total gastrectomy with Roux-en-Y esophagojejunosto...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-3180-8
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to evaluate the effects of surgically induced weight loss on the metabolic profile and adipocytokine levels in premenopausal morbidly obese females. METHODS:Twenty premenopausal morbidly obese (MO) women with a median age of 34 years (range: 24-48 years) and a median body ma...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1165-9
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Although laparoscopic appendectomy (LA) is widely performed in many countries, LA for complicated appendicitis, which includes perforated or gangrenous appendicitis with or without localized or disseminated peritonitis, has not become a common practice yet. METHODS:We retrospectively analyzed the clinical r...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9843-y
更新日期:2009-02-01 00:00:00
abstract::Patients with short bowel syndrome (SBS) receiving total parenteral nutrition (TPN) have a high incidence of catheter-related sepsis, one of its major complications. The aim of this study was to correlate the length of remaining small bowel (RSB) with septic episodes related to the central venous catheter in a group o...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002680010274
更新日期:2000-12-01 00:00:00
abstract::In the original article, Mehreen K. Bhettani's last name and Mubarik Rehman's first name are misspelled. ...
journal_title:World journal of surgery
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00268-019-05334-y
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the available resources for trauma care at health centers (HCs) and referral hospitals (RHs) in rural Cambodia and to examine whether the resources at HCs are allocated on the basis of actual need based on the referral distance and number of severely injured patients ref...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9900-6
更新日期:2009-04-01 00:00:00
abstract:INTRODUCTION:In India, half of the annual 200,000 road traffic deaths occur in hospitals, but the exact in-hospital trauma mortality rate remains unknown. A research consortium of universities, with a mandate to reduce trauma mortality, measured the baseline 30-day in-hospital mortality rate. METHODS:Between September...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究
doi:10.1007/s00268-016-3452-y
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:We sought to assess the status of availability of technology for trauma care in a state in India and to identify factors contributing to both adequate levels of availability and to deficiencies. We also sought to identify potential solutions to deficiencies in terms of health system management and product de...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2805-7
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:The role of circular staplers in gastroduodenostomy during subtotal gastrectomy for gastric cancer has not been defined clearly. METHODS:A randomized clinical trial included patients with gastric cancer who underwent subtotal gastrectomy with either stapled (99 patients) or handsewn gastroduodenostomy (98 p...
journal_title:World journal of surgery
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00268-011-1038-2
更新日期:2011-05-01 00:00:00
abstract::We evaluated the clinicopathologic findings and surgical results of 140 patients with thoracic esophageal cancer treated at Shinshu University, Japan (Shinshu group), and compared them with those from 1164 patients treated at Hebei Medical College, China (Hebei group) to determine if the two groups showed any differen...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900053
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Enhanced Recovery After Surgery (ERAS®) Society guidelines integrate evidence-based practices into multimodal care pathways that have improved outcomes in multiple adult surgical specialties. There are currently no pediatric ERAS® Society guidelines. We created an ERAS® guideline designed to enhance quality ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05530-1
更新日期:2020-08-01 00:00:00
abstract::Reported incidence rates of carcinoma in patients with achalasia and the prevalence of achalasia in patients with esophageal cancer vary widely in the literature. The prognosis of an "achalasia-carcinoma" is generally considered poor, although systematic studies assessing the incidence, prevalence, and prognosis of pa...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-001-0026-3
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:The recent development and spread of ultrasonography and ultrasonography-guided fine needle aspiration biopsy (FNAB) has facilitated the detection of small papillary microcarcinomas of the thyroid measuring 1 cm or less (PMC). The marked difference in prevalence between clinical thyroid carcinoma and PMC det...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0303-0
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Inflammation is integral to the pathogenesis of abdominal aortic aneurysm (AAA). This study examines preoperative biomarkers of systemic inflammation in patients undergoing open repair of intact and ruptured AAA. METHODS:One-hundred twelve patients were entered into a prospective observational study. Preope...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9014-6
更新日期:2007-06-01 00:00:00
abstract::Factors responsible for recurrence of esophageal cancer were investigated in 90 patients who underwent extended radical esophagectomy with three-field dissection for a squamous cell carcinoma in the thoracic esophagus. The initial tumor recurrence was grouped as either locoregional (site of the primary tumor, anastomo...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689900228
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Every day thousands of surgeons and patients negotiate their way through the complex process of decision-making about operative treatments. We conducted a series of qualitative studies, asking patients and surgeons to describe their experience and beliefs about informed decision-making and consent. This stud...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0021-7
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:The purposes of this study were to determine clinical presentations and surgical outcomes of perforated peptic ulcer (PPU), and to evaluate the accuracy of the Boey scoring system in predicting mortality and morbidity. METHODS:We carried out a retrospective study of patients undergoing emergency surgery for...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9796-1
更新日期:2009-01-01 00:00:00
abstract::There is little information on the pharmacokinetics and pharmacodynamics of doxorubicin (DXR) administered during locoregional treatments of colon carcinoma under hyperthermic conditions. The aim of this study was to evaluate distribution and activity of DXR in healthy tissue and tumor tissues under hyperthermic condi...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-003-6804-3
更新日期:2003-06-01 00:00:00
abstract::Whether for hepatic trauma or transplantation, a surgeon's knowledge of hepatic anatomy commonly determines a patient's outcome. The first medically relevant anatomic studies of the liver emerged with the endeavors of Herophilus and Erasistratus between 310 and 280 bc. Yet it was not until after the development of ane...
journal_title:World journal of surgery
pub_type: 传,历史文章,杂志文章
doi:10.1007/s002689900238
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:The incidence, pattern, and severity of sleep disturbance and cognitive dysfunction has not been well characterized for patients with primary hyperparathyroidism (PHPT). There is no agreement on the mechanism of the development or resolution of such symptoms, and in no previous study has cerebral activity be...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-0361-x
更新日期:2006-05-01 00:00:00
abstract::Benign esophageal obstruction is virtually always responsive to dilation therapy. Dilation therapy should, therefore, be the initial approach. The introduction of the Savary-type dilating equipment and of balloon dilation systems are, or will become, standard practice. These systems will increasingly be preferred over...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF01658390
更新日期:1989-03-01 00:00:00
abstract:: ...
journal_title:World journal of surgery
pub_type: 评论,信件
doi:10.1007/s00268-018-4704-9
更新日期:2019-03-01 00:00:00
abstract::Local recurrence in differentiated and medullary thyroid carcinoma develops frequently from metastatic infiltration of cervical lymph nodes. Despite an aggressive surgical approach, postoperative calcitonin levels as biochemical evidence for residual cancer cells remain often elevated in patients with medullary thyroi...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-001-0197-y
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Over the past decade, assessments of surgical capacity in low- and middle-income countries (LMICs) have contributed to our understanding of barriers to the delivery of surgical services in a number of countries. It is yet unclear, however, how the findings of these assessments have been applied and built upo...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-014-2938-8
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:Jejunal diverticula are rare lesions, and when complications arise, they pose diagnostic difficulties. Perforation is a common complication resulting in an acute abdomen, although preoperative diagnosis is usually not possible. The "gold standard" for management for patients with complications is surgery. ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-008-9469-0
更新日期:2008-07-01 00:00:00
abstract::Endoscopic management of upper gastrointestinal bleeding has been expanded from a purely diagnostic role to a therapeutic role in many patients. In addition to controlling active bleeding, it is an option in a patient who is clinically at a high risk of rebleeding, or in patients who have peptic ulcers with visible ve...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF02067057
更新日期:1992-11-01 00:00:00