Abstract：
BACKGROUND:Mutations in BRCA1 and BRCA2 confer an increased risk to breast and other cancers, but to date there have only been limited numbers of studies of BRCA1- and BRCA2-associated cancers among Asians. Malaysia is a multiracial country with three main races: Malays, Chinese, Indians. We determined whether tumor pathologic features and clinical features differ in patients with and without BRCA mutations in this Asian population. METHODS:We conducted a retrospective review of the medical records of 152 women with breast cancer who underwent genetic testing for BRCA mutations. The patients self-reported ethnicity, age at onset, and clinical stage at diagnosis and tumor pathology were reviewed. RESULTS:A total of 31 patients carried germline deleterious mutations (16 BRCA1, 15 BRCA2). We found that tumors in BRCA1 carriers were more likely to be estrogen receptor (ER)-negative and progesterone receptor (PR)-negative. HER2 was more likely to be negative in both BRCA1 and BRCA2 subjects compared with non-BRCA subjects. We found a strong association between triple-negative status and BRCA1 carriers. In addition, tumors in BRCA1 carriers were more likely to be higher grade than those in BRCA2 and non-BRCA carriers; but the difference was not statistically significant. CONCLUSIONS:These results suggest that tumors associated with BRCA1 mutations are distinct from those of BRCA2-associated and non-BRCA-associated breast cancers, and that the tumors associated with BRCA2 mutations are similar to the non-BRCA-associated breast cancers. Further studies are required to determine if the prognosis is different in each of these groups and the best management strategy for each group.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Yip CH,Taib NA,Choo WY,Rampal S,Thong MK,Teo SHdoi
10.1007/s00268-009-0146-8subject
Has Abstractpub_date
2009-10-01 00:00:00pages
2077-81issue
10eissn
0364-2313issn
1432-2323journal_volume
33pub_type
杂志文章abstract：:Thoracic and thoracoabdominal penetrating wounds are frequently encountered in urban medical centers in the United States. This study was undertaken to determine the clinical characteristics and in hospital outcome of these injuries. This was a longitudinal, nonblinded study using the established standard of care of p...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF03215862
更新日期：2001-09-01 00:00:00
abstract：:Bacterial biofilms develop on a number of living and inert surfaces within the urinary tract, producing chronic intractable infections. The role of exopolysaccharides in producing a variety of extracellular polymeric substances according to the infection site and bacterial species and the clinical features of the resu...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002680010203
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Continuous vagal intraoperative neuromonitoring (CIONM) of the recurrent laryngeal nerve (RLN) may reduce the risk of RLN lesions during high-risk endocrine neck surgery such as operation for large goiter potentially requiring transsternal surgery, advanced thyroid cancer, and recurrence. METHODS:Fifty-five...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3368-y
更新日期：2016-03-01 00:00:00
abstract：:This paper describes a model humanitarian mission to Guyana; it illustrates the value of excellent ongoing care in collaboration with local physicians and surgeons, cooperation with local government and medical officials, and frequent periodic follow-up missions (always to the same hospital, working with the same staf...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3049-x
更新日期：2015-08-01 00:00:00
abstract：:Malignant melanoma is notoriously resistant to chemotherapy. Standard single agents include dacarbazine and the nitrosoureas, but most series treating patients with metastatic melanoma report response rates of about 20%. Occasional patients, however, achieve long term remission, amounting to cure, after such treatment...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02071532
更新日期：1992-03-01 00:00:00
abstract：INTRODUCTION:Recently, more aggressive variants of so-called well-differentiated thyroid carcinomas have been identified such as the tall cell variant, columnar cell variant, diffuse sclerosing variant, insular carcinoma, and Hürthle cell (oncocytic, oxyphilic) carcinomas. METHODS:An evidence-based review was performe...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-006-0837-3
更新日期：2007-05-01 00:00:00
abstract：:We determined the relative value of the metastatic colorectal cancer doubling time as a predictor of recurrence and survival after hepatectomy in comparison with other established predictors. Consecutive patients who underwent hepatic resection ( n = 144) for colorectal cancer liver metastases were studied retrospecti...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-7088-3
更新日期：2004-03-01 00:00:00
abstract：:A randomized, double-blind multicenter trial was performed to compare the safety and efficacy of a new low-molecular-weight heparin (LMWH) (LU 47311, Clivarine) and standard unfractionated heparin for the prophylaxis of postoperative venous thromboembolism. Altogether 1351 patients scheduled to undergo abdominal surge...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/s002689900185
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:Splenic trauma is a common organ injury following blunt abdominal trauma. In order to establish the contemporary epidemiology of blunt splenic trauma in Scotland and to detect risk factors associated with patient outcomes, analysis of a multi-center database of trauma patients was performed. METHODS:The stu...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9218-9
更新日期：2007-11-01 00:00:00
abstract：:This study described the various components of access to care for resectable colorectal cancer, and correlated the timeliness of these components with patient satisfaction. With a prospective/retrospective cohort design, all patients undergoing surgical resection for primary colorectal cancer from 2/1/01 to 15/12/01, ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7955-1
更新日期：2005-11-01 00:00:00
abstract：:This paper summarizes the place of thoracic surgery in the management of hydatid disease. Although based on the author's 31-year personal experience, it draws on the experience of others where that of the author is deficient. The treatment of pulmonary, pleural, liver, and cardiac cysts is discussed. The importance of...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900631
更新日期：1999-11-01 00:00:00
abstract：BACKGROUND:The aim of the study was to compare the changes in health-related quality of life (QOL) after lung surgery between young and old patients. METHODS:We performed a prospective, population-based, cohort study to investigate health-related QOL before and 6 months after lung surgery. We used the validated instru...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0430-7
更新日期：2010-04-01 00:00:00
abstract：:Worldwide, traffic deaths are 500,000 per year and growing. Four nations, China, India, Russia, and the United States of America, have reached levels of 45,000-50,000 traffic deaths per year, although the nature of the problem is quite different in fully motorized countries from what it is in motorizing countries. In ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02104436
更新日期：1992-05-01 00:00:00
abstract：AIMS:Post-operative urinary retention (POUR) is a common cause of unplanned admission following day-case surgery and has negative effects on both patient and surgical institution. We aimed to prospectively evaluate potential risk factors for the development of POUR following day-case general surgical procedures. METHO...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4697-4
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Binding of the lectin Helix pomatia agglutinin (HPA) has been shown to be associated with poor prognosis in many human cancers, but not in thyroid cancer. The aims of the present study were to assess alteration in cellular glycosylation, detected by HPA binding, in thyroid tumors; to determine if such altere...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-011-1196-2
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:As more patients undergo diagnostic thyroid surgery, the development of posthemithyroidectomy hypothyroidism is becoming a major concern. We hypothesized that the preoperative thyrotropin (thyroid-stimulating hormone, TSH) level and ultrasonographically measured thyroid volume, both commonly available in thy...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-008-9717-3
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND AND AIM:Previous studies have shown that microscopic vessel invasion (MVI) occurs in hepatocellular carcinoma (HCC) with a treatment history due to its poorer malignant behavior in comparison with primary HCC. The aim of the present study was to determine the predictors of MVI and overall survival in HCC pat...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4658-y
更新日期：2018-11-01 00:00:00
abstract：:Most adrenal incidentalomas are nonfunctioning cortical adenomas that do not require surgery. Operative treatment is indicated if the incidentaloma has malignant features as seen during the radiologic workup, is hormonally active, or grows during follow-up. A conservative attitude is justified in asymptomatic patients...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689910095
更新日期：2000-05-01 00:00:00
abstract：:The appropriate role for additional radiotherapy in patients with resectable rectal cancer is not yet settled. Irradiation has been considered by surgeons and radiotherapists as superfluous since no effect on survival has been shown. However, numerous trials have demonstrated that peri-operative radiotherapy decreases...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF02066982
更新日期：1992-09-01 00:00:00
abstract：:A group of 105 consecutive patients with venographically proved major acute deep vein thrombosis (DVT) were randomized in an open prospective study to evaluate the comparative efficacy and safety of a fixed dose of subcutaneous low-molecular-weight heparin (LMWH) and warfarin for the prevention of recurrent venous thr...
journal_title：World journal of surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002689900081
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:This study is intended to ascertain if outcome of acute abdominal surgery among elderly patients with acute abdominal pain have improved. METHODS:Altogether 456 patients aged >65 years underwent emergency abdominal surgery between the years 2007 and 2009 in our hospital. After excluding emergency reoperatio...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-015-3207-1
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:A precise understanding of anastomotic recurrence (AR) permits efficient surveillance and treatment strategies. This study aimed to evaluate the clinicopathologic characteristics of patients with AR undergoing curative resection for colorectal cancer (CRC), compare colonic with rectal tumors and investigate ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3663-2
更新日期：2017-01-01 00:00:00
abstract：:Cost-benefit and cost-effectiveness analyses (CEAs) are only now beginning to be used by business, government, and policymakers to evaluate various medical treatments. The evolution of why CEAs are being demanded is reviewed. To date, a formal CEA of obesity treatments has not been published. This article outlines how...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900508
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:PDGFR-β is used as a stromal biomarker and is functional in mesenchymal cells of the tumor microenvironment. The significance of stromal PDGFR-β expression in non-small cell lung cancer (NSCLC) in patients undergoing preoperative chemo- or chemoradiotherapy had not been determined. METHODS:Patients with NSC...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4560-7
更新日期：2018-09-01 00:00:00
abstract：:The aim of this study was to investigate the epidemiologic characteristics and changing patterns of gallstone disease in Korea over a recent 20-year period. A total of 4020 gallstone patients who had undergone surgery at Seoul National University Hospital during 1981-2000 were analyzed according to periods: period I (...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-6879-x
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:Billions of people worldwide lack access to safe affordable surgery. Surgical missions and non-governmental organisations (NGO) are vital in meeting this need, but long-term outcomes are rarely reported. Mercy Ships is a surgical NGO, and we aimed to measure disability-free survival, impact and patient satis...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-016-3745-1
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Measurement of the parathyroid hormone (PTH) level following total thyroidectomy (TTx) may allow prediction of postoperative hypocalcemia. We present an algorithmic method of managing hypocalcemia pre-emptively, based on the PTH level 1 h after operation. MATERIALS AND METHODS:We examined 423 consecutive pa...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0348-0
更新日期：2010-03-01 00:00:00
abstract：:A marked change toward a more conservative approach in the treatment of abdominal trauma has been noted, especially during the last decade. This change in regimen was first seen in the handling of splenic trauma, initiated by pediatric surgeons. Later, the concept of conservative management was also introduced among a...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF01658672
更新日期：1990-07-01 00:00:00
abstract：:Primary hyperparathyroidism was investigated using the presence of basic fibroblast growth factor (bFGF) from the immunohistochemical viewpoint with an anti-bFGF antibody in hyperplastic parathyroid glands of patients with multiple endocrine neoplasia type I (MEN-I) and of patients with non-MEN. The results correspond...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00299109
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND:Acute colonic diverticulitis is a common clinical condition. Severity of the disease is based on clinical, laboratory, and radiological investigations and dictates the need for medical or surgical intervention. Recent clinical trials have improved the understanding of the natural history of the disease resul...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-016-3560-8
更新日期：2016-10-01 00:00:00
