Abstract:
BACKGROUND:The aim of the present study was to evaluate the efficacy of cholestyramine ointment (15 %) in reducing postoperative pain at rest and during defecation after open hemorrhoidectomy. METHODS:A total of 91 patients with third and fourth degree hemorrhoids undergoing open hemorrhoidectomy were included in this prospective, double-blind, randomized controlled trial. The patients were randomly assigned to either cholestyramine ointment or placebo immediately after surgery, 12 h after surgery, and then every 8 h for 14 days. The primary outcomes were intensity of pain at rest and during defecation, measured with a visual analog scale, and the analgesic requirement, measured by amount of tramadol consumption. RESULTS:The cholestyramine group had less postoperative pain than the placebo group at the 24th hour (1.84 ± 2.54 vs. 4.07 ± 3.35; P = 0.001) and 48th hour (0.18 ± 0.88 vs. 3.57 ± 3.45; P < 0.001) and less pain during defecation starting at the 48th hour (2.28 ± 2.96 vs. 4.77 ± 4.09; P = 0.001). Similarly, the average tramadol consumption at hours 24 and 48 was significantly lower for the cholestyramine group (5.32 ± 21.45 vs. 43.18 ± 61.56 mg at 24 h, and 4.48 ± 16.65 vs. 57.63 ± 65.47 mg at 48 h; P < 0.001). The only adverse event was pruritus, which had a lower frequency in the cholestyramine group but the difference was not significant until postoperative week 4 (P < 0.001). CONCLUSIONS:Compared with placebo, cholestyramine ointment (15%) reduced postoperative pain at rest and on defecation, and consequently lowered the analgesic requirement after open hemorrhoidectomy.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Ala S,Eshghi F,Enayatifard R,Fazel P,Rezaei B,Hadianamrei Rdoi
10.1007/s00268-012-1895-3subject
Has Abstractpub_date
2013-03-01 00:00:00pages
657-62issue
3eissn
0364-2313issn
1432-2323journal_volume
37pub_type
杂志文章,随机对照试验abstract::Biliopancreatic diversion is a malabsorptive technique of bariatric surgery that has gained wide acceptance in the Western world. It is performed in one of two ways: In its classic form it consists of partial gastrectomy with a Roux-en-Y gastroenterostomy; in its duodenal switch form a vertical sleeve gastrectomy is c...
journal_title:World journal of surgery
pub_type: 社论,评审
doi:10.1007/s00268-004-7364-x
更新日期:2004-05-01 00:00:00
abstract::Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer. It can be diagnosed based on a clinical or pathologic basis. We evaluated the usefulness of (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) scans for diagnosing and staging IBC. We retrospectively reviewed t...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-003-6893-z
更新日期:2003-10-01 00:00:00
abstract::This study aimed to investigate the effects and timing of local anesthesia during laparoscopic surgery in terms of postoperative pain, nausea, and the need for opioids and antiemetics. This prospective study was carried out on 142 patients who underwent laparoscopic cholecystectomy. Peroperative local anesthesia was n...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-004-7350-3
更新日期:2004-08-01 00:00:00
abstract::The aim of this study was to investigate the epidemiologic characteristics and changing patterns of gallstone disease in Korea over a recent 20-year period. A total of 4020 gallstone patients who had undergone surgery at Seoul National University Hospital during 1981-2000 were analyzed according to periods: period I (...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-003-6879-x
更新日期:2004-02-01 00:00:00
abstract:INTRODUCTION:The quantification and analysis of adverse events is essential to benchmark surgical outcomes and establish a foundation for quality improvement interventions. We developed a hybrid electronic medical record (HEMR) system for the accurate collection and integration of data into a structured morbidity and m...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2766-x
更新日期:2015-01-01 00:00:00
abstract::Laparoscopic cholecystectomy is widely used and may be performed as an ambulatory procedure. We undertook a randomized comparison of the benefits of intraperitoneal pethidine compared with intramuscular pethidine for postoperative analgesia following laparoscopic cholecystectomy. A series of 100 consecutive American S...
journal_title:World journal of surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00268-002-6339-z
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Open surgical cricopharyngeal myotomy(CM) is considered standard of care for Zenker's diverticulum(ZD). Trans-oral CM has been described using a rigid stapling device for two decades; however, this remains problematic for severely kyphotic patients. This problem can be overcome with flexible endoscopy utiliz...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-016-3442-0
更新日期:2016-06-01 00:00:00
abstract::Squamous cell carcinoma of the anus (SCCA) is a rare disease in the average population but is an increasing concern among immunocompromised individuals, such as the HIV-seropositive. Coinfection with human papillomavirus (HPV) in this population is common. HPV infection is difficult to clear with a compromised immune ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-008-9835-y
更新日期:2009-04-01 00:00:00
abstract::Hereditary breast cancers, mainly due to BRCA1 and BRCA2 mutations, account for only 5-10% of this disease. The threshold for genetic testing is a 10% likelihood of detecting a mutation, as determined by validated models such as BOADICEA and Manchester Scoring System. A 90-95% reduction in breast cancer risk can be ac...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-018-04897-6
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Segmentectomy for radiologically pure solid tumors is still controversial because these tumors are more aggressive in malignancy than those with ground-glass opacity. This study aimed to determine the feasibility of intentional segmentectomy for pure solid small-sized lung cancer. METHODS:We retrospectively...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4514-0
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Surgeon performed ultrasound (US) is being increasingly embraced by breast surgeons worldwide as an integral part of patient assessment. The extent of its application within Australia and New Zealand is not well documented. The present study aimed to evaluate its current usage patterns and to determine suita...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-013-2076-8
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Fast-track surgery (FTS) is a promising program for surgical patients and has been applied to several surgical diseases. FTS is much superior to conventional perioperative care. Our aim was to evaluate and compare the safety and efficacy of FTS and conventional perioperative care for patients undergoing gast...
journal_title:World journal of surgery
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s00268-014-2690-0
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Although the low central venous pressure (LCVP) technique is used to decrease blood loss during liver resection, its efficacy and safety during transplant procedures are still debatable. Our study aimed to assess the effects of this technique and its clinical safety for recipients undergoing liver transplant...
journal_title:World journal of surgery
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00268-010-0544-y
更新日期:2010-08-01 00:00:00
abstract:INTRODUCTION:Difficulties with liver transplantation (LT)-related surgical techniques are great challenges for young surgeons. Thus, young surgeons need to undergo systematic preclinical training. However, an optimal training system for LT is still lacking. This study aims to evaluate the safety and educational value o...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05300-8
更新日期:2020-04-01 00:00:00
abstract::Nuss described a minimally invasive technique for correcting pectus excavatum in children. A curved stainless-steel bar is inserted behind the sternum through the chest cavity with the convex surface face down, then rotated 180 degrees to elevate the sternum and correct the deformity. The procedure gained wide accepta...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-002-6519-x
更新日期:2002-10-01 00:00:00
abstract::The role of liver transplantation in malignancy has been discussed, but controversially, over the past two decades. This is particularly true for hepatic metastases from neuroendocrine tumors, which have a wide variety of primary tumor localizations, morphologic types, functional activities, and clinical presentations...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-001-0016-5
更新日期:2001-06-01 00:00:00
abstract::Dissemination of new surgical knowledge, skills, and techniques across the wide spectrum of practicing surgeons in the community is often difficult and slow. This is even more problematic in countries such as Canada, where geographic distances separate a large portion of community surgeons from the large teaching cent...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9076-5
更新日期:2007-08-01 00:00:00
abstract::Gastric emptying times and symptoms were recorded in 18 patients after total gastrectomy and either a 15-cm J-pouch (n = 10) or a standard esophagojejunal anastomosis (n = 8). A solid test meal labeled with 99mTc was used to compare the emptying times. The postoperative symptoms and nutritional status were also assess...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01659117
更新日期:1993-09-01 00:00:00
abstract::We investigated the effect of radiofrequency ablation (RFA) of the liver on cell-mediated immunity in rats. Sprague-Dawley rats were divided into five groups: control group that did not have any procedure, a sham-operation group that underwent laparotomy, a lobectomy group that had left lateral lobectomy of the liver,...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-7728-x
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Acute appendicitis is the most common abdominal emergency in clinical surgery. This study was designed to compare the diagnostic value of the Pediatric Appendicitis Score (PAS) with that of the Alvarado score based on different time points in children with right lower quadrant (RLQ) abdominal pain. METHODS:...
journal_title:World journal of surgery
pub_type: 临床试验,杂志文章
doi:10.1007/s00268-011-1310-5
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:We investigated the implications of HER2 amplification in Asian women with small, node-negative breast cancer in low- and middle-income countries (LMCs). METHODS:We reviewed the charts patients treated between 1989 and 2009 with breast conservation therapy for node-negative breast cancers measuring ≤ 2 cm. ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1353-7
更新日期:2012-02-01 00:00:00
abstract::The most common causes of variceal bleeding are cirrhosis, schistosomiasis, and extrahepatic portal venous obstruction. The prognosis for an individual patient depends on the severity of the bleeding episode and the underlying liver function. Liver function is determined to a large extent by the underlying liver patho...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF00294397
更新日期:1994-03-01 00:00:00
abstract:INTRODUCTION:Urogenital dysfunction is a well recognized complication of rectal cancer surgery. The aim of this study was to assess the impact of autonomic nerve preservation (ANP) and lateral node dissection (LND) on male urogenital function after total mesorectal excision for lower rectal cancer. METHODS:We studied,...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-005-0050-9
更新日期:2006-06-01 00:00:00
abstract::In 141 patients with chronic pancreatitis and an inflammatory enlargement of the head of the pancreas, a duodenum-preserving resection of the head of the pancreas was performed within a 16-year period. The hospital mortality was 0.7%; the late mortality was 5%. Seventy-seven percent of the patients were completely fre...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF01670550
更新日期:1990-01-01 00:00:00
abstract::Familial Mediterranean fever (FMF) also known as hereditary polyserositis, is an inherited disorder commonly found in Armenians, Turks, Arabs, Balkans, and Jews originating from North African countries. The diagnosis of FMF is based on clinical findings and family history, as no specific diagnostic test is yet availab...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00348205
更新日期:1994-01-01 00:00:00
abstract::Some patients are prone to persisting intraabdominal infection regardless of initial eradication of the source of infection. Our aim was to characterize patients who had to undergo relaparotomy for persisting abdominal sepsis using simple clinical parameters and to define those patients who are susceptible to benefit ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s002689910007
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND STUDY AIMS:Post-lobectomy bronchopleural fistula is a rare complication of lung resection surgery, and proper management is crucial for the successful resolution. Most published papers deal with surgical treatment. We report our experience with a new interventional management, endobronchial naso-bronchia...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-016-3779-4
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Laparoscopic hepatectomy (LH) is established as a safe and feasible treatment option for liver tumors. However, whether the adoption of laparoscopic approach for malignant tumors, such as hepatocellular carcinoma (HCC), will compromise the long-term result is still unknown. This study was designed to evaluat...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-011-1212-6
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Existing data suggest a large burden of surgical conditions in low- and middle-income countries (LMICs). However, surgical care for children in LMICs remains poorly understood. Our goal was to define the hospital infrastructure, workforce, and delivery of surgical care for children across Somaliland and prov...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05079-8
更新日期:2019-11-01 00:00:00
abstract::Surgery is the main modality in the treatment of hepatic hydatid disease. In this report, a laparoscopic surgical method is described, and the results in the first 16 cases are presented. The method involves the use of an aspirator-grinder apparatus that achieves effective evacuation of viable cyst contents with the p...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00295914
更新日期:1995-09-01 00:00:00